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Objective To understand intake frequency of sugar-sweetened beverages (SSBs) and the consumption habit among primary and secondary students. To explore the relationship of SSBs cognition and behavior, and to provide a basis for reducing students' intake of SSBs. Methods A multi-stage sampling process was employed to select subjects from primary and middle school in Shenzhen. Network questionnaire survey was conducted to collecting information in September and October, 2021. Spearman rank correlations was used to analyze relationships of various types of SSBs consumption frequency. Multivariable linear regression model was used to examine the relationship between SSBs cognition score and consumption frequency score. Hierarchical analysis to explore the interactions. Results A total of 16 840 primary and secondary students aged 6 to 18 years old were included. The prevalence of SSBs consumption at least 3 time/week was 58.9%, the grades 1-3, 4-6 and middle school students were 52.3%, 60.3% and 67.6%. Parents (73.3%) were the main buyers of SSBs, convenience stores (73.7%) were the main places and delicious (77.2%) was the major cause of choices. There was a positive correlation between the intake frequency of different types of SSBs (P < 0.001). The results of multivariate linear regression showed that the higher the cognition was, the lower the intake frequency of SSBs was (β = 0.179, 95%CI: 0.155-0.204). There was a multiplicative interaction between the cognitive score of SSBs and the educational level of parents (P < 0.00l). Conclusion The intake frequency of SSBs was high among primary and middle school students in Shenzhen, and the cognitive level of SSBs was related to the intake frequency and the educational level of parents. [ABSTRACT FROM AUTHOR]

Objective To study the interaction between snoring and hyperuricemia on metabolic syndrome (MetS) in children and adolescents, putting forward targeted countermeasures to prevent and control MetS in the specific subpopulation. Methods Demography data, snoring, anthropometric measurements, and biochemical indicators were obtained from children and adolescents aged 7 - 17 years old who participated in the evaluation and monitoring on school - based nutrition and growth in Shenzhen. Logistic regression model was conducted to evaluate the association between snoring and hyperuricemia on MetS, and an additive model to evaluate the impact of their interaction on MetS. Results The median age of 4 466 participants was 12. 16 years, and 2 454 (54. 9% ) were boys. The detection rates of MetS, snoring, and hyperuricemia accounted for 3. 2%, 29. 3%, and 33. 4% of the total population, respectively. The frequency of snoring < 1 time/week, 1-2 times/week, and ^ 3 times/week were positively correlated with MetS disease and showed a gradually increasing trend (P trend <0. 001). Snoring (OR =2.085, 95% CI- 1.462 -2.902) and hyperuricemia (OR = 4. 741, 95% CI- 3. 144 -7. 148) were both associated with MetS. In addition, there was no multiplicative interaction between snoring frequency, snoring, and high uric acid on MetS, but snoring and high uric acid had an additive interaction on MetS [ relative excess risk due to interaction = 3. 801 (0. 060 - 7. 542), attributable proportion of interaction = 0. 418 (0. 154 - 0. 683), synergy index = 1. 887 (1. 101 - 3. 234) ] . Conclusion Snoring and hyperuricemia are both risk factors for MetS. There is a synergistic effect between snoring and hyperuricemia on the risk of MetS. Therefore, it is necessary to actively control weight, maintain positive airway pressure ventilation, orthodontic treatment, limit fried foods, meat, seafood, and increase vegetable intake to improve snoring and uric acid levels in children and adolescents, in order to achieve prevention and management of MetS. [ABSTRACT FROM AUTHOR]

Background/Aims: After myocardial infarction (MI), cardiac fibrosis greatly contributes to left ventricular remodeling and heart failure. The intermediate-conductance calcium-activated potassium Channel (KCa3.1) has been recently proposed as an attractive target of fibrosis. The present study aimed to detect the effects of KCa3.1 blockade on ventricular remodeling following MI and its potential mechanisms. Methods: Myocardial expression of KCa3.1 was initially measured in a mouse MI model by Western blot and real time-polymerase chain reaction. Then after treatment with TRAM-34, a highly selective KCa3.1 blocker, heart function and fibrosis were evaluated by echocardiography, histology and immunohistochemistry. Furthermore, the role of KCa3.1 in neonatal mouse cardiac fibroblasts (CFs) stimulated by angiotensin II (Ang II) was tested. Results: Myocardium expressed high level of KCa3.1 after MI. Pharmacological blockade of KCa3.1 channel improved heart function and reduced ventricular dilation and fibrosis. Besides, a lower prevalence of myofibroblasts was found in TRAM-34 treatment group. In vitro studies KCa3.1 was up regulated in CFs induced by Ang II and suppressed by its blocker.KCa3.1 pharmacological blockade attenuated CFs proliferation, differentiation and profibrogenic genes expression and may regulating through AKT and ERK1/2 pathways. Conclusion: Blockade of KCa3.1 is able to attenuate ventricular remodeling after MI through inhibiting the pro-fibrotic effects of CFs. [ABSTRACT FROM AUTHOR]

This study was aimed to investigate the effects of blockade of Ca(2+) activated channel KCa3.1 and voltage-gated potassium channel Kv1.3 of the monocytes/macrophages on inflammatory monocyte chemotaxis. Chemotaxis assay was used to test the inflammatory Ly-6C(hi) monocyte chemotaxis caused by the monocytes/macrophages. The proliferation of monocytes/macrophages was detected by cell counting kit-8 (CCK8). Enzyme-linked immunosorbent assay (ELISA) was applied to detect the C-C motif ligand 7 (CCL7) in cultured media. The results showed that the recruitment of Ly-6C(hi) monocyte induced by monocytes/macrophages was suppressed by the potent Kv1.3 blocker Stichodactyla helianthus neurotoxin (ShK) or the specific KCa3.1 inhibitor TRAM-34. Meanwhile, the proliferation of monocytes/macrophages was significantly inhibited by ShK. The response of Ly-6C(hi) monocyte pretreated with ShK or TRAM-34 to CCL2 was declined. These results suggest that KCa3.1 and Kv1.3 may play an important role in monocytes/macrophages' proliferation and migration.