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27 results on '"Uharek, Lutz"'

1. Efficacy and safety of keratinocyte growth factor (palifermin) for prevention of oral mucositis in TBI-based allogeneic hematopoietic stem cell transplantation

Author

Schmidt, Volker, Niederwieser, Dietger, Schenk, Thomas, Behre, Gerhard, Klink, Anne, Pfrepper, Christian, Hinke, Axel, Beelen, Dietrich W., Junghanss, Christian, Uharek, Lutz, Krüger, William H., Hochhaus, Andreas, Sayer, Herbert G., and for the East German Study Group for Hematology and Oncology (OSHO)

Published
2018
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5. Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte Infusions—A Retrospective Multicenter Analysis from the German Cooperative Transplant Study Group

Author

Schroeder, Thomas, Rachlis, Elena, Bug, Gesine, Stelljes, Matthias, Klein, Stefan, Steckel, Nina Kristin, Wolf, Dominik, Ringhoffer, Mark, Czibere, Akos, Nachtkamp, Kathrin, Dienst, Ariane, Kondakci, Mustafa, Stadler, Michael, Platzbecker, Uwe, Uharek, Lutz, Luft, Thomas, Fenk, Roland, Germing, Ulrich, Bornhäuser, Martin, Kröger, Nicolaus, Beelen, Dietrich W., Haas, Rainer, and Kobbe, Guido

Published
2015
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7. Impact of telomere length on the outcome of allogeneic stem cell transplantation for poor‐risk chronic lymphocytic leukaemia: results from the GCLLSG CLL3X trial

Author

Scheffold, Annika, Jebaraj, Billy Michael Chelliah, Jaramillo, Sonia, Tausch, Eugen, Steinbrecher, Daniela, Hahn, Michael, Böttcher, Sebastian, Ritgen, Matthias, Bunjes, Donald, Zeis, Matthias, Stadler, Michael, Uharek, Lutz, Scheid, Christoph, Hegenbart, Ute, Hallek, Michael, Kneba, Michael, Schmitz, Norbert, Döhner, Hartmut, Dreger, Peter, and Stilgenbauer, Stephan

Published
2017
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12. Treatment of Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse after Allogeneic Stem Cell Transplantation with Azacitidine and Donor Lymphocyte Infusions—A Retrospective Multicenter Analysis from the German Cooperative Transplant Study Group

Author

Schroeder, Thomas, Rachlis, Elena, Bug, Gesine, Stelljes, Matthias, Klein, Stefan, Steckel, Nina Kristin, Wolf, Dominik, Ringhoffer, Mark, Czibere, Akos, Nachtkamp, Kathrin, Dienst, Ariane, Kondakci, Mustafa, Stadler, Michael, Platzbecker, Uwe, Uharek, Lutz, Luft, Thomas, Fenk, Roland, Germing, Ulrich, Bornhäuser, Martin, Kröger, Nicolaus, Beelen, Dietrich W., Haas, Rainer, and Kobbe, Guido

Abstract

To expand the current knowledge about azacitidine (Aza) and donor lymphocyte infusions (DLI) as salvage therapy for relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and to identify predictors for response and survival, we retrospectively analyzed data of 154 patients with acute myeloid leukemia (AML, n = 124), myelodysplastic (MDS, n = 28), or myeloproliferative syndrome (n = 2). All patients received a median number of 4 courses of Aza (range, 4 to 14) and DLI were administered to 105 patients (68%; median number of DLI, 2; range, 1 to 7). Complete and partial remission rates were 27% and 6%, respectively, resulting in an overall response rate of 33%. Multivariate analysis identified molecular-only relapse (hazard ratio [HR], 9.4; 95% confidence interval [CI], 2.0 to 43.5; P = .004) and diagnosis of MDS (HR, 4.1; 95% CI, 1.4 to 12.2; P = .011) as predictors for complete remission. Overall survival (OS) at 2 years was 29% ± 4%. Molecular-only relapse (HR, .14; 95% CI, .03 to .59; P = .007), diagnosis of MDS (HR, .33; 95% CI, .16 to .67; P = .002), and bone marrow blasts <13% (HR, .54; 95% CI, .32 to .91; P = .021) were associated with better OS. Accordingly, 2-year OS rate was higher in MDS patients (66% ± 10%, P = .001) and correlated with disease burden in patients with AML. In summary, Aza and DLI is an effective and well-tolerated treatment option for patients with relapse after allo-HSCT, in particular those with MDS or AML and low disease burden. The latter finding emphasizes the importance of stringent disease monitoring and early intervention.

Published
2024
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13. Safety and Efficacy of Donor T Cells Engineered with Herpes Simplex Virus Thymidine-Kinase Suicide Gene (TK Cells) Given after T-Cell Depleted (TCD) Haploidentical Hematopoietic Transplantation (Haplo-HSCT): Results of a 14-Year Follow-Up in 45 Patients

Author

Ciceri, Fabio, primary, Bonini, Chiara, additional, Labopin, Myriam, additional, Oliveira, Giacomo, additional, Nagler, Arnon, additional, Yannaki, Evangelia, additional, Stanghellini, Maria Teresa Lupo, additional, Bondanza, Attilio, additional, Greco, Raffaella, additional, Olavarria, Eduardo, additional, Weissinger, Eva, additional, Stadler, Michael, additional, Bunjes, Donald, additional, Niederwieser, Dietger, additional, Uharek, Lutz, additional, Bethge, Wolfgang, additional, DiPersio, John, additional, Pecora, Andrew L., additional, Donato, Michele, additional, Colombi, Scialini, additional, Lambiase, Antonio, additional, Bordignon, Claudio, additional, and Mohty, Mohamad, additional

Published
2017
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14. Impact of Immune Reconstitution (IR) and Graft-Versus-Host Disease (GvHD) on Clinical Outcomes after Treatment with Donor T Cells Transduced to Express the Herpes Simplex Virus Thymidine-Kinase Suicide Gene (TK cells) in Acute Leukemia Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplantation (HSCT)

Author

Ciceri, Fabio, primary, Bonini, Chiara, additional, Nagler, Arnon, additional, Yannaki, Evangelia, additional, Lupo Stanghellini, Maria Teresa, additional, Bondanza, Attilio, additional, Greco, Raffaella, additional, Olovarria, Eduardo, additional, Mischak-Weissinger, Eva M., additional, Stadler, Michael, additional, Bunjes, Donald w., additional, Niederwieser, Dietger, additional, Uharek, Lutz, additional, Betghe, Wolfgang, additional, DiPersio, John F, additional, Donato, Michele L., additional, Pecora, Andrew L., additional, Colombi, Scialini, additional, Lambiase, Antonio, additional, and Bordignon, Claudio, additional

Published
2016
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15. Impact of telomere length on the outcome of allogeneic stem cell transplantation for poor-risk chronic lymphocytic leukaemia: results from the GCLLSG CLL3X trial

Author

Scheffold, Annika, primary, Jebaraj, Billy Michael Chelliah, additional, Jaramillo, Sonia, additional, Tausch, Eugen, additional, Steinbrecher, Daniela, additional, Hahn, Michael, additional, Böttcher, Sebastian, additional, Ritgen, Matthias, additional, Bunjes, Donald, additional, Zeis, Matthias, additional, Stadler, Michael, additional, Uharek, Lutz, additional, Scheid, Christoph, additional, Hegenbart, Ute, additional, Hallek, Michael, additional, Kneba, Michael, additional, Schmitz, Norbert, additional, Döhner, Hartmut, additional, Dreger, Peter, additional, and Stilgenbauer, Stephan, additional

Published
2016
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16. Prospective evaluation of the Septi FAST multiplex real-time PCR assay for surveillance and diagnosis of infections in haematological patients after allogeneic stem cell transplantation compared to routine microbiological assays and an in-house real-time PCR method

Author

Elges, Sandra, Arnold, Renate, Liesenfeld, Oliver, Kofla, Grzegorz, Mikolajewska, Agata, Schwartz, Stefan, Uharek, Lutz, and Ruhnke, Markus

Subjects
DIAGNOSTIC use of polymerase chain reaction, POLYMERIZATION reactors, HEMATOLOGIC malignancies, GENETICS of staphylococcus aureus infections, GENETICS of bacterial diseases, GENETICS
Abstract

We prospectively evaluated a multiplex real-time PCR assay (SeptiFast, SF) in a cohort of patients undergoing allo- BMT in comparison to an in-house PCR method ( IH- PCR). Overall 847 blood samples (mean 8 samples/patient) from 104 patients with haematological malignancies were analysed. The majority of patients had acute leukaemia (62%) with a mean age of 52 years (54% female). Pathogens could be detected in 91 of 847 (11%) samples by SF compared to 38 of 205 (18.5%) samples by BC, and 57 of 847 (6.7%) samples by IH- PCR. Coagulase-negative staphylococci (n=41 in SF, n=29 in BC) were the most frequently detected bacteria followed by Escherichia coli (n=9 in SF, n=6 in BC). Candida albicans (n=17 in SF, n=0 in BC, n=24 in IH- PCR) was the most frequently detected fungal pathogen. SF gave positive results in 5% of samples during surveillance vs in 26% of samples during fever episodes. Overall, the majority of blood samples gave negative results in both PCR methods resulting in 93% overall agreement resulting in a negative predictive value of 0.96 (95% CI: 0.95-0.97), and a positive predictive value of 0.10 (95% CI: −0.01 to 0.21). SeptiFast appeared to be superior over BC and the IH- PCR method. [ABSTRACT FROM AUTHOR]

Published
2017
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18. Haploidentical Second Allogeneic Hematopoietic Stem Cell Transplantation for the Treatment of Acute Leukemia Relapse after First Allo-HSCT: A Retrospective Registry Analysis of 60 Patients on Behalf of the German Cooperative Transplant Group

Author

Christopeit, Maximilian, primary, Tischer, Johanna, additional, Bornhäuser, Martin, additional, Uharek, Lutz, additional, Pfrepper, Christian, additional, Behre, Gerhard, additional, Niederwieser, Dietger, additional, Kröger, Nicolaus, additional, Rösler, Wolf, additional, Klein, Stefan A., additional, Beelen, Dietrich, additional, Hausmann, Andreas, additional, Bethge, Wolfgang, additional, and Schmid, Christoph, additional

Published
2014
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19. Minimum Tolerable Interval of Radioimmunotherapy and Autologous Stem Cell Transplantation after High-Dose Chemotherapy for Relapsed or Refractory Aggressive B Cell Non-Hodgkin-Lymphoma Provides Excellent Disease Control

Author

Hasenkamp, Justin, primary, Hess, Georg, additional, Hertenstein, Bernd, additional, Witzens-Harig, Mathias, additional, Uharek, Lutz, additional, Gramatzki, Martin, additional, Pfreundschuh, Michael, additional, Wulf, Gerald, additional, Truemper, Lorenz H., additional, Schmitz, Norbert, additional, and Glass, Bertram, additional

Published
2014
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20. Long Term Follow up of the AML97-Study for Patients with AML Older Than 60 Years: A Study of the East German Hematology and Oncology Study Group (OSHO)

Author

Kahl, Christoph, primary, Krahl, Rainer, additional, Al-Ali, Haifa Kathrin, additional, Sayer, Herbert G., additional, Schulze, Antje, additional, Herold, Michael, additional, Hänel, Mathias, additional, Scholl, Sebastian, additional, Hochhaus, Andreas, additional, Uharek, Lutz, additional, Maschmeyer, Georg, additional, Hähling, Detlev, additional, Junghanss, Christian, additional, Peter, Norma, additional, Kämpfe, Dietrich, additional, Kettner, Erika, additional, Heinicke, Thomas, additional, Fischer, Thomas, additional, Kreibich, Ute, additional, Wolf, Hans-Heinrich, additional, and Niederwieser, Dietger, additional

Published
2014
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21. Telomere Lenght and Outcome of Allogeneic Stem Cell Transplantation for Poor Risk Chronic Lymphocytic Leukemia: Results from the GCLLSG CLL3X Trial

Author

Scheffold, Annika, primary, Jebaraj, Billy Michael Chelliah, additional, Tausch, Eugen, additional, Boettcher, Sebastian, additional, Ritgen, Matthias, additional, Bunjes, Donald, additional, Zeis, Matthias, additional, Stadler, Michael, additional, Uharek, Lutz, additional, Scheid, Christof, additional, Hegenbart, Ute, additional, Hallek, Michael, additional, Kneba, Michael, additional, Schmitz, Norbert, additional, Doehner, Hartmut, additional, Dreger, Peter, additional, and Stilgenbauer, Stephan, additional

Published
2014
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22. Infusion of Donor Lymphocytes Genetically Engineered to Express the Herpes Simplex Virus Thymidine Kinase (HSV-TK) Suicide Gene after Haploidentical Hematopoietic Stem Cell Transplantation (HSCT): Preliminary Efficacy Data from the Randomized TK008 Study

Author

Bonini, Chiara, primary, Ciceri, Fabio, additional, Nagler, Arnon, additional, Yannaki, Evangelia, additional, Lupo Stanghellini, Maria Teresa, additional, Oliveira, Giacomo, additional, Bondanza, Attilio, additional, Vago, Luca, additional, Greco, Raffaella, additional, Peccatori, Jacopo, additional, Olovarria, Eduardo, additional, Mischak-Weissinger, Eva M., additional, Stadler, Michael, additional, Bunjes, Donald, additional, Niederwieser, Dietger, additional, Uharek, Lutz, additional, Bethge, Wolfgang A., additional, DiPersio, John F., additional, Donato, Michele L, additional, Pecora, Andrew L, additional, Colombi, Scialini, additional, Antonio, Lambiase, additional, and Bordignon, Claudio, additional

Published
2014
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23. Randomised, double-blind, placebo-controlled trial of oral budesonide for prophylaxis of acute intestinal graft-versus-host disease after allogeneic stem cell transplantation (PROGAST)

Author

Schmelz, Renate, primary, Bornhäuser, Martin, additional, Schetelig, Johannes, additional, Kiani, Alexander, additional, Platzbecker, Uwe, additional, Schwanebeck, Uta, additional, Grählert, Xina, additional, Uharek, Lutz, additional, Aust, Daniela, additional, Baretton, Gustavo, additional, Schwerdtfeger, Rainer, additional, Hampe, Jochen, additional, Greinwald, Roland, additional, Mueller, Ralph, additional, Ehninger, Gerhard, additional, and Miehlke, Stephan, additional

Published
2014
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24. Single-Nucleotide Polymorphisms Within the Thrombomodulin Gene (THBD) Predict Mortality in Patients With Graft-Versus-Host Disease

Author

Rachakonda, Sivaramakrishna P., primary, Penack, Olaf, additional, Dietrich, Sascha, additional, Blau, Olga, additional, Blau, Igor Wolfgang, additional, Radujkovic, Aleksandar, additional, Isermann, Berend, additional, Ho, Anthony D., additional, Uharek, Lutz, additional, Dreger, Peter, additional, Kumar, Rajiv, additional, and Luft, Thomas, additional

Published
2014
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25. 29 - Safety and Efficacy of Donor T Cells Engineered with Herpes Simplex Virus Thymidine-Kinase Suicide Gene (TK Cells) Given after T-Cell Depleted (TCD) Haploidentical Hematopoietic Transplantation (Haplo-HSCT): Results of a 14-Year Follow-Up in 45 Patients

Author

Ciceri, Fabio, Bonini, Chiara, Labopin, Myriam, Oliveira, Giacomo, Nagler, Arnon, Yannaki, Evangelia, Stanghellini, Maria Teresa Lupo, Bondanza, Attilio, Greco, Raffaella, Olavarria, Eduardo, Weissinger, Eva, Stadler, Michael, Bunjes, Donald, Niederwieser, Dietger, Uharek, Lutz, Bethge, Wolfgang, DiPersio, John, Pecora, Andrew L., Donato, Michele, Colombi, Scialini, Lambiase, Antonio, Bordignon, Claudio, and Mohty, Mohamad

Published
2017
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26. Tracking in vivo dynamics of NK cells transferred in patients undergoing stem cell transplantation.

Author

Killig, Monica, Friedrichs, Birte, Meisig, Johannes, Gentilini, Chiara, Blüthgen, Nils, Loddenkemper, Christoph, Labopin, Myriam, Basara, Nadezda, Pfrepper, Christian, Niederwieser, Dietger W., Uharek, Lutz, and Romagnani, Chiara

Abstract

Haploidentical stem cell transplantation (haploSCT) offers an alternative treatment option for advanced leukemia patients lacking a HLA-compatible donor. Transfer of NK cells represents a promising therapeutic option in combination with SCT, as NK cells can promote graft versus leukemia with low risk of GVH disease. In this study, we show results from a phase I/II trial in which 24 acute myeloid leukemia patients underwent haploSCT in combination with early transfer of unmodified NK cells and observed a promising 2-year overall survival rate of 37%. By performing immunomonitoring and subsequent principal component analysis, we tracked donor NK-cell dynamics in the patients and distinguished between NK cells reconstituting from CD34+ precursors, giving rise over time to a continuum of multiple differentiation stages, and adoptively transferred NK cells. Transferred NK cells displayed a mature phenotype and proliferated in vivo during the early days after haploSCT even in the absence of exogenous IL-2 administration. Moreover, we identified the NK-cell phenotype associated with in vivo expansion. Thus, our study indicates a promising path for adoptive transfer of unmodified NK cells in the treatment of high-risk acute myeloid leukemia. [ABSTRACT FROM AUTHOR]

Published
2014
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27. Management of Chronic Myeloid Leukemia Patients Resistant to Tyrosine Kinase Inhibitors Treatment.

Author

Wieczorek A and Uharek L

Abstract

Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with a characteristic chromosomal translocation called the Philadelphia chromosome. This oncogene is generated by the fusion of breakpoint cluster region (BCR) and Abelson leukemia virus (ABL) genes and encodes a novel fusion gene translating into a protein with constitutive tyrosine kinase activity. The discovery and introduction of tyrosine kinase inhibitors (TKIs) irreversibly changed the landscape of CML treatment, leading to dramatic improvement in long-term survival rates. The majority of patients with CML in the chronic phase have a life expectancy comparable with that of healthy age-matched individuals. Although an enormous therapeutic improvement has been accomplished, there are still some unresolved issues in the treatment of patients with CML. One of the most important problems is based on the fact that TKIs can efficiently target proliferating mature cells but do not eradicate leukemic stem cells, allowing persistence of the malignant clone. Owing to the resistance mechanisms arising during the course of the disease, treatment with most of the approved BCR-ABL1 TKIs may become ineffective in a proportion of patients. This article highlights the different molecular mechanisms of acquired resistance being developed during treatment with TKIs as well as the pharmacological strategies to overcome it. Moreover, it gives an overview of novel drugs and therapies that are aiming in overcoming drug resistance, loss of response, and kinase domain mutations.

Published
2016
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