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In order to cope with the grid fluctuation caused by large‐scale wind power connected to the grid, the wind thermal power generation system has been proposed and extensively studied. The wind thermal power generation system uses a wind turbine to drive a heat generation device to heat the heat storage medium, which is further exchanged to drive a turbine to generate electricity. A superconducting magnetic eddy current heater (SMH) is proposed for the characteristics of wind thermal power generation system, which uses non‐resistive, large current‐carrying superconducting coils for excitation, and has high output efficiency and power density. The working principle of magnetic eddy current heating is analysed, and the structure of SMH with no ferromagnetic material and two heating screens inside and outside is proposed according to the characteristics of SMH. An analytical model of the SMH is established, and the influence of the structure and materials of the SMH on the magnetic field distribution is analysed. Based on this, a 22‐pole SMH was designed and analysed for output power at 10–20 rpm. A three‐dimensional magnetism‐stress combined analysis model of SMH is established, and the strain and stress characteristics of SMH are simulated under the condition of maximum output power, which verifies the feasibility of the mechanical properties of existing superconducting materials for application in SMH. [ABSTRACT FROM AUTHOR]

Inverted (p‐i‐n) perovskite solar cells (PSCs) are advantageous in terms of easy fabrication, low‐temperature processibility, negligible hysteresis, and excellent compatibility with the tandem devices in comparison with the regular (n‐i‐p) counterparts. Hole‐blocking layer is crucial for efficient electron transport of inverted PSCs, and only a single hole‐blocking layer of bathocuproine (BCP) is used typically. Herein, bis[2‐(diphenylphosphino)phenyl] ether oxide (DPEPO) with a deep highest occupied molecular orbital (HOMO) energy level is incorporated atop of perovskite film as an auxiliary hole‐blocking layer, resulting in an enhanced electron transport of inverted PSC devices. The P=O group within DPEPO can coordinate with Pb2+ cations of perovskite, leading to passivation of surface defects of perovskite. Besides, incorporation of DPEPO hole‐blocking layer prohibits undesired hole transport from perovskite to PCBM electron transport layer (ETL), thus suppressing non‐radiative electron–hole recombination. As a result, combined with BCP hole‐blocking layer, inverted PSC devices based on double hole‐blocking layers exhibit a decent power conversion efficiency (PCE) of 24.17% with a high open‐circuit voltage (Voc) of 1.15 V which dramatically surpasses that based on single hole‐blocking layer (22.26%). Moreover, incorporation of hydrophobic DPEPO helps to improve the ambient and thermal stabilities of inverted PSC devices. [ABSTRACT FROM AUTHOR]

Organic semiconductors with noncovalently conformational locks (OSNCs) are promising building blocks for hole‐transporting materials (HTMs). However, lack of satisfied neighboring building blocks negatively impacts the optoelectronic properties of OSNCs‐based HTMs and imperils the stability of perovskite solar cells (PSCs). To address this limitation, we introduce the benzothieno[3,2‐b]thiophene (BTT) to construct a new OSNC, and the resulting HTM ZS13 shows improved intermolecular charge extraction/transport properties, proper energy level, efficient surface passivation effect. Consequently, the champion devices based on doped ZS13 yield an efficiency of 24.39 % and 20.95 % for aperture areas of 0.1 and 1.01 cm2, respectively. Furthermore, ZS13 shows good thermal stability and the capability of inhibiting I− ion migration, thus, leading to enhanced device stability. The success in neighboring‐group engineering can triggered a strong interest in developing thienoacene‐based OSNCs toward efficient and stable PSCs. [ABSTRACT FROM AUTHOR]

Mandarinfish ranavirus (MRV), also known as a variant of largemouth bass virus (LMBV), is an emerging pathogen in mandarinfish aquaculture. In this study, monoclonal antibodies (mAbs) against MRV were produced and characterized, and 7 mAbs were obtained through Western blotting screening and all 7 mAbs specifically recognized MRV/LMBV but not several piscine iridoviruses as ISKNV, GIV and TFV. By LC MS/MS analysis, the recognized viral proteins by seven mAbs were identified as MRV‐pORF47L, MRV‐pORF55R, MRV‐pORF57L, MRV‐pORF77L and MRV‐pORF78L, respectively, and all five viral proteins are late expression structural proteins by Western blotting. Based on mAb 1C4, immuno‐histochemistry and immuno‐histo‐fluorescence were performed to re‐assess the tissue tropism of MRV. The result showed that abundant reactive signals were observed in infected spleen, kidney as well as intestine and pyloric caecum. Real‐time quantitative PCR also demonstrated that spleen as well as pyloric caecum and intestines are the major target tissue upon MRV infection. In infected intestines and pyloric caecum, numerous enlarged, multinucleated cells with intracytoplasmic inclusions were identified as the target cells of MRV, suggesting that MRV serves as a digestive tract pathogen to mandarinfish, which may explain why acute infection of MRV can cause the typical clinicopathology featured by severe ascites. [ABSTRACT FROM AUTHOR]

Summary: More than half of the world's food is provided by cereals, as humans obtain >60% of daily calories from grains. Producing more carbohydrates is always the final target of crop cultivation. The carbohydrate partitioning pathway directly affects grain yield, but the molecular mechanisms and biological functions are poorly understood, including rice (Oryza sativa L.), one of the most important food sources. Here, we reported a prolonged grain filling duration mutant 1 (gfd1), exhibiting a long grain‐filling duration, less grain number per panicle and bigger grain size without changing grain weight. Map‐based cloning and molecular biological analyses revealed that GFD1 encoded a MATE transporter and expressed high in vascular tissues of the stem, spikelet hulls and rachilla, but low in the leaf, controlling carbohydrate partitioning in the stem and grain but not in the leaf. GFD1 protein was partially localized on the plasma membrane and in the Golgi apparatus, and was finally verified to interact with two sugar transporters, OsSWEET4 and OsSUT2. Genetic analyses showed that GFD1 might control grain‐filling duration through OsSWEET4, adjust grain size with OsSUT2 and synergistically modulate grain number per panicle with both OsSUT2 and OsSWEET4. Together, our work proved that the three transporters, which are all initially classified in the major facilitator superfamily family, could control starch storage in both the primary sink (grain) and temporary sink (stem), and affect carbohydrate partitioning in the whole plant through physical interaction, giving a new vision of sugar transporter interactome and providing a tool for rice yield improvement. [ABSTRACT FROM AUTHOR]

With the widespread applications of electric vehicles, power grid stabilization, and high‐pulsed power loads, high‐power lithium‐ion batteries (LIBs) are in urgent demand. However, the existing experimental‐based design of high‐power batteries is usually costly and inefficient, and provides limited information on the complex physicochemical processes inside the batteries. Digital twin concept is promising for capturing the batteries' electrochemical performance, and optimizing the power capability of LIBs. Here, an electrochemical‐thermal coupled model is developed as a digital twin model for rational design of ultrahigh‐power LiFePO4/graphite LIBs. The model can accurately predict the batteries' performance and help to predetermine the optimal parameters to achieve an ultrahigh power capability. After model‐guided optimization, the battery shows a high energy density of 92.38 Wh kg−1 at an ultrafast discharging current of 50 C and can withstand 150 C pulse discharging tests. Notably, the digital twin model can reveal experimentally inaccessible time‐ and space‐resolved information and identify the rate‐determining steps inside the battery. Hence, model‐driven optimization of ultrahigh‐power LiFePO4/graphite batteries is successfully realized aiming at the critical factors in the rate‐determining steps. The work provides an instructive design of ultrahigh‐power LiFePO4/graphite batteries, which might guide the future direction to boost the power capability of LIBs. [ABSTRACT FROM AUTHOR]

Cytokine‐induced killer (CIK) cells are a group of highly heterogeneous T cells expressing diverse T‐cell antigen receptors (TCRs), but possessing wide major histocompatibility complex (MHC)‐unrestricted antitumour activity, which have been used in the treatment of many tumours. However, the clonal diversity of different T‐cell subsets and whether there is a certain clonal preference during CIK culture remains to be clarified. We found that the proportion of oligoclones seen in some subfamilies of freshly isolated T cells decreased in varying degrees after culturing. This indicates that the diversity of T‐cell clones had been restored to a certain extent. The diversity differed among different T‐cell subsets, as some TCR subfamily oligoclones mainly appeared in CD3+CD56+ cells, which also indicates the heterogeneity of the CIK cell composition. [ABSTRACT FROM AUTHOR]

Ni‐rich layered oxides have been considered one of the most promising cathode materials for lithium‐ion batteries on account of their high reversible capacity. However, their chemical sensitivity to moisture and carbon dioxide results in the formation and growth of residual lithium compounds, leading to a deterioration in electrochemical performance and difficulty in cathode electrode preparation. In this work, a passivation coating of polydimethylsiloxane with 5 molecular layers is successfully coated on LiNi0.8Co0.1Mn0.1O2 particles. To examine the hydrophobicity of polydimethylsiloxane, bare and coated NCM811 are exposed to a hot and humid chamber for dozens of hours, even exposure to damp air over 120 h. The results indicate that the hydrophobic coating can inhibit the formation and growth of residual lithium compounds on the surface of LiNi0.8Co0.1Mn0.1O2, resulting in slightly less degradation in electrochemical performance. Herein, a rapid, low‐cost, and easily employed method to generate an even hydrophobic/passivation surface is developed, which provides a generic approach to treat various electrode materials, especially nanosized and water‐sensitive ones, to improve their tolerance to extreme environments. [ABSTRACT FROM AUTHOR]

Besides the widely investigated potential as alternative to silicon in microelectronics, semiconducting 2D transition metal dichalcogenides (TMDs) also show appealing prospects in thin film transistors (TFTs)‐based applications, while still suffer from insufficient demonstration. Herein, the authors systematically report high‐performance and low‐power chemical vapor deposition‐grown polycrystalline molybdenum ditelluride (MoTe2) TFTs with solution‐processed ternary Hf0.5Zr0.5O2/HfAlO2 high‐k dielectric. Benefitting from the optimized high quality HfAlO2 film synthesis and proper postannealing treatment, the constructed MoTe2 TFTs exhibit a high mobility ≈27.24 cm2 V−1 S−1, a current on/off ratio ≈6.43 × 105, threshold voltage ≈−3.27 V, and subthreshold swing (SS) value ≈152.4 mV dec−1, respectively. Moreover, by supplementing another solution‐processed layer of ferroelectric Hf0.5Zr0.5O2 to form double layer of HfAlO2/Hf0.5Zr0.5O2 dielectric, the device performance can be further improved with an ignorable hysteresis, increased mobility of ≈55.53 cm2 V−1 S−1, and significantly reduced SS value of ≈110.16 mV dec−1, respectively. The current investigation offers a feasible strategy to fabricate high‐performance and low‐power MoTe2 TFTs for potential TMDs‐based TFTs applications. [ABSTRACT FROM AUTHOR]

The combination of semiconductivity and tunable ferromagnetism is pivotal for electrical control of ferromagnetism and next‐generation low‐power spintronic devices. However, Curie temperatures (TC) for most traditional intrinsic ferromagnetic semiconductors (≤200 K) and recently discovered two‐dimensional (2D) ones (<70 K) are far below room temperature. 2D van der Waals (vdW) semiconductors with intrinsic room‐temperature ferromagnetism remain elusive considering the unfavored 2D long‐range ferromagnetic order indicated by Mermin–Wagner theorem. Here, vdW semiconductor CrxGa1−xTe crystals exhibiting highly tunable above‐room‐temperature ferromagnetism with bandgap 1.62–1.66 eV are reported. The saturation magnetic moment (Msat) of CrxGa1−xTe crystals can be effectively regulated up to ≈5.4 times by tuning Cr content and ≈75.9 times by changing the thickness. vdW CrxGa1−xTe ultrathin semiconductor crystals show robust room‐temperature ferromagnetism with the 2D quantum confinement effect, enabling TC 314.9–329 K for nanosheets, record‐high for intrinsic vdW 2D ferromagnetic semiconductors. This work opens an avenue to room‐temperature 2D vdW ferromagnetic semiconductor for 2D electronic and spintronic devices. [ABSTRACT FROM AUTHOR]

Background: Pre‐existing immunities hamper the application of human adenovirus (HAdV) vectors in gene therapy or vaccine development. Fowl adenovirus (FAdV)‐based vector might represent an alternative. Methods: An intermediate plasmid containing FAdV‐4 fiber genes, pMD‐FAV4Fs, was separated from FAdV‐4 adenoviral plasmid pKFAV4GFP. An overlap extension polymerase chain reaction (PCR) was employed for fiber modification in pMD‐FAV4Fs, and the modified fibers were restored to generate new adenoviral plasmids through restriction‐assembly. FAdV‐4 vectors were rescued and amplified in chicken LMH cells. Fluorescence microscopy and flow cytometry were used to evaluate the gene transfer efficiency. The amount of viruses binding to cells was determined by a real‐time PCR. A plaque‐forming assay and one‐step growth curve were used to evaluate virus growth. Results: Four sites in the CD‐, DE‐, HI‐ and IJ‐loop of fiber1 knob could tolerate the insertion of exogenous peptide. The insertion of RGD4C peptide in the fiber1 knob significantly promoted FAdV‐4 transduction to human adherent cells such as 293, A549 and HEp‐2, and the insertion to the IJ‐loop demonstrated the best performance. The replacement of the fiber2 knob of FAdV‐4 with that of HAdV‐35 improved the gene transfer to human suspension cells such as Jurkat, K562 and U937. Fiber‐modified FAdV‐4 vectors could transduce approximately 80% human cells at an acceptable multiplicity of infection. Enhanced gene transfer mainly resulted from increased virus binding. Fiber modifications did not significantly influence the growth of recombinant FAdV‐4 in packaging cells. Conclusions: As a proof of principle, it was feasible to enhance gene transduction of FAdV‐4 vectors to human cells by modifying the fibers. [ABSTRACT FROM AUTHOR]

The natural course of coronavirus disease 2019 (COVID‐19) patients without clinical intervention has not yet been documented. One hundred and fifty‐eight patients from two hospitals were enrolled to identify the indicators of severe COVID‐19 and observe the natural course of COVID‐19 patients without clinical intervention. The total computed tomography (CT) score, a quantitative score based on assessment of the number, quadrant, and area of the lesions in CT, tended to perform better than assessment based only on the number or area of the lesions (p = 0.0004 and p = 0.0887, respectively). Multivariate logistic regression showed that the total CT score, chest tightness, lymphocyte, and lactate dehydrogenase (LDH) were independent factors for severe COVID‐19. For patients admitted in 2 weeks from onset to hospitalization, the frequency of severe COVID‐19 was gradually increased with the delayed hospitalization. The symptoms of fatigue, dry cough, sputum production, chest tightness, and polypnea were gradually more frequent. The levels of C‐reactive protein, alanine aminotransferase, aspartate aminotransferase, total bilirubin, direct bilirubin, γ‐glutamyl transpeptidase, LDH, and d‐dimer were also gradually increased, as well as the scores based on CT. Conversely, the lymphocyte count and the albumin level were gradually decreased with the delayed hospitalization. Detail turning points of the above alterations were observed after 10–14 days from onset to hospitalization. Total CT score was a simple and feasible score for identifying severe COVID‐19. COVID‐19 patients without clinical intervention deteriorated gradually during the initial 10–14 days but gradually improved thereafter. Highlights: Present study developed a simple and feasible score based on CT to identify severe COVID‐19.Present study was the first to investigate the natural course of COVID‐19 patients without clinical intervention.COVID‐19 patients without clinical intervention deteriorated gradually during the initial 10‐14 days but gradually improved thereafter. [ABSTRACT FROM AUTHOR]

Weyl semimetal Td‐phase WTe2 possesses the spin‐resolved band structure with strong spin–orbit coupling, holding promises as a useful spin source material. The noncentrosymmetric crystalline structure of Td‐WTe2 endows the generation of the out‐of‐plane polarized spin, which is of great interest in magnetic memory applications. Previously, WTe2 was explored in spin devices based on mechanically exfoliated single crystal flakes with a size of micrometers. For practical spintronics applications, it is highly desirable to implement wafer‐scale thin films. In this work, centimeter‐scale chemical vapor deposition (CVD) grown Td‐WTe2 thin films are used and the spin current generation is studied by the spin torque ferromagnetic resonance (ST‐FMR) technique. The in‐plane and out‐of‐plane spin conductivities of 7.36 × 103 (ℏ/2e) (Ωm)–1 and 1.76 × 103 (ℏ/2e) (Ωm)–1, respectively, are found in CVD‐growth 5 nm‐WTe2. The current‐induced magnetization switching in WTe2/NiFe is demonstrated at room temperature in the domain wall motion regime, which may invigorate potential spintronic device innovations based on Weyl semimetals. [ABSTRACT FROM AUTHOR]

Magnetic tunnel junctions (MTJs) are widely applied in spintronic devices for efficient spin detection through the imbalance of spin polarization at the Fermi level. The van der Waals (vdW) property of 2D magnets with atomically flat surfaces and negligible surface roughness greatly facilitates the development of MTJs, primarily in ferromagnets. Here, A‐type antiferromagnetism in 2D vdW single‐crystal (Fe0.8Co0.2)3GaTe2 is reported with TN ≈ 203 K in bulk and ≈ 185 K in 9‐nm nanosheets. The metallic nature and out‐of‐plane magnetic anisotropy make it a suitable candidate for MTJ electrodes. By constructing heterostructures based on (Fe0.8Co0.2)3GaTe2/WSe2/Fe3GaTe2, a large tunneling magnetoresistance (TMR) ratio of 180% at low temperature is obtained, with the TMR signal persisting at near‐room temperature 280 K. Furthermore, the TMR is tunable by the electric field, and the MTJ device operates stably with a low applied bias down to 1 mV (≈0.6 nA), highlighting its potential for energy‐efficient spintronic devices. This work opens up new opportunities for 2D antiferromagnetic spintronics and quantum devices. [ABSTRACT FROM AUTHOR]

Developing novel high‐temperature van der Waals ferromagnetic semiconductor materials and investigating their interface coupling effects with 2D topological semimetals are pivotal for advancing next‐generation spintronic and quantum devices. However, most van der Waals ferromagnetic semiconductors exhibit ferromagnetism only at low temperatures, limiting the proximity research on their interfaces with topological semimetals. Here, an intrinsic, van der Waals layered room‐temperature ferromagnetic semiconductor crystal, FeCr0.5Ga1.5Se4 (FCGS), is reported with a Curie temperature (TC) as high as 370 K, setting a new record for van der Waals ferromagnetic semiconductors. The saturation magnetization at low temperature (2 K) and room temperature (300 K) reaches 8.2 and 2.7 emu g−1, respectively. Furthermore, FCGS possesses a bandgap of ≈1.2 eV, which is comparable to the widely used commercial silicon. The FCGS/graphene 2D heterostructure exhibits an impeccably smooth and gapless interface, thereby inducing a robust van der Waals magnetic proximity coupling effect between FCGS and graphene. After the proximity coupling, graphene undergoes a charge carrier transition from electrons to holes, accompanied by a transition from non‐magnetic to ferromagnetic transport behavior with robust anomalous Hall effect (AHE). Notably, the van der Waals magnetic proximity‐induced AHE remains robust even up to 400 K. [ABSTRACT FROM AUTHOR]