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In the cooperative multi-agent pathfinding and motion planning, given a unique start position and a unique goal position for each agent, all agents are able to pursue their own goals without colliding with each other. To aim at realizing the collision-free motion of the agents within the tractable time, this work proposes a polynomial-time solver, called the HBD-AOI, hybridizing centralized and decentralized schemes. Firstly, an algorithm of centralized pathfinding is utilized to plan the optimal paths of all agents. Afterwards, each of the agents updates the local motion pattern to tracks its own planned waypoints with the obstacle avoidance in a decentralized manner. Furthermore, to resolve unavoidable egoistic conflicts occurring in the decentralized scheme, a centralized intervener with the route replanning is invoked to coach the involved agents to abort the existing deadlocks. Bounded by an amount of time, the performances of the proposed and benchmarked algorithms are simulated on the same instance, from the evaluated testbeds that consists of various maps and scenarios. In the simulations, it is proved that this work outperforms other benchmarked algorithms for all presented instances in the term of the success rate. The experimental results are also demonstrated to verify the feasibility of the proposed methodology.

To evaluate the molluscicidal effect of 50% wettable powder of niclosamide ethanolamine salt (WPNES) againstFollowing immersion with 50% WPNES at concentrations of 2 mg/L and 1 mg/L outdoors in winter, the 3-day corrected snail mortality rates were 98.0% and 76.0% on the soil surface, and the 7-day corrected snail mortality rate was both 100.0%. Following immersion with 50% WPNES at concentrations of 2 mg/L and 1 mg/L outdoors in winter, the 7-day corrected snail mortality rates were 95.5% and 85.6% 2 cm below the soil layer, 66.0% and 6.4% 5 cm below the soil layer. However, the 7-day snail mortality rate swere comparable between the 50% WPNES treatment group (at 2 mg/L and 1 mg/L) and controls 10 cm below the soil layer (bothImmersion of 50% WPNES at a concentration of 2 mg/L for 7 days presents a high molluscicidal efficacy against

An annular venturi injector (AVI) was proposed to form an intermittent flow structure in airlift pump for a good pump performance. Experiments were conducted to investigate the performance of the airlift pump with this AVI by comparing with pump performance with traditional injectors, at a series of air flow rates . It was found that airlift pump with AVI had higher flow rates of output liquid and particle, than those with the traditional injectors. This AVI promoted the gas core to collapse and formed an intermittent flow structure in rising pipe. For this intermittent structure, its slug length, firstly increased to a maximal value with increasing gas flow rate and then remained stable even under a high gas flow rate, while its slug frequency decreased with gas flow rate and then remained to a minimal value under a high gas flow rate.

Double-peaked distribution (DPD) of particle flux has only been observed on the outer divertor target in electron cyclotron resonance heating deuterium plasmas with [Formula: see text] toward the X-point in the HL-2A tokamak using high spatiotemporal Langmuir probe arrays. The experimental results demonstrate that the formation of the DPD is mainly due to the enhanced poloidal [Formula: see text] drift flow stimulated in the divertor region, which is dependent on the plasma density, heating power, and divertor structure. The experimental results are qualitatively consistent with the SOLPS simulation. The experiment also shows that the formation of the DPD might be related to the enhanced cross field transport in the far scrape-off layer. This experimental findings presented here reveal the crucial role played by the synergistic effect of poloidal E × B drift flow and the closed divertor structure in the redistribution of the particle flux, which provides a potential way for the control of high heat flux in future fusion devices.

For the first time, we proposed a 2T complementary architecture of one-time-programmable memory (OTP) in a foundry logic CMOS chip. It was then used to realize the PUF (Physical unclonable function), and the combination with the AI technology to provide a one-time password capability. At first, an OTP was developed based on a novel 2T CMOS unit cell. The experimental results show that the macro exhibits high speed operation, excellent data retention under more than 1 month baking at 200oC, and fairly large memory window. Next, a PUF is developed and because of the gate oxide integrity in the 40nm planar transistor technology, a superb randomness, i.e., an ideal and un-biased normal distribution of hamming distance, and narrow distribution of hamming weight can be achieved. Moreover, we use AI deep learning algorithms to generate a pseudo-PUF for one-time password successfully. Overall, this OTP provides an ideal and reliable solution either for the storage purpose or the security application in 5G era.

The pathfinding is generally regarded as a multi-objective optimization problem that simultaneously optimizes the shortest path and the least collision-free distance to obstacles. This work develops an MOEA-based algorithm of pathfinding to navigate a mobile robot to avoid the obstacles in a given finite environment. A grid-based method is also introduced for mapping of the environment to efficiently encode the robot’s position to be chromosomes. The hardware architecture is built by a mobile robot and its working environment, as well as the Aruco system and a computer running the algorithms of pathfinding and image processing. Both simulations and experimental results are presented to verify the feasibility of the proposed method. In applications, this work can be employed in a commercial ball collecting or object-carrying robot.

The reactions of manganese(II) chloride tetrahydrate and four bulky Schiff base ligands derived from amantadine (or rimantadine) and salicylaldehyde (or 4-methoxysalicylaldehyde) generated four novel complexes, C34H42Cl2MnN2O2 (I), C36H46Cl2MnN2O4 (II), C38H50Cl2MnN2O2 (III), and C40H54Cl2MnN2O4 (IV), respectively. These complexes were characterized by melting point, infrared spectra, elemental analysis, magnetic susceptibility, molar conductance and single-crystal X-ray diffraction (CIF files CCDC nos. 1 540 253 (I), 1 540 254 (II), 1 540 255 (III), 1 540 256 (IV)). Single-crystal X-ray diffraction analysis reveals that I, III and IV crystallize in the orthorhombic system with space groups P212121, Pbcn and Pcan, respectively, whereas II crystallizes in the monoclinic system with space group P21/n. Each asymmetric unit for I–IV consists of one manganese(II) atom, two Schiff base ligands and two chlorine atoms. The central manganese(II) atoms lie on a twofold rotation axis in III and IV, whereas manganese(II) atoms lie on general positions in I and II. In these complexes molecules, manganese(II) atoms is four-coordinated via two chlorine atoms and two oxygen atoms from the corresponding Schiff base ligands, forming a distorted tetrahedral geometry.

Probiotics reduce stress-related inflammation and abnormal behaviors in humans and rodents via regulation of the microbiota-gut-brain axis. The objective of this study was to determine if probiotic, Bacillus subtilis, has similar functions in broiler chickens under heat stress (HS). Two hundred forty 1-d-old broiler chicks were assigned to 48 pens with 4 treatments: Thermoneutral (TN)-RD (regular diet), TN-PD (the regular diet mixed with 1 × 106 CFU/g feed probiotic), HS-RD and HS-PD. Probiotic (Sporulin) was fed from day 1; and HS at 32°C for 10 h daily was initiated at day 15. The data showed that final BW, average daily gain , and feed conversion efficiency were improved in PD groups as compared to RD groups regardless of the ambient temperature (P HS-PD > TN-RD > TN-PD birds (P < 0.01). Compared to TN birds, HS birds spent more time in wing spreading, panting, squatting close to the ground, drinking, sleeping, dozing, and sitting but spent less time in eating, standing, and walking (P < 0.05 or 0.01). In addition, HS birds had greater levels of hepatic IL-6, IL-10, heat shock protein (HSP)70, and HSP70 mRNA expression (P < 0.01) and greater levels of cecal IgA and IgY (P < 0.01) compared to TN birds. Within TN groups, TN-PD birds had greater concentrations of hepatic IL-10 (P < 0.05) and cecal IgA (P < 0.01) than TN-RD birds. Within HS groups, HS-PD birds spent less time in wing spreading, panting, squatting close to the ground, drinking, sleeping, dozing, and sitting but spent more time in eating, foraging, standing, and walking than HS-RD birds (P < 0.05 or 0.01). The HS-PD birds also had lower concentrations of hepatic IL-6 and HSP70 (P < 0.01), whereas greater levels of IL-10 (P < 0.05) and lower concentrations of cecal IgA and IgY (P < 0.01). These results indicate that broilers fed the probiotic, B. subtilis, are able to cope with HS more effectively by ameliorating heat-induced behavioral and inflammatory reactions through regulation of microbiota-modulated immunity.

A mixture of copper(II) chloride dihydrate and ligands derived from amantadine and 5-halogenated salicylaldehyde in anhydrous methanol generated two novel complexes C34H38Cl2CuN2O2 (I) and C34H38Br2CuN2O2 (II), respectively. The complexes were characterized by melting point, elemental analysis, molar conductance, IR, UV-Vis, and single-crystal X-ray diffraction (CIF files nos. 1435429 (I), 1435430 (II)). Single-crystal X-ray diffraction analysis reveals that both complexes crystallize in monoclinic system, P21/c space group. Each asymmetric unit consists of two mononuclear copper(II) complex molecules and each complex molecule includes one copper(II) atom two corresponding deprotonated ligands. The central copper(II) atom is four-coordinated via two nitrogen atoms and two oxygen atoms from the corresponding Schiff base ligands, forming a distorted tetrahedral geometry. Electrochemical properties of the complexes were studied by cyclic voltammetry.

OBJECTIVE: To evaluate the tooth loss status of mandibular molars with furcation involvements after 5-year non-surgical periodontal treatment,and to analyze the factors that affected the tooth loss. METHODS: A retrospective analysis was conducted in 79 patients with chronic periodontitis, who had received non-surgical periodontal treatment and 5 years of periodontal maintenance treatment in Department of Periodontology, Peking University School and Hospital of Stomatology from 1988 to 2012. Their clinical indexes, including probing depth (PD), bleeding index (BI), furcation index (FI) and tooth mobility were both evaluated before treatment and at the last time of the maintenance treatment. Bone resorption at furcation area was measured at the first visit by periapical radiographs taken by professional doctors of medical imaging. The status of tooth loss after 5-year non-surgical periodontal treatment on mandibular molars with furcation involvement, and the factors that affected the tooth loss were analyzed. RESULTS: (1) Non-surgical treatment was significantly effective on the changes of PD in the patients of chronic periodontitis with furcation involvement, while the presence of furcation involvement could affect the improvement of PD here. (2) PD at the furcation area, tooth mobility, vertical bone resorption, and bone resorption area were all significant risk factors of mandibular molar missing (P

Preoperative acetabular cup templating has an important auxiliary effect on hip surgery. The traditional acetabular cup templating method requires the measuring person to have some experience in total hip replacement (THA) surgery since the measurement results vary from person to person with differences between different measuring persons. To obtain stable templating results, we designed a new acetabular cup templating method and tested the inter-person measuring differences and measurement accuracy of this method. Meanwhile, the clinical application of this method was preliminarily explored.The pattern of this new method was manual labeling of imaging characteristic points and then programmed automatic measurements. The measurement process was performed entirely by orthopedic graduate students without any experience in hip replacement surgery. The inter-person measuring difference was evaluated by comparing the templating results of three measuring persons. The accuracy of the templating was evaluated by comparing the templating results with the actual size of the prosthesis in the surgery. The correlation between the position of the acetabular cup and the templating error was analyzed to explore the clinical significance of the templating results. This study was a retrospective study which included templating in a total of 406 cases for total hip replacement with cementless cup prosthesis. Digital measurements were performed using the Matlab software from MathWorks. The statistical comparison was performed using Kendall's W test.The results of the three measuring persons were completely identical in 61.8% (251/406) of cases, and the variation in 38.2% (155/406) of cases did not exceed one size of the acetabular cup. The Kendall's W coefficient was 0.977, and p 0.01. The measurement accuracy is not as good as the traditional method in exactly accurate measurement and ±1 cup size, but it is similar to the traditional method in the ±2 cup sizes. The correlation between the templating error and the position evaluation of the implanted acetabular cups reveals: (1) larger the templating error, larger the proportion of the acetabular cups with poor position; (2) the proportion of acetabular cup with poor position slowly increased when the templating error was from 0 to 1 size, and the proportion rapidly increased when the templating error was from 1 to 2 size.All the patients with clear teardrop bottom and lateral superior edge of acetabulum were able to use our method to predict the size of the acetabular cup. The method has the following advantages: (1) it does not require the measuring person to have any previous experience of the THA surgery, which reduces the labor cost of the templating; (2) the differences between the measuring persons is small, the measurement result can be repeated; (3) it can predict the probability of acetabular cup with poor positioning according to the templating error, and thereby reminding the surgeon to recheck and correct the position of the acetabular cup in time during the surgery.

Background Chemo- and target therapies may induce myocardial dysfunction and lead to poor prognoses. Early detection of minor myocardial dysfunction is important for the prevention of subsequent cardiotoxicity. Cardio-oncology is a multidisciplinary field focusing on managing and preventing cardiovascular complications in cancer patients. However, whether Cardio-oncology program truly makes difference in cardiovascular outcomes remains unknown. Herein, we are sharing our experiences in our Medical Center. Methods Since 2014 till 2017, we recruited 154 patients with newly diagnosed breast cancer preparing for Epirubicin therapy. Echocardiography, biomarkers, six minute walking distance and cardiovascular adverse events including new onset of hypertension, stroke, myocardial infarction (MI) and mortality were recorded at baseline, three months, six months and one year. Any functional decline was reported to oncologists for the consideration of changing regimens. Otherwise, cardiologists would be consulted for cardiovascular educations and therapies. The echocardiographic and clinical records of 450 breast patients receiving Epirubicin therapy during 2010 to 2013 were also collected as comparison. Results Compared with the ratio of 20% patients receiving echocardiography prior to 2014, the ratio increased to 100% since Cardio-Oncology program started. Also, the drop of left ventricular ejection fraction (LVEF) from 25% attenuated to 5%. Before Cardio-Oncology Program, there were 1.7% of new onset hypertension, 0.8% of MI, 0.8% of stroke and 16.8% of mortality. Conversely, after the program, there were only 0.6% of new onset hypertension while no other cardiovascular complications were reported. Furthermore, compared with previous reports of the effectiveness of Cardio-Oncology Program, our result also displayed a superior impact on the cardiovascular outcomes. Conclusions Collectively, through a comprehensive monitoring and an early intervention of myocardial dysfunction post chemotherapies, Cardio-Oncology Program truly decreased the cardiovascular complications in breast cancer patients. Acknowledgement/Funding Chi-Mei Medical Center

Robot-path-planning is an important research that seeks the shortest path to optimize the motion cost for robots. In robot-path-planning, the computational time will significantly increase if the moving targets for a robot rise largely, while the current algorithms for the shortest path planning may be invalidated due to large input data. This work thus proposes a hybrid algorithm, called the k-means-based pointer network, to tackle the problem mentioned above. By combining the k-means clustering and pointer network, unsupervised and supervised learning respectively, this work demonstrates how to lower the learning cost drastically with smaller training data. The simulation results show that the computational time cost of the Held-Karp algorithm grows significantly when the input size increases in some amount, while the proposed algorithm climbs slightly during the increments of input size because of using smaller input data for Ptr-Net. In applications, the proposed work can be applied practically to the case of large input size, for example, the employment for the ball-collecting robot in a golf court.

We investigate and compare the electronic structure of a bulk single crystal of ${\mathrm{Y}}_{3}{\mathrm{Fe}}_{5}{\mathrm{O}}_{12}$ garnet [YIG, a high-${T}_{C}$ (= 560 K) ferrimagnet] with that of an epitaxial ultrathin (3.3 nm) film of YIG with a reduced ferrimagnetic temperature ${T}_{C}=380\phantom{\rule{0.16em}{0ex}}\mathrm{K}$, using bulk-sensitive hard x-ray photoelectron spectroscopy (HAXPES), x-ray absorption spectroscopy (XAS), and x-ray magnetic circular dichroism (XMCD). The Fe $2p$ HAXPES spectrum of the bulk single crystal exhibits a purely trivalent ${\mathrm{Fe}}^{3+}$ state for octahedral and tetrahedral sites. The Fe $3s$ spectrum shows a clear splitting which allows us to estimate the on-site Fe $3s\text{\ensuremath{-}}3d$ exchange interaction energy. The valence band HAXPES spectrum shows Fe $3d$, O $2p$, and Fe $4s$ derived features and a band gap of $\ensuremath{\sim}2.3\phantom{\rule{0.16em}{0ex}}\mathrm{eV}$ in the occupied density of states, consistent with the known optical band gap of $\ensuremath{\sim}2.7\phantom{\rule{0.16em}{0ex}}\mathrm{eV}$. Fe $L$-edge XAS identifies the octahedral ${\mathrm{Fe}}^{3+}$ and tetrahedral ${\mathrm{Fe}}^{3+}$ site features. XMCD spectra at the Fe ${L}_{2,3}$ edges show that bulk single-crystal YIG exhibits antiferromagnetic coupling between the octahedral- and tetrahedral-site spins. The calculated Fe $2p$ HAXPES, Fe $L$-edge XAS, and XMCD spectra using full multiplet cluster calculations match well with the experimental results and confirm the full local spin moments. In contrast, HAXPES, XAS, and XMCD of the Pt/YIG (3.3 nm) ultrathin epitaxial film grown by a pulsed laser deposition method show a finite ${\mathrm{Fe}}^{2+}$ contribution and a reduced ${\mathrm{Fe}}^{3+}$ local spin moment. The ${\mathrm{Fe}}^{2+}$ state is attributed to a combination of oxygen deficiency and charge transfer effects from the Pt capping layer to the ultrathin film. However, the conserved XMCD spectral shape for the ultrathin film indicates that the 3.3-nm epitaxial film is genuinely ferrimagnetic, in contrast to recent studies on films grown by radio-frequency magnetron sputtering which have shown a magnetic dead layer of $\ensuremath{\sim}6$ nm. The presence of ${\mathrm{Fe}}^{2+}$ and the reduced local spin moment in the epitaxial ultrathin film lead to a reduced Curie temperature, quantitatively consistent with well-known mean-field theory. The results establish a coupling of the local Fe spin moments, valency, and long-range magnetic ordering temperature in bulk single crystal and epitaxial ultrathin-film YIG.

Multi-walled carbon nanotubes (MWCNTs) were functionalized by polydopamine (PDA)-coating and mixed with natural rubber (NR) via latex compounding. Compared with pristine MWCNTs, the surface of MWCNT-PDA was covered by an amorphous and nanometer-scale PDA layer which had a large amount of oxygenic and nitric functional groups. So the MWCNT-PDA showed a perfect dispersion in NR matrix. The tensile strength of NR/MWCNT-PDA (5 phr) composites is 28.6 MPa, compared with the pure NR, which increased by 42%. For the electrical properties, when the content of MWCNTPDA or MWCNTs is 2 phr, the volume resistivity of NR/MWCNT-PDA composites falls to about 2.7·109 Ω·cm, compared with 3.3·1013 Ω·cm of NR/MWCNT composites. The thermal conductivity of NR composites increased only by 28.2% when 5 phr MWCNT-PDA was added. A model proposed by Nan was used to calculate the thermal conductivity of NR/MWCNT composites, and the calculated values were compared with the experimental values, the results showed that the interface thermal resistance is the main reason why MWCNTs could not significantly increase the thermal conductivity of natural rubber.

For resin-based composite materials, the hot and humid environment has a very obvious impact on its performance. Moisture can penetrate into the composite material through diffusion and capillary action, which causes the resin matrix with plasticization, swelling and hydrolysis, and swelling and infiltration of liquid will lead to micro-stress inside the material. Thus, the polymer macromolecular chain will stretche or even break, and it can lead to the weakening of the interface properties of the resin and the fiber, which in turn leads to fluctuations in the mechanical properties of the composite material. In this paper, we carried out damp and heat tests on multilayer composite structures to study the effects of different temperature and humidity environments on the physical and chemical properties and mechanical properties of composite materials. The law of moisture absorption characteristics of composite materials is clarified, and the moisture absorption in the initial stage of moisture absorption is proportional to the moisture absorption time t1/2. With time increasing, the moisture absorption gradually tends to balance, and the higher are the damp and heat conditions, the greater the moisture absorption of the composite material will be. The moisture absorption is between 0.13% and 0.78% with different damp and heat environments. The chemical structure of the composite material itself has not changed significantly, and the damp-heat effect will induce the destruction of the fiber-matrix interface and the expansion of cracks along the pores, which weakens the bonding strength of the interface. As a result, the moisture makes the transverse performance and shear performance of the composite material greatly reducing, but has little effect on the longitudinal performance.

We describe the design and implementation of climate fast input/output (CFIO), a fast input/output (I/O) library for high-resolution climate models. CFIO provides a simple method for modelers to overlap the I/O phase with the computing phase automatically, so as to shorten the running time of numerical simulations. To minimize the code modifications required for porting, CFIO provides similar interfaces and features to parallel Network Common Data Form (PnetCDF), which is one of the most widely used I/O libraries in climate models. We deployed CFIO in three high-resolution climate models, including two ocean models (POP and LICOM) and one sea ice model (CICE). The experimental results show that CFIO improves the performance of climate models significantly versus the original serial I/O approach. When running with CFIO at 0.1° resolution with about 1000 CPU cores, we managed to reduce the running time by factors of 7.9, 4.6 and 2.0 for POP, CICE, and LICOM, respectively. We also compared the performance of CFIO against two existing libraries, PnetCDF and parallel I/O (PIO), in different scenarios. For scenarios with both data output and computations, CFIO decreases the I/O overhead compared to PnetCDF and PIO.

Probiotics reduce stress-related inflammation and abnormal behaviors in humans and rodents via regulation of the microbiota-gut-brain axis. The objective of this study was to determine if probiotic, Bacillus subtilis, has similar functions in broiler chickens under heat stress (HS). Two hundred forty 1-d-old broiler chicks were assigned to 48 pens with 4 treatments: Thermoneutral (TN)-RD (regular diet), TN-PD (the regular diet mixed with 1 × 10(6) CFU/g feed probiotic), HS-RD and HS-PD. Probiotic (Sporulin) was fed from day 1; and HS at 32°C for 10 h daily was initiated at day 15. The data showed that final BW, average daily gain , and feed conversion efficiency were improved in PD groups as compared to RD groups regardless of the ambient temperature (P < 0.01). Heterophil to lymphocyte ratio was affected by treatment and its value was in the order of HS-RD > HS-PD > TN-RD > TN-PD birds (P < 0.01). Compared to TN birds, HS birds spent more time in wing spreading, panting, squatting close to the ground, drinking, sleeping, dozing, and sitting but spent less time in eating, standing, and walking (P < 0.05 or 0.01). In addition, HS birds had greater levels of hepatic IL-6, IL-10, heat shock protein (HSP)70, and HSP70 mRNA expression (P < 0.01) and greater levels of cecal IgA and IgY (P < 0.01) compared to TN birds. Within TN groups, TN-PD birds had greater concentrations of hepatic IL-10 (P < 0.05) and cecal IgA (P < 0.01) than TN-RD birds. Within HS groups, HS-PD birds spent less time in wing spreading, panting, squatting close to the ground, drinking, sleeping, dozing, and sitting but spent more time in eating, foraging, standing, and walking than HS-RD birds (P < 0.05 or 0.01). The HS-PD birds also had lower concentrations of hepatic IL-6 and HSP70 (P < 0.01), whereas greater levels of IL-10 (P < 0.05) and lower concentrations of cecal IgA and IgY (P < 0.01). These results indicate that broilers fed the probiotic, B. subtilis, are able to cope with HS more effectively by ameliorating heat-induced behavioral and inflammatory reactions through regulation of microbiota-modulated immunity.

To investigate the expression of long non-coding RNA zinc-finger E-box binding homeobox 1-AS1 (lncRNA ZEB1-AS1) in gastric cancer cells and tissues, to study its effect on the gastric cancer cell metastasis capacity, and analyze its clinical significance.The relative expression level of lncRNA ZEB1-AS1 in gastric cancer cells was detected via quantitative reverse transcription polymerase chain reaction (qRT-PCR). Transwell assay was used to detect the effects of lncRNA ZEB1-AS1 on the invasion and metastasis capacities of gastric cancer cells. qRT-PCR was used to detect the relative expression level of lncRNA ZEB1-AS1 in 75 pairs of gastric cancer tissues, and the correlations of its expression with the pathological characteristics and prognosis of patients were statistically analyzed.qRT-PCR showed that compared with that in the normal gastric epithelial cell (GES-1), the expression level of lncRNA ZEB1-AS1 was up-regulated in gastric cancer cells (MKN28, MKN45, BGC823, MGC803, KATOIII, and SGC7901). LncRNA ZEB1-AS1 interfering sequence was transfected into model cells, and Transwell assay showed that the cell invasion and migration capacities were significantly inhibited. qRT-PCR also revealed that the expression of lncRNA ZEB1-AS1 was up-regulated in 55 out of 75 cases of gastric cancer and para-carcinoma tissues (fold change1). Statistical analysis showed that the high expression of lncRNA ZEB1-AS1 was positively correlated with TNM staging (p = 0.002), lymph node metastasis (p = 0.002), and invasion degree (p = 0.004). The survival time of patients with high expression of lncRNA ZEB1-AS1 in gastric cancer tissues was shorter than that of patients with low expression (p = 0.004).LncRNA ZEB1-AS1 is highly expressed in gastric cancer tissues and cells, and it is expected to be a new prognostic marker of gastric cancer used for the clinical diagnosis and prognostic evaluation. After intervention in lncRNA ZEB1-AS1 expression, the cell invasion and migration are inhibited, and lncRNA ZEB1-AS1 may be an important target to reverse the malignant phenotype of gastric cancer.

The paper is focuses on the development of a theoretical framework together with an experimental validation to investigate rotational piezoelectric energy harvesting. The proposed device includes an electrically rectified piezoelectric bimorph mounted on a stationary base with a magnet attached to its free end. Energy is harvested by vibration of beam induced by non-contact rotary magnetic plucking. The DC power frequency response is predicted and found to be in good agreement with experiment. It shows that the harvested DC power is around 1 mW in average with the rotational frequency ranging from 5 Hz to 14 Hz. In addition, the parallel connection of two piezoelectric oscillators with respective electrical rectification is considered. It is observed that the power output of the array is the addition of the response from each individual piezoelectric oscillator.

To analyze the role of oxycodone in acute lung injury(ALI) induced by lipopolysaccharide (LPS) in rats.Male SD rats were randomly allocated into 4 groups: control group, oxycodone group, LPS group, LPS+ oxycodone group. The effects of oxycodone on LPS-induced neutrophils influx, inflammatory cytokines release, pulmonary edema, apoptotic cell were examined. In addition, the toll-like receptor 4 (TLR4) in lung tissues was detected by Western blotting.Oxycodone significantly attenuated LPS-induced pulmonary histopathologic changes, alveolar hemorrhage, and neutrophil infiltration. The lung wet-to-dry weight ratio, was markedly decreased by oxycodone(5.60±0.24 vs 6.80±0.27, P0.05 ). Moreover, oxycodone decreased the productions of the inflammatory cytokines including IL-1β, TNF-α, HMGB-1((1 208±18)pg/ml, (1 660±14) pg/ml, (61±4) pg/ml , all P0.05). Oxycodone treatment also reduced the concentration of apoptosis in lung tissues(18.6%±0.5%, P0.05). Furthermore, the expression of TLR4 was significantly suppressed by oxycodone treatment in lung tissues(1.20±0.15, P0.05).Oxycodone exerts protective effects on LPS-induced ALI in rats. The potential mechanism of this action may attribute partly to the inhibition of TLR4 activation.

Correction for ‘ROCK inhibitor Y-27632 attenuated early endothelial dysfunction caused by occupational environmental concentrations of carbon black nanoparticles’ by J. Y. Yan et al., Environ. Sci.: Nano, 2017, 4, 1525–1533.

International audience; BACKGROUND: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers. METHODS: We did a systematic review and meta-analysis of individual patient data for trials published before Sept 21, 2020. Randomised trials of intravenous alteplase versus standard of care or placebo in adults with stroke with unknown time of onset with perfusion-diffusion MRI, perfusion CT, or MRI with diffusion weighted imaging-fluid attenuated inversion recovery (DWI-FLAIR) mismatch were eligible. The primary outcome was favourable functional outcome (score of 0-1 on the modified Rankin Scale [mRS]) at 90 days indicating no disability using an unconditional mixed-effect logistic-regression model fitted to estimate the treatment effect. Secondary outcomes were mRS shift towards a better functional outcome and independent outcome (mRS 0-2) at 90 days. Safety outcomes included death, severe disability or death (mRS score 4-6), and symptomatic intracranial haemorrhage. This study is registered with PROSPERO, CRD42020166903. FINDINGS: Of 249 identified abstracts, four trials met our eligibility criteria for inclusion: WAKE-UP, EXTEND, THAWS, and ECASS-4. The four trials provided individual patient data for 843 individuals, of whom 429 (51%) were assigned to alteplase and 414 (49%) to placebo or standard care. A favourable outcome occurred in 199 (47%) of 420 patients with alteplase and in 160 (39%) of 409 patients among controls (adjusted odds ratio [OR] 1·49 [95% CI 1·10-2·03]; p=0·011), with low heterogeneity across studies (I(2)=27%). Alteplase was associated with a significant shift towards better functional outcome (adjusted common OR 1·38 [95% CI 1·05-1·80]; p=0·019), and a higher odds of independent outcome (adjusted OR 1·50 [1·06-2·12]; p=0·022). In the alteplase group, 90 (21%) patients were severely disabled or died (mRS score 4-6), compared with 102 (25%) patients in the control group (adjusted OR 0·76 [0·52-1·11]; p=0·15). 27 (6%) patients died in the alteplase group and 14 (3%) patients died among controls (adjusted OR 2·06 [1·03-4·09]; p=0·040). The prevalence of symptomatic intracranial haemorrhage was higher in the alteplase group than among controls (11 [3%] vs two [\textless1%], adjusted OR 5·58 [1·22-25·50]; p=0·024). INTERPRETATION: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care. A net benefit was observed for all functional outcomes despite an increased risk of symptomatic intracranial haemorrhage. Although there were more deaths with alteplase than placebo, there were fewer cases of severe disability or death. FUNDING: None.