27 results on '"Tabata, Kaori"'
Search Results
2. Induction of IGHV3-53 public antibodies with broadly neutralising activity against SARS-CoV-2 including Omicron subvariants in a Delta breakthrough infection case
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Ito, Jumpei, Misawa, Naoko, Plianchaisuk, Arnon, Guo, Ziyi, Hina, Alfredo, Jr., Uriu, Keiya, Usui, Kaoru, Saikruang, Wilaiporn, Lytras, Spyridon, Yoshimura, Ryo, Kawakubo, Shusuke, Nishimura, Luca, Kosugi, Yusuke, Fujita, Shigeru, Chen, Luo, Tolentino, Jarel Elgin M., Pan, Lin, Li, Wenye, Yo, Maximilian Stanley, Horinaka, Kio, Suganami, Mai, Strange, Adam P., Chiba, Mika, Iida, Keiko, Ohsumi, Naomi, Okumura, Kaho, Tanaka, Shiho, Ogawa, Eiko, Yasuda, Kyoko, Fukuda, Tsuki, Osujo, Rina, Fukuhara, Takasuke, Tamura, Tomokazu, Suzuki, Rigel, Suzuki, Saori, Ito, Hayato, Matsuno, Keita, Sawa, Hirofumi, Nao, Naganori, Tanaka, Shinya, Tsuda, Masumi, Wang, Lei, Oda, Yoshikata, Ferdous, Zannatul, Shishido, Kenji, Mizuma, Keita, Kojima, Isshu, Li, Jingshu, Tsubo, Tomoya, Tsujino, Shuhei, Nakagawa, So, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Nagata, Kayoko, Nomura, Ryosuke, Horisawa, Yoshihito, Tashiro, Yusuke, Kawai, Yugo, Takayama, Kazuo, Hashimoto, Rina, Deguchi, Sayaka, Watanabe, Yukio, Sakamoto, Ayaka, Yasuhara, Naoko, Suzuki, Tateki, Kimura, Kanako, Sasaki, Jiei, Nakajima, Yukari, Yajima, Hisano, Nakata, Yoshitaka, Futatsusako, Hiroki, Irie, Takashi, Kawabata, Ryoko, Tabata, Kaori, Nasser, Hesham, Shimizu, Ryo, Begum, MST Monira, Jonathan, Michael, Mugita, Yuka, Takahashi, Otowa, Ichihara, Kimiko, Motozono, Chihiro, Leong, Sharee, Saito, Akatsuki, Shofa, Maya, Shibatani, Yuki, Nishiuchi, Tomoko, Asakura, Hiroyuki, Zahradnik, Jiri, Andrikopoulos, Prokopios, Padilla-Blanco, Miguel, Konar, Aditi, Kuwata, Takeo, Kaku, Yu, Biswas, Shashwata, Matsumoto, Kaho, Shimizu, Mikiko, Kawanami, Yoko, Uraki, Ryuta, Okazaki, Kyo, Minami, Rumi, Nagasaki, Yoji, Nagashima, Mami, Yoshida, Isao, Sadamasu, Kenji, Yoshimura, Kazuhisa, Ito, Mutsumi, Kiso, Maki, Yamayoshi, Seiya, Imai, Masaki, Ikeda, Terumasa, Sato, Kei, Toyoda, Mako, Ueno, Takamasa, Inoue, Takako, Tanaka, Yasuhito, Kimura, Kanako Tarakado, Hashiguchi, Takao, Sugita, Yukihiko, Noda, Takeshi, Morioka, Hiroshi, Kawaoka, Yoshihiro, and Matsushita, Shuzo
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- 2024
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3. Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236
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Sawa, Hirofumi, Mizuma, Keita, Li, Jingshu, Mimura, Yume, Ohari, Yuma, Tsubo, Tomoya, Ferdous, Zannatul, Shishido, Kenji, Mohri, Hiromi, Iida, Miki, Tsujino, Shuhei, Misawa, Naoko, Usui, Kaoru, Saikruang, Wilaiporn, Lytras, Spyridon, Kawakubo, Shusuke, Nishumura, Luca, Mendoza Tolentino, Jarel Elgin, Li, Wenye, Yo, Maximilian Stanley, Horinaka, Kio, Suganami, Mai, Chiba, Mika, Yoshimura, Ryo, Yasuda, Kyoko, Iida, Keiko, Strange, Adam Patrick, Ohsumi, Naomi, Tanaka, Shiho, Ogawa, Eiko, Okumura, Kaho, Fukuda, Tsuki, Osujo, Rina, Yoshida, Isao, Nakagawa, So, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Nagata, Kayoko, Nomura, Ryosuke, Horisawa, Yoshihito, Tashiro, Yusuke, Kawai, Yugo, Nakata, Yoshitaka, Futatsusako, Hiroki, Sakamoto, Ayaka, Yasuhara, Naoko, Hashiguchi, Takao, Suzuki, Tateki, Kimura, Kanako, Sasaki, Jiei, Nakajima, Yukari, Yajima, Hisano, Irie, Takashi, Kawabata, Ryoko, Sasaki-Tabata, Kaori, Shimizu, Ryo, Monira Begum, M.S.T., Jonathan, Michael, Mugita, Yuka, Leong, Sharee, Takahashi, Otowa, Ichihara, Kimiko, Ueno, Takamasa, Motozono, Chihiro, Toyoda, Mako, Saito, Akatsuki, Kosaka, Anon, Kawano, Miki, Matsubara, Natsumi, Nishiuchi, Tomoko, Zahradnik, Jiri, Andrikopoulos, Prokopios, Padilla-Blanco, Miguel, Konar, Aditi, Fujita, Shigeru, Plianchaisuk, Arnon, Deguchi, Sayaka, Ito, Hayato, Nao, Naganori, Wang, Lei, Nasser, Hesham, Tamura, Tomokazu, Kimura, Izumi, Kashima, Yukie, Suzuki, Rigel, Suzuki, Saori, Kida, Izumi, Tsuda, Masumi, Oda, Yoshitaka, Hashimoto, Rina, Watanabe, Yukio, Uriu, Keiya, Yamasoba, Daichi, Guo, Ziyi, Hinay, Alfredo A., Jr., Kosugi, Yusuke, Chen, Luo, Pan, Lin, Kaku, Yu, Chu, Hin, Donati, Flora, Temmam, Sarah, Eloit, Marc, Yamamoto, Yuki, Nagamoto, Tetsuharu, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Suzuki, Yutaka, Ito, Jumpei, Ikeda, Terumasa, Tanaka, Shinya, Matsuno, Keita, Fukuhara, Takasuke, Takayama, Kazuo, and Sato, Kei
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- 2024
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- View/download PDF
4. Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant
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Ito, Jumpei, Suzuki, Rigel, Uriu, Keiya, Itakura, Yukari, Zahradnik, Jiri, Kimura, Kanako Terakado, Deguchi, Sayaka, Wang, Lei, Lytras, Spyros, Tamura, Tomokazu, Kida, Izumi, Nasser, Hesham, Shofa, Maya, Begum, Mst Monira, Tsuda, Masumi, Oda, Yoshitaka, Suzuki, Tateki, Sasaki, Jiei, Sasaki-Tabata, Kaori, Fujita, Shigeru, Yoshimatsu, Kumiko, Ito, Hayato, Nao, Naganori, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Yamamoto, Yuki, Nagamoto, Tetsuharu, Kuramochi, Jin, Schreiber, Gideon, Saito, Akatsuki, Matsuno, Keita, Takayama, Kazuo, Hashiguchi, Takao, Tanaka, Shinya, Fukuhara, Takasuke, Ikeda, Terumasa, and Sato, Kei
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- 2023
- Full Text
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5. Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
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Tamura, Tomokazu, Ito, Jumpei, Uriu, Keiya, Zahradnik, Jiri, Kida, Izumi, Anraku, Yuki, Nasser, Hesham, Shofa, Maya, Oda, Yoshitaka, Lytras, Spyros, Nao, Naganori, Itakura, Yukari, Deguchi, Sayaka, Suzuki, Rigel, Wang, Lei, Begum, MST Monira, Kita, Shunsuke, Yajima, Hisano, Sasaki, Jiei, Sasaki-Tabata, Kaori, Shimizu, Ryo, Tsuda, Masumi, Kosugi, Yusuke, Fujita, Shigeru, Pan, Lin, Sauter, Daniel, Yoshimatsu, Kumiko, Suzuki, Saori, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Yamamoto, Yuki, Nagamoto, Tetsuharu, Schreiber, Gideon, Maenaka, Katsumi, Hashiguchi, Takao, Ikeda, Terumasa, Fukuhara, Takasuke, Saito, Akatsuki, Tanaka, Shinya, Matsuno, Keita, Takayama, Kazuo, and Sato, Kei
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- 2023
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6. Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant
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Saito, Akatsuki, Tamura, Tomokazu, Zahradnik, Jiri, Deguchi, Sayaka, Tabata, Koshiro, Anraku, Yuki, Kimura, Izumi, Ito, Jumpei, Yamasoba, Daichi, Nasser, Hesham, Toyoda, Mako, Nagata, Kayoko, Uriu, Keiya, Kosugi, Yusuke, Fujita, Shigeru, Shofa, Maya, Monira Begum, MST, Shimizu, Ryo, Oda, Yoshitaka, Suzuki, Rigel, Ito, Hayato, Nao, Naganori, Wang, Lei, Tsuda, Masumi, Yoshimatsu, Kumiko, Kuramochi, Jin, Kita, Shunsuke, Sasaki-Tabata, Kaori, Fukuhara, Hideo, Maenaka, Katsumi, Yamamoto, Yuki, Nagamoto, Tetsuharu, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Ueno, Takamasa, Schreiber, Gideon, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Sawa, Hirofumi, Irie, Takashi, Hashiguchi, Takao, Takayama, Kazuo, Matsuno, Keita, Tanaka, Shinya, Ikeda, Terumasa, Fukuhara, Takasuke, and Sato, Kei
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- 2022
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7. A morphometric analysis of the osteocyte canaliculus using applied automatic semantic segmentation by machine learning
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Tabata, Kaori, Hashimoto, Mana, Takahashi, Haruka, Wang, Ziyi, Nagaoka, Noriyuki, Hara, Toru, and Kamioka, Hiroshi
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- 2022
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8. A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues.
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Zenmyo, Naoki, Matsumoto, Yuya, Yasuda, Akihiro, Uchinomiya, Shohei, Shindo, Naoya, Sasaki-Tabata, Kaori, Mishiro-Sato, Emi, Tamura, Tomonori, Hamachi, Itaru, and Ojida, Akio
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- 2025
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9. Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236
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Fujita, Shigeru, primary, Plianchaisuk, Arnon, additional, Deguchi, Sayaka, additional, Ito, Hayato, additional, Nao, Naganori, additional, Wang, Lei, additional, Nasser, Hesham, additional, Tamura, Tomokazu, additional, Kimura, Izumi, additional, Kashima, Yukie, additional, Suzuki, Rigel, additional, Suzuki, Saori, additional, Kida, Izumi, additional, Tsuda, Masumi, additional, Oda, Yoshitaka, additional, Hashimoto, Rina, additional, Watanabe, Yukio, additional, Uriu, Keiya, additional, Yamasoba, Daichi, additional, Guo, Ziyi, additional, Hinay, Alfredo A., additional, Kosugi, Yusuke, additional, Chen, Luo, additional, Pan, Lin, additional, Kaku, Yu, additional, Chu, Hin, additional, Donati, Flora, additional, Temmam, Sarah, additional, Eloit, Marc, additional, Yamamoto, Yuki, additional, Nagamoto, Tetsuharu, additional, Asakura, Hiroyuki, additional, Nagashima, Mami, additional, Sadamasu, Kenji, additional, Yoshimura, Kazuhisa, additional, Suzuki, Yutaka, additional, Sawa, Hirofumi, additional, Mizuma, Keita, additional, Li, Jingshu, additional, Mimura, Yume, additional, Ohari, Yuma, additional, Tsubo, Tomoya, additional, Ferdous, Zannatul, additional, Shishido, Kenji, additional, Mohri, Hiromi, additional, Iida, Miki, additional, Tsujino, Shuhei, additional, Misawa, Naoko, additional, Usui, Kaoru, additional, Saikruang, Wilaiporn, additional, Lytras, Spyridon, additional, Kawakubo, Shusuke, additional, Nishumura, Luca, additional, Mendoza Tolentino, Jarel Elgin, additional, Li, Wenye, additional, Yo, Maximilian Stanley, additional, Horinaka, Kio, additional, Suganami, Mai, additional, Chiba, Mika, additional, Yoshimura, Ryo, additional, Yasuda, Kyoko, additional, Iida, Keiko, additional, Strange, Adam Patrick, additional, Ohsumi, Naomi, additional, Tanaka, Shiho, additional, Ogawa, Eiko, additional, Okumura, Kaho, additional, Fukuda, Tsuki, additional, Osujo, Rina, additional, Yoshida, Isao, additional, Nakagawa, So, additional, Takaori-Kondo, Akifumi, additional, Shirakawa, Kotaro, additional, Nagata, Kayoko, additional, Nomura, Ryosuke, additional, Horisawa, Yoshihito, additional, Tashiro, Yusuke, additional, Kawai, Yugo, additional, Nakata, Yoshitaka, additional, Futatsusako, Hiroki, additional, Sakamoto, Ayaka, additional, Yasuhara, Naoko, additional, Hashiguchi, Takao, additional, Suzuki, Tateki, additional, Kimura, Kanako, additional, Sasaki, Jiei, additional, Nakajima, Yukari, additional, Yajima, Hisano, additional, Irie, Takashi, additional, Kawabata, Ryoko, additional, Sasaki-Tabata, Kaori, additional, Shimizu, Ryo, additional, Monira Begum, M.S.T., additional, Jonathan, Michael, additional, Mugita, Yuka, additional, Leong, Sharee, additional, Takahashi, Otowa, additional, Ichihara, Kimiko, additional, Ueno, Takamasa, additional, Motozono, Chihiro, additional, Toyoda, Mako, additional, Saito, Akatsuki, additional, Kosaka, Anon, additional, Kawano, Miki, additional, Matsubara, Natsumi, additional, Nishiuchi, Tomoko, additional, Zahradnik, Jiri, additional, Andrikopoulos, Prokopios, additional, Padilla-Blanco, Miguel, additional, Konar, Aditi, additional, Ito, Jumpei, additional, Ikeda, Terumasa, additional, Tanaka, Shinya, additional, Matsuno, Keita, additional, Fukuhara, Takasuke, additional, Takayama, Kazuo, additional, and Sato, Kei, additional
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- 2024
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10. Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant
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50632098, 10759509, Tamura, Tomokazu, Irie, Takashi, Deguchi, Sayaka, Yajima, Hisano, Tsuda, Masumi, Nasser, Hesham, Mizuma, Keita, Plianchaisuk, Arnon, Suzuki, Saori, Uriu, Keiya, Begum, Mst Monira, Shimizu, Ryo, Jonathan, Michael, Suzuki, Rigel, Kondo, Takashi, Ito, Hayato, Kamiyama, Akifumi, Yoshimatsu, Kumiko, Shofa, Maya, Hashimoto, Rina, Anraku, Yuki, Kimura, Kanako Terakado, Kita, Shunsuke, Sasaki, Jiei, Sasaki-Tabata, Kaori, Maenaka, Katsumi, Nao, Naganori, Wang, Lei, Oda, Yoshitaka, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ikeda, Terumasa, Saito, Akatsuki, Matsuno, Keita, Ito, Jumpei, Tanaka, Shinya, Sato, Kei, Hashiguchi, Takao, Takayama, Kazuo, Fukuhara, Takasuke, 50632098, 10759509, Tamura, Tomokazu, Irie, Takashi, Deguchi, Sayaka, Yajima, Hisano, Tsuda, Masumi, Nasser, Hesham, Mizuma, Keita, Plianchaisuk, Arnon, Suzuki, Saori, Uriu, Keiya, Begum, Mst Monira, Shimizu, Ryo, Jonathan, Michael, Suzuki, Rigel, Kondo, Takashi, Ito, Hayato, Kamiyama, Akifumi, Yoshimatsu, Kumiko, Shofa, Maya, Hashimoto, Rina, Anraku, Yuki, Kimura, Kanako Terakado, Kita, Shunsuke, Sasaki, Jiei, Sasaki-Tabata, Kaori, Maenaka, Katsumi, Nao, Naganori, Wang, Lei, Oda, Yoshitaka, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ikeda, Terumasa, Saito, Akatsuki, Matsuno, Keita, Ito, Jumpei, Tanaka, Shinya, Sato, Kei, Hashiguchi, Takao, Takayama, Kazuo, and Fukuhara, Takasuke
- Abstract
Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring the S486P spike (S) mutation, subsequent to the acquisition of a nonsense mutation in ORF8. Neutralization assays showed similar abilities of immune escape between XBB.1.5 and XBB.1. We determine the structural basis for the interaction between human ACE2 and the S protein of XBB.1.5, showing similar overall structures between the S proteins of XBB.1 and XBB.1.5. We provide the intrinsic pathogenicity of XBB.1 and XBB.1.5 in hamsters. Importantly, we find that the ORF8 nonsense mutation of XBB.1.5 resulted in impairment of MHC suppression. In vivo experiments using recombinant viruses reveal that the XBB.1.5 mutations are involved with reduced virulence of XBB.1.5. Together, our study identifies the two viral functions defined the difference between XBB.1 and XBB.1.5.
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- 2024
11. Design and synthesis of an environment-sensitive 3-methyleneisoindolin-1-one fluorophore for labeling DNA-interacting proteins.
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Aso, Mariko, Ohta, Chiyoe, Liu, Yixuan, Sasaki-Tabata, Kaori, Abe-Sadamatsu, Yukiko, Gatanaga, Chiemi, Wang, Yichun, Pei, Yang, Gao, Guosheng, Katayama, Tsutomu, Taniguchi, Yosuke, and Sasaki, Shigeki
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- 2024
- Full Text
- View/download PDF
12. Gibberellin DELLA signaling targets the retromer complex to redirect protein trafficking to the plasma membrane
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Salanenka, Yuliya, Verstraeten, Inge, Löfke, Christian, Tabata, Kaori, Naramoto, Satoshi, Glanc, Matouš, and Friml, Jiří
- Published
- 2018
13. Expanding the Chemistry of Dihaloacetamides as Tunable Electrophiles for Reversible Covalent Targeting of Cysteines
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Yamane, Daiki, primary, Tetsukawa, Ryo, additional, Zenmyo, Naoki, additional, Tabata, Kaori, additional, Yoshida, Yuya, additional, Matsunaga, Naoya, additional, Shindo, Naoya, additional, and Ojida, Akio, additional
- Published
- 2023
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14. Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant
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80833334, 10759509, 50632098, Ito, Jumpei, Suzuki, Rigel, Uriu, Keiya, Itakura, Yukari, Zahradnik, Jiri, Kimura, Kanako Terakado, Deguchi, Sayaka, Wang, Lei, Lytras, Spyros, Tamura, Tomokazu, Kida, Izumi, Nasser, Hesham, Shofa, Maya, Begum, Mst Monira, Tsuda, Masumi, Oda, Yoshitaka, Suzuki, Tateki, Sasaki, Jiei, Sasaki-Tabata, Kaori, Fujita, Shigeru, Yoshimatsu, Kumiko, Ito, Hayato, Nao, Naganori, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Yamamoto, Yuki, Nagamoto, Tetsuharu, Kuramochi, Jin, Schreiber, Gideon, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito, Akatsuki, Matsuno, Keita, Takayama, Kazuo, Hashiguchi, Takao, Tanaka, Shinya, Fukuhara, Takasuke, Ikeda, Terumasa, Sato, Kei, 80833334, 10759509, 50632098, Ito, Jumpei, Suzuki, Rigel, Uriu, Keiya, Itakura, Yukari, Zahradnik, Jiri, Kimura, Kanako Terakado, Deguchi, Sayaka, Wang, Lei, Lytras, Spyros, Tamura, Tomokazu, Kida, Izumi, Nasser, Hesham, Shofa, Maya, Begum, Mst Monira, Tsuda, Masumi, Oda, Yoshitaka, Suzuki, Tateki, Sasaki, Jiei, Sasaki-Tabata, Kaori, Fujita, Shigeru, Yoshimatsu, Kumiko, Ito, Hayato, Nao, Naganori, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Yamamoto, Yuki, Nagamoto, Tetsuharu, Kuramochi, Jin, Schreiber, Gideon, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito, Akatsuki, Matsuno, Keita, Takayama, Kazuo, Hashiguchi, Takao, Tanaka, Shinya, Fukuhara, Takasuke, Ikeda, Terumasa, and Sato, Kei
- Abstract
In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These variants convergently acquired amino acid substitutions at critical residues in the spike protein, including residues R346, K444, L452, N460, and F486. Here, we characterize the convergent evolution of Omicron subvariants and the properties of one recent lineage of concern, BQ.1.1. Our phylogenetic analysis suggests that these five substitutions are recurrently acquired, particularly in younger Omicron lineages. Epidemic dynamics modelling suggests that the five substitutions increase viral fitness, and a large proportion of the fitness variation within Omicron lineages can be explained by these substitutions. Compared to BA.5, BQ.1.1 evades breakthrough BA.2 and BA.5 infection sera more efficiently, as demonstrated by neutralization assays. The pathogenicity of BQ.1.1 in hamsters is lower than that of BA.5. Our multiscale investigations illuminate the evolutionary rules governing the convergent evolution for known Omicron lineages as of 2022.
- Published
- 2023
15. Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants
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50632098, 10759509, Tamura, Tomokazu, Ito, Jumpei, Uriu, Keiya, Zahradnik, Jiri, Kida, Izumi, Anraku, Yuki, Nasser, Hesham, Shofa, Maya, Oda, Yoshitaka, Lytras, Spyros, Nao, Naganori, Itakura, Yukari, Deguchi, Sayaka, Suzuki, Rigel, Wang, Lei, Begum, MST Monira, Kita, Shunsuke, Yajima, Hisano, Sasaki, Jiei, Sasaki-Tabata, Kaori, Shimizu, Ryo, Tsuda, Masumi, Kosugi, Yusuke, Fujita, Shigeru, Pan, Lin, Sauter, Daniel, Yoshimatsu, Kumiko, Suzuki, Saori, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Yamamoto, Yuki, Nagamoto, Tetsuharu, Schreiber, Gideon, Maenaka, Katsumi, The Genotype to Phenotype Japan (G2P-Japan), Hashiguchi, Takao, Ikeda, Terumasa, Fukuhara, Takasuke, Saito, Akatsuki, Tanaka, Shinya, Matsuno, Keita, Takayama, Kazuo, Sato, Kei, 50632098, 10759509, Tamura, Tomokazu, Ito, Jumpei, Uriu, Keiya, Zahradnik, Jiri, Kida, Izumi, Anraku, Yuki, Nasser, Hesham, Shofa, Maya, Oda, Yoshitaka, Lytras, Spyros, Nao, Naganori, Itakura, Yukari, Deguchi, Sayaka, Suzuki, Rigel, Wang, Lei, Begum, MST Monira, Kita, Shunsuke, Yajima, Hisano, Sasaki, Jiei, Sasaki-Tabata, Kaori, Shimizu, Ryo, Tsuda, Masumi, Kosugi, Yusuke, Fujita, Shigeru, Pan, Lin, Sauter, Daniel, Yoshimatsu, Kumiko, Suzuki, Saori, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Yamamoto, Yuki, Nagamoto, Tetsuharu, Schreiber, Gideon, Maenaka, Katsumi, The Genotype to Phenotype Japan (G2P-Japan), Hashiguchi, Takao, Ikeda, Terumasa, Fukuhara, Takasuke, Saito, Akatsuki, Tanaka, Shinya, Matsuno, Keita, Takayama, Kazuo, and Sato, Kei
- Abstract
In late 2022, SARS-CoV-2 Omicron subvariants have become highly diversified, and XBB is spreading rapidly around the world. Our phylogenetic analyses suggested that XBB emerged through the recombination of two cocirculating BA.2 lineages, BJ.1 and BM.1.1.1 (a progeny of BA.2.75), during the summer of 2022. XBB.1 is the variant most profoundly resistant to BA.2/5 breakthrough infection sera to date and is more fusogenic than BA.2.75. The recombination breakpoint is located in the receptor-binding domain of spike, and each region of the recombinant spike confers immune evasion and increases fusogenicity. We further provide the structural basis for the interaction between XBB.1 spike and human ACE2. Finally, the intrinsic pathogenicity of XBB.1 in male hamsters is comparable to or even lower than that of BA.2.75. Our multiscale investigation provides evidence suggesting that XBB is the first observed SARS-CoV-2 variant to increase its fitness through recombination rather than substitutions.
- Published
- 2023
16. Monitoring fusion kinetics of viral and target cell membranes in living cells using a SARS-CoV-2 spike-protein-mediated membrane fusion assay
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Nasser, Hesham, primary, Shimizu, Ryo, additional, Ito, Jumpei, additional, Saito, Akatsuki, additional, Sato, Kei, additional, Ikeda, Terumasa, additional, Matsuno, Keita, additional, Nao, Naganori, additional, Sawa, Hirofumi, additional, Kishimoto, Mai, additional, Tanaka, Shinya, additional, Tsuda, Masumi, additional, Wang, Lei, additional, Oda, Yoshikata, additional, Kato, Marie, additional, Ferdous, Zannatul, additional, Mouri, Hiromi, additional, Shishido, Kenji, additional, Fukuhara, Takasuke, additional, Tamura, Tomokazu, additional, Suzuki, Rigel, additional, Ito, Hayato, additional, Yamasoba, Daichi, additional, Kimura, Izumi, additional, Misawa, Naoko, additional, Uriu, Keiya, additional, Kosugi, Yusuke, additional, Fujita, Shigeru, additional, Suganami, Mai, additional, Chiba, Mika, additional, Yoshimura, Ryo, additional, Nakagawa, So, additional, Wu, Jiaqi, additional, Takaori-Kondo, Akifumi, additional, Shirakawa, Kotaro, additional, Nagata, Kayoko, additional, Kazuma, Yasuhiro, additional, Nomura, Ryosuke, additional, Horisawa, Yoshihito, additional, Tashiro, Yusuke, additional, Kawai, Yugo, additional, Irie, Takashi, additional, Kawabata, Ryoko, additional, Begum, MST Monira, additional, Takahashi, Otowa, additional, Ichihara, Kimiko, additional, Ueno, Takamasa, additional, Motozono, Chihiro, additional, Toyoda, Mako, additional, Tanaka, Yuri L., additional, Butlertanaka, Erika P., additional, Shofa, Maya, additional, Takayama, Kazuo, additional, Hashimoto, Rina, additional, Deguchi, Sayaka, additional, Hashiguchi, Takao, additional, Suzuki, Tateki, additional, Kimura, Kanako, additional, Sasaki, Jiei, additional, Nakajima, Yukari, additional, and Tabata, Kaori, additional
- Published
- 2022
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17. Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5
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Kimura, Izumi, primary, Yamasoba, Daichi, additional, Tamura, Tomokazu, additional, Nao, Naganori, additional, Suzuki, Tateki, additional, Oda, Yoshitaka, additional, Mitoma, Shuya, additional, Ito, Jumpei, additional, Nasser, Hesham, additional, Zahradnik, Jiri, additional, Uriu, Keiya, additional, Fujita, Shigeru, additional, Kosugi, Yusuke, additional, Wang, Lei, additional, Tsuda, Masumi, additional, Kishimoto, Mai, additional, Ito, Hayato, additional, Suzuki, Rigel, additional, Shimizu, Ryo, additional, Begum, MST Monira, additional, Yoshimatsu, Kumiko, additional, Kimura, Kanako Terakado, additional, Sasaki, Jiei, additional, Sasaki-Tabata, Kaori, additional, Yamamoto, Yuki, additional, Nagamoto, Tetsuharu, additional, Kanamune, Jun, additional, Kobiyama, Kouji, additional, Asakura, Hiroyuki, additional, Nagashima, Mami, additional, Sadamasu, Kenji, additional, Yoshimura, Kazuhisa, additional, Shirakawa, Kotaro, additional, Takaori-Kondo, Akifumi, additional, Kuramochi, Jin, additional, Schreiber, Gideon, additional, Ishii, Ken J., additional, Hashiguchi, Takao, additional, Ikeda, Terumasa, additional, Saito, Akatsuki, additional, Fukuhara, Takasuke, additional, Tanaka, Shinya, additional, Matsuno, Keita, additional, and Sato, Kei, additional
- Published
- 2022
- Full Text
- View/download PDF
18. Application of machine learning for the semantic segmentation and morphological analysis of osteocyte processes and canaliculi
- Author
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Tabata, Kaori, Hashimoto, Mana, Nagaoka, Noriyuki, Hara, Toru, and Kamioka, Hiroshi
- Published
- 2022
- Full Text
- View/download PDF
19. Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant
- Author
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80728270, 50632098, 10759509, Saito, Akatsuki, Tamura, Tomokazu, Zahradnik, Jiri, Deguchi, Sayaka, Tabata, Koshiro, Anraku, Yuki, Kimura, Izumi, Ito, Jumpei, Yamasoba, Daichi, Nasser, Hesham, Toyoda, Mako, Nagata, Kayoko, Uriu, Keiya, Kosugi, Yusuke, Fujita, Shigeru, Shofa, Maya, Monira Begum, M.S.T., Shimizu, Ryo, Oda, Yoshitaka, Suzuki, Rigel, Ito, Hayato, Nao, Naganori, Wang, Lei, Tsuda, Masumi, Yoshimatsu, Kumiko, Kuramochi, Jin, Kita, Shunsuke, Sasaki-Tabata, Kaori, Fukuhara, Hideo, Maenaka, Katsumi, Yamamoto, Yuki, Nagamoto, Tetsuharu, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Ueno, Takamasa, Schreiber, Gideon, Takaori-Kondo, Akifumi, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Shirakawa, Kotaro, Sawa, Hirofumi, Irie, Takashi, Hashiguchi, Takao, Takayama, Kazuo, Matsuno, Keita, Tanaka, Shinya, Ikeda, Terumasa, Fukuhara, Takasuke, Sato, Kei, 80728270, 50632098, 10759509, Saito, Akatsuki, Tamura, Tomokazu, Zahradnik, Jiri, Deguchi, Sayaka, Tabata, Koshiro, Anraku, Yuki, Kimura, Izumi, Ito, Jumpei, Yamasoba, Daichi, Nasser, Hesham, Toyoda, Mako, Nagata, Kayoko, Uriu, Keiya, Kosugi, Yusuke, Fujita, Shigeru, Shofa, Maya, Monira Begum, M.S.T., Shimizu, Ryo, Oda, Yoshitaka, Suzuki, Rigel, Ito, Hayato, Nao, Naganori, Wang, Lei, Tsuda, Masumi, Yoshimatsu, Kumiko, Kuramochi, Jin, Kita, Shunsuke, Sasaki-Tabata, Kaori, Fukuhara, Hideo, Maenaka, Katsumi, Yamamoto, Yuki, Nagamoto, Tetsuharu, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Ueno, Takamasa, Schreiber, Gideon, Takaori-Kondo, Akifumi, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Shirakawa, Kotaro, Sawa, Hirofumi, Irie, Takashi, Hashiguchi, Takao, Takayama, Kazuo, Matsuno, Keita, Tanaka, Shinya, Ikeda, Terumasa, Fukuhara, Takasuke, and Sato, Kei
- Abstract
The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5.
- Published
- 2022
20. Enzyme Immunoassay for Salvinorin A (a Main Component in Salvia divinorum)
- Author
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Tanaka, Hiroyuki, primary, Paudel, Madan Kumar, additional, Shirota, Osamu, additional, Sasaki-Tabata, Kaori, additional, Sekita, Setsuko, additional, and Morimoto, Satoshi, additional
- Published
- 2016
- Full Text
- View/download PDF
21. List of Contributors
- Author
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Abdalla, Renata Rigacci, primary, Abekawa, Tomohiro, additional, Adamczyk, Przemysław, additional, Adams, Wendy, additional, Addy, Peter H., additional, Ago, Yukio, additional, Álvaro-Bartolomé, María, additional, Andellini, Martina, additional, Andrzejewski, Matthew E., additional, Angarita, Gustavo A., additional, Angoa-Pérez, Mariana, additional, Anneken, John H., additional, Antunes, Luís, additional, Ardakani, Yalda Hosseinzadeh, additional, Aydin, Mustafa, additional, Badri, Nima, additional, Bajpai, Ram C., additional, Barbosa, Daniel José, additional, Barrós-Loscertales, Alfonso, additional, Basu, Debasish, additional, Becker, Benjamin, additional, Beckley, Jacob T., additional, Bermejo, Pablo García, additional, Berro, Laís F., additional, Blaker, Amanda L., additional, Bodoki, Ede, additional, Borowiak, Krzysztof, additional, Bowen, Scott E., additional, Broderick, Patricia A., additional, Brogaard, Berit, additional, Brolese, Giovana, additional, Brunt, T.M., additional, Buchborn, T., additional, Butelman, Eduardo R., additional, Caetano, Raul, additional, Campos, Sónia, additional, Canavan, Sofija V., additional, Capela, João Paulo, additional, Carta, Manolo, additional, Carvalho, Félix, additional, Carvelli, Lucia, additional, Catlow, Briony J., additional, Chang, Young-Tae, additional, Chaturvedi, Himanshu K., additional, Chilachava, Lela, additional, Choodum, Aree, additional, Clough, Shannon J., additional, Coelho-Santos, Vanessa, additional, Coimbra, Ana Maria, additional, Collins, Stuart A., additional, Cormand, Bru, additional, Dahan, Albert, additional, Dakwar, Elias, additional, Dávalos E., Antonio, additional, de Jong, Cor, additional, de Lourdes Bastos, Maria, additional, Del Bigio, Marc R., additional, Dembińska, Teresa, additional, Deveci, Ugur, additional, Dieterich, D.C., additional, Dijkstra, Boukje, additional, Dluzen, Dean E., additional, Dubocovich, Margarita L., additional, Esperón, Carlos García, additional, Fang, Chun-Kai, additional, Farnia, Vahid, additional, Félix, Luís, additional, Fernàndez-Castillo, Noelia, additional, Flack, Daniel, additional, Frauger, Elisabeth, additional, Frohlich, Joel, additional, Fukushiro, Daniela F., additional, García, Daniel A., additional, Julia García-Fuster, M., additional, García-Sevilla, Jesús A., additional, Garland, Eric L., additional, Gatzia, Dimitria Electra, additional, Gelazonia, Lia, additional, Ghosh, Abhishek, additional, Gigengack, Roy, additional, Golshani, Senobar, additional, Gonçalves, Joana, additional, González-Maeso, Javier, additional, Gorman, Ingmar, additional, Grandy, David K., additional, Grecksch, G., additional, Greer, Alissa M., additional, Gudelsky, Gary A., additional, Guillot, Casey, additional, Gulley, Joshua M., additional, Hagino, Yoko, additional, Hallock, Robert M., additional, Hankosky, Emily R., additional, Hanks, James B., additional, Hart, Carl, additional, Hasselmann, H.W.W., additional, Hida, Hirotake, additional, Hodges, Sarah E., additional, Holder, Nicole, additional, Hollais, André W., additional, Höllt, V., additional, Horacek, Jiri, additional, Howard, Matthew O., additional, Howells, Fleur Margaret, additional, Hsin-Hsien Yeh, Skye, additional, Huang, Mei, additional, Hutchinson, Anthony J., additional, Hwang, Jeng-Jong, additional, Ikeda, Kazutaka, additional, Iudicello, Jennifer E., additional, Jalloh, Ahmad, additional, Jamali, Bardia, additional, Japaridze, Nadezhda, additional, Jodo, Eiichi, additional, Joordens, Chantele, additional, Kalayasiri, Rasmon, additional, Kamal, Rama, additional, Kamegaya, Etsuko, additional, Katayama, Tadahiro, additional, Keasling, Adam W., additional, Kikura-Hanajiri, Ruri, additional, Kirkpatrick, Matthew, additional, Kiss, Béla, additional, Kočárová, Rita, additional, Kokane, Saurabh S., additional, Kreek, Mary Jeanne, additional, Kufahl, Peter R., additional, Kuhn, Donald M., additional, Kumazawa, Takeshi, additional, Kusljic, Snezana, additional, Łabuz, Krzysztof, additional, Lapeyre-Mestre, Maryse, additional, Laranjeira, Ronaldo Ramos, additional, Lawrence, Andrew J., additional, Lee, Byung Dae, additional, Leitão, Ricardo Alexandre, additional, Leung, L. Stan, additional, Li, Chiang-Shan R., additional, Li, Meng, additional, Lin, Qing, additional, Loghin, Felicia, additional, López-Cancio M., Elena, additional, Lyke, Jennifer, additional, Lyvers, Michael, additional, Macdonald, Scott, additional, Madruga, Clarice Sandi, additional, Maes, Michael, additional, Maher, Timothy J., additional, Ma, Jingyi, additional, Mandyam, Chitra D., additional, Mardones, Claudia, additional, Martin, Gina, additional, Massaro, Luciana, additional, Matsuda, Toshio, additional, McMaster, M.T.B., additional, Melloni, Richard H., additional, Meltzer, Herbert Y., additional, Micallef, Joëlle, additional, Mironidou-Tzouveleki, Maria, additional, Mishina, Masayoshi, additional, Mitsuhiro, Sandro, additional, Montag, Christian, additional, Moore, Elisabeth, additional, Morgan, Erin E., additional, Morgan, Peter T., additional, Morimoto, Satoshi, additional, Morrison, Thomas R., additional, Moszczynska, Anna, additional, Mouri, Akihiro, additional, Napolitano, Antonio, additional, Neugebauer, Nichole M., additional, NicDaeid, Niamh, additional, Nichols, Charles D., additional, Nizama-Valladolid, Martin, additional, Noda, Yukihiro, additional, Northrop, Nicole A., additional, Olive, M. Foster, additional, Ostrow, Rory D., additional, Oudejans, Linda C.J., additional, Palenicek, Tomas, additional, Pandey, Arvind, additional, Papp, Mariusz, additional, Passos, Ioannis D., additional, Paudel, Madan Kumar, additional, Perillo, Maria A., additional, Perry, Christina J., additional, Petronijević, Nataša, additional, Phattanarudee, Siripan, additional, Pinsky, Ilana, additional, Pochkhidze, Nino, additional, Pop, Anca, additional, Possa, Marianne, additional, Potocka-Banaś, Barbara, additional, Quednow, Boris B., additional, Radonjić, Nevena V., additional, Rajagopal, Lakshmi, additional, Ribasés, Marta, additional, Ricci, Lesley A., additional, Rosales, Carola Vergara, additional, Rouini, Mohammad-Reza, additional, Sanchez-Ramos, Juan, additional, Santos-Baldaia, Renan, additional, Sarkar, Siddharth, additional, Sasaki-Tabata, Kaori, additional, Sato, Naomi, additional, Sato, Tomonori, additional, Sawada, Wakako, additional, Schuch, Silvia Bassani, additional, Sekita, Setsuko, additional, Serrano, Eduardo Alvear, additional, Sheikholeslami, Behjat, additional, Shirota, Osamu, additional, Silva, Ana Paula, additional, Simola, Nicola, additional, Simon, Derek P., additional, Sora, Ichiro, additional, Sordi, Anne Orgler, additional, Spring, Mitchell G., additional, Stebelska, Katarzyna, additional, Sugimura, Haruhiko, additional, Suzuki, Yoshiaki, additional, Takuma, Kazuhiro, additional, Tanaka, Hiroyuki, additional, Torkamanian, Meshkat, additional, Towiwat, Pasarapa, additional, Turina, Anahí V., additional, Tyls, Filip, additional, van Amsterdam, J.G.C., additional, van den Brink, W., additional, van den Buuse, Maarten, additional, Van Horn, John Darrell, additional, van Noorden, Martijn, additional, van Velzen, Monique, additional, Venâncio, Carlos, additional, von Baer, Dietrich, additional, von Diemen, Lisia, additional, Walter, Martin, additional, Wang, Fang, additional, Weber, Erica, additional, Winkler, Petr, additional, Woods, Steven Paul, additional, Woodward, John J., additional, Wu, Chun-Fu, additional, Wuo-Silva, Raphael, additional, Xu, Wang, additional, Yamamoto, Bryan K., additional, Yamamoto, Hideko, additional, Yamamoto, Toshifumi, additional, Yang, Jing-Yu, additional, Zhai, Duanting, additional, Zhvania, Mzia, additional, and Zjawiony, Jordan K., additional
- Published
- 2016
- Full Text
- View/download PDF
22. Characteristics of the SARS-CoV-2 omicron HK.3 variant harbouring the FLip substitution
- Author
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Misawa, Naoko, Guo, Ziyi, Tolentino, Jarel Elgin M, Fujita, Shigeru, Pan, Lin, Suganami, Mai, Chiba, Mika, Yoshimura, Ryo, Yasuda, Kyoko, Iida, Keiko, Ohsumi, Naomi, Strange, Adam P, Tanaka, Shiho, Fukuhara, Takasuke, Tamura, Tomokazu, Suzuki, Rigel, Suzuki, Saori, Ito, Hayato, Matsuno, Keita, Sawa, Hirofumi, Nao, Naganori, Tanaka, Shinya, Tsuda, Masumi, Wang, Lei, Oda, Yoshikata, Ferdous, Zannatul, Shishido, Kenji, Nakagawa, So, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Nagata, Kayoko, Nomura, Ryosuke, Horisawa, Yoshihito, Tashiro, Yusuke, Kawai, Yugo, Takayama, Kazuo, Hashimoto, Rina, Deguchi, Sayaka, Watanabe, Yukio, Sakamoto, Ayaka, Yasuhara, Naoko, Hashiguchi, Takao, Suzuki, Tateki, Kimura, Kanako, Sasaki, Jiei, Nakajima, Yukari, Yajima, Hisano, Irie, Takashi, Kawabata, Ryoko, Tabata, Kaori, Ikeda, Terumasa, Nasser, Hesham, Shimizu, Ryo, Begum, MST Monira, Jonathan, Michael, Mugita, Yuka, Takahashi, Otowa, Ichihara, Kimiko, Ueno, Takamasa, Motozono, Chihiro, Toyoda, Mako, Saito, Akatsuki, Shofa, Maya, Shibatani, Yuki, Nishiuchi, Tomoko, Kosugi, Yusuke, Plianchaisuk, Arnon, Putri, Olivia, Uriu, Keiya, Kaku, Yu, Hinay, Alfredo A, Jr, Chen, Luo, Kuramochi, Jin, Sadamasu, Kenji, Yoshimura, Kazuhisa, Asakura, Hiroyuki, Nagashima, Mami, Ito, Jumpei, and Sato, Kei
- Published
- 2024
- Full Text
- View/download PDF
23. Monitoring fusion kinetics of viral and target cell membranes in living cells using a SARS-CoV-2 spike-protein-mediated membrane fusion assay
- Author
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Matsuno, Keita, Nao, Naganori, Sawa, Hirofumi, Kishimoto, Mai, Tanaka, Shinya, Tsuda, Masumi, Wang, Lei, Oda, Yoshikata, Kato, Marie, Ferdous, Zannatul, Mouri, Hiromi, Shishido, Kenji, Fukuhara, Takasuke, Tamura, Tomokazu, Suzuki, Rigel, Ito, Hayato, Yamasoba, Daichi, Kimura, Izumi, Misawa, Naoko, Uriu, Keiya, Kosugi, Yusuke, Fujita, Shigeru, Suganami, Mai, Chiba, Mika, Yoshimura, Ryo, Nakagawa, So, Wu, Jiaqi, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Nagata, Kayoko, Kazuma, Yasuhiro, Nomura, Ryosuke, Horisawa, Yoshihito, Tashiro, Yusuke, Kawai, Yugo, Irie, Takashi, Kawabata, Ryoko, Begum, MST Monira, Takahashi, Otowa, Ichihara, Kimiko, Ueno, Takamasa, Motozono, Chihiro, Toyoda, Mako, Tanaka, Yuri L., Butlertanaka, Erika P., Shofa, Maya, Takayama, Kazuo, Hashimoto, Rina, Deguchi, Sayaka, Hashiguchi, Takao, Suzuki, Tateki, Kimura, Kanako, Sasaki, Jiei, Nakajima, Yukari, Tabata, Kaori, Nasser, Hesham, Shimizu, Ryo, Ito, Jumpei, Saito, Akatsuki, Sato, Kei, and Ikeda, Terumasa
- Published
- 2022
- Full Text
- View/download PDF
24. Chapter 70 - Enzyme Immunoassay for Salvinorin A (a Main Component in Salvia divinorum)
- Author
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Tanaka, Hiroyuki, Paudel, Madan Kumar, Shirota, Osamu, Sasaki-Tabata, Kaori, Sekita, Setsuko, and Morimoto, Satoshi
- Published
- 2016
- Full Text
- View/download PDF
25. Determination of cell fate in skeletal muscle following BMP gene transfer by in vivo electroporation
- Author
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Kawai, Mariko, primary, Ohmori, Yu-Ki, additional, Nishino, Mai, additional, Yoshida, Masayo, additional, Tabata, Kaori, additional, Hirota, Do-Saku, additional, Ryu-Mon, Ayako, additional, Yamamoto, Hiromitsu, additional, Sonobe, Junya, additional, Kataoka, Yo-Hei, additional, Shiotsu, Noriko, additional, Ikegame, Mika, additional, Maruyama, Hiroki, additional, Yamamoto, Toshio, additional, Bessho, Kazuhisa, additional, and Ohura, Kiyoshi, additional
- Published
- 2017
- Full Text
- View/download PDF
26. Three-dimensional morphometry of collagen fibrils in membranous bone
- Author
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Hashimoto, Mana, primary, Nagaoka, Noriyuki, additional, Tabata, Kaori, additional, Tanaka, Tomoyo, additional, Osumi, Ryuta, additional, Odagaki, Naoya, additional, Hara, Toru, additional, and Kamioka, Hiroshi, additional
- Published
- 2017
- Full Text
- View/download PDF
27. Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant.
- Author
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Tsujino S, Deguchi S, Nomai T, Padilla-Blanco M, Plianchaisuk A, Wang L, Begum MM, Uriu K, Mizuma K, Nao N, Kojima I, Tsubo T, Li J, Matsumura Y, Nagao M, Oda Y, Tsuda M, Anraku Y, Kita S, Yajima H, Sasaki-Tabata K, Guo Z, Hinay AA Jr, Yoshimatsu K, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Nasser H, Jonathan M, Putri O, Kim Y, Chen L, Suzuki R, Tamura T, Maenaka K, Irie T, Matsuno K, Tanaka S, Ito J, Ikeda T, Takayama K, Zahradnik J, Hashiguchi T, Fukuhara T, and Sato K
- Subjects
- Humans, Animals, Antiviral Agents pharmacology, Chlorocebus aethiops, Vero Cells, Cryoelectron Microscopy, Mice, SARS-CoV-2 genetics, Phylogeny, COVID-19 virology, Spike Glycoprotein, Coronavirus genetics, Spike Glycoprotein, Coronavirus chemistry
- Abstract
In middle to late 2023, a sublineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron XBB, EG.5.1 (a progeny of XBB.1.9.2), is spreading rapidly around the world. We performed multiscale investigations, including phylogenetic analysis, epidemic dynamics modeling, infection experiments using pseudoviruses, clinical isolates, and recombinant viruses in cell cultures and experimental animals, and the use of human sera and antiviral compounds, to reveal the virological features of the newly emerging EG.5.1 variant. Our phylogenetic analysis and epidemic dynamics modeling suggested that two hallmark substitutions of EG.5.1, S:F456L and ORF9b:I5T are critical to its increased viral fitness. Experimental investigations on the growth kinetics, sensitivity to clinically available antivirals, fusogenicity, and pathogenicity of EG.5.1 suggested that the virological features of EG.5.1 are comparable to those of XBB.1.5. However, cryo-electron microscopy revealed structural differences between the spike proteins of EG.5.1 and XBB.1.5. We further assessed the impact of ORF9b:I5T on viral features, but it was almost negligible in our experimental setup. Our multiscale investigations provide knowledge for understanding the evolutionary traits of newly emerging pathogenic viruses, including EG.5.1, in the human population., (© 2024 The Author(s). Microbiology and Immunology published by The Societies and John Wiley & Sons Australia, Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
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