1. Building smart CAR T cell therapies: The path to overcome current challenges.
- Author
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Cai, Qi, Warren, Sarah, Pietrobon, Violena, Maeurer, Markus, Qi, Lei S., Lu, Timothy K., Lajoie, Marc J., Barrett, David, Stroncek, David F., and Marincola, Francesco M.
- Subjects
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CHIMERIC antigen receptors , *AUTOMATIC systems in automobiles , *INTELLIGENT buildings , *CELLULAR therapy - Abstract
Successful implementation of adoptive cell therapy (ACT) of cancer requires comprehensively addressing biological and practical challenges. This approach has been largely overlooked, resulting in a gap between the potential of ACT and its actual effectiveness. We summarize the most promising technical strategies in creating an "ideal" ACT product, focusing on chimeric antigen receptor (CAR)-engineered cells. Since many requirements for effective ACT are common to most cancers, what we outline here might have a broader impact. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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