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1. Bile acids regulate MAdCAM-1 expression to link the gut microbiota to cancer immunosurveillance.

Author

Fidelle, Marine, Tian, Ai-Ling, Zitvogel, Laurence, and Kroemer, Guido

Subjects
*BILE acids, *GUT microbiome, *LYMPHOID tissue, *IMMUNE checkpoint proteins, *T cells
Abstract

In a recent paper in Science, Fidelle et al. unravel a gut immune checkpoint that is subverted by antibiotic treatment. Post-antibiotic dysbiosis of the ileum causes an increase in bile acids that downregulate MAdCAM−1, thereby triggering the exodus of immunosuppressive T cells from gut-associated lymphoid tissues toward tumors. [ABSTRACT FROM AUTHOR]

Published
2023
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