144 results on '"Zecchin, M"'
Search Results
2. Seismic hazard for the Trans Adriatic Pipeline (TAP). Part 2: broadband scenarios at the Fier Compressor Station (Albania)
- Author
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Moratto, L., Vuan, A., Saraò, A., Slejko, D., Papazachos, C., Caputo, R., Civile, D., Volpi, V., Ceramicola, S., Chatzipetros, A., Daja, S., Fabris, P., Garcia-Pelaez, J., Geletti, R., Karvelis, P., Pavlides, S., Rapti, D., Rebez, A., Rossi, G., Sandron, D., Santulin, M., Sboras, S., Tamaro, A., Zecchin, M., Zgur, F., and Zuliani, D.
- Published
- 2021
- Full Text
- View/download PDF
3. DIAGNOSTIC REFERENCE LEVELS IN INTERVENTIONAL RADIOLOGY FOR THE ADULT PATIENT: NATIONAL SURVEY RESULTS FOR THE RAPPORTI ISTISAN 20/22 UPDATE
- Author
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D’Ercole, L., primary, Bernardi, G., additional, Compagnone, G., additional, Grande, S., additional, Klersy, C., additional, Orlacchio, A., additional, Padovani, R., additional, Palma, A., additional, Zecchin, M., additional, and Rosi, A., additional
- Published
- 2023
- Full Text
- View/download PDF
4. Short and long-term survival in patients over ninety years-old undergoing pacemaker implantation
- Author
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Zecchin, M, primary, Bessi, R, additional, Baggio, C, additional, Trevisan, B, additional, Longaro, F, additional, Salvatore, L, additional, Bianco, E, additional, Saitta, M, additional, Zorzin-Fantasia, A, additional, Piccicin, F, additional, Del Monte, G, additional, Carriere, C, additional, and Sinagra, G, additional
- Published
- 2023
- Full Text
- View/download PDF
5. PM and ICD trends during COVID-19 pandemic in Italy. A global analysis of the national hospital discharge database
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Zecchin, M, primary, Ciminello, E, additional, Torre, M, additional, Carrani, E, additional, Sampaolo, L, additional, Proclemer, A, additional, Boriani, G, additional, Zanotto, G, additional, D'onofrio, A, additional, De Ponti, R, additional, and Sinagra, G, additional
- Published
- 2023
- Full Text
- View/download PDF
6. MO-07.1 - DIAGNOSTIC REFERENCE LEVELS IN INTERVENTIONAL RADIOLOGY FOR THE ADULT PATIENT: NATIONAL SURVEY RESULTS FOR THE RAPPORTI ISTISAN 20/22 UPDATE
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D’Ercole, L., Bernardi, G., Compagnone, G., Grande, S., Klersy, C., Orlacchio, A., Padovani, R., Palma, A., Zecchin, M., and Rosi, A.
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- 2023
- Full Text
- View/download PDF
7. Temporal association between drops in throracic impedance and malignant ventricular arrhythmia:A longitudinal analysis of remote monitoring trends
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Rodio, G., Iacopino, S., Pisanò, E., Calvi, V., Rovasis, G., Marini, M., Giammaria, M., Caravati, F., Maglia, G., Zanotto, G., Dellabella, P., Biffi, M., Curnis, A., Maines, M., Orsida, D., Santamaria, M., Bisignani, G., Forleo, G. B., Piemontese, C., Desalvia, A., Miracapillo, G., Celentano, E., Zecchin, M., Luzzi, G., Giacopelli, D., Gargaro, A., and D'Onofrio, A.
- Published
- 2023
8. Influence of obesity and overweight on the association between sleep-disordered breathing and atrial fibrillation: the DASAP-HF study
- Author
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Boriani, G, primary, Diemberger, I, additional, Pisano', E C L, additional, Pieragnoli, P, additional, Locatelli, A, additional, Capucci, A, additional, Talarico, A, additional, Zecchin, M, additional, Rapacciuolo, A, additional, Piacenti, M, additional, Indolfi, C, additional, Arias, M A, additional, Checchinato, C, additional, and D'Onofrio, A, additional
- Published
- 2022
- Full Text
- View/download PDF
9. Medium term survival in patients over ninety years-old undergoing pacemaker implantation
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Zecchin, M, primary, Trevisan, B, additional, Bessi, R, additional, Baggio, C, additional, Salvatore, L, additional, Cappelletto, C, additional, Gregorio, C, additional, Bianco, E, additional, Carriere, C, additional, Longaro, F, additional, Zorzin-Fantasia, A, additional, Saitta, M, additional, Piccinin, F, additional, Dal Monte, G, additional, and Sinagra, G, additional
- Published
- 2022
- Full Text
- View/download PDF
10. Cardiac resynchronization therapy: association between genetically determinated dilated cardiomyopathy and dissinchronopathy
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Bessi, R, primary, Dal Ferro, M, additional, Gregorio, C, additional, Paldino, A, additional, De Angelis, G, additional, De Bellis, A, additional, Mase, M, additional, Zaffalon, D, additional, Gigli, M, additional, Stolfo, D, additional, Merlo, M, additional, Zecchin, M, additional, and Sinagra, G, additional
- Published
- 2022
- Full Text
- View/download PDF
11. Cardiac contractility modulation in heart failure with reduced ejection fraction: critical review of evidence and application perspectives [Modulazione della contrattilità cardiaca nello scompenso cardiaco a frazione di eiezione ridotta: revisione critica delle evidenze ed aspetti decisionali pratici]
- Author
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Biffi, M, Aspromonte, N, Bongiorni, M, Clemenza, F, D'Onofrio, A, De Ferrari, G, Giallauria, F, Grimaldi, M, Oliva, F, Senni, M, Tondo, C, Zecchin, M, Cappannoli, L, Giannotti Santoro, M, Ziacchi, M, Porcari, A, Sinagra, G, Biffi M, Aspromonte N, Bongiorni MG, Clemenza F, D'Onofrio A, De Ferrari GM, Giallauria F, Grimaldi M, Oliva F, Senni M, Tondo C, Zecchin M, Cappannoli L, Giannotti Santoro M, Ziacchi M, Porcari A, Sinagra G, Biffi, M, Aspromonte, N, Bongiorni, M, Clemenza, F, D'Onofrio, A, De Ferrari, G, Giallauria, F, Grimaldi, M, Oliva, F, Senni, M, Tondo, C, Zecchin, M, Cappannoli, L, Giannotti Santoro, M, Ziacchi, M, Porcari, A, Sinagra, G, Biffi M, Aspromonte N, Bongiorni MG, Clemenza F, D'Onofrio A, De Ferrari GM, Giallauria F, Grimaldi M, Oliva F, Senni M, Tondo C, Zecchin M, Cappannoli L, Giannotti Santoro M, Ziacchi M, Porcari A, and Sinagra G
- Abstract
This critical review illustrates the pathophysiological aspects and available scientific evidence about cardiac contractility modulation therapy. A useful algorithm dealing with the essential decisional knots to consider for device implantation in patients with heart failure in NYHA class >II and ejection fraction <= 45% is presented. The present review paves the way for the development of an Italian registry aiming at analyzing the characteristics of implanted patients based on a multiparametric approach, including cardiac bio markers, to identify clinical profiles and predictors of response to therapy. The "Answers and Questions" section provides useful insights into pathophysiology, technical specifications, clinically relevant scenarios and future perspectives.
- Published
- 2021
12. Radiofrequency ablation for benign thyroid nodules
- Author
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Bernardi, S., Stacul, F., Zecchin, M., Dobrinja, C., Zanconati, F., and Fabris, B.
- Published
- 2016
- Full Text
- View/download PDF
13. The Petilia-Sosti Shear Zone (Calabrian Arc, southern Italy): An onshore-offshore regional active structure
- Author
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Civile D.[1], Zecchin M.[1], Tosi L.[2], Da Lio C.[2], Muto F.[3], Sandron D.[1], Affatato A.[1], Accettella D.[1], and Mangano G.[1
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Geophysics ,Stratigraphy ,Economic Geology ,Geology ,Petilia-Sosti shear zone ,Calabrian arc ,tectonic and gravity-driven deformation ,seismogenic source ,Sila massif ,Crotone basin ,Oceanography - Abstract
The integrated interpretation of different types of data, consisting of a detailed Digital Terrain Model, field structural and morphotectonic observations, high resolution seismic data, seismological and Synthetic Aperture Radar interferometry information (vertical and horizontal movements), associated with a review of the available literature, has allowed to analyze the shallow expression of the regional-scale Petilia-Sosti Shear Zone (PSSZ). It is one of the major NW-trending tectonic lineaments affecting the Calabrian Arc and is characterized by a present-day tectonic and gravity-driven deformation. This study investigated the portion of the PSSZ between the offshore Crotone Peninsula, located along the Ionian sea of Calabria, and the central part of the Sila Massif. A complex tectonic history is documented since middle Miocene onward for the PSSZ. It consists of an alternation of sinistral and dextral transpressional and transtensional tectonic phases correlated with the geodynamic events occurred during the SE migration of the Calabrian Arc. The shallow expression of the investigated part of the PSSZ consists of a roughly 14 km wide, ca. 80 km long NW-trending tectonic zone including synthetic NW- to NNW-trending faults and N-NE antithetic minor structures. The main identified NW-trending faults, which show a development between 30 and 50 km, are the Sila and Lakes faults in the Sila Massif, and the Marcedusa-Steccato, Fosso Umbro and Tacina faults located in the SW part of the Crotone Basin and in its offshore area. Currently, the fault segments of the Sila Massif exhibit a prevailing normal kinematics with a left-lateral component, whereas a more complex geological framework occurs in the south-western part of the onshore-offshore Crotone Basin. The latter is dominated by gravity-driven movements, associated with the SE migration of the Crotone Megalandslide and with the regional uplift of Calabria, whereas normal kinematics with a small left-lateral component of movement, locally replaced by reverse/transpressional tectonics, was observed along the southern coast in the late Pleistocene deposits of the Le Castella marine terrace. The seismological data highlight that some strong earthquakes occurred in 1638, 1744 and 1832, with magnitude Mw between 5.7 and 6.8, might be associated with the Lakes, Fosso Umbro and Tacina faults respectively. In this frame, the PSSZ is proposed as a new potential NW-oriented active composite seismogenic source for the central-northern Calabria.
- Published
- 2022
14. Cardiac contractility modulation in heart failure with reduced ejection fraction: critical review of evidence and application perspectives
- Author
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Biffi M., Aspromonte N., Bongiorni M. G., Clemenza F., D'Onofrio A., De Ferrari G. M., Giallauria F., Grimaldi M., Oliva F., Senni M., Tondo C., Zecchin M., Cappannoli L., Giannotti Santoro M., Ziacchi M., Porcari A., Sinagra G., Biffi, M., Aspromonte, N., Bongiorni, M. G., Clemenza, F., D'Onofrio, A., De Ferrari, G. M., Giallauria, F., Grimaldi, M., Oliva, F., Senni, M., Tondo, C., Zecchin, M., Cappannoli, L., Giannotti Santoro, M., Ziacchi, M., Porcari, A., and Sinagra, G.
- Subjects
Registrie ,Heart Failure ,Treatment Outcome ,Stroke Volume ,Myocardial Contraction ,Human - Abstract
This critical review illustrates the pathophysiological aspects and available scientific evidence about cardiac contractility modulation therapy. A useful algorithm dealing with the essential decisional knots to consider for device implantation in patients with heart failure in NYHA class >II and ejection fraction ≤45% is presented. The present review paves the way for the development of an Italian registry aiming at analyzing the characteristics of implanted patients based on a multiparametric approach, including cardiac biomarkers, to identify clinical profiles and predictors of response to therapy. The "Answers and Questions" section provides useful insights into pathophysiology, technical specifications, clinically relevant scenarios and future perspectives.
- Published
- 2021
15. Cardiac contractility modulation in heart failure with reduced ejection fraction: critical review of evidence and application perspectives [Modulazione della contrattilità cardiaca nello scompenso cardiaco a frazione di eiezione ridotta: revisione critica delle evidenze ed aspetti decisionali pratici]
- Author
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Biffi M, Aspromonte N, Bongiorni MG, Clemenza F, D'Onofrio A, De Ferrari GM, Giallauria F, Grimaldi M, Oliva F, Senni M, Tondo C, Zecchin M, Cappannoli L, Giannotti Santoro M, Ziacchi M, Porcari A, Sinagra G, Biffi, M, Aspromonte, N, Bongiorni, M, Clemenza, F, D'Onofrio, A, De Ferrari, G, Giallauria, F, Grimaldi, M, Oliva, F, Senni, M, Tondo, C, Zecchin, M, Cappannoli, L, Giannotti Santoro, M, Ziacchi, M, Porcari, A, and Sinagra, G
- Subjects
Heart Failure ,Registrie ,Treatment Outcome ,Stroke Volume ,Myocardial Contraction ,Human - Abstract
This critical review illustrates the pathophysiological aspects and available scientific evidence about cardiac contractility modulation therapy. A useful algorithm dealing with the essential decisional knots to consider for device implantation in patients with heart failure in NYHA class >II and ejection fraction
- Published
- 2021
16. [The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual report 2019]
- Author
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Proclemer, A., Zecchin, M., Zanotto, G., D'Onofrio, A., De Ponti, R., Ricci, R. P., Facchin, D., Rebellato, L., Ghidina, M., Bianco, G., Bernardelli, E., Miconi, A., Zorzin, A. F., and Gregori, D.
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Aged, 80 and over ,Pacemaker, Artificial ,Implantable cardioverter-defibrillator ,Defibrillators, Implantable ,Pacemaker ,Italy ,Artificial ,Atrial Fibrillation ,Aged ,Humans ,Registries ,80 and over ,Implantable ,Defibrillators - Abstract
The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2019 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers.The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards.PM Registry: data about 22 889 PM implantations were collected (19 621 first implants and 3268 replacements). The number of collaborating centers was 173. Median age of treated patients was 81 years (75 quartile I; 87 quartile III). ECG indications included atrioventricular conduction disorders in 33.3% of first PM implants, sick sinus syndrome in 16.4%, atrial fibrillation plus bradycardia in 11.6%, other in 38.7%. Among atrioventricular conduction defects, third-degree atrioventricular block was the most common type (18.3% of first implants). Use of single-chamber PMs was reported in 25.5% of first implants, of dual-chamber PMs in 67.1%, of PMs with cardiac resynchronization therapy (CRT) in 1.5%, and of single lead atrial-synchronized ventricular stimulation (VDD/R PMs) in 5.8%. ICD Registry: data about 17 328 ICD implantations were collected (12 129 first implants and 5199 replacements). The number of collaborating centers was 425. Median age of treated patients was 71 years (62 quartile I; 77 quartile III). Primary prevention indication was reported in 83.1% of first implants, secondary prevention in 16.9% (cardiac arrest in 5.9%). A single-chamber ICD was used in 26.1% of first implants, dual-chamber ICD in 28.0% and biventricular ICD in 45.9%.The PM and ICD Registry appears fundamental for monitoring PM and ICD utilization on a large national scale with rigorous examination of demographics and clinical indications. The PM Registry showed stable electrocardiographic and symptom indications, with an important prevalence of dual-chamber pacing. The use of CRT-PM regards a very limited number of patients. The ICD Registry documented a large use of prophylactic and biventricular ICD, reflecting a favorable adherence to trials and guidelines in clinical practice. In order to increase and optimize the cooperation of Italian implanting centers, online data entry (https://www.aiac.it/riprid) should be adopted at large scale.
- Published
- 2021
17. Tavola 8 Calabria Ionica
- Author
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Ceramicola, S., Fanucci, F., Corselli, C., Colizza, E., Morelli, D., Cova, A., Savini, A., Praeg, D., Zecchin, M., Caburlotto, A., Candoni, O., Civile, D., Coste, M., Cotterle, D., Critelli, S., Cuppari, A., De Ponte, M., Dominici, R., Forlin, E., Gordini, E., Tessarolo, C., Marchese, F., Muto, F., Palamara, S., Ramella, R., Facchin, L., and Romeo, R.
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Marine geohazard, seafloor mapping, Magic Project, Ionian Sea ,Magic Project ,Ionian Sea ,Marine geohazard ,seafloor mapping - Published
- 2021
18. Consulenza cardiologica e gestione perioperatoria del paziente cardiopatico. Protocollo dell’Azienda Sanitaria Universitaria Integrata di Trieste – Anno 2019
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Massa, L., Mascaretti, L. G., Ratti, C., Zecchin, M., Perkan, A., Fabris, E., Vitrella, G., Fabro, M., Luzzati, R., Di Lenarda, A., Pelusi, L., Bergamini, P. R., Sinagra, G., Massa, L., Mascaretti, L. G., Ratti, C., Zecchin, M., Perkan, A., Fabris, E., Vitrella, G., Fabro, M., Luzzati, R., Di Lenarda, A., Pelusi, L., Bergamini, P. R., and Sinagra, G.
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Invasive procedure ,Endocarditis ,Antiplatelet therapy ,Cardiac implantable electronic device ,Anticoagulant ,Anticoagulants ,Invasive procedures ,Cardiovascular risk ,Direct oral anticoagulants ,Cardiac implantable electronic devices ,Surgery ,Endocarditi ,Direct oral anticoagulant - Abstract
La gestione dei pazienti con nota o sospetta cardiopatia, che sono ricoverati o che devono essere sottoposti ad intervento chirurgico non cardiaco o ad una procedura invasiva, è molto complessa, sia per le comorbilità spesso presenti, sia per le molteplici terapie assunte, sia perché spesso sono portatori di dispositivi cardiaci impiantabili. Scopo di questo documento è di fornire indicazioni e standardizzare i comportamenti dei vari medici nella gestione dei pazienti cardiopatici o sospetti tali, al fine di (a) gestire le acuzie cardiologiche con timing e accuratezza adeguati, e (b) definire il rischio cardiologico nel singolo paziente con tempi ed indicazioni appropriate, permettendogli di affrontare la procedura chirurgica o invasiva con il rischio più basso correlato alla presenza della cardiopatia.
- Published
- 2019
19. 853Could baseline electrical parameters be a marker of arrhythmia occurrence and poorer prognosis in implantable cardioverter defibrillator patients?
- Author
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Zecchin, M, primary, Solimene, F, additional, D"onofrio, A, additional, Zanotto, G, additional, Iacopino, S, additional, Pignalberi, C, additional, Calvi, V, additional, Maglia, G, additional, Della Bella, P, additional, Quartieri, F, additional, Curnis, A, additional, Biffi, M, additional, Giacopelli, D, additional, Gargaro, A, additional, and Pisano", E, additional
- Published
- 2020
- Full Text
- View/download PDF
20. The Pacemaker and Implantable Cardioverter-Defibrillator Registry of the Italian Association of Arrhythmology and Cardiac Pacing - Annual Report 2017
- Author
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Proclemer, A, Zecchin, M, D'Onofrio, A, Ricci, Rp, Boriani, G, Facchin, D, Rebellato, L, Ghidina, M, Bianco, G, Bernardelli, E, Miconi, A, Zorzin, Af, and Gregori, D
- Subjects
Aged, 80 and over ,Male ,Pacemaker, Artificial ,Arrhythmias, Cardiac ,Middle Aged ,Defibrillators, Implantable ,Cardiac Resynchronization Therapy ,Primary Prevention ,Implantable defibrillator ,Pacemaker ,Electrocardiography ,Italy ,Surveys and Questionnaires ,Secondary Prevention ,Humans ,Female ,Registries ,Aged - Abstract
The pacemaker (PM) and implantable cardioverter-defibrillator (ICD) Registry of the Italian Association of Arrhythmology and Cardiac Pacing (AIAC) monitors the main epidemiological data in real-world practice. The survey for the 2017 activity collects information about demographics, clinical characteristics, main indications for PM/ICD therapy and device types from the Italian collaborating centers.The Registry collects prospectively national PM and ICD implantation activity on the basis of European cards.PM Registry: data about 23 457 PM implantations were collected (19 378 first implant and 4079 replacements). The number of collaborating centers was 185. Median age of treated patients was 81 years (75 quartile I; 86 quartile III). ECG indications included atrioventricular conduction disorders in 37.1% of first PM implants, sick sinus syndrome in 19.5%, atrial fibrillation plus bradycardia in 13.2%, other in 30.2%. Among atrioventricular conduction defects, third-degree atrioventricular block was the most common type (21.0% of first implants). Use of single-chamber PMs was reported in 25.6% of first implants, of dual-chamber PMs in 66.7%, of PMs with cardiac resynchronization therapy (CRT) in 1.4%, and of single lead atrial-synchronized ventricular stimulation (VDD/R PMs) in 6.3%. ICD Registry: data about 19 023 ICD implantations were collected (13 898 first implants and 5125 replacements). The number of collaborating centers was 437. Median age of treated patients was 71 years (63 quartile I; 78 quartile III). Primary prevention indication was reported in 81.8% of first implants, secondary prevention in 18.2% (cardiac arrest in 6.4%). A single-chamber ICD was used in 27.0% of first implants, dual-chamber in 33.6% and biventricular in 39.3%.The PM and ICD Registry appears fundamental for monitoring PM and ICD utilization on a large national scale with rigorous examination of demographics and clinical indications. The PM Registry showed stable electrocardiographic and symptom indications, with an important prevalence of dual-chamber pacing. The use of CRT-PM regards a very limited number of patients. The ICD Registry documented a large use of prophylactic and biventricular ICD, reflecting a favorable adherence to trials and guidelines in clinical practice. In order to increase and optimize the cooperation of Italian implanting centers, online data entry (http://www.aiac.it/riprid) should be adopted at large scale.
- Published
- 2019
21. Pliocene-Quaternary mass wasting processes along the Ionian Calabrian margin
- Author
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Candoni O, Ceramicola S, Praeg D, Zecchin M, Brancatelli G, Gorini C, Bohrmann G, and Cova A
- Published
- 2018
- Full Text
- View/download PDF
22. P287015 year trend in ICD utilization according to the Italian national administrative database: an analysis of age groups
- Author
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Zecchin, M, primary, Torre, M, additional, Ortis, B, additional, Proclemer, A, additional, Carrani, E, additional, Sampaolo, L, additional, Ricci, R P, additional, and Boriani, G, additional
- Published
- 2019
- Full Text
- View/download PDF
23. MO-07.1 - DIAGNOSTIC REFERENCE LEVELS IN INTERVENTIONAL RADIOLOGY FOR THE ADULT PATIENT: NATIONAL SURVEY RESULTS FOR THE RAPPORTI ISTISAN 20/22 UPDATE.
- Author
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D'Ercole, L., Bernardi, G., Compagnone, G., Grande, S., Klersy, C., Orlacchio, A., Padovani, R., Palma, A., Zecchin, M., and Rosi, A.
- Published
- 2023
- Full Text
- View/download PDF
24. Evaluating early communicative development
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Molina, Paola Fausta Maria, Guidetti, M., Thommen, E., Sala, MARIA NIVES, Bulgarelli, Daniela, Ongari, B., Schadee, H., Berland, A., Cochard, N., Barone, P., Deguine, O., Rossini, E., Di Fulvio, A., Rudelli, N., Cattelan, C., Zecchin, M., and Molteni, M.
- Published
- 2016
25. Hypertrophic Cardiomyopathy: An unexpected finding in a surgical variant of Heterotopic Heart Transplantation
- Author
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Negri, F., primary, Gamba, A., additional, Belgrano, M., additional, Bussani, R., additional, Pinamonti, B., additional, Zecchin, M., additional, and Sinagra, G., additional
- Published
- 2016
- Full Text
- View/download PDF
26. Role of the nuclear receptor Rev-erb-alpha in the development of atherosclerosis
- Author
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Pourcet, B., primary, Zecchin, M., additional, Vanhoutte, J., additional, Delhaye, S., additional, Rommens, C., additional, Woldt, E., additional, Eeckhoute, J., additional, Staels, B., additional, and Duez, H., additional
- Published
- 2015
- Full Text
- View/download PDF
27. PO-1007: Neutron induced soft errors in cardiac implantable devices following radiation therapy
- Author
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Severgnini, M., primary, Sergi, E., additional, Baratto Roldan, A., additional, Toscano, L., additional, Milan, V., additional, Zecchin, M., additional, Zorzin Fantasia, A., additional, Morea, G., additional, Vidimari, R., additional, Sinagra, G., additional, Beorchia, A., additional, De Denaro, M., additional, and Giannini, G., additional
- Published
- 2015
- Full Text
- View/download PDF
28. Linking Health Care Administrative Databases And National Registry Data In Order To Monitor Icd Therapy In Italy
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Madotto, F., primary, Fornari, C., additional, Chiodini, V., additional, Mantovani, L.G., additional, Zecchin, M., additional, Proclemer, A., additional, Conti, S., additional, and Cesana, G., additional
- Published
- 2014
- Full Text
- View/download PDF
29. PCV76 - Linking Health Care Administrative Databases And National Registry Data In Order To Monitor Icd Therapy In Italy
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Madotto, F., Fornari, C., Chiodini, V., Mantovani, L.G., Zecchin, M., Proclemer, A., Conti, S., and Cesana, G.
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- 2014
- Full Text
- View/download PDF
30. Poster session 3
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Winter, R, Lindqvist, P, Sheehan, F, Fazlinezhad, A, Vojdanparast, M, Nezafati, P, Martins Fernandes, S, Teixeira, R, Pellegrino, M, Generati, G, Bandera, F, Labate, V, Alfonzetti, E, Guazzi, M, Iriart, X, Dinet, ML, Jalal, Z, Cochet, H, Thambo, JB, Moustafa, S, Ho, TH, Shah, P, Murphy, K, Nelluri, BK, Lee, H, Wilansky, S, Mookadam, F, Stolfo, D, Tonet, E, Merlo, M, Barbati, G, Gigli, M, Pinamonti, B, Ramani, F, Zecchin, M, Sinagra, G, Bieseviciene, M, Vaskelyte, JJ, Mizariene, V, Lesauskaite, V, Verseckaite, R, Karaliute, R, Jonkaitiene, R, Patel, S, Li, L, Craft, M, Danford, D, Kutty, S, Vriz, O, Pellegrinet, M, Zito, C, Carerj, S, Di Bello, V, Cittadini, A, Bossone, E, Antonini-Canterin, F, Sarvari, S I, Rodriguez, M, Sitges, M, Sepulveda-Martinez, A, Gratacos, E, Bijnens, B, Crispi, F, Santos, M, Leite, L, Martins, R, Baptista, R, Barbosa, A, Ribeiro, N, Oliveira, A, Castro, G, Pego, M, Berezin, A, Samura, T, Kremzer, A, Stoebe, S, Tarr, A, Pfeiffer, D, Hagendorff, A, Benyounes Iglesias, N, Van Der Vynckt, C, Gout, O, Devys, JM, Cohen, A, De Chiara, B, Musca, F, D'angelo, L, Cipriani, MG, Parolini, M, Rossi, A, Santambrogio, GM, Russo, C, Giannattasio, C, Moreo, A, Soliman, A, Moharram, M, Gamal, A, Reda, A, Oni, O, Adebiyi, A, Aje, A, Ricci, F, Aquilani, R, Dipace, G, Bucciarelli, V, Bianco, F, Miniero, E, Scipioni, G, De Caterina, R, Gallina, S, Tumasyan, LR, Adamyan, KG, Chilingaryan, AL, Tunyan, LG, Kim, KH, Cho, JY, Yoon, HJ, Ahn, Y, Jeong, MH, Cho, JG, Park, JC, Popa, B A, Popa, A, Cerin, G, Ecocardiografico, Campagna Provinciale di Screening, Yiangou, K, Azina, CH, Yiangou, A, Georgiou, C, Zitti, M, Ioannides, M, Chimonides, S, Olsen, R H, Pedersen, LR, Snoer, M, Christensen, TE, Ghotbi, AA, Hasbak, P, Kjaer, A, Haugaard, SB, Prescott, E, Cacicedo, A, Velasco Del Castillo, S, Gomez Sanchez, V, Anton Ladislao, A, Onaindia Gandarias, J, Rodriguez Sanchez, I, Jimenez Melo, O, Garcia Cuenca, E, Zugazabeitia Irazabal, G, Romero Pereiro, A, Monti, L, Nardi, B, Di Giovine, G, Malanchini, G, Scardino, C, Balzarini, L, Presbitero, P, Gasparini, GL, Holte, E, Orlic, D, Tesic, M, Zamaklar-Trifunovic, D, Vujisic-Tesic, B, Borovic, M, Milasinovic, D, Zivkovic, M, Kostic, J, Belelsin, B, Ostojic, M, investigators, PATA STEMI, Trifunovic, D, Krljanac, G, Savic, L, Asanin, M, Aleksandric, S, Petrovic, M, Zlatic, N, Lasica, R, Mrdovic, I, Nucifora, G, Muser, D, Zanuttini, D, Tioni, C, Bernardi, G, Spedicato, L, Proclemer, A, Casalta, AC, Galli, E, Szymanski, C, Salaun, E, Lavoute, C, Haentjens, J, Tribouilloy, C, Mancini, J, Donal, E, Habib, G, Cavalcante, JL, Delgado-Montero, A, Dahou, A, Caballero, L, Rijal, S, Gorcsan, J, Monin, JL, Pibarot, P, Lancellotti, P, Keramida, K, Kouris, N, Kostopoulos, V, Giannaris, V, Trifou, E, Markos, L, Mihalopoulos, A, Mprempos, G, Olympios, CD, Calin, A, Mateescu, AD, Rosca, M, Beladan, CC, Enache, R, Gurzun, MM, Varga, P, Calin, C, Ginghina, C, Popescu, BA, Almeida Morais, L, Galrinho, A, Branco, L, Gomes, V, Timoteo, A T, Daniel, P, Rodrigues, I, Rosa, S, Fragata, J, Ferreira, R, Bandera, F, Generati, G, Pellegrino, M, Carbone, F, Labate, V, Alfonzetti, E, Guazzi, M, Galli, E, Leclercq, C, Samset, E, Donal, E, Kamal, H M, Oraby, MA, Eleraky, A Z, Yossuef, M A, Leite, L, Baptista, R, Teixeira, R, Ribeiro, N, Oliveira, AP, Barbosa, A, Castro, G, Martins, R, Elvas, L, Pego, M, Polte, CL, Gao, SA, Lagerstrand, KM, Johnsson, AA, Bech-Hanssen, O, Martinez Santos, P, Vilacosta, I, Batlle Lopez, E, Sanchez Sauce, B, Jimenez Valtierra, J, Espana Barrio, E, Campuzano Ruiz, R, De La Rosa Riestra, A, Alonso Bello, J, Perez Gonzalez, F, Jin, CN, Wan, S, Sun, JP, Lee, AP, Generati, G, Bandera, F, Pellegrino, M, Carbone, F, Labate, V, Alfonzetti, E, Guazzi, M, Reali, M, Cimino, S, Salatino, T, Silvetti, E, Mancone, M, Pennacchi, M, Giordano, A, Sardella, G, Agati, L, Kalcik, M, Yesin, M, Gunduz, S, Gursoy, MO, Astarcioglu, MA, Karakoyun, S, Bayam, E, Cersit, S, Ozkan, M, Cacicedo, A, Velasco Del Castillo, S, Gomez Sanchez, V, Anton Ladislao, A, Onaindia Gandarias, J, Rodriguez Sanchez, I, Jimenez Melo, O, Quintana Razcka, O, Romero Pereiro, A, Zugazabeitia Irazabal, G, Nascimento, H, Braga, M, Flores, L, Ribeiro, V, Melao, F, Dias, P, Maciel, MJ, Bettencourt, P, Ferreiro Quero, C, Mesa Rubio, M D, Ruiz Ortiz, M, Delgado Ortega, M, Sanchez Fernandez, J, Duran Jimenez, E, Morenate Navio, C, Romero, M, Pan, M, Suarez De Lezo, J, Kazum, S, Vaturi, M, Weisenberg, D, Monakier, D, Valdman, A, Vaknin- Assa, H, Assali, A, Kornowski, R, Sagie, A, Shapira, Y, Madeira, S, Ribeiras, R, Abecasis, J, Teles, R, Castro, M, Tralhao, A, Horta, E, Brito, J, Andrade, M, Mendes, M, Villagra, JM, Avegliano, G, Ronderos, R, Matta, MG, Camporrotondo, M, Castro, F, Albina, G, Aranda, A, Navia, D, Muraru, D, Siciliano, M, Migliore, F, Cavedon, S, Folino, F, Pedrizzetti, G, Bertaglia, M, Corrado, D, Iliceto, S, Badano, LP, Gobbo, M, Merlo, M, Stolfo, D, Losurdo, P, Ramani, F, Barbati, G, Pivetta, A, Pinamonti, B, Sinagra, GF, Di Lenarda, A, Generati, G, Bandera, F, Pellegrino, M, Labate, V, Carbone, F, Alfonzetti, E, Guazzi, M, D'andrea, A, Di Palma, E, Baldini, L, Verrengia, M, Vastarella, R, Limongelli, G, Bossone, E, Calabro', R, Russo, MG, Pacileo, G, Azevedo, O, Cruz, I, Correia, E, Bento, D, Teles, L, Lourenco, C, Faria, R, Domingues, K, Picarra, B, Marques, N, Group, SUNSHINE, Nucifora, G, Muser, D, Gianfagna, P, Morocutti, G, Proclemer, A, Cruz, I, Gomes, AC, Lopes, LR, Stuart, B, Caldeira, D, Morgado, G, Almeida, AR, Canedo, P, Bagulho, C, Pereira, H, Lozano Granero, VC, Pardo Sanz, A, Marco Del Castillo, A, Monteagudo Ruiz, JM, Rincon Diaz, LM, Ruiz Rejon, F, Casas, E, Hinojar, R, Fernandez-Golfin, C, Zamorano Gomez, JL, Stampfli, S F, Erhart, L, Staehli, BE, Kaufmann, BA, Tanner, FC, Marketou, M, Kontaraki, J, Parthenakis, F, Maragkoudakis, S, Zacharis, E, Patrianakos, A, Vardas, P, Bento, D, Domingues, K, Correia, E, Lopes, L, Teles, L, Picarra, B, Magalhaes, P, Faria, R, Lourenco, C, Azevedo, O, Group, SUNSHINE, Mohty, D, Boulogne, C, Magne, J, Damy, T, Martin, S, Boncoeur, MP, Aboyans, V, Jaccard, A, Hernandez Jimenez, V, Saavedra Falero, J, Alberca Vela, MT, Molina Blazquez, L, Mata Caballero, R, Serrano Rosado, JA, Elviro, R, Gascuena, R, Di Gioia, C, Fernandez Rozas, I, Manzano, MC, Martinez Sanchez, JI, Molina, M, Palma, J, Ingvarsson, A, Werther Evaldsson, A, Radegran, G, Stagmo, M, Waktare, J, Roijer, A, Meurling, CJ, Cameli, M, Righini, FM, Sparla, S, Di Tommaso, C, Focardi, M, D'ascenzi, F, Tacchini, D, Maccherini, M, Henein, M, Mondillo, S, Werther Evaldsson, A, Ingvarsson, A, Waktare, J, Thilen, U, Stagmo, M, Roijer, A, Radegran, G, Meurling, C, Greiner, S, Jud, A, Aurich, M, Katus, HA, Mereles, D, Michelsen, MM, Faber, R, Pena, A, Mygind, ND, Suhrs, HE, Zander, M, Prescott, E, El Eraky, AZZA, Handoka, NESRIN, Ghali, MONA, Eldahshan, NAHED, Ibrahim, AHMED, Kamal, H M, Al-Eraky, A Z, El Attar, M A, Omar, A S, D'ascenzi, F, Pelliccia, A, Alvino, F, Solari, M, Cameli, M, Focardi, M, Bonifazi, M, Mondillo, S, Spinelli, L, Giudice, C A, Assante Di Panzillo, E, Castaldo, D, Riccio, E, Pisani, A, Trimarco, B, Stojanovic, S, Deljanin Ilic, M, Ilic, S, Mincu, RI, Magda, LS, Florescu, M, Velcea, A, Mihalcea, D, Chiru, A, Popescu, BO, Tiu, C, Vinereanu, D, Vindis, D, Hutyra, M, Cechakova, E, Littnerova, S, Taborsky, M, Mantovani, F, Lugli, R, Bursi, F, Fabbri, M, Modena, MG, Stefanelli, G, Mussini, C, Barbieri, A, Yi, JE, Youn, HJ, O, JH, Yoon, HJ, Jung, HO, Shin, GJ, Styczynski, G, Rdzanek, A, Pietrasik, A, Kochman, J, Huczek, Z, Milewska, A, Marczewska, M, Szmigielski, C A, Battah, AHMED, Abd Eldayem, SOHA, El Magd El Bohy, ABO, O'driscoll, J, Slee, A, Peresso, V, Nazir, S, Sharma, R, Generati, G, Bandera, F, Pellegrino, M, Labate, V, Carbone, F, Alfonzetti, E, Guazzi, M, Velasco Del Castillo, S, Anton Ladislao, A, Gomez Sanchez, V, Cacidedo Fernandez Bobadilla, A, Onaindia Gandarias, JJ, Rodriguez Sanchez, I, Romero Pereira, A, Quintana Rackza, O, Jimenez Melo, O, Zugazabeitia Irazabal, G, Voilliot, D, Huttin, O, Venner, C, Deballon, R, Manenti, V, Villemin, T, Olivier, A, Sadoul, N, Juilliere, Y, Selton-Suty, C, Scali, MC, Simioniuc, A, Mandoli, GE, Dini, FL, Marzilli, M, Picano, E, Garcia Campos, A, Martin-Fernandez, M, De La Hera Galarza, JM, Corros-Vicente, C, Leon-Aguero, V, Velasco-Alonso, E, Colunga-Blanco, S, Fidalgo-Arguelles, A, Rozado-Castano, J, Moris De La Tassa, C, Opitz, B, Stelzmueller, ME, Wisser, W, Reichenfelser, W, Mohl, W, Herold, IHF, Saporito, S, Mischi, M, Bouwman, RA, Van Assen, HC, Van Den Bosch, HCM, De Lepper, A, Korsten, HHM, Houthuizen, P, Veiga, CESAR, I, JAVIER. Randulfe Juanjo Andina Jose Fanina Francisco Calvo Emilio Paredes-Galan Pablo Pazos Andres, Ageing, Diseases, Cardiovascular, Santos Furtado, M, Rodrigues, A, Leal, G, Silvestre, O, Andrade, J, Khan, UM, Hjertaas, JJ, Greve, G, Matre, K, Leite, L, Teixeira, R, Baptista, R, Barbosa, A, Ribeiro, N, Castro, G, Martins, R, Cardim, N, Goncalves, L, Pego, M, Leite, L, Teixeira, R, Baptista, R, Barbosa, A, Ribeiro, N, Castro, G, Martins, R, Cardim, N, Goncalves, L, Pego, M, Leite, L, Teixeira, R, Baptista, R, Barbosa, A, Oliveira, AP, Castro, G, Martins, R, Cardim, N, Goncalves, L, Pego, M, Keramida, K, Kouris, N, Kostopoulos, V, Markos, L, Olympios, CD, Molnar, AA, Kovacs, A, Tarnoki, AD, Tarnoki, DL, Kolossvary, M, Apor, A, Maurovich-Horvat, P, Jermendy, G, Sengupta, P, Merkely, B, Rio, P, Viveiros Monteiro, A, Galrinho, A, Pereira-Da-Silva, T, Moura Branco, L, Timoteo, A, Abreu, J, Leal, A, Varela, F, Cruz Ferreira, R, Huang, MS, Yang, LT, Tsai, WC, Papadopoulos, C, Mpaltoumas, K, Fotoglidis, A, Triantafyllou, K, Pagourelias, E, Kassimatis, E, Tzikas, S, Kotsiouros, G, Mantzogeorgou, E, Vassilikos, V, Venneri, L, Calicchio, F, Manivarmane, R, Pareek, N, Baksi, J, Rosen, S, Senior, R, Lyon, AR, Khattar, RS, Onut, R, Marinescu, C, Onciul, S, Zamfir, D, Tautu, O, Dorobantu, M, Casas Rojo, E, Carbonell San Roman, A, Rincon Diez, LM, Gonzalez Gomez, A, Fernandez Santos, S, Lazaro Rivera, C, Moreno Vinues, C, Sanmartin Fernandez, M, Fernandez-Golfin, C, Zamorano Gomez, JL, Bayat, F, Alirezaei, T, Karimi, AS, hospital, cardiovascular research center of shahid beheshti, Aggeli, C, Kakiouzi, V, Felekos, I, Panagopoulou, V, Latsios, G, Karabela, M, Petras, D, Tousoulis, D, Ben Kahla, S, Abid, L, Abid, D, Kammoun, S, Abid, L, Ben Kahla, S, Choi, JH, Lee, JW, Barreiro Perez, M, Martin Fernandez, M, Costilla Garcia, SM, Diaz Pelaez, E, and Moris De La Tassa, C
- Abstract
Purpose: We developed a transthoracic echo simulator that can measure psychomotor skill in echo to assist in training as well as for certification of competence. The simulator displays cine loops on a computer in response to the user scanning a mannequin with a mock transducer. The skill metric is the deviation angle between the image acquired by the user and the anatomically correct plane for the specified view. We sought to determine whether the simulator-based test could distinguish levels of expertise. Methods: Attendees at an echo course or at the annual meeting of the Swedish Heart Association were invited to take a 15 min test on the simulator. On the test, the user scanned the mannequin and acquired 4 views: parasternal long axis (pLAX) in patient 1, apical 4 chamber (a4c) and aLAX in patient 2, and pLAX in patient 3. Scan time was limited to 15 min. Attendees were asked regarding current work status, position, and experience with echo assessed from duration in years and procedure volume in the past 12 months. Results: Of the 61 participants there were 22 sonographers, 2 nurses, and 37 doctors who were all in practice except 1 doctor who was a resident. The data of nurses was combined with that of sonographers because their procedure volume was nearer to that of sonographers (850 ± 599 tests/yr) than doctors (312 ± 393, p < 0.001). Doctors and non-doctors had similar duration of experience (9 ± 8 vs. 12 ± 11 yrs, p=NS). The test was not completed by 12 participants (18%) but unfamiliarity with the simulator may have contributed because the deviation angle for pLAX dropped between the first and third patients (23 ± 11 to 18 ± 10 degrees, p<0.020). The average deviation angle over the 4 views was slightly lower for sonographers than for doctors (26 ± 11 vs. 30 ± 14 degrees, p=NS). The deviation angle for pLAX (55 ± 37 degrees) was higher than for a4C (17 ± 22 degrees) or either pLAX view (p<0.00001). pLAX was the only view whose deviation angle correlated significantly with experience and only with procedure volume (r=-0.302, p=0.025). Conclusions: The results of this study demonstrate that the skill metric employed, angle of deviation between the plane of an acquired view and the plane of the anatomically correct image for that view, can distinguish the relative experience of sonographers and doctors in practice. Simulation-based testing provides objective and quantitative assessment of the psychomotor skill of image acquisition and may be of value in certification of trainees and in maintenance of certification examination of practicing sonographers and doctors.
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- 2015
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31. Prevalence, clinical and instrumental features of left bundle branch block‐induced cardiomyopathy: the CLIMB registry
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Patrizia Carta, Gianfranco Sinagra, Giuseppe D. Sanna, Massimo Zecchin, Marco Merlo, Annamaria De Bellis, Eleonora Beccu, Mario E Canonico, Eleonora Moccia, Guido Parodi, Sanna, G. D., De Bellis, A., Zecchin, M., Beccu, E., Carta, P., Moccia, E., Canonico, M. E., Parodi, G., Sinagra, G., and Merlo, M.
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Registrie ,Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Short Communication ,Left ,Bundle-Branch Block ,Cardiomyopathy ,Cardiac resynchronization therapy ,Short Communications ,Dilated cardiomyopathy ,Contrast Media ,Gadolinium ,Ventricular Function, Left ,QRS complex ,Retrospective Studie ,Internal medicine ,medicine ,Prevalence ,Ventricular Function ,Diseases of the circulatory (Cardiovascular) system ,Humans ,cardiovascular diseases ,Registries ,Left bundle branch block ,Left bundle branch block-induced cardiomyopathy ,Aged ,Female ,Middle Aged ,Retrospective Studies ,Stroke Volume ,Cardiomyopathies ,New York Heart Association Class I ,Ejection fraction ,business.industry ,Left bundle branch block‐induced cardiomyopathy ,medicine.disease ,Heart failure ,RC666-701 ,Cardiology ,cardiovascular system ,Cardiology and Cardiovascular Medicine ,business ,Human - Abstract
Aims Although increasingly recognized as a distinct pathological entity, left bundle branch block‐induced cardiomyopathy (LBBB‐ICMP) is not included among the possible aetiologies of acquired dilated cardiomyopathies (DCM). While diagnostic criteria have been proposed, its recognition remains principally retrospective, in the presence of clinical and instrumental red flags. We aimed to assess the prevalence and clinical and instrumental features of LBBB‐ICMP in a large cohort of patients with DCM. Methods and results We analysed a cohort of 242 DCM patients from a two‐centre registry. Inclusion criteria were age > 18, non‐ischaemic or non‐valvular DCM, and LBBB on electrocardiogram. LBBB‐ICMP was defined according to previously proposed diagnostic criteria: (i) neither family history nor clinically identifiable potential causes for DCM; (ii) negative genetic testing; (iii) echocardiographic features including non‐severe chamber dilation, normal absolute and relative wall thickness, marked dyssynchrony, and normal right ventricular function; and (iv) absence of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR). From the entire cohort, we identified 30 subjects (similar in terms of New York Heart Association class I or II in 80% vs. 75%, P = 0.56; QRS width of 150 ± 22 vs. 151 ± 24 ms, P = 0.82; and cardiac remodelling of baseline end‐diastolic diameter 66 ± 8 vs. 65 ± 10 mm, P = 0.53) with a comprehensive dataset including CMR and genetic testing, required to verify the presence of the diagnostic criteria proposed for LBBB‐ICMP. The main characteristics of this subgroup were 73% males, age 45 ± 13 years, left ventricular ejection fraction (LVEF) 30 ± 10%, LGE in 38% of patients, and QRS complex of 150 ± 22 ms. Patients were under guideline‐directed medical therapy, and 57% of them were treated with cardiac resynchronization therapy (CRT). Two patients (6.67%, 50% males, age 53 ± 13 years) fulfilled the diagnostic criteria proposed for LBBB‐ICMP. After a follow‐up of 44 (12–76) months, LVEF was normal and QRS width significantly reduced (from 154 ± 25 to 116 ± 52 ms) in patients with LBBB‐ICMP. Both patients were under optimal medical treatment, and one was implanted with CRT‐D. Neither of the two patients experienced death, malignant ventricular arrhythmia, or heart failure hospitalization at follow‐up. Conclusions Left bundle branch block‐induced cardiomyopathy emerges as a distinct pathological entity, promptly identifiable in a minority but not negligible proportion of patients with newly diagnosed DCM and LBBB, using a series of diagnostic criteria including CMR and genetic testing. Further studies are needed to better elucidate the clinical course of LBBB‐ICMP.
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- 2021
32. Seventeen-year trend (2001–2017) in pacemaker and implantable cardioverter-defibrillator utilization based on hospital discharge database data: An analysis by age groups
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Gianfranco Sinagra, Renato Pietro Ricci, Eugenio Carrani, Alessandro Proclemer, Letizia Sampaolo, Enrico Ciminello, Massimo Zecchin, Benedetta Ortis, Giuseppe Boriani, Marina Torre, Zecchin, M., Torre, M., Carrani, E., Sampaolo, L., Ciminello, E., Ortis, B., Ricci, R., Proclemer, A., Sinagra, G., and Boriani, G.
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Cardiac Resynchronization Therapy ,Health administrative data, Registry, Pacemaker ,Implantable cardioverter-defibrillator ,Aged, 80 and over ,Hospitals ,Humans ,Italy ,Patient Discharge ,Registries ,Defibrillators, Implantable ,Heart Failure ,Pacemaker, Artificial ,Registrie ,Registry ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,Cardiac resynchronization therapy ,030204 cardiovascular system & hematology ,Ventricular tachycardia ,Hospital ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,80 and over ,Internal Medicine ,Medicine ,030212 general & internal medicine ,education ,Aged ,education.field_of_study ,business.industry ,Hospital discharge database ,medicine.disease ,Health administrative data ,Pacemaker ,Heart failure ,Artificial ,Ventricular fibrillation ,Implant ,Implantable ,business ,Defibrillators ,Human - Abstract
Aims: To analyze temporal trends (2001 -2017) of Pacemakers (PM) and Implantable Cardioverter-Defibrillators (ICD) procedures in Italy, according to the national Hospital Discharge Database (HDD). Methods: Frequency and implant rate (IR) in the Italian population were analyzed by age groups (
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- 2021
33. ECG in dilated cardiomyopathy
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Davide Stolfo, Denise Zaffalon, Marco Merlo, Giulia Barbati, Gianfranco Sinagra, Massimo Zecchin, Stefano Bardari, Alessandro Altinier, Merlo, M., Zaffalon, D., Stolfo, D., Altinier, A., Barbati, G., Zecchin, M., Bardari, S., and Sinagra, G.
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Male ,Time Factors ,Dilated cardiomyopathy ,Cardiomyopathy ,Arrhythmic stratification ,Predictive Value of Test ,Arrhythmias ,030204 cardiovascular system & hematology ,Left ventricular hypertrophy ,Electrocardiography ,0302 clinical medicine ,Long-term ,Retrospective Studie ,Heart Rate ,Risk Factors ,Dilated ,030212 general & internal medicine ,medicine.diagnostic_test ,Description ,General Medicine ,Middle Aged ,Prognosis ,Death ,Predictive value of tests ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Cardiac ,Human ,Adult ,Cardiomyopathy, Dilated ,medicine.medical_specialty ,Time Factor ,Prognosi ,Sudden death ,ECG ,Arrhythmias, Cardiac ,Death, Sudden, Cardiac ,Heart Transplantation ,Humans ,Predictive Value of Tests ,Retrospective Studies ,03 medical and health sciences ,Internal medicine ,Heart rate ,medicine ,cardiovascular diseases ,business.industry ,Risk Factor ,Retrospective cohort study ,medicine.disease ,Sudden ,business - Abstract
Objective The objective was to provide an exhaustive characterization of ECG features in a large cohort of dilated cardiomyopathies (DCMs) and then investigate their possible prognostic role in the long term. Background ECG is an accessible, reproducible, low-cost diagnostic and prognostic tool. However, an extensive description of ECG features and their long-term prognostic role in a large cohort of DCM is lacking. Methods All available baseline ECGs of DCM patients enrolled from 1992 to 2013 were systematically analysed. Patients underwent to a complete clinical-laboratory evaluation. The study outcome measures were death or heart transplant (D/HT) and sudden death or malignant ventricular arrhythmias (SD/MVA). Results Four hundred and fourteen DCM patients were enrolled. During a median follow-up of 125 months, 55 and 57 patients experienced D/HT and SD/MVA, respectively. At multivariate analysis, left ventricular hypertrophy (P = 0.017), heart rate (HR, P = 0.005) and anterolateral T-wave inversion (P = 0.041) predicted D/HT. Regarding SD/MVA, S wave amplitude in V2 (P = 0.008), R wave amplitude in DIII (P = 0.007), anterolateral T-wave inversion (P = 0.017) emerged as predictors. At receiver-operating curve analyses, the addition of ECG models to the clinical-laboratory evaluation significantly increased the area under the curve both for D/HT (from 0.68 to 0.74, P = 0.042) and SD/MVA (from 0.70 to 0.77, P = 0.048). Conclusion The exhaustive systematic evaluation of ECG has an incremental impact in the prognostication of a large cohort of DCM patients, also regarding the arrhythmic stratification.
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- 2019
34. Arrhythmic risk stratification in patients with dilated cardiomyopathy and intermediate left ventricular dysfunction
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Marta Gigli, Gianfranco Sinagra, Fabrizio Pirozzi, Giulia Barbati, Marco Alonge, Giulia De Angelis, Antonio Cannatà, Jessica Artico, Davide Stolfo, Bruno Pinamonti, Piero Gentile, Marco Merlo, Alessia Paldino, Massimo Zecchin, Federica Ramani, Merlo, M., Gentile, P., Artico, J., Cannata, A., Paldino, A., De Angelis, G., Barbati, G., Alonge, M., Gigli, M., Pinamonti, B., Ramani, F., Zecchin, M., Pirozzi, F., Stolfo, D., and Sinagra, G.
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Male ,Registrie ,Time Factors ,medicine.medical_treatment ,Left ,Dilated cardiomyopathy ,Cardiomyopathy ,Arrhythmias ,030204 cardiovascular system & hematology ,Ventricular tachycardia ,Ventricular Function, Left ,Sudden cardiac death ,Ventricular Dysfunction, Left ,0302 clinical medicine ,Risk Factors ,Retrospective Studie ,Dilated ,Implantable cardioverter defibrillator ,Ventricular Dysfunction ,Prevalence ,Ventricular Function ,Registries ,030212 general & internal medicine ,Prognostic stratification ,Ejection fraction ,Incidence ,Hazard ratio ,General Medicine ,Middle Aged ,Prognosis ,Implantable cardioverter-defibrillator ,Death ,Italy ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,Cardiac ,Human ,Adult ,Cardiomyopathy, Dilated ,medicine.medical_specialty ,Time Factor ,Prognosi ,Risk Assessment ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Retrospective Studies ,business.industry ,Risk Factor ,Cardiovascular Agents ,Arrhythmias, Cardiac ,Stroke Volume ,medicine.disease ,Sudden ,Death, Sudden, Cardiac ,Cardiovascular Agent ,Cardiovascular agent ,business - Abstract
AIMS: Arrhythmic risk stratification is a challenging issue in patients with dilated cardiomyopathy (DCM), particularly when left ventricular ejection fraction (LVEF) is more than 35%. We studied the prevalence and predictors of sudden cardiac death or malignant ventricular arrhythmias (SCD/MVAs) in DCM patients categorized at low arrhythmic risk because of intermediate left ventricular dysfunction under optimal medical treatment (OMT). METHODS: DCM patients considered at low arrhythmic risk (LVEF >35% and New York Heart Association class I-III after 6 ± 3 months of OMT) were analysed. An arrhythmogenic profile was defined as the presence of at least one among a history of syncope, nonsustained ventricular tachycardia, at least 1000 premature ventricular contractions/24 h, at least 50 ventricular couplets/24 h at Holter ECG monitoring. SCD/MVAs was considered as the study end-point. RESULTS: During a median follow-up of 152 months (interquartile range 100-234), 30 out of 360 (8.3%) patients at low arrhythmic risk (LVEF 47 ± 7%) experienced the study end-point [14 (3.9%) SCD and 16 (4.4%) MVA]. Compared with survivors, patients who experienced SCD/MVAs had more frequently an arrhythmogenic profile and a larger left atrium. Their LVEF at the last available evaluation before the arrhythmic event was 36 ± 12%. At multivariable analysis, left atrial end-systolic area [hazard ratio 1.107; 95% confidence interval (95% CI) 1.039-1.179, P = 0.002 for 1 mm increase] and arrhythmogenic profile (hazard ratio 3.667; 95% CI 1.762-7.632, P = 0.001) emerged as predictors of SCD/MVAs during follow-up. CONCLUSION: A consistent quota of DCM patients with intermediate left ventricular dysfunction receiving OMT experienced SCD/MVA during follow-up. Left atrial dilatation and arrhythmogenic pattern were associated with a higher risk of SCD/MVA.
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- 2019
35. Prognostic value of implantable defibrillator-computed respiratory disturbance index: The DASAP-HF study
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Igor Diemberger, Gianfranco Sinagra, Marcello Piacenti, R. P. Ricci, Antonio D'Onofrio, Michele Emdin, A Talarico, Paolo Pieragnoli, Alessandro Capucci, Massimo Zecchin, Ennio Pisano, Giuseppe Boriani, Miguel A. Arias, Antonio Rapacciuolo, Ciro Indolfi, Maria Teresa La Rovere, Alessandro Locatelli, Catia Checchinato, Boriani, G., Pisano, E. C. L., Pieragnoli, P., Locatelli, A., Capucci, A., Talarico, A., Zecchin, M., Rapacciuolo, A., Piacenti, M., Indolfi, C., Arias, M. A., Diemberger, I., Checchinato, C., La Rovere, M. T., Sinagra, G., Emdin, M., Ricci, R. P., D'Onofrio, A., Boriani, Giuseppe, Pisanò, Ennio C L, Pieragnoli, Paolo, Locatelli, Alessandro, Capucci, Alessandro, Talarico, Antonello, Zecchin, Massimo, Rapacciuolo, Antonio, Piacenti, Marcello, Indolfi, Ciro, Arias, Miguel Angel, Diemberger, Igor, Checchinato, Catia, La Rovere, Maria Teresa, Sinagra, Gianfranco, Emdin, Michele, Ricci, Renato Pietro, and D'Onofrio, Antonio
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Male ,Respiratory disturbances ,Time Factors ,medicine.medical_treatment ,Polysomnography ,030204 cardiovascular system & hematology ,Implantable defibrillator ,Ventricular Function, Left ,0302 clinical medicine ,Risk Factors ,Respiratory disturbance ,030212 general & internal medicine ,Diagnosis, Computer-Assisted ,Prospective Studies ,Ejection fraction ,medicine.diagnostic_test ,Incidence ,Hazard ratio ,Sleep apnea ,Implantable cardioverter-defibrillator ,Prognosis ,Defibrillators, Implantable ,Survival Rate ,Italy ,Cardiology ,Female ,France ,Cardiology and Cardiovascular Medicine ,Algorithms ,medicine.medical_specialty ,Prognosi ,Heart failure ,03 medical and health sciences ,Sleep Apnea Syndromes ,Physiology (medical) ,Internal medicine ,Respiratory disturbance index ,medicine ,Humans ,Aged ,business.industry ,Stroke Volume ,medicine.disease ,business ,Follow-Up Studies - Abstract
Background Sleep apnea, as measured by polysomnography, is associated with adverse outcomes in heart failure. The DASAP-HF (Diagnosis and Treatment of Sleep Apnea in Patient With Heart Failure) study previously demonstrated that the respiratory disturbance index (RDI) computed by the ApneaScan algorithm (Boston Scientific) accurately identifies severe sleep apnea in implantable cardioverter-defibrillator (ICD) patients. Objective The purpose of the long-term study phase was to assess the incidence of clinical events after 24 months and investigate the association with RDI values. Methods Patients with left ventricular ejection fraction ≤35% implanted with an ICD were enrolled and followed-up for 24 months. The RDI calculated at 1 month after implantation was used to stratify patients (below or above 30 episodes/h). The endpoints were all-cause death and a combination of all-cause death or cardiovascular hospitalization. Results Of the 265 enrolled patients, 224 had usable RDI values. Severe sleep apnea (RDI ≥30 episodes/h) was diagnosed in 115 patients (51%). These patients were more frequently male (84% vs 72%; P = .030) and had higher creatinine levels. During median follow-up of 25 months, 19 patients (8%) died. Cardiovascular hospitalizations were reported in 19 patients (8%). The risk of all-cause death was higher in patients with RDI ≥30 episodes/h (hazard ratio [HR] 3.33; 95% confidence interval [CI] 1.35–8.21; P = .023), as well as the risk of all-cause death or cardiovascular hospitalization (HR 1.94; 95% CI 1.01–3.76; P = .048). At multivariate analysis, independent predictors of death were RDI ≥30 episodes/h (HR 4.02; 95% CI 1.16–13.97; P = .029) and creatinine levels (HR 2.36; 95% CI 1.26–4.42; P = .008). Conclusion In heart failure patients implanted with an ICD, higher RDI values are associated with death and cardiovascular hospitalizations. Device-detected severe sleep apnea independently predicts death.
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- 2021
36. Supraventricular Tachycardia Causing Left Ventricular Dysfunction
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Gianfranco Sinagra, Giulia Barbati, Laura Vitali Serdoz, Gherardo Finocchiaro, Denise Zaffalon, Enrico Fabris, Linda Pagura, Marco Merlo, Caterina Gregorio, Antonio Cannatà, Massimo Zecchin, Zaffalon, D., Pagura, L., Cannata, A., Barbati, G., Gregorio, C., Finocchiaro, G., Serdoz, L. V., Zecchin, M., Fabris, E., Merlo, M., and Sinagra, G.
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Adult ,Male ,medicine.medical_specialty ,LV systolic dysfunction ,New onset ,Ventricular Dysfunction, Left ,Lv dysfunction ,Internal medicine ,Heart rate ,medicine ,Tachycardia, Supraventricular ,Humans ,cardiovascular diseases ,Limited evidence ,Aged ,Retrospective Studies ,Ejection fraction ,business.industry ,Middle Aged ,medicine.disease ,Natural history ,cardiovascular system ,Cardiology ,Female ,Supraventricular tachycardia ,Cardiology and Cardiovascular Medicine ,business - Abstract
There is limited evidence on characterization and natural history of supraventricular tachycardia (SVT)-induced left ventricular (LV) dysfunction. The aim of this work was to characterize clinical features and long-term evolution of SVT-induced LV dysfunction. Patients consecutively admitted with sustained SVT and heart rate >100 bpm as the only known cause of a new onset LV systolic dysfunction (i.e., LV ejection fraction [EF]
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- 2021
37. Atrial fibrillation in dilated cardiomyopathy: Outcome prediction from an observational registry
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Enrico Fabris, Giulia Barbati, Antonio Cannatà, Matteo Castrichini, Gianfranco Sinagra, Marco Merlo, Paolo Manca, Vincenzo Nuzzi, Aneta Aleksova, Massimo Zecchin, Giuseppe Boriani, Nuzzi, V., Cannata, A., Manca, P., Castrichini, M., Barbati, G., Aleksova, A., Fabris, E., Zecchin, M., Merlo, M., Boriani, G., and Sinagra, G.
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Adult ,Cardiomyopathy, Dilated ,Male ,medicine.medical_specialty ,Heart disease ,medicine.medical_treatment ,Dilated cardiomyopathy ,030204 cardiovascular system & hematology ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Internal medicine ,Atrial Fibrillation ,Permanent atrial fibrillation ,Medicine ,Humans ,Sinus rhythm ,030212 general & internal medicine ,Registries ,Heart transplantation ,Ejection fraction ,business.industry ,Atrial fibrillation ,Stroke Volume ,Middle Aged ,medicine.disease ,Prognosis ,Long-term outcome ,Chronic heart failure ,Treatment Outcome ,Heart failure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background: Little is known about the role of different types of atrial fibrillation (AF) in dilated cardiomyopathy (DCM). We investigated the epidemiological and prognostic impact of different types of AF in DCM during long-term follow-up. Method: We evaluated consecutive DCM patients enrolled in the Trieste Muscle Heart Disease Registry. Uni- and multivariable, extended Kaplan-Meier and propensity score-matching analyses were performed for a composite outcome including death/heart transplantation/ventricular-assist device implantation. Results: Out of 1181 DCM patients (71% males, age 49 ± 15 years, left ventricular ejection fraction 33 ± 11%), 46 (3.9%) had baseline permanent AF (permAF), while 66 (5.6%) had a history of paroxysmal/persistent AF. Compared with sinus rhythm (SR) patients, permAF patients were older (48 ± 15 vs. 61 ± 11 respectively, p = 0.001), were more frequently in NYHA class III-IV (18% vs. 30%, p = 0.002) and had larger left atrium diameter (40 ± 8 vs. 50 ± 10 mm, respectively). Paroxysmal/persistent AF patients had intermediate characteristics between permAF and SR. During a median follow-up of 135 (75–210) months, 63 patients developed permAF (0.45 new cases/100patients/year). At multivariable analysis, permAF as a time-dependent variable was an independent outcome predictor (HR 2.45; 95% C.I. 2.61–3.63, p < 0.001), together with creatinine, NYHA class, restrictive filling pattern and moderate-severe mitral regurgitation, while paroxysmal/persistent AF was neutral. Propensity score-matching analysis confirmed the higher rate of primary outcome events in patients with baseline or incident permAF versus patients without permAF during a very long-term follow-up (70% vs. 20%, p < 0.001). Conclusions: PermAF in a large DCM cohort had low prevalence and incidence but had a relevant. prognostic role on hard outcomes.
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- 2020
38. Arrhythmic risk stratification in non-ischaemic dilated cardiomyopathy beyond ejection fraction
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Giulia De Angelis, Jessica Artico, Piero Gentile, Camilla Normand, Andrea Boscutti, Massimo Zecchin, Gianfranco Sinagra, Marco Merlo, Stephane Heymans, Antonio Cannatà, Cannata, A., De Angelis, G., Boscutti, A., Normand, C., Artico, J., Gentile, P., Zecchin, M., Heymans, S., Merlo, M., and Sinagra, G.
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Cardiomyopathy, Dilated ,STIMULATION ,medicine.medical_specialty ,PROGNOSIS ,IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR ,multiparametric ,030204 cardiovascular system & hematology ,Global Health ,arrhythmic risk stratification ,dilated cardiomyopathy ,left ventricular reverse remodeling ,sudden cardiac death ,Risk Assessment ,Ventricular Function, Left ,Sudden cardiac death ,LMNA ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Late gadolinium enhancement ,Humans ,In patient ,030212 general & internal medicine ,FLNC ,MUTATION ,Ejection fraction ,Arrhythmic risk ,Ventricular Remodeling ,business.industry ,Incidence ,LATE GADOLINIUM ENHANCEMENT ,Dilated cardiomyopathy ,Stroke Volume ,medicine.disease ,INDUCIBILITY ,Survival Rate ,NONSUSTAINED VENTRICULAR-TACHYCARDIA ,Death, Sudden, Cardiac ,Cardiology ,TRIAL ,Cardiology and Cardiovascular Medicine ,business ,PRIMARY PREVENTION - Abstract
Sudden cardiac death and arrhythmia-related events in patients with non-ischaemic dilated cardiomyopathy (NICM) have been significantly reduced over the last couple of decades as a result of evidence-based pharmacological and non-pharmacological therapeutic strategies. Nevertheless, the arrhythmic stratification in patients with NICM remains extremely challenging, and the simple indication based on left ventricular ejection fraction appears to be insufficient. Therefore, clinicians need to go beyond the current criteria for implantable cardioverter-defibrillator implantation in the direction of a multiparametric evaluation of arrhythmic risk. Several parameters for arrhythmic risk stratification, ranging from electrocardiographic, echocardiographic, imaging-derived and genetic markers, are crucial for proper arrhythmic risk stratification and a multiparametric evaluation of risk in patients with NICM. In particular, integration of cardiac magnetic resonance parameters (mostly late gadolinium enhancement) and specific genetic information (ie, presence of LMNA, PLN, FLNC mutations) appears fundamental for proper implementation of the current arrhythmic risk stratification. Finally, a novel approach focused on both arrhythmic risk and prediction of left ventricular reverse remodelling during follow-up might be useful for effective multiparametric and dynamic arrhythmic risk stratification in NICM. In the future, a complete and integrated evaluation might be mandatory to implement arrhythmic risk prediction in patients with NICM and to discriminate the competing risk between heart failure-related events and life-threatening arrhythmias.
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- 2020
39. Atrial signal amplitude predicts atrial high-rate episodes in implantable cardioverter defibrillator patients: Insights from a large database of remote monitoring transmissions
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Valeria Calvi, Ennio Pisano, Alessio Gargaro, Massimo Zecchin, Gaetano Senatore, Mauro Biffi, Alessandro Capucci, Daniele Giacopelli, Michele Manzo, Giampiero Maglia, Francesco Solimene, Antonio D'Onofrio, Antonio Curnis, Fabio Lissoni, Gianfranco Sinagra, Saverio Iacopino, Carlo Pignalberi, Massimiliano Marini, Gabriele Zanotto, Paolo Della Bella, Fabrizio Caravati, Massimo Giammaria, Matteo Santamaria, Antonio Rapacciuolo, Fabio Quartieri, Zecchin, M., Solimene, F., D'Onofrio, A., Zanotto, G., Iacopino, S., Pignalberi, C., Calvi, V., Maglia, G., Della Bella, P., Quartieri, F., Curnis, A., Biffi, M., Capucci, A., Caravati, F., Senatore, G., Santamaria, M., Lissoni, F., Manzo, M., Marini, M., Giammaria, M., Rapacciuolo, A., Sinagra, G., Giacopelli, D., Gargaro, A., and Pisano, E. C.
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lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,implantable cardioverter defibrillator ,medicine.medical_treatment ,Cardiac resynchronization therapy ,cardiac resynchronization therapy ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,pacing threshold ,Internal medicine ,Statistical significance ,medicine ,Sinus rhythm ,030212 general & internal medicine ,impedance ,sensing ,Univariate analysis ,business.industry ,Implantable cardioverter-defibrillator ,lcsh:RC666-701 ,Shock (circulatory) ,Cohort ,Cardiology ,Original Article ,Implant ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Parameters measured during implantable cardioverter defibrillator (ICD) implant also depend on bioelectrical properties of the myocardium. We aimed to explore their potential association with clinical outcomes in patients with single/dual‐chamber ICD and cardiac resynchronization therapy defibrillator (CRT‐D). Methods In the framework of the Home Monitoring Expert Alliance, baseline electrical parameters for all implanted leads were compared by the occurrence of all‐cause mortality, adjudicated ventricular arrhythmia (VA), and atrial high‐rate episode lasting ≥24 hours (24 h AHRE). Results In a cohort of 2976 patients (58.1% ICD) with a median follow‐up of 25 months, event rates were 3.1/100 patient‐years for all‐cause mortality, 18.1/100 patient‐years for VA, and 9.3/100 patient‐years for 24 h AHRE. At univariate analysis, baseline shock impedance was consistently lower in groups with events than without, with a 40 Ω cutoff that better identified high‐risk patients. However, at multivariable analysis, the adjusted‐hazard ratios (HRs) lost statistical significance for any endpoint. Baseline atrial sensing amplitude during sinus rhythm was lower in patients with 24 h AHRE than in those without (2.45 [IQR: 1.65‐3.85] vs 3.51 [IQR: 2.37‐4.67] mV, P 1.5 mV vs those with values ≤1.5 mV was 0.52 (95% CI: 0.33‐0.83), P = .006. Conclusions Although lower baseline shock impedance was observed in patients with events, the association lost statistical significance at multivariable analysis. Conversely, low sinus rhythm atrial sensing (≤1.5 mV) measured with standard transvenous leads could identify subjects at high risk of atrial arrhythmia., Some of the electrical parameters routinely measured at ICD/CRT‐D implant differed according to long‐term clinical outcome. Shock impedance values were lower in patients who experienced death and both atrial and ventricular arrhythmias during follow‐up. Subjects with atrial signal amplitude below 1.5 mV showed a significant higher risk of atrial arrhythmias as compared to those with >1.5 mV, potentially revealing the presence of a more impaired atrial tissue.
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- 2020
40. Risk of sudden cardiac death in New York Heart Association class I patients with dilated cardiomyopathy: A competing risk analysis
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Gianfranco Sinagra, Davide Stolfo, Marta Gigli, Massimo Zecchin, Stefano Albani, Federico Biondi, Giulia Barbati, Gianluigi Savarese, Marco Merlo, Federica Ramani, Matteo Dal Ferro, Stolfo, D., Albani, S., Savarese, G., Barbati, G., Ramani, F., Gigli, M., Biondi, F., Dal Ferro, M., Zecchin, M., Merlo, M., and Sinagra, G.
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Cardiomyopathy, Dilated ,medicine.medical_specialty ,New York Heart Association Class ,Dilated cardiomyopathy ,Implantable cardioverter defibrillator ,New York Heart Association class ,Sudden cardiac death ,Symptoms ,medicine.medical_treatment ,New York ,Cardiac resynchronization therapy ,030204 cardiovascular system & hematology ,Risk Assessment ,Ventricular Function, Left ,03 medical and health sciences ,0302 clinical medicine ,New York Heart Association cla ,Risk Factors ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,New York Heart Association Class I ,Ejection fraction ,business.industry ,Stroke Volume ,equipment and supplies ,medicine.disease ,Implantable cardioverter-defibrillator ,humanities ,Defibrillators, Implantable ,Death, Sudden, Cardiac ,Heart failure ,cardiovascular system ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,circulatory and respiratory physiology - Abstract
Aims Primary prevention implantable cardioverter defibrillator (ICD) is not generally recommended in New York Heart Association (NYHA) I class patients with dilated cardiomyopathy (DCM). This study sought to assess the competing risk of sudden cardiac death (SCD) in DCM patients with left ventricular ejection fraction (EF) ≤35% and NYHA I class. Methods A total of 272 DCM patients with EF ≤35% and NYHA class I–III after ≥3 months of guideline-directed medical therapy were included. The risk of SCD and SCD/malignant ventricular arrhythmias (MVA) was assessed in NYHA I vs. NYHA II and NYHA III groups by competing risk analysis. Results NYHA I patients were younger, had higher EF and smaller left atrium, were less likely receiving mineral corticoid receptor antagonists. The cumulative incidence of SCD (p = 0.92) and SCD/MVA (p = 0.42) did not differ between NYHA I vs NYHA II–III classes. NYHA class did not influence the association between ICD and SCD risk (p for interaction = 0.125). Conclusions In this cohort of DCMs, patients with EF ≤35% and NYHA I class were exposed to a risk of SCD and life-threatening arrhythmias not different from NYHA II–III. Therefore, inclusion of asymptomatic patients with DCM and systolic dysfunction should be strongly considered in future randomized studies on primary prevention ICD.
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- 2020
41. Long-term patient satisfaction with implanted device remote monitoring: A comparison among different systems
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Giulia Barbati, Benedetta Ortis, Massimo Zecchin, Stefano Albani, Jacopo Cristallini, Giulia Skerl, Jessica Artico, Gianfranco Sinagra, Anna Zorzin Fantasia, Antonio Cannatà, Stefania Franco, Artico, J., Zecchin, M., Zorzin Fantasia, A., Skerl, G., Ortis, B., Franco, S., Albani, S., Barbati, G., Cristallini, J., Cannata, A., and Sinagra, G.
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Adult ,Male ,Pacemaker, Artificial ,Time Factors ,Activities of daily living ,implantable cardioverter defibrillator ,medicine.medical_treatment ,Electric Countershock ,MEDLINE ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Patient satisfaction ,Predictive Value of Tests ,Surveys and Questionnaires ,Activities of Daily Living ,Implantable loop recorder ,medicine ,Humans ,030212 general & internal medicine ,Implanted device ,remote monitoring ,Aged ,Aged, 80 and over ,business.industry ,Cardiac Pacing, Artificial ,pacemaker ,patient preferences ,Usability ,General Medicine ,Satisfaction questionnaire ,Middle Aged ,Implantable cardioverter-defibrillator ,medicine.disease ,Telemedicine ,Defibrillators, Implantable ,Treatment Outcome ,Patient Satisfaction ,Remote Sensing Technology ,Female ,Medical emergency ,Cardiology and Cardiovascular Medicine ,business ,patient preference - Abstract
Aims Remote monitoring is an effective strategy to improve patients' outcomes and reduce hospitalization in patients with cardiac implantable electronic devices. However, data on patients' satisfaction are scarce. The aim of the current study was to assess patients' satisfaction, ease of use and impact on daily activities of the remote monitoring and to investigate whether there are differences among different devices and different manufacturers. Methods A modified Home Monitoring Acceptance and Satisfaction Questionnaire telephone survey on the perceived quality of the different systems was performed with all patients followed with remote monitoring for at least 3 months. Results Among 604 patients with remote monitoring screened by telephone, 466 patients (77%) answered the questionnaire [142 patients (30.5%) had a pacemaker, 317 patients (68%) had an implantable cardioverter defibrillator, and seven patients (1.5%) had an implantable loop recorder]. Ninety-seven percent of patients were satisfied by the remote monitoring system during the entire follow-up and found it easy to use. Similarly, 85% of patients did not experience any restriction in daily activities, and for 99% of patients it did not affect their privacy. Importantly, for the vast majority of patients, remote monitoring gave a great (56.7%) or moderate (33.4%) sense of security. Conclusion Daily impact of cardiac implantable electronic devices still remains a challenging issue for caregivers. The introduction of remote monitoring allowed closer follow-up and improved outcomes. Our results highlighted patients' satisfaction, who also felt safer, with the remote monitoring, its ease of use, and the absence of any disturbances in patients' everyday activities or in their privacy.
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- 2019
42. ICD replacement in patients with intermediate left ventricular dysfunction under optimal medical treatment
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Federico Biondi, Giulia Barbati, Antonio Cannatà, Massimo Zecchin, Roberto Ceolin, Gianfranco Sinagra, Stefania Franco, Piero Gentile, Marco Merlo, Jessica Artico, Alessia Paldino, Cosimo Carriere, Artico, J., Ceolin, R., Franco, Stefania, Paldino, A., Biondi, F., Barbati, G., Gentile, P., Cannata, A., Zecchin, M., Carriere, C., Merlo, M., and Sinagra, G.
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Male ,Arrhythmias ,Device replacement ,Intermediate left ventricular dysfunction ,medicine.medical_specialty ,medicine.medical_treatment ,Cardiac resynchronization therapy ,030204 cardiovascular system & hematology ,Cardiac Resynchronization Therapy ,03 medical and health sciences ,Ventricular Dysfunction, Left ,0302 clinical medicine ,Internal medicine ,Lv dysfunction ,medicine ,Humans ,In patient ,cardiovascular diseases ,030212 general & internal medicine ,Aged ,Retrospective Studies ,Ejection fraction ,Medical treatment ,business.industry ,Outcome measures ,Middle Aged ,medicine.disease ,SEVERE DYSFUNCTION ,Defibrillators, Implantable ,Treatment Outcome ,Heart failure ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Arrhythmia ,circulatory and respiratory physiology ,Follow-Up Studies - Abstract
Background: Implantable cardioverter-defibrillators (ICD) have a pivotal role in preventing major arrhythmic events in patients with severely reduced left ventricular ejection fraction (LVEF). Device replacement strategy is still controversial in patients without severely reduced left ventricular ejection fraction (LVEF) at the end of battery life. Objective: To evaluate the long-term arrhythmic outcome of patients with ICD or and cardiac resynchronization therapy defibrillators (CRT-D) with normal or intermediate LVEF at the time of device replacement. Methods: All consecutive patients with reduced ejection fraction heart failure, both from ischemic and non-ischemic origin, implanted with ICD or CRT-D for primary prevention from 2002 to 2009, were considered. The study population included patients without previous ICD interventions and without severe dysfunction (i.e. LVEF ≥ 35%) 60 [53–65] months after implantation (average battery duration). The outcome measure was the occurrence of appropriate ICD interventions in the long-term. Results: Among the 255 patients (150 ICDs; 105 CRT-D) evaluated, 45 (18%) had LVEF ≥ 35% without ICD interventions 5-year follow-up after implantation (15 ICD [10%]; 30 CRT-D [29%]). In the long term, ICD interventions were 4 (27%) in the ICD group and 5 (17%) in the CRT-D group. Conclusions: Despite the absence of severe left ventricular dysfunction at the time of battery replacement, a not negligible number of patients with ICD and CRT-D maintained a high risk of appropriate interventions in the long term, suggesting the opportunity of replacing the ICD regardless the amount of LV dysfunction. © 2019 Elsevier B.V.
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- 2019
43. Pliocene-Quaternary mass wasting along the Ionian Calabrian margin, offshore southern Italy
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Candoni, Oliviero, Ceramicola, Silvia, Praeg, Daniel, Zecchin, Massimo, Brancatelli, Giuseppe, Gorini, Christian, Bohrmann, Gerhard, Cova, Andrea, Istituto Nazionale di Geofisica e di Oceanografia Sperimentale (OGS), Università degli studi di Trieste = University of Trieste, Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Pontifical Catholic University of Rio Grande do Sul (PUC-RS), Institut des Sciences de la Terre de Paris (iSTeP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Center for Marine Environmental Sciences [Bremen] (MARUM), Universität Bremen, The European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie grant agreement No. 656821, EC SEAGAS (656821), European Project: 656821,H2020,H2020-MSCA-IF-2014,SEAGAS(2016), Praeg, Daniel, Multi-disciplinary Comparison of Fluid Venting from Gas Hydrate Systems on the Mediterranean and Brazilian Continental Margins over Glacial-Interglacial Timescales - SEAGAS - - H20202016-04-30 - 2019-04-29 - 656821 - VALID, EGU General Assembly Conference, Candoni, O., Ceramicola, S., Praeg, D., Zecchin, M., Brancatelli, G., Gorini, C., Bohrmann, G., Cova, A., Università degli studi di Trieste, Pontifícia Universidade Católica do Rio Grande do Sul [Porto Alegre] (PUCRS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), and Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)
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[SDE] Environmental Sciences ,mass wasting ,Plio-Quaternary ,[SDE]Environmental Sciences ,[SDE.ES] Environmental Sciences/Environmental and Society ,Crotone-Spartivneto basin ,[SDE.ES]Environmental Sciences/Environmental and Society - Abstract
International audience; The Ionian Calabrian margin, offshore southern Italy, is a tectonically active area, located above a subduction zone dominated by rollback of the African plate. A variety of mass wasting features are known to occur along the inner continental slope, based on seafloor mapping during the Italian project MaGIC (Marine Geohazards Along the Italian Coasts). New high-resolution geophysical data are available from a wider area following two surveys, in 2014 of the German RV Meteor, which acquired multibeam bathymetry (50 m DTM) and Parasound sub-bottom profiles, and in 2015 of the Italian RV OGS Explora, which acquired Chirp sub-bottom and multichannel seismic reflection profiles. Here we integrate these data with existing geophysical datasets and published exploration wells to map submarine slope failures and mass wasting deposits within the Pliocene-Quaternary succession. The results show that features of mass failures are widespread along the steep (higher than 10˚) slopes of the Ionian margin south of Calabria, and within the intra-slope basins of the margin east of Calabria. Seafloor features range from small-scale features (hundreds of meters in extent), mainly located on the canyon headwalls and sidewalls, to larger slides (up to 10 km in extent) on open slopes. Subsurface profiles across open slopes and intra-slope basins provide evidence of repeated failures, particularly in the upper Quaternary. The stratigraphic distribution of failures suggests that widespread mass wasting features occur above an unconformity tentatively dated to the Middle Pleistocene (
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- 2018
44. Hypertrophic Cardiomyopathy: An unexpected finding in a surgical variant of Heterotopic Heart Transplantation
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Manuel Belgrano, Francesco Negri, A. Gamba, Massimo Zecchin, Rossana Bussani, Gianfranco Sinagra, Bruno Pinamonti, Negri, F, Gamba, A, Belgrano, MANUEL GIANVALERIO, Bussani, Rossana, Pinamonti, B, Zecchin, M, and Sinagra, Gianfranco
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Heart transplantation ,Adult ,medicine.medical_specialty ,Cardiomyopathy, Restrictive ,Transplantation, Heterotopic ,business.industry ,medicine.medical_treatment ,Hypertrophic cardiomyopathy ,Hypertrophic Cardiomyopathy ,Heart failure ,Cardiomyopathy, Hypertrophic ,medicine.disease ,Tissue Donors ,Unexpected finding ,Internal medicine ,Heterotopic Heart Transplantation ,Cardiology ,Medicine ,Heart Transplantation ,Humans ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
A 42 years old woman was admitted to the Cardiology Department for heart failure. The woman had a diagnosis of Idiopathic Restrictive Cardiomyopathy. At the age of 29 she underwent a variant of the traditional intervention of Heterotopic Heart Transplantation (HHT). The donor Left Ventricular (dLV)was implanted towork as a biologic left ventricular device in series with the recipient Left Ventricular (rLV). This variant of the traditional intervention (Fig. 1 Panel A; G; H) was necessary to prevent the failure of the donor Right Ventricular (dRV) because the patient at the time of transplantation had a pulmonary resistance of 12Wood Unit. The patient had an abdominal pacemaker with three epicardial electrodes to allow the counter pulsation of the two hearts (Fig. 1 Panel A; B; C; D; F). The atrial electrode was added four years after the transplantation because the patient developed a third-degree atrioventricular block in the native heart. At the echocardiography examination the donor heart showed a severe hypertrophy (maximum 30 mm; anterior-septum; Video 1; transthoracic echocardiography) and a severe hypertrophy of papillary muscles, maximum 26 mm (Video 2; transesophageal echocardiography). The angiography showed normal coronary arteries. The patient underwent endomyocardial biopsy specimens that reveal no evidence of active myocarditis or amyloid but myocardial fiber disarray (Fig. 1 Panel I). Inside the heterogeneity of presentation of heart failure after HHT, Hypertrophic Cardiomyopathy of the donor heart can be a possibility which needs a knowledge of the type of intervention (traditional or variant) for a proper evaluation and a correct diagnosis.
- Published
- 2016
45. Radiofrequency ablation for benign thyroid nodules
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Stella Bernardi, Bruno Fabris, Fulvio Stacul, Fabrizio Zanconati, Massimo Zecchin, Chiara Dobrinja, Bernardi, Stella, Stacul, F, Zecchin, M, Dobrinja, Chiara, Zanconati, Fabrizio, and Fabris, Bruno
- Subjects
Thyroid nodules ,medicine.medical_specialty ,Pathology ,Minimally invasive nonsurgical techniques ,Radiofrequency ablation ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,030209 endocrinology & metabolism ,Catheter ablation ,Ultrasound-guided procedure ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,law ,medicine ,Humans ,Minimally invasive nonsurgical technique ,Thyroid nodule ,business.industry ,medicine.disease ,Pacemaker ,Tolerability ,Treatment modality ,030220 oncology & carcinogenesis ,Catheter Ablation ,Implantable cardioverter-defbrillator ,Radiology ,business - Abstract
Benign thyroid nodules are an extremely common occurrence. Radiofrequency ablation (RFA) is gaining ground as an effective technique for their treatment, in case they become symptomatic. Here we review what are the current indications to RFA, its outcomes in terms of efficacy, tolerability, and cost, and also how it compares to the other conventional and experimental treatment modalities for benign thyroid nodules. Moreover, we will also address the issue of treating with this technique patients with cardiac pacemakers (PM) or implantable cardioverter-defibrillators (ICD), as it is a rather frequent occurrence that has never been addressed in detail in the literature.
- Published
- 2016
46. Linking Health Care Administrative Databases And National Registry Data In Order To Monitor Icd Therapy In Italy
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M. Zecchin, Giancarlo Cesana, Fabiana Madotto, Lorenzo G. Mantovani, Carla Fornari, A Proclemer, Sara Conti, V. Chiodini, Madotto, F, Fornari, C, Chiodini, V, Mantovani, L, Zecchin, M, Proclemer, A, Conti, S, and Cesana, G
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business.industry ,Health Policy ,medicine.medical_treatment ,Public Health, Environmental and Occupational Health ,Implantable cardioverter-defibrillator ,medicine.disease ,Icd therapy ,Health Care Administrative Databases ,Order (business) ,Implantable cardioverter defibrillator ,Health care ,medicine ,National registry ,Medical emergency ,business - Published
- 2014
47. Long-Term Outcomes in ICD: All-Causes Mortality and First Appropriate Intervention in Ischemic and Nonischemic Etiologies.
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Cittar M, Zecchin M, Merlo M, Piccinin F, Baggio C, Salvatore L, Longaro F, Carriere C, Zorzin AF, Saitta M, Pagura L, Barbati G, Lardieri G, and Sinagra G
- Abstract
Real-life data comparing the long-term outcome in patients with different heart diseases carrying an implantable cardioverter defibrillator (ICD) are scarce. This study aimed to compare the long-term risk of the first appropriate ICD intervention and overall survival in patients with ICD and heart disease of different etiologies. Patients with an ICD implanted between January 1, 2010, and December 31, 2022, followed in our center were included. Study outcomes were all-cause mortality and first appropriate ICD intervention. A comparison between ischemic heart disease (IHD) and non-IHD (NIHD) was performed. In NIHD different etiologies of dilated cardiomyopathy (DCM) were analyzed. Overall, 1184 patients (592 IDH; 592 NIHD) were included. During a median follow-up of 53 months all-cause death occurred in 399 patients (34%) whereas first appropriate ICD intervention occurred in 320 (27%). All-cause mortality was significantly higher in IHD vs NIHD patients (60% vs 43%; p <0.0001) but no differences in appropriate ICD intervention rate at 10 years (34% vs 40%; p = 0.125) were observed. In patients with NIHD, a higher 10-year mortality rate was found in valvular heart disease, post-radio/chemotherapy DCM (rctDCM), and hypertensive DCM. Hypertrophic cardiomyopathy, alcoholic DCM, and rctDCM were the least arrhythmic phenotypes in NIHD. Of note, inappropriate interventions in alcoholic DCM and rctDCM were higher than appropriate ones. In conclusion, the rate of ICD-appropriate interventions and mortality is different according to the etiology of heart disease and cardiovascular risk profile; this should be taken into consideration in the prognostic stratification of these patients at the time of implantation., Competing Interests: Declaration of competing interest The authors have no competing interests to declare., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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48. Impact of DCM-Causing Genetic Background on Long-Term Response to Cardiac Resynchronization Therapy.
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Dal Ferro M, Paldino A, Gregorio C, Bessi R, Zaffalon D, De Angelis G, Severini GM, Stolfo D, Gigli M, Brun F, Massa L, Korcova R, Salvatore L, Bianco E, Mestroni L, Merlo M, Zecchin M, and Sinagra G
- Subjects
- Humans, Female, Male, Middle Aged, Retrospective Studies, Aged, Treatment Outcome, Heart Failure genetics, Heart Failure therapy, Heart Failure physiopathology, Adult, Ventricular Dysfunction, Left genetics, Ventricular Dysfunction, Left physiopathology, Ventricular Dysfunction, Left therapy, Bundle-Branch Block genetics, Bundle-Branch Block therapy, Bundle-Branch Block physiopathology, Cardiac Resynchronization Therapy, Cardiomyopathy, Dilated genetics, Cardiomyopathy, Dilated therapy, Cardiomyopathy, Dilated physiopathology, Ventricular Remodeling genetics, Ventricular Remodeling physiology
- Abstract
Background: Patients with nonischemic dilated cardiomyopathy (DCM), severe left ventricular (LV) dysfunction, and complete left bundle branch block benefit from cardiac resynchronization therapy (CRT). However, a large heterogeneity of response to CRT is described. Several predictors of response to CRT have been identified, but the role of the underlying genetic background is still poorly explored., Objectives: In the present study, the authors sought to define differences in LV remodeling and outcome prediction after CRT when stratifying patients according to the presence or absence of DCM-causing genetic background., Methods: From our center, 74 patients with DCM subjected to CRT and available genetic testing were retrospectively enrolled. Carriers of causative monogenic variants in validated DCM-causing genes, and/or with documented family history of DCM, were classified as affected by genetically determined disease (GEN+DCM) (n = 25). Alternatively, by idiopathic dilated cardiomyopathy (idDCM) (n = 49). The primary outcome was long-term LV remodeling and prevalence of super response to CRT (evaluated at 24-48 months after CRT); the secondary outcome was heart failure-related death/heart transplant/LV assist device., Results: GEN+DCM and idDCM patients were homogeneous at baseline with the exception of QRS duration, longer in idDCM. The median follow-up was 55 months. Long-term LV reverse remodeling and the prevalence of super response were significantly higher in the idDCM group (27% in idDCM vs 5% in GEN+DCM; P = 0.025). The heart failure-related death/heart transplant/LV assist device outcome occurred more frequently in patients with GEN+DCM (53% vs 24% in idDCM; P = 0.028)., Conclusions: Genotyping contributes to the risk stratification of patients with DCM undergoing CRT implantation in terms of LV remodeling and outcomes., Competing Interests: Funding Support and Author Disclosures This study was supported by CRTrieste Foundation and Cassa di Risparmio di Gorizia Foundation to Dr Sinagra. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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- 2024
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49. Comprehensive Cardiovascular Management of Myotonic Dystrophy Type 1 Patients: A Report from the Italian Neuro-Cardiology Network.
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Russo V, Antonini G, Massa R, Casali C, Mauriello A, Martino AM, Marconi R, Garibaldi M, Franciosa P, Zecchin M, Gaudio C, D'Andrea A, and Strano S
- Abstract
Myotonic dystrophy is a hereditary disorder with systemic involvement. The Italian Neuro-Cardiology Network-"Rete delle Neurocardiologie" (INCN-RNC) is a unique collaborative experience involving neurology units combined with cardio-arrhythmology units. The INCN facilitates the creation of integrated neuro-cardiac teams in Neuromuscular Disease Centers for the management of cardiovascular involvement in the treatment of myotonic dystrophy type 1 (MD1).
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- 2024
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50. A global analysis of implants and replacements of pacemakers and cardioverter-defibrillators before, during, and after the COVID-19 pandemic in Italy.
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Zecchin M, Ciminello E, Mari V, Proclemer A, D'Onofrio A, Zanotto G, De Ponti R, Capovilla TM, Laricchiuta P, Biondi A, Sampaolo L, Pascucci S, Sinagra G, Boriani G, Carrani E, and Torre M
- Subjects
- Humans, Pandemics, Registries, Italy epidemiology, COVID-19 epidemiology, Pacemaker, Artificial, Defibrillators, Implantable
- Abstract
At the beginning of the COVID-19 emergency, non-urgent surgical procedures had to be deferred, but also emergencies were reduced. To assess the global trend of pacemaker (PM) and implantable cardiac-defibrillator (ICD) procedures performed in Italy before, during, and after the first COVID-19 emergency, all the Italian hospital discharge records related to PM/ICD procedures performed between 2012 and 2021, sent to the National Institute of Health, were reviewed. Compared to 2019, in 2020, there was a reduction of first PM implants (52,216 to 43,962, -16%; p < 0.01), but not replacements (16,591 to 17,331, + 4%; p = 0.16). In particular, in April 2020, there was a drop of first implants (- 53,4% vs the average value of April 2018 and April 2019; p < 0.01), while the reduction of replacements was less evident (-32.6%; p = NS). In 2021, PM procedures increased to values similar to the pre-pandemic period. A reduction of ICD procedures was observed in 2020 (22,355, -7% toward 2019), mainly in April 2020 (- 46% vs April 2018/April 2019; p = 0.03). In 2021, the rate of ICD procedures increased (+ 14% toward 2020). A non-significant reduction of "urgent" procedures (complete atrioventricular block for PM and ventricular fibrillation for ICD), even in April 2020, was observed. In 2020, there was a reduction of first PM implants and ICDs, offset by increased activity in 2021. No decrease in PM replacements was observed, and the drop in "urgent" PM and ICD procedures was not statistically significant., (© 2023. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
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