157 results on '"Zhu, Chen"'
Search Results
2. Extracellular Vesicle Clicking on Osteoimplants Through Biomimetic Molecular Adhesion Enables Immune‐Enhanced Osseointegration in Diabetics.
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Ge, Gaoran, Wang, Wei, Wang, Qing, Wang, Miao, Wang, Tao, Yu, Lei, Zhang, Xianzuo, Zhu, Chen, Xu, Yaozeng, Yang, Huilin, Bai, Jiaxiang, Pan, Guoqing, and Geng, Dechun
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Extracellular vesicles (EVs) derived from differentiating induced stem cells maintain their original stemness and differentiating trends and possess strong immunoregulatory capability. Biomaterials equipped with EVs are very promising in regenerative medicine. However, surface EV‐decoration on osteoimplants remains a challenge, due to the complexity of traditional molecular conjugations and the fragility of EVs. Here, mussel‐like molecular adhesion is combined with bioorthogonal click conjugation to introduce EVs on titanium (Ti) implants. The biomimetic adhesion and clickable molecular linkage allow mild and stable tethering of pre‐osteogenic mesenchymal stem cell (MSC)‐derived EVs on Ti implants. EV‐decorated implants exhibit significantly enhanced osseointegration on the bone‐implant surface under diabetic conditions, promoting increased expression of osteogenic genes. Modified surfaces impelled phenotypic alterations in macrophage polarization via multi‐pathway regulation, decreasing proinflammatory M1 macrophage formation, which can lead to the promotion of surface osteogenesis. On Ti rods implanted in a diabetic rat model, EV coating inhibited M1macrophages around the prosthesis, resulting in satisfactory long‐term osseointegration. This study offers a new perspective to represent a simple and effective means for surface EV decoration, providing an osteoimmunomodulatory effect to enhance the diabetic osseointegration of implants. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Epigenetic Regulatory Axis MIR22‐TET3‐MTRNR2L2 Represses Fibroblast‐Like Synoviocyte–Mediated Inflammation in Rheumatoid Arthritis.
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Fang, Yilong, Huang, Wei, Zhu, Xiangling, Wang, Xinming, Wu, Xuming, Wang, Huihui, Hong, Wenming, Yan, Shangxue, Zhang, Lingling, Deng, Yujie, Wei, Wei, Tu, Jiajie, and Zhu, Chen
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INFLAMMATION prevention ,GENETICS of rheumatoid arthritis ,BIOLOGICAL models ,IN vitro studies ,SYNOVIAL membranes ,RESEARCH funding ,EPIGENOMICS ,MICRORNA ,RHEUMATOID arthritis ,POLYMERASE chain reaction ,IN vivo studies ,FIBROBLASTS ,MICE ,IMMUNOHISTOCHEMISTRY ,BIOINFORMATICS ,GENE expression profiling ,ANIMAL experimentation ,FLUORESCENCE in situ hybridization ,WESTERN immunoblotting ,ARTHRITIS ,PRECIPITIN tests - Abstract
Objective: The specific role of fibroblast‐like synoviocytes (FLSs) in the pathogenesis of rheumatoid arthritis (RA) is still not fully elucidated. This study aimed to explore the molecular mechanisms of epigenetic pathways, including three epigenetic factors, microRNA (miRNA)‐22 (MIR22), ten‐eleven translocation methylcytosine dioxygenase 3 (TET3), and MT‐RNR2 like 2 (MTRNR2L2), in RA‐FLSs. Methods: The expression of MIR22, TET3, and MTRNR2L2 in the synovium of patients with RA and arthritic mice were determined by fluorescence in situ hybridization, quantitative polymerase chain reaction (qPCR), immunohistochemistry, and Western blot. Mir22−/− and Tet3+/− mice were used to establish a collagen antibody–induced arthritis (CAIA) model. Mir22 angomir and Tet3 small interfering RNA (siRNA) were used to illustrate the therapeutic effects on arthritis using a collagen‐induced (CIA) model. Bioinformatics, luciferase reporter assay, 5‐hydroxymethylcytosine (5hmC) dot blotting, chromatin immunoprecipitation–qPCR, and hydroxymethylated DNA immunoprecipitation were conducted to show the direct repression of MIR22 on the TET3 and transcriptional activation of TET3 on MTRNR2L2. Results: The Mir22−/− CAIA model and RA‐FLS–related in vitro experiments demonstrated the inhibitory effect of MIR22 on inflammation. MIR22 can directly inhibit the translation of TET3 in RA‐FLSs by binding to its 3′ untranslated region in TET3. The Tet3+/− mice–established CAIA model showed less severe symptoms of arthritis in vivo. In vitro experiments further confirmed the proinflammatory effect of TET3 in RA. In addition, the CIA model was used to validate the therapeutic effects of Mir22 angomir and Tet3 siRNA. Finally, TET3 exerts its proinflammatory effect by promoting 5hmC production in the promoter of its target MTRNR2L2 in RA‐FLSs. Conclusion: The key role of the MIR22‐TET3‐MTRNR2L2 pathway in RA‐FLSs provided an experimental basis for further studies into the pathogenesis and related targets of RA from the perspective of FLSs. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Electron Orbital Hybridization‐Enhanced Copper‐Nanocatalysis for Anti‐Infection.
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Luo, Yao, Ruan, Zesong, Guo, Zhao, Chen, Yunfeng, Lin, Han, Ge, Min, and Zhu, Chen
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ORBITAL hybridization ,COPPER ,DRUG resistance in bacteria ,BACTERIAL diseases ,ELECTRONS ,MICROBIAL fuel cells - Abstract
Recurrent bacterial infections, impenetrable microbial biofilms, and irremediable antibiotic resistance are the most perilous threats in orthopedic implant‐associated infections (IAIs). Recently, chemodynamic therapy (CDT) has been considered a promising therapy, while the clinical practices for existing CDT agents are limited by the low therapeutic efficiency in physiological circumstances. Herein, it is demonstrated that silica‐copper nanosheets (Si@Cu NSs) exhibit a combined therapeutic photothermal‐chemodynamic strategy for IAIs treatment with superior capacity and biocompatibility. This unique design endows the nanostructure with enhanced copper‐based Fenton‐like properties via p‐d orbital hybridization by incorporating copper nanoclusters (Cu NCs) on silicene nanosheets (Si NSs) matrix, integrating inherent photothermal performance of Si NSs with specific catalytic anti‐infection of Cu NCs against planktonic bacteria and biofilms both in vitro and in vivo. This study not only reveals the promising bio‐application prospects of 2D nanocatalytic biomaterials but also demonstrates the feasibility of constructing novel CDT agents by orbital hybridization for the catalytic treatment of IAIs. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Photothermal Microneedle Hydrogel Patch for Refractory Soft Tissue Injuries through Thermosensitized Anti‐Inflammaging Modulation.
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Zhu, Wanbo, Liu, Quan, Zhang, Ziheng, Wang, Yingjie, Mei, Jiawei, Xu, Dongdong, Zhou, Jun, Su, Zheng, Zhang, Xianzuo, Zhu, Chen, Wang, Jiaxing, Zhu, Junchen, Peng, Xiaochun, and Zhang, Xianlong
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SOFT tissue injuries ,HYDROGELS ,PHOTOTHERMAL effect ,PRUSSIAN blue ,TIBIALIS anterior ,CHRONIC wounds & injuries - Abstract
Soft tissue injuries (STIs) are the most common cause of extremity pain and motion dysfunction. Persistent inflammatory activation of immune cells characterized by senescence‐associated secretory phenotype (SASP) and mitochondrial stress are considered the primary causes of STIs, a pathological process also termed inflammaging. Meanwhile, scavenging excessive "cellular waste" in the inflammaging microenvironment and further activating tissue repair processes remain elusive. Herein, an anti‐inflammaging photothermal hydrogel microneedle patch for treating STIs is developed. Taurine‐loaded Prussian blue nanoparticles (Taurine@PB) are encapsulated in a methacrylate‐based hyaluronic acid hydrogel (HAMA) and further fabricated into taurine@PB@HAMA@microneedles (TPH@MN) patches. The acidic microenvironment of chronic inflammation and mild photothermal effects promote taurine release and anti‐inflammaging immunomodulation, inhibiting mitochondrial stress via the SIRT3‐NF‐κB axis to promote glycolytic metabolic microenvironment of neutrophils reprogramming toward oxidative phosphorylation metabolism. Furthermore, TPH@MN activates macrophage efferocytosis and initiates the process of tissue repair. In mouse models of chronic diabetic wounds and tibialis anterior (TA) muscle injury, TPH@MN inhibits SASP expression and promotes STIs healing through thermosensitized anti‐inflammaging immunomodulation. In summary, TPH@MN circumvents the side effects of systemic administration, providing new translatable options in the treatment modalities for patients suffering from STIs worldwide. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Selective Mono‐Defluorinative Cross‐Coupling of Trifluoromethyl arenes via Multiphoton Photoredox Catalysis.
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Jia, Jiaqi, Zhumagazy, Serik, Zhu, Chen, Lee, Shao‐Chi, Alsharif, Salman, Yue, Huifeng, and Rueping, Magnus
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AROMATIC compounds ,CATALYSIS ,RADICAL anions ,FUNCTIONAL groups ,ALKYLATION - Abstract
A new cross‐coupling of trifluoromethyl arenes has been realized via multiphoton photoredox catalysis. Trifluoromethyl arenes were demonstrated to undergo selective mono‐defluorinative alkylation under mild reaction conditions providing access to a series of valuable α,α‐difluorobenzylic compounds. The reaction shows broad substrate scope and general functional group tolerance. In addition to the electron‐deficient trifluoromethyl arenes that are easily reduced to the corresponding radical anion, more challenging electron‐rich substrates were also successfully applied. Steady‐State Stern‐Volmer quenching studies indicated that the trifluoromethyl arenes were reduced by the multiphoton excited Ir‐based photocatalyst. [ABSTRACT FROM AUTHOR]
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- 2024
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7. E‐Selective Radical Difunctionalization of Unactivated Alkynes: Preparation of Functionalized Allyl Alcohols from Aliphatic Alkynes.
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Wang, Jie, Wu, Xinxin, Cao, Zhu, Zhang, Xu, Wang, Xinxin, Li, Jie, and Zhu, Chen
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RADICALS (Chemistry) ,ALKYNES ,ALIPHATIC alcohols ,ABSTRACTION reactions ,ALLYL alcohol ,ARYL group ,GLUCOSINOLATES - Abstract
Radical difunctionalization of aliphatic alkynes provides direct access to valuable multi‐substituted alkenes, but achieving a high level of chemo‐ and stereo‐control remains a formidable challenge. Herein a novel photoredox neutral alkyne di‐functionalization is reported through functional group migration followed by a radical‐polar crossover and energy transfer‐enabled stereoconvergent isomerization of alkenes. In this sequence, a hydroxyalkyl and an aryl group are incorporated concomitantly into an alkyne, leading to diversely functionalized E‐allyl alcohols. The scope of alkynes is noteworthy, and the reaction tolerates aliphatic alkynes containing hydrogen donating C─H bonds that are prone to intramolecular hydrogen atom transfer. The protocol features broad functional group compatibility, high product diversity, and exclusive chemo‐ and stereoselectivity, thus providing a practical strategy for the elusive radical di‐functionalization of unactivated alkynes. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Subcutaneous Administration of a Zwitterionic Chitosan‐Based Hydrogel for Controlled Spatiotemporal Release of Monoclonal Antibodies.
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Gréa, Thomas, Jacquot, Guillaume, Durand, Arthur, Mathieu, Clélia, Gasser, Adeline, Zhu, Chen, Banerjee, Mainak, Hucteau, Elyse, Mallard, Joris, Lopez Navarro, Pedro, Popescu, Bogdan V., Thomas, Eloise, Kryza, David, Sidi‐Boumedine, Jacqueline, Ferrauto, Giuseppe, Gianolio, Eliana, Fleith, Guillaume, Combet, Jérôme, Brun, Susana, and Erb, Stéphane
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- 2024
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9. Inorganic Hydrogeochemistry in the 21st Century.
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Zhu, Chen, Fryar, Alan E., and Apps, John
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WATER chemistry , *MINERAL waters , *CLIMATE change mitigation , *ATMOSPHERIC carbon dioxide , *GROUNDWATER tracers , *GLOBAL warming , *GEOCHEMICAL modeling - Abstract
Chemical and isotopic processes occur in every segment of the hydrological cycle. Hydrogeochemistry—the subdiscipline that studies these processes—has seen a transformation from "witch's brew" to credible science since 2000. Going forward, hydrogeochemical research and applications are critical to meeting urgent societal needs of climate change mitigation and clean energy, such as (1) removing CO2 from the atmosphere and storing gigatons of CO2 in soils and aquifers to achieve net‐zero emissions, (2) securing critical minerals in support of the transition from fossil fuels to renewable energies, and (3) protecting water resources by adapting to a warming climate. In the last two decades, we have seen extensive activity and progress in four research areas of hydrogeochemistry related to water‐rock interactions: arsenic contamination of groundwater; the use of isotopic and chemical tracers to quantify groundwater recharge and submarine groundwater discharge; the kinetics of chemical reactions and the mineral‐water interface's control of contaminant fate and transport; and the transformation of geochemical modeling from an expert‐only exercise to a widely accessible tool. In the future, embracing technological advances in machine learning, cyberinfrastructure, and isotope analytical tools will allow breakthrough research and expand the role of hydrogeochemistry in meeting society's needs for climate change mitigation and the transition from fossil fuels to renewable energies. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Preparation of α‐Deuterated Lactic Acid Derivatives through Remote Heteroaryl Migration and Radical‐Polar Crossover Deuteration.
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Chen, Yinwen, Liu, Jige, Sun, Yuqian, Wu, Xinxin, and Zhu, Chen
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ACID derivatives ,DEUTERATION ,RADICALS (Chemistry) ,ALKENES ,LACTIC acid - Abstract
A novel photoredox‐neutral 1,2,5‐trifunctionalization of α‐hydroxyhexenoates is disclosed. The radical cascade proceeds via heteroaryl migration‐enabled alkene fluoroalkylheteroarylation and radical‐polar crossover deuteration, leading to functionalized α‐deuterated lactic acid derivatives. The reaction features mild photochemical conditions and provides an efficient approach for the synthesis of valuable deuterated molecules. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Biomimetic Metal–Organic Framework Combats Biofilm‐Associated Infections via Hyperthermia‐Enhanced Bacterial Metabolic Interference and Autophagy‐Promoted Adaptive Immunity.
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Hu, Xianli, Ma, Ruixiang, Zhang, Peng, Dong, Jiale, Sun, Jiaxuan, Wang, Wenzhi, Liu, Quan, Kong, Lingtong, Zhang, Xudong, Wang, Zhengxi, Mei, Jiawei, Shang, Xifu, Zhu, Wanbo, Su, Zheng, and Zhu, Chen
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BIOMIMETICS ,METAL-organic frameworks ,PHOTOTHERMAL effect ,BACTERIAL antigens ,BACTERIAL metabolism ,IMMUNITY - Abstract
Robust bacterial metabolism and the immunosuppression on peripheral immune cells cause biofilm‐associated infections (BAIs) extremely refractory to be eradicated via antibiotics alone. Herein, hierarchical mesoporous UiO‐66 metal–organic framework is decorated with selenite, polypyrrole, and macrophage membrane (MM) to develop a biomimetic nanosphere (USPM). Following the recruitment of USPM to the biofilm microenvironment (BME) via the pathogen‐targeting ability derived from MM. The BME‐responsive USPM can precisely release selenite to penetrate the loosened biofilm in synergy with near‐infrared‐induced mild photothermal therapy (mPTT). Selenite can quickly react with reducing substances to generate hydrogen selenide (H2Se) inside the biofilm. H2Se can competitively inhibit bacterial metabolic processes and disrupt biofilm metabolic homeostasis by cascade amplification effects. Furthermore, H2Se inside the biofilm further sensitizes photothermia to exert a precise local photothermal effect. Outside the biofilm, USPM can simultaneously promote the phagocytosis and autophagy of macrophages to kill and decompose the phagocytosed bacteria. Finally, the well‐decomposed bacterial antigens in macrophages can be presented to antigen‐presenting cells to arouse adaptive immune responses and enhance anti‐biofilm effectiveness further. Such powerful mPTT‐enhanced bacterial metabolic disruption and macrophagic autophagy‐promoted adaptive immune activation suggest an alternative therapeutic strategy to cure refractory BAIs. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Generalist and topologically central avian frugivores promote plant invasion unequally across land‐bridge islands.
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Zhu, Chen, Dalsgaard, Bo, Li, Wande, Gonçalves, Fernando, Vollstädt, Maximilian G. R., Ren, Peng, Zhang, Xue, Shao, Junjie, Ding, Ping, and Si, Xingfeng
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Seed dispersal by frugivorous birds facilitates plant invasions, but it is poorly known how invasive plants integrate into native communities in fragmented landscapes. We surveyed plant–frugivore interactions, including an invasive plant (Phytolacca americana), on 22 artificial land‐bridge islands (fragmented forests) in the Thousand Island Lake, China. Focusing on frugivory interactions that may lead to seed dispersal, we built ecological networks of studied islands both at the local island (community) and at landscape (metacommunity) levels. On islands with P. americana, we found that P. americana impacted local avian frugivory networks more on islands with species‐poor plant communities and on isolated islands. Moreover, as P. americana interacted mainly with local core birds (generalists), this indicates reduced seed dispersal of native plants on invaded islands. At the landscape level, P. americana had established strong interactions with generalist birds that largely maintain seed‐dispersal functions across islands, as revealed by their topologically central roles both in the regional plant–bird trophic network and in the spatial metanetwork. This indicates that generalist frugivorous birds may have facilitated the dispersal of P. americana across islands, making P. americana well integrated into the plant–frugivore mutualistic metacommunity. Taken together, our study demonstrates that the impact of plant invasion is context‐dependent and that generalist native frugivores with high dispersal potential may accelerate plant invasion in fragmented landscapes. These findings highlight the importance of taking the functional roles of animal mutualists and habitat fragmentation into account when managing plant invasions and their impact on native communities. [ABSTRACT FROM AUTHOR]
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- 2024
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13. A two‐phase method of moments model for high‐impact polystyrene phase inversion conversion and molecular properties.
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Zhu, Chen‐Xu, Jin, Jie, Wu, Yi‐Yang, Figueira, Freddy L., Edeleva, Mariya, Van Steenberge, Paul H. M., D'hooge, Dagmar R., Zhou, Yin‐Ning, and Luo, Zheng‐Hong
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MOMENTS method (Statistics) ,POLYSTYRENE ,PHASE separation ,MASS transfer ,INDUSTRIAL goods ,GRAFT copolymers - Abstract
A challenge for high‐impact polystyrene (HIPS) production and design is the more accurate and low computational cost prediction of the phase separation and phase inversion conversion, the first conversion determining the onset of the two‐phase system and the second conversion defining the pathway toward a complex, for example, salami‐like morphology. In this work, a two‐phase deterministic method of moments (MoM) model running in several minutes is therefore developed in the intermediate styrene conversion range (up to around 30%), considering for simplicity only diffusional limitations on termination on an average basis. It is showcased that the phase separation conversion can be taken as 2 m%, and the phase inversion conversion should be calculated by algebraic means. Interestingly, the latter conversion varies with the initial reaction conditions either on a time basis (e.g., variation of initial radical concentration) or both a time and conversion basis (e.g., relative contribution of rubber and St partitioning coefficient). A comparison with the commonly used pseudo‐homogeneous MoM model reveals that by accounting for mass transfer in a more representative two‐phase model, the amount of monomer consumed is slightly reduced, the grafting efficiency decreases with increasing conversion instead of increasing, and the styrene composition in the graft copolymer decreases. The current work additionally puts forward two‐phase MoM data to facilitate future benchmarking with other (stochastic) modeling approaches and enables kinetic insights into heterogeneous grafting polymerization, further promoting the production of multiphase industrial polymer products. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Effects of direct grain subsidies on food consumption of rural residents in China.
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Xu, Wenyan, Zhao, Qiran, Fan, Shenggen, and Zhu, Chen
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FOOD consumption ,AGRICULTURAL subsidies ,SUBSIDIES ,CONSUMPTION (Economics) ,RENMINBI ,RURAL planning - Abstract
The agricultural subsidy is an important policy instrument that aims to maintain food security and promote agricultural development in several countries. China introduced its first nationwide agricultural subsidy (i.e., the direct grain subsidy) for farmers in 2004. This study examines the impacts of direct grain subsidies on rural residents' food consumption patterns and nutritional intake on an individual basis. Based on a nationally representative sample of rural households from the National Rural Fixed Observation Points Survey data collected by the Ministry of Agriculture and Rural Affairs of China between 2003 and 2015, high‐dimensional fixed‐effects estimates show that the direct grain subsidy has boosted rural residents' grain consumption but reduced aquatic products, eggs, and dairy consumption in China. Specifically, an increase of 100 Chinese Yuan in per capita subsidies is associated with a rise of 14.94 g in daily grain consumption but a decrease of 0.57, 0.46, and 0.90 g in aquatic products, eggs, and dairy consumption, respectively. Furthermore, direct grain subsidies intensified rural residents' dietary imbalance and declined their dietary diversity. Observed dietary imbalance can be primarily attributed to the subsidy encouraging households' self‐sufficient grain consumption, leading to excessive cereal consumption and relatively lower consumption of meat, eggs, and milk. Our findings suggest that direct grain subsidies emphasizing the production of staple grains may inadvertently skew farmers' food consumption and nutritional intake, which may require consideration when evaluating the overall costs and benefits of agricultural subsidy policies. [EconLit Citations: D12, H20, I12, Q18]. [ABSTRACT FROM AUTHOR]
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- 2023
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15. Intercellular mitochondrial transfer in the brain, a new perspective for targeted treatment of central nervous system diseases.
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Geng, Ziang, Guan, Shu, Wang, Siqi, Yu, Zhongxue, Liu, Tiancong, Du, Shaonan, and Zhu, Chen
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CENTRAL nervous system diseases ,ORGANELLES ,MITOCHONDRIA ,MITOCHONDRIAL DNA ,CENTRAL nervous system ,CENTRAL nervous system injuries - Abstract
Aim: Mitochondria is one of the important organelles involved in cell energy metabolism and regulation and also play a key regulatory role in abnormal cell processes such as cell stress, cell damage, and cell canceration. Recent studies have shown that mitochondria can be transferred between cells in different ways and participate in the occurrence and development of many central nervous system diseases. We aim to review the mechanism of mitochondrial transfer in the progress of central nervous system diseases and the possibility of targeted therapy. Methods: The PubMed databank, the China National Knowledge Infrastructure databank, and Wanfang Data were searched to identify the experiments of intracellular mitochondrial transferrin central nervous system. The focus is on the donors, receptors, transfer pathways, and targeted drugs of mitochondrial transfer. Results: In the central nervous system, neurons, glial cells, immune cells, and tumor cells can transfer mitochondria to each other. Meanwhile, there are many types of mitochondrial transfer, including tunneling nanotubes, extracellular vesicles, receptor cell endocytosis, gap junction channels, and intercellular contact. A variety of stress signals, such as the release of damaged mitochondria, mitochondrial DNA, or other mitochondrial products and the elevation of reactive oxygen species, can trigger the transfer of mitochondria from donor cells to recipient cells. Concurrently, a variety of molecular pathways and related inhibitors can affect mitochondrial intercellular transfer. Conclusion: This study reviews the phenomenon of intercellular mitochondrial transfer in the central nervous system and summarizes the corresponding transfer pathways. Finally, we propose targeted pathways and treatment methods that may be used to regulate mitochondrial transfer for the treatment of related diseases. [ABSTRACT FROM AUTHOR]
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- 2023
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16. Inflammation‐Responsive Hydrogel Spray for Synergistic Prevention of Traumatic Heterotopic Ossification via Dual‐Homeostatic Modulation Strategy.
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Yang, Jiazhao, Zhang, Xudong, Lu, Baoliang, Mei, Jiawei, Xu, Lei, Zhang, Xianzuo, Su, Zheng, Xu, Wei, Fang, Shiyuan, Zhu, Chen, Xu, Dongdong, and Zhu, Wanbo
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HETEROTOPIC ossification ,HOMEOSTASIS ,REACTIVE oxygen species ,STEM cells - Abstract
Traumatic heterotopic ossification (THO) represents one of the most prominent contributors to post‐traumatic joint dysfunction, which currently lacks an effective and definitive preventative approach. Inflammatory activation due to immune dyshomeostasis during the early stages of trauma is believed to be critical in initiating the THO disease process. This study proposes a dual‐homeostatic modulation (DHM) strategy to synergistically prevent THO without compromising normal trauma repair by maintaining immune homeostasis and inducing stem cell homeostasis. A methacrylate‐hyaluronic acid‐based hydrogel spray device encapsulating a curcumin‐loaded zeolitic imidazolate framework‐8@ceric oxide (ZIF‐8@CeO2, CZC) nanoparticles (CZCH) is designed. Photo‐crosslinked CZCH is used to form hydrogel films fleetly in periosteal soft tissues to achieve sustained curcumin and CeO2 nanoparticles release in response to acidity and reactive oxygen species (ROS) in the inflammatory microenvironment. In vitro experiments and RNA‐seq results demonstrated that CZCH achieved dual‐homeostatic regulation of inflammatory macrophages and stem cells through immune repolarization and enhanced efferocytosis, maintaining immune cell homeostasis and normal differentiation. These findings of the DHM strategy are also validated by establishing THO mice and rat models. In conclusion, the CZCH hydrogel spray developed based on the DHM strategy enables synergistic THO prevention, providing a reference for a standard procedure of clinical operations. [ABSTRACT FROM AUTHOR]
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- 2023
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17. Alternative proteins as fish meal substitution in diets for largemouth bass (Micropterus salmoides): a mini review.
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Cheng, Yan, Wu, You Jun, Zhu, Chen Bin, Zhou, Xian Ke, Yang, Shun, and Fei, Hui
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FISH meal ,LARGEMOUTH bass ,DIETARY proteins ,PROTEINS ,SUSTAINABILITY ,AQUACULTURE industry - Abstract
Summary: Aquaculture has been challenged to explore alternative proteins to develop efficient feed formulations that foster a sustainable future growth. Largemouth bass (LMB) are economically important cultured fish with a high demand for protein. One of the traditional ingredients used to develop protein diets is fish meal (FM). With the aquaculture industry expanding, the FM price climbs with broadening the imbalance between the supply and requirement. Hence, there is a requisite to explore novel alternative proteins sources. In this review, we summarised recent knowledge about the alternative sources of proteins with potential to partially or fully substitute FM in LMB feed and the shortcomings of present alternative proteins. We also highlight the challenges faced for LMB feed in the substitution of FM with alternative proteins, which need more in‐depth investigations in the future. [ABSTRACT FROM AUTHOR]
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- 2023
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18. Single‐cell RNA sequencing analysis of the embryogenic callus clarifies the spatiotemporal developmental trajectories of the early somatic embryo in Dimocarpus longan.
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Zhang, Shuting, Zhu, Chen, Zhang, Xueying, Liu, Mengyu, Xue, Xiaodong, Lai, Chunwang, Xuhan, Xu, Chen, Yukun, Zhang, Zihao, Lai, Zhongxiong, and Lin, Yuling
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SOMATIC embryogenesis , *RNA sequencing , *LONGAN , *EMBRYOLOGY , *CALLUS , *GENE expression - Abstract
SUMMARY: Plant embryogenic calli (ECs) can undergo somatic embryogenesis to regenerate plants. This process is mediated by regulatory factors, such as transcription factors and specifically expressed genes, but the precise molecular mechanisms underlying somatic embryogenesis at the single‐cell level remain unclear. In this study, we performed high‐resolution single‐cell RNA sequencing analysis to determine the cellular changes in the EC of the woody plant species Dimocarpus longan (longan) and clarify the continuous cell differentiation trajectories at the transcriptome level. The highly heterogeneous cells in the EC were divided into 12 putative clusters (e.g., proliferating, meristematic, vascular, and epidermal cell clusters). We determined cluster‐enriched expression marker genes and found that overexpression of the epidermal cell marker gene GDSL ESTERASE/LIPASE‐1 inhibited the hydrolysis of triacylglycerol. In addition, the stability of autophagy was critical for the somatic embryogenesis of longan. The pseudo‐timeline analysis elucidated the continuous cell differentiation trajectories from early embryonic cell division to vascular and epidermal cell differentiation during the somatic embryogenesis of longan. Moreover, key transcriptional regulators associated with cell fates were revealed. We found that ETHYLENE RESPONSIVE FACTOR 6 was characterized as a heat‐sensitive factor that negatively regulates longan somatic embryogenesis under high‐temperature stress conditions. The results of this study provide new spatiotemporal insights into cell division and differentiation during longan somatic embryogenesis at single‐cell resolution. Significance Statement: Plant embryogenic calli can undergo somatic embryogenesis to regenerate plants. The single‐cell RNA‐seq results described herein provide new spatiotemporal insights into cell division and differentiation in the Dimocarpus longan (longan) embryogenic callus. The generated gene expression map will enable us to investigate how embryonic cells differentiate into vascular and epidermal cells. The results may provide the foundation for future molecular and cellular investigations into the mechanisms mediating longan somatic embryogenesis and zygotic embryogenesis. [ABSTRACT FROM AUTHOR]
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- 2023
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19. How to Perform Better on Oxford UKA? A Technical Note from over 500 Surgical Experiences.
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Zhang, Peng, Bai, Jiaxiang, Wang, Jing, Zhu, Chen, and Zhou, Wei
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OPERATIVE surgery ,PROSTHETICS ,OSTEOTOMY ,ARTHROPLASTY ,KNEE - Abstract
Oxford unicompartmental knee arthroplasty (UKA) has been particularly prevalent because the concept of knee preservation is deeply rooted in people's minds. Mobile bearing UKA is a surgical type of UKA with considerable advantages. This note describes some surgical techniques, including patient position, surgical field exposure, selection of the size of the prosthesis, sagittal tibial osteotomy, placement of the femoral prosthesis and gap balance, to assist surgeons with less experience in performing these operations successfully. The techniques described in this note have been used in over 500 Oxford UKA cases, and nearly 95% patients achieved good prosthesis position and satisfactory postoperative outcome. We hope that the empirical summaries from numerous cases will help surgeons to learn Oxford UKA quickly and effectively, driving the spread of the technique and benefiting more patients. [ABSTRACT FROM AUTHOR]
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- 2023
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20. Merging Fluorine Incorporation and Functional Group Migration.
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Ma, Zhigang, Wu, Xinxin, and Zhu, Chen
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FUNCTIONAL groups ,FLUOROALKYL group ,ABSTRACTION reactions ,RADICALS (Chemistry) ,FLUORINE - Abstract
Fluorine incorporation by concomitant fluoroalkyl radical addition to alkene or alkyne and functional group migration (FGM) represents an ingenious and robust strategy for the synthesis of structurally diverse fluorinated compounds. This account gives an overview of related studies in our group, in which three main reaction modes are discussed: 1) radical fluoroalkylative difunctionalization of unactivated alkenes via intramolecular FGM; 2) alkene difunctionalization by docking‐migration process using fluoroalkyl‐containing bifunctional reagents; 3) incorporation of fluoroalkyl group into C(sp3)−H bond via consecutive hydrogen atom transfer (HAT) and FGM. Relying on these methods, a variety of trifluoromethylation and di‐/mono‐fluoroalkylation reactions along with the migration of cyano, heteroaryl, oximino, formyl, alkynyl, and alkenyl groups have been accomplished under mild conditions. [ABSTRACT FROM AUTHOR]
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- 2023
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21. Biofilm Microenvironment‐Responsive Self‐Assembly Nanoreactors for All‐Stage Biofilm Associated Infection through Bacterial Cuproptosis‐like Death and Macrophage Re‐Rousing.
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Mei, Jiawei, Xu, Dongdong, Wang, Lingtian, Kong, Lingtong, Liu, Quan, Li, Qianming, Zhang, Xianzuo, Su, Zheng, Hu, Xianli, Zhu, Wanbo, Ye, Ming, Wang, Jiaxing, and Zhu, Chen
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- 2023
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22. Mitigating Jahn–Teller Effect in Layered Cathode Material Via Interstitial Doping for High‐Performance Sodium‐Ion Batteries.
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Fang, Hui, Ji, Haocheng, Zhai, Jingjun, Wang, Chaoqi, Zhu, Chen, Chen, Guojie, Chu, Mihai, Zhang, Taolve, Ma, Zhewen, Zhao, Wenguang, Ji, Wenhai, and Xiao, Yinguo
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- 2023
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23. Group 14 Elements Hetero‐Difunctionalizations via Nickel‐Catalyzed Electroreductive Cross‐Coupling.
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Chen, Haifeng, Zhu, Chen, Yue, Huifeng, and Rueping, Magnus
- Subjects
- *
GROUP 14 elements , *ALKYL bromides , *PALLADIUM catalysts , *CHLOROSILANES , *ENYNES , *ALKENES , *SUZUKI reaction , *NICKEL catalysts - Abstract
The difunctionalization of unsaturated bonds plays a vital role in the enrichment of molecular complexity. While various catalytic methods for alkene and alkyne difunctionalization have been developed in recent years, hetero‐functionalization the introduction of two different atoms has been less explored. This is mainly due to the challenges associated with achieving high chemo‐, regio‐, and stereoselectivity, especially when adding two similar atoms from the same group across unsaturated bonds. In this study, we describe a nickel‐catalyzed, three‐component reductive protocol for group 14 element hetero‐difunctionalization of 1,3‐enynes using electrochemistry. This new method is mild, selective, and general, allowing for the silyl‐, germanyl‐, and stannyl‐alkylation of enynes. Various chlorosilanes as well as chlorogermans, and chlorostannanes can be successfully used in combination with aryl/alkyl‐substituted 1,3‐enynes and primary, secondary, and tertiary alkyl bromides in the electroreductive coupling. [ABSTRACT FROM AUTHOR]
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- 2023
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24. Organic Photonic Synaptic Devices with UV‐Stimulated Inhibition and Adaptive Short‐Term Plasticity.
- Author
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Zhu, Chen‐Hui, Gao, Xu, Huang, Hai‐Tian, Li, Li‐Xing, Xu, Jian‐Long, Zhong, Ya‐Nan, Tang, Wei, Guo, Xiao‐Jun, and Wang, Sui‐Dong
- Subjects
- *
ORGANIC thin films , *THIN film devices , *ELECTRODE potential - Abstract
Bidirectional modulation of synaptic weight lays the basis for learning and memory in the brain, and the development of brain‐inspired photonic synaptic devices is hindered by deficient light‐stimulated inhibition. In this report, a type of organic thin film neuromorphic devices with a planar two‐terminal architecture, featuring as the inhibitory regulation of synaptic weight over two orders of magnitude upon selective UV illumination is developed. The in situ monitoring on the floating electrode potential and the corresponding simulation results demonstrate the effect of cumulative hole trapping in the polymer electret layer, which modulates the device conductance in a nonvolatile manner. Remarkably, UV‐induced long‐term depression is accompanied by enhanced short‐term potentiation in the device that may preserve a stable level of total synaptic activities. The UV‐stimulated inhibition and the adaptive short‐term plasticity, as well as the ON and OFF responses to light in the organic photonic synaptic device, suggest its potential applications in photonic neuromorphic computing. [ABSTRACT FROM AUTHOR]
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- 2023
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25. Biotic and Abiotic Factors Controlling Spatial Variation of Mean Carbon Turnover Time in Forest Soil.
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Wang, Jing, Zhu, Chen, Wei, Ning, Liu, Ruiqiang, Zhang, Bingwei, Chu, Chengjin, Su, Hongxin, Xu, Yaozhan, Cheng, Zhineng, Zhu, Sanyuan, Wang, Xugao, Yan, Liming, and Xia, Jianyang
- Subjects
FOREST soils ,SPATIAL variation ,CLIMATE feedbacks ,STRUCTURAL equation modeling ,SOIL depth - Abstract
Soil carbon persistence in forests plays a pivotal role in regulating terrestrial feedback to climate change. However, the relative contributions of biotic and abiotic factors in controlling geographic variation of forest soil carbon turnover time (τsoc) remains unclear. Here, we first sampled soils from 12 permanent forest plots across eastern China and detected higher radiocarbon‐derived mean turnover time of soil organic carbon in the deep (30–100 cm; 2,087 ± 246 years) than the surface (0–30 cm; 249 ± 80 years) layer. Further analyses based on the partial Mantel test and structural equation model illustrated that the interactions of climate, vegetation, and soil factors are more complex in deep than surface soils. Then, we established a global database of radiocarbon‐derived τsoc from 1897 forest soil samples. On the global scale, τsoc was significantly higher in the deep (3,081 ± 398 years) than the surface (332 ± 56 years) layer. Soil depth alone explained 11.7% of the spatial variation in τsoc, and the interactions between climate, stand age, and soil depth account for 68.6% of the variation. These findings highlight the joint control of climate, vegetation, and soil depth in the spatial variation of soil carbon persistence in global forests. Plain Language Summary: The soil in the forest ecosystem plays a vital role in modulating feedback between the atmosphere and biosphere under climate change. However, the underlying mechanism of climatic, vegetation, and soil properties regulating soil carbon turnover time (τsoc) at a geographic scale is still unclear. Here, we established a local data set by collecting soil samples from 12 permanent forest plots in eastern China. The statistical results showed significantly longer τsoc in the deep layer than in the surface layers and different processes at two depths. We then established a global database of forest stand age and radiocarbon‐derived τsoc. This study provides fundamental evidence of joint control of climate, vegetation, and soil factors in the spatial variation of soil carbon persistence in global forests. Key Points: Vegetation, climatic, and soil properties jointly dominated the geographic pattern of soil carbon persistence on a regional and global scaleSoil depth and forest stand age are important factors regulating the spatial variation of τsoc at global and regional scalesOur study calls for more efforts on the mechanisms underlying the multiple in driving soil carbon persistence in global forests [ABSTRACT FROM AUTHOR]
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- 2023
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26. Transforming agri‐food systems for nutrition and health: Insights from emerging economies.
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Zhu, Chen and Fan, Shenggen
- Subjects
EMERGING markets ,NUTRITION ,FAST food restaurants ,INTERNET access ,DEVELOPING countries - Abstract
This article discusses the challenges and potential solutions for transforming agri-food systems to improve nutrition and health in emerging economies. The triple burden of malnutrition, which includes hunger, hidden hunger, and overweight/obesity, is a significant issue in these countries due to shifts in dietary patterns towards Western and processed foods. The article presents a collection of papers that examine various aspects of this transformation, including the impact of agricultural and food policies, internet access, homestead gardening, and access to fast food restaurants. The findings from these studies can provide valuable insights for other developing countries undergoing similar transformations in their agri-food systems. [Extracted from the article]
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- 2023
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27. Isolated Electron Trap‐Induced Charge Accumulation for Efficient Photocatalytic Hydrogen Production.
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Huang, Wenhuan, Su, Chenyang, Zhu, Chen, Bo, Tingting, Zuo, Shouwei, Zhou, Wei, Ren, Yuanfu, Zhang, Yanan, Zhang, Jing, Rueping, Magnus, and Zhang, Huabin
- Subjects
HYDROGEN production ,ELECTRON-hole recombination ,ELECTRONS ,WATER efficiency ,CHARGE exchange ,HYDROGEN evolution reactions - Abstract
The solar‐driven evolution of hydrogen from water using particulate photocatalysts is considered one of the most economical and promising protocols for achieving a stable supply of renewable energy. However, the efficiency of photocatalytic water splitting is far from satisfactory due to the sluggish electron‐hole pair separation kinetics. Herein, isolated Mo atoms in a high oxidation state have been incorporated into the lattice of Cd0.5Zn0.5S (CZS@Mo) nanorods, which exhibit photocatalytic hydrogen evolution rate of 11.32 mmol g−1 h−1 (226.4 μmol h−1; catalyst dosage 20 mg). Experimental and theoretical simulation results imply that the highly oxidized Mo species lead to mobile‐charge imbalances in CZS and induce the directional photogenerated electrons transfer, resulting in effectively inhibited electron‐hole recombination and greatly enhanced photocatalytic efficiency. [ABSTRACT FROM AUTHOR]
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- 2023
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28. Sieving and hydrothermal pre‐treatments for preparing ultra‐high mechanical strength particleboard.
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Zhou, Tong, Pang, Bo, Cao, Xue‐Fei, Bao, Ningzhong, Zhu, Chen‐Jie, Sun, Zhuohua, Yang, Sheng, and Yuan, Tong‐Qi
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PARTICLE board ,SIEVES ,CARBON sequestration ,BENDING strength ,BOND strengths ,CONSTRUCTION materials - Abstract
The application of non woody biomass materials in the manufacture of wood‐based panels has been confirmed as an efficient carbon sequestration approach. In this study, reed straw was recommended to produce reed‐based particleboards (RPs). Sieving and hydrothermal pre‐treatments were conducted on the inner layer reed particles to reduce the adverse influence of the waxy layer on the mechanical strength of RPs. The thickness swelling rate was merely 1.04% (2 h), and the internal bonding strength could reach up to 0.88 MPa, which met the ISO requirements for heavy‐duty load bearing in dry conditions (P‐HLB REG). More importantly, this study constructed the plate forming process that retains the natural morphological characteristics of reed to the maximum extent. Generally, the mechanical strength of RPs was markedly higher than mostly straw‐based and even wood‐based panels. The static bending strength of RPs could reach 35.6 MPa after sieving pre‐treatment. In addition, according to the LCA, the net carbon flux could reach −1227.55 kg CO2 eq. when producing 1 m3 RPs. The obtained RPs could be utilized as wood substitutes to produce furniture and building materials with promising environmental and economic benefits. [ABSTRACT FROM AUTHOR]
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- 2023
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29. Biofilm Homeostasis Interference Therapy via 1O2‐Sensitized Hyperthermia and Immune Microenvironment Re‐Rousing for Biofilm‐Associated Infections Elimination.
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Li, Qianming, Liu, Quan, Wang, Zhengxi, Zhang, Xianzuo, Ma, Ruixiang, Hu, Xianli, Mei, Jiawei, Su, Zheng, Zhu, Wanbo, and Zhu, Chen
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- 2023
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30. Decoding Li+/Na+ Exchange Route Toward High‐Performance Mn‐Based Layered Cathodes for Li‐Ion Batteries.
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Cao, Bo, Chen, Zhefeng, Cao, Hongbin, Zhu, Chen, Yang, Hongkai, Li, Tianyi, Xu, Wenqian, Pan, Feng, and Zhang, Mingjian
- Subjects
LITHIUM-ion batteries ,CATHODES ,ELECTRIC batteries ,DENSITY functional theory ,ION exchange (Chemistry) ,PHASE transitions - Abstract
Li+/Na+ exchange has been extensively explored as an effective method to prepare high‐performance Mn‐based layered cathodes for Li‐ion batteries, since the first report in 1996 by P. G. Bruce (Nature, 1996. 381, 499–500). Understanding the detailed structural changes during the ion‐exchange process is crucial to implement the synthetic control of high‐performance layered Mn‐based cathodes, but less studied. Herein, in situ synchrotron X‐ray diffraction, density functional theory calculations, and electrochemical tests are combined to conduct the systemic studies into the structural changes during the ion‐exchange process of an Mn‐only layered cathode O3‐type Li0.67[Li0.22Mn0.78]O2 (LLMO) from the corresponding counterpart P3‐type Na0.67[Li0.22Mn0.78]O2 (NLMO). The temperature‐resolved observations combined with theoretical calculations reveal that the Li+/Na+ exchange is favorable thermodynamically and composited with two tandem topotactic phase transitions: 1) from NLMO to a layered intermediate through ≈60% of Li+/Na+ exchange. 2) then to the final layered product LLMO through further Li insertion. Moreover, the intermediate‐dominate composite is obtained by slowing down the exchange kinetics below room temperature, showing better electrochemical performance than LLMO obtained by the traditional molten‐salt method. The findings provide guides for the synthetic control of high‐performance Mn‐based cathodes under mild conditions. [ABSTRACT FROM AUTHOR]
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- 2023
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31. Overcoming the Oxygen Dilemma in Photoredox Catalysis: Near‐Infrared (NIR) Light‐Triggered Peroxynitrite Generation for Antibacterial Applications.
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Shen, Zhiqiang, Zheng, Shaoqiu, Fang, Yuanmeng, Zhang, Guoying, Zhu, Chen, Liu, Shiyong, and Hu, Jinming
- Subjects
CATALYSIS ,PEROXYNITRITE ,PHOTOSENSITIZATION ,SUPEROXIDES ,DILEMMA ,NITRIC oxide ,REACTIVE oxygen species - Abstract
The peroxynitrite anion (ONOO−) is closely associated with many diseases and the creation of ONOO− donors is an essential means of understanding its pathophysiological functions. However, it is challenging to develop ONOO− donors due to the difficulties in simultaneously producing highly reactive and short‐lived nitric oxide (NO) and superoxide anion (O2⋅−). Here, we report a novel strategy for constructing ONOO− donors by combining near‐infrared (NIR)‐mediated type I photosensitization and photoredox catalysis. The key design using a Nile blue analogue that can serve as both a type I photosensitizer and a metal‐free photocatalyst. Intriguingly, the formation of O2⋅− via type I photosensitization avoids oxygen interference and instead activates nitrobenzofurazan‐based NO donors via oxygen‐tolerant NIR photoredox catalysis. The simultaneous release of O2⋅− and NO leads to ONOO− release, showing both antibacterial and antibiofilm activities. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
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32. Degradation mechanism of AtrA mediated by ClpXP and its application in daptomycin production in Streptomyces roseosporus.
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Xu, Wei‐Feng, Sun, Chen‐Fan, Gao, Wen‐Li, Scharf, Daniel H., Zhu, Chen‐Yang, Bu, Qing‐Ting, Zhao, Qing‐Wei, and Li, Yong‐Quan
- Abstract
The efficiency of drug biosynthesis depends on different transcriptional regulatory pathways in Streptomyces, and the protein degradation system adds another layer of complexity to the regulatory processes. AtrA, a transcriptional regulator in the A‐factor regulatory cascade, stimulates the production of daptomycin by binding to the dptE promoter in Streptomyces roseosporus. Using pull‐down assays, bacterial two‐hybrid system and knockout verification, we demonstrated that AtrA is a substrate for ClpP protease. Furthermore, we showed that ClpX is necessary for AtrA recognition and subsequent degradation. Bioinformatics analysis, truncating mutation, and overexpression proved that the AAA motifs of AtrA were essential for initial recognition in the degradation process. Finally, overexpression of mutated atrA (AAA‐QQQ) in S. roseosporus increased the yield of daptomycin by 225% in shake flask and by 164% in the 15 L bioreactor. Thus, improving the stability of key regulators is an effective method to promote the ability of antibiotic synthesis. [ABSTRACT FROM AUTHOR]
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- 2023
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33. Prescribed fire alters nematode communities in an old‐field grassland.
- Author
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Song, Min, McDaniel, Marshall D., Zhu, Chen, Lin, Feng, and Zhang, Yaojun
- Subjects
PRESCRIBED burning ,NEMATODES ,PLANT parasites ,GRASSLANDS ,FIRE management ,NUTRIENT cycles ,PLANT diversity ,ECOSYSTEMS - Abstract
Fire is a common disturbance in many biomes, with both beneficial and detrimental effects on soil biology, which largely depend on fire intensity. However, little is known about the impact of fire on soil nematode communities in terrestrial ecosystem. In the present study, we investigated the effects of short‐term prescribed fire on soil nematode communities and soil properties in an old‐field grassland in Northern China. The results showed that burning significantly increased soil nematode abundance by 77% and genus richness by 49% compared to the control. Burning also decreased taxon dominance by 45% (Simpson's D) and increased nematode diversity by 31% (Shannon‐Weaver H'). However, burning increased plant parasites (particularly genera Cephalenchus and Pratylenchus) and shifted community to more bacterial‐feeding genera (i.e., decreased Channel Index). Generally, burning increased soil bio‐available nitrogen (NH4+–N and NO3−–N) content, which would be the main drivers causing nematode community to flourish via a "bottom‐up" effect. These results suggest that prescribed fire increases nematode diversity and alters community composition toward more plant parasites and bacterial feeders. Our findings highlight the importance of prescribed fire management in shaping short‐term nematode community structure and function, but the long‐term effects and impacts of these changes on soil nutrient and carbon cycling remain unknown. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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34. Clinically Translatable Transcrocetin Delivery Platform for Correction of Tumor Hypoxia and Enhancement of Radiation Therapy Effects.
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Diringer, Marie‐Charlotte, Coliat, Pierre, Mathieu, Clélia, Laurent, Nina, Mura, Carole, Banerjee, Mainak, Zhu, Chen, Grabowska, Anna, Ritchie, Alison, Clarke, Philip, Bernard, Alexandre, Vit, Claire, Burckel, Hélène, Noel, Georges, Harvey, Peter, Pivot, Xavier, and Detappe, Alexandre
- Published
- 2023
- Full Text
- View/download PDF
35. Spatiotemporal On-Off Immunomodulatory Hydrogel Targeting NLRP3 Inflammasome for the Treatment of Biofilm-Infected Diabetic Wounds.
- Author
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Zhou, Jun, Mei, Jiawei, Liu, Quan, Xu, Dongdong, Wang, Xiaoli, Zhang, Xianzuo, Zhu, Wanbo, Zhu, Chen, and Wang, Jiaxing
- Subjects
NLRP3 protein ,INFLAMMASOMES ,BACTERIAL colonies ,NATURAL immunity ,GRAPHENE oxide ,HYPERGLYCEMIA - Abstract
Biofilm-infected diabetic wounds (BIDWs) with hyperglycemia and bacterial colonization are characterized by disordered inflammation and abnormal activation ofNLRP3 inflammasome, leading to sustained macrophage M1 polarization and neutrophil extracellular traps (NETs) formation. An immoderate anti-inflammatory treatment that downregulates NLRP3 in turn promotes the persistence of biofilm infections and impairs the healing ofBIDWs. Therefore, reconciling biofilm elimination and immune regulation holds the promise of curing BIDWs. Herein, a novel spatiotemporal on-off immunomodulatory therapy (SOIT) is proposed for treating BIDWs through biphasic regulation of NLRP3. Methacrylate gelatin hydrogels (Gel-MA) incorporated with graphene oxide (GO) and metformin-loaded mesoporous silicone nanospheres are synthesized and photo cross-linked to construct a nanocomposite hydrogel (MGO@GM). First, GO nanosheets released from MGO@GM inhibit bacterial biofilm formation and disrupt mature biofilms under near-infrared irradiation. Meanwhile, GO activates the NLRP3 to induce a macrophage-associated proinflammatory response against biofilms. Afterward, with the subsequent degradation ofMGO@GM, released metformin reduces local hyperglycemia, downregulates NLRP3, and inhibits NETs formation. Furthermore, repolarized M2 macrophages alleviate the inflammatory microenvironment and promote tissue regeneration. Briefly, this SOIT strategy regulates the NLRP3 and rescues impaired innate immunity to facilitate anti-infection and tissue repair, which provides a new perspective for the future clinical treatment of BIDWs. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
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36. Organoboron Reagent‐Controlled Selective (Deutero)Hydrodefluorination.
- Author
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Shen, Zheng‐Jia, Zhu, Chen, Zhang, Xiao, Yang, Chao, Rueping, Magnus, Guo, Lin, and Xia, Wujiong
- Subjects
- *
CHEMOSELECTIVITY , *MOLECULAR structure , *DRUG discovery , *MOIETIES (Chemistry) , *DEUTERIUM , *DENSITY functional theory , *PHARMACEUTICAL chemistry - Abstract
(Deuterium‐labeled) CF2H‐ and CFH2‐moieties are of high interest in drug discovery. The high demand for the incorporation of these fluoroalkyl moieties into molecular structures has witnessed significant synthetic progress, particularly in the (deutero)hydrodefluorination of CF3‐containing compounds. However, the controllable replacement of fluorine atoms while maintaining high chemoselectivity remains challenging. Herein, we describe the development of a selective (deutero)hydrodefluorination reaction via electrolysis. The reaction exhibits a remarkable chemoselectivity control, which is enabled by the addition of different organoboron sources. The procedure is operationally simple and scalable, and provides access in one step to high‐value building blocks for application in medicinal chemistry. Furthermore, density functional theory (DFT) calculations have been carried out to investigate the reaction mechanism and to rationalize the chemoselectivity observed. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
37. Fabrication of a Periodic Inverse Micropyramid (PIMP)‐Si/In2Se3 Heterojunction Photodetector Array for RGB‐IR Image Sensing Application.
- Author
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Zhang, Chao, Zhu, Chen‐Yue, Yang, Zhen, Lin, Di‐Hua, Wu, Chun‐Yan, Chen, Shi‐Rong, Yang, Yi‐Zhong, Wang, Li, Zhou, Yu‐Xue, and Luo, Lin‐Bao
- Subjects
- *
PHOTODETECTORS , *HETEROJUNCTIONS , *COLLOIDAL crystals , *SILICON nanowires , *SEX work - Abstract
Here, the fabrication of an addressable 8 × 8 photodetector array is reported by combining In2Se3 nanofilm with periodic inverse micropyramid‐Si (PIMP‐Si), which is obtained through colloidal lithography and anisotropic wet etching. Due to the unique configuration and the outstanding light trapping effect, the as‐fabricated heterojunction device presents an excellent self‐powered photoresponse over the broadband wavelength range from 265 to 1300 nm, with a peak sensitivity at ≈810 nm. The responsivity, specific detectivity, and rise/fall time are estimated to be 0.58 A W−1, 1.76 × 1012 Jones, and 5.1/18 µs, respectively, which are competitive in comparison with other devices with similar geometries. Meanwhile, the photodetector array displays a satisfactory pixel‐to‐pixel uniformity, which allows the device to record the full‐color image of "HFUT" with satisfying resolution, revealing the potential application of the PIMP‐Si/In2Se3 heterojunction photodetector array for real‐time red‐green‐blue‐infrared image sensing and video capturing. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
38. Single‐Step Oxidation of Low‐Concentration Methane to Methanol in the Gaseous Phase Using Ceria‐Based Iridium‐Copper Catalysts.
- Author
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Wu, Mingwei, Li, Wenzhi, Zhu, Chen, Wu, Wenjian, Zhang, Lulu, Zheng, Taimin, Fu, Yan, and Yuan, Liang
- Subjects
IRIDIUM catalysts ,METHANOL ,OXIDATION of methanol ,COPPER ,METHANE ,CATALYSTS ,TEMPERATURE-programmed reduction - Abstract
Single‐step conversion of methane to methanol in the gaseous phase is required for high value added application of methane and environmental protection, but it is challenging. Here, direct oxidation of methane to methanol under gaseous condition on iridium promoted Cu/CeO2 catalyst, prepared using a sol‐gel method, is investigated. The addition of iridium can effectively upgrade the redox properties and oxygen storage capacity due to intense metal interaction, stimulating a prominent catalytic performance for methane conversion to methanol on Cu−Ir@CeO2 catalyst. Approximately 26.2 μmol/gcat methanol yield and 68 % methanol selectivity are achieved on the trimetallic 5Cu0.5Ir@CeO2 catalyst at 550 °C in 2 h. Consequences of the analysis of XRD, SEM, HRTEM, Raman, FI‐IR and XPS demonstrate that highly‐dispersed Ir and Cu species are uniformly distributed on CeO2 surface, and partial Cu or Ir atoms replace Ce4+ in CeO2 lattice due to the metal interaction in the colloidal structure, which can impact the catalyst's electronic properties. H2 temperature‐programmed reduction (H2‐TPR) and CH4 temperature‐programmed desorption (CH4‐TPD) results disclose that the unique ternary surface exhibits excellent redox properties and strong adsorption capacity for methane, which can activate the first C−H bond of methane to methyl species, and then react with OH− to form methanol. The good stability in cyclic operation is an additional attribute, rendering this type of catalyst a "front‐runner" in future catalyst development for direct methane‐to‐methanol. This composite catalyst design provides hope for developing ternary metal‐oxide catalysts for functionalization of methane. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
39. Critical care nurses' knowledge, attitudes, and practices of pressure injury prevention in China: A multicentric cross‐sectional survey.
- Author
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Li, Jiamin, Zhu, Chen, Liu, Ying, Li, Zhaoyu, Sun, Xiangyu, Bai, Yunfeng, Song, Baoyun, Jin, Jingfen, Liu, Yilan, Wen, Xianxiu, Cheng, Shouzhen, and Wu, Xinjuan
- Subjects
RESEARCH ,NURSES' attitudes ,NURSING ,PRESSURE ulcers ,CROSS-sectional method ,CRITICAL care nurses ,NURSING practice ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,RESEARCH funding ,JOB performance ,SECONDARY analysis - Abstract
Pressure injury is a serious and preventable problem in intensive care units. Translating guidelines into clinical practice can reduce the incidence of pressure injury. Identifying clinical status, barriers and facilitators contribute to guideline implementation. To identify the knowledge, attitudes, and practices of pressure injury prevention in Chinese critical care nurses. Secondary data were extracted from a multicentric clinical trial. Knowledge and attitudes toward pressure injury prevention were assessed by a fourteen‐item questionnaire. The observed practices were recorded using a case report form. The report complies with the STROBE statement. A total of 950 critical care nurses in 15 hospitals from six provinces of China were investigated. A total of 53.1% of nurses received a median score of 6 points or less. Knowledge regarding the repositioning procedure, risk assessment, and heel pressure injury prevention was insufficient. Over 99% of nurses strongly or somewhat agreed that pressure injury prevention was very important and that they were willing to take measures to prevent pressure injury. A total of 27 781 patient days of pressure injury prevention practice were recorded. Repositioning was the most commonly used prevention measure, followed by support surfaces and prophylactic dressings. A combination of repositioning, support surface, and prophylactic dressing was lacking. Chinese critical nurses showed a low level of knowledge and a positive attitude toward pressure injury prevention. Practices of pressure injury prevention were unsatisfactory. There is a clear gap between the guidelines and clinical practices. The barrier (low‐level knowledge) and facilitator (positive attitude) were identified in this study. According to these findings, strategies need to be developed to promote guideline implementation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
40. Enhancing lactose recognition of a key enzyme in 2'-fucosyllactose synthesis: α-1,2-fucosyltransferase.
- Author
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Wenxian Liu, Shizhe Tang, Jing Peng, Yuling Zhu, Lina Pan, Jiaqi Wang, Xiaoyu Peng, Haina Cheng, Zhu Chen, Yuguang Wang, and Hongbo Zhou
- Subjects
LACTOSE ,BREAST milk ,RECOGNITION (Psychology) ,FUCOSYLTRANSFERASES ,ENZYMES ,BIOSYNTHESIS - Abstract
BACKGROUND: 2'-Fucosyllactose, a representative oligosaccharide in human milk, is an emerging and promising food and pharmaceutical ingredient due to its powerful health benefits, such as participating in immune regulation, regulation of intestinal flora, etc. To enable economically viable production of 2'-fucosyllactose, different biosynthesis strategies using precursors and pathway enzymes have been developed. The α-1,2-fucosyltransferases are an essential part involved in these strategies, but their strict substrate selectivity and unsatisfactory substrate tolerance are one of the key roadblocks limiting biosynthesis. RESULTS: To tackle this issue, a semi-rational manipulation combining computer-aided designing and screening with biochemical experiments were adopted. The mutant had a 100-fold increase in catalytic efficiency compared to the wild-type. The highest 2'-fucosyllactose yield was up to 0.65 mol mol-1 lactose with a productivity of 2.56 g mL-1 h-1 performed by enzymatic catalysis in vitro. Further analysis revealed that the interactions between the mutant and substrates were reduced. The crucial contributions of wild-type and mutant to substrate recognition ability were closely related to their distinct phylotypes in terms of amino acid preference. CONCLUSION: It is envisioned that the engineered α-1,2-fucosyltransferase could be harnessed to relieve constraints imposed on the bioproduction of 2'-fucosyllactose and lay a theoretical foundation for elucidating the substrate recognition mechanisms of fucosyltransferases. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
41. Photothermal Nanozyme‐Based Microneedle Patch against Refractory Bacterial Biofilm Infection via Iron‐Actuated Janus Ion Therapy.
- Author
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Zhu, Wanbo, Mei, Jiawei, Zhang, Xianzuo, Zhou, Jun, Xu, Dongdong, Su, Zheng, Fang, Shiyuan, Wang, Jiaxing, Zhang, Xianlong, and Zhu, Chen
- Published
- 2022
- Full Text
- View/download PDF
42. Acidity‐Activatable Nanoparticles with Glucose Oxidase‐Enhanced Photoacoustic Imaging and Photothermal Effect, and Macrophage‐Related Immunomodulation for Synergistic Treatment of Biofilm Infection.
- Author
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Dai, Yong, Mei, Jiawei, Li, Zhe, Kong, Lingtong, Zhu, Wanbo, Li, Qianming, Wu, Kerong, Huang, Yan, Shang, Xifu, and Zhu, Chen
- Published
- 2022
- Full Text
- View/download PDF
43. Effects of high‐pressure processing on aquatic products with an emphasis on sensory evaluation.
- Author
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Chen, Lihang, Wang, Yuying, Zhu, Chen, Zhang, Dali, and Liu, Huimin
- Subjects
CONSUMER attitudes ,SENSORY evaluation ,CYTOSKELETAL proteins ,ELECTRONIC noses ,MYOGLOBIN ,COMPLEX matrices - Abstract
Summary: Previous intensive research has described the molecular impacts of high‐pressure processing (HPP) on fish meat chemical composition, such as myofibril structural proteins, enzymes, myoglobin and lipids. This work aims to collect articles on sensory evaluation of pressure‐treated aquatic products to determine the practical effects of HPP on aquatic products, especially sensory properties, by comparing the differences between instrumental tests and sensory evaluation, between trained sensory assessors and consumers to guide and improve the processing of aquatic products. The findings indicate that laboratory devices such as spectrophotometers, texture analysers and electronic noses, and trained sensory assessors can detect pressure‐induced changes in appearance, texture, off‐odour, and flavour, such as discoloration, whitening, increased hardness and initiation of lipids oxidation. However, consumers did not perceive the pressure‐induced changes in odour and colour. Besides, consumers' attitudes towards pressure‐treated aquatic products are ambiguous in the range of 300 to 600 MPa, and professional testing and assessment fail to replace hedonic tests. In complex matrices of aquatic products, particular attention is needed to be paid to changes in sensory qualities dominated by microorganisms, endogenous enzymes and bioactive compounds after HPP treatment and throughout commercial storage. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
44. Anti‐CD38 monoclonal antibody interference with blood compatibility testing: Differentiating isatuximab and daratumumab via functional epitope mapping.
- Author
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Chami, Btissam, Okuda, Makoto, Moayeri, Morvarid, Pirenne, France, Hidaka, Yoko, Nambiar, Ashok, Song, Zhili, Bedel, Olivier, Zhang, Bailin, Hopke, Joern, Deng, Gejing, Zhu, Chen, Macé, Sandrine, Chiron, Marielle, Adrian, Francisco, Fukao, Taro, Basile, Frank G., and Martin, Thomas
- Abstract
Background: There are two FDA‐approved anti‐CD38 monoclonal antibodies for treatment of multiple myeloma: isatuximab and daratumumab. Owing to expression of CD38 on reagent red blood cells (RBCs), these antibodies interfere with indirect antiglobulin tests (IATs). We sought to understand differences in such interference by performing binding experiments. Study Design and Methods: In vitro experiments to compare the binding to RBCs of isatuximab and daratumumab alone or in the presence of a mouse anti‐human CD38 antibody (HB‐7 or AT13/5) or a nicotinamide adenine dinucleotide‐analog CD38 inhibitor were performed and quantified by flow cytometry, imaging, mass spectrometry, surface plasmon resonance, and LigandTracer technologies. Serologic testing was performed on plasma samples spiked with isatuximab or daratumumab. Results: CD38 expressed on RBCs can be directly bound by daratumumab, whereas isatuximab requires a co‐factor, such as HB‐7, AT13/5, or a CD38 inhibitor, suggesting that the isatuximab epitope on RBCs is masked in vitro. Daratumumab samples more frequently showed interference and had stronger reactions than isatuximab samples. Dithiothreitol treatment was equally effective in mitigating the interference caused by either drug. Discussion: Both isatuximab and daratumumab interfere with IATs but at different magnitudes, reflecting distinct binding to CD38 on RBCs. From the binding studies, we conclude that the isatuximab epitope on RBCs is masked in vitro and binding requires a certain CD38 conformation or co‐factor. This circumstance may explain why interference is seen only in a subset of patients receiving isatuximab when compared with interference seen in most patients on daratumumab therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
45. Shrimp (Penaeus monodon) preservation by using chitosan and tea polyphenol coating combined with high‐pressure processing.
- Author
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Chen, Lihang, Jiao, Dexin, Zhou, Bihe, Zhu, Chen, Liu, Jingsheng, Zhang, Dali, and Liu, Huimin
- Subjects
PENAEUS monodon ,SHRIMPS ,PLANT polyphenols ,CHITOSAN ,SURFACE coatings ,EDIBLE coatings ,TEA - Abstract
The present work investigated the effects of high‐pressure processing (200 and 400 MPa, 5 min) combined with chitosan‐tea polyphenol (1.5% and 0.5% [w/v], respectively) coating to improve the quality and stability of shrimp (Penaeus monodon) during 28 days of storage. The chemical (pH, TVB‐N, TBARS), microbiological, textural, chromatic characteristics, protein oxidation, and endogenous enzyme activities of shrimps were regularly evaluated. Results showed that the combination treatment exerted a better intense antimicrobial effect, stabilized shrimp's freshness, and resulted in lower pH and TVB‐N than the control sample. Also, combined treated samples had better oxidative stability than a single treatment until the end of shelf life. Although combination treatment had no significant effect on endogenous proteases, the combined use of 400 MPa high‐pressure and chitosan‐tea polyphenol coating was most effective in inhibiting the bacteria and improved the hardness and chromatic characteristics of shrimp within the storage. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
46. Ultralow Lattice Thermal Conductivity and High Thermoelectric Figure of Merit in Dually Substituted Cu12Sb4S13 Tetrahedrites.
- Author
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Zhu, Chen, Ming, Hongwei, Zhang, Jian, Li, Di, Chen, Tao, and Qin, Xiaoying
- Subjects
THERMAL conductivity ,PHONON scattering ,THERMOELECTRIC materials ,POINT defects ,THERMOELECTRIC power - Abstract
The thermoelectric properties of dually substituted Cu12−xInxSb4S12.8Se0.2 tetrahedrites are studied in temperature range from 300 to 723 K. The results indicate that dual substitution of In for Cu and Se for S not only causes the enhancement of thermopower S but also gives rise to a significant decrease in lattice thermal conductivity κL. An ultralow κL ≈0.2 W m−1 K−1 is obtained at 723 K in Cu11.95In0.05Sb4S12.8Se0.2 sample due to the enhanced phonon scattering mainly by point defects. Consequently, a high figure of merit ZTmax ≈1.0 is achieved in Cu11.95In0.05Sb4S12.8Se0.2 sample, which is ≈56% larger than that of pristine Cu12Sb4S13, indicating that dual substitution is effective in boosting the thermoelectric properties of tetrahedrites. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
47. Reductive Cross‐Coupling of α‐Oxy Halides Enabled by Thermal Catalysis, Photocatalysis, Electrocatalysis, or Mechanochemistry.
- Author
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Zhu, Chen, Lee, Shao‐Chi, Chen, Haifeng, Yue, Huifeng, and Rueping, Magnus
- Subjects
- *
MECHANICAL chemistry , *PHOTOCATALYSIS , *CATALYSIS , *HALIDES , *ARYL halides , *ELECTROPHILES , *ACYL chlorides , *ELECTROCATALYSIS - Abstract
Herein, we report a reductive cross‐coupling reaction of α‐oxy halides, simply generated from aldehydes, with a series of C(sp2)‐ and C(sp)‐electrophiles. A wide range of aryl and heteroatom aryl halides, vinyl bromides, alkynyl bromides, and acyl chlorides react with unhindered and hindered aldehyde‐derived α‐oxy halides by providing protected alcohols as well as α‐hydroxy ketones. Noteworthy, the reductive couplings are achieved not only through thermal catalysis with the use of metal reductants but also by photocatalysis, electrochemistry, and mechanochemistry. The unrestricted interchange of the four strategies indicates their underlying mechanistic similarities. The generation of NiI intermediate is proposed to be the key point for ketyl radical formation via a single‐electron transfer (SET) event, which was rationalized by an array of control experiments and density functional theory (DFT) calculations. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
48. Reactivity in Nickel‐Catalyzed Multi‐component Sequential Reductive Cross‐Coupling Reactions.
- Author
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Chen, Haifeng, Yue, Huifeng, Zhu, Chen, and Rueping, Magnus
- Subjects
HALOALKANES ,ARYL halides ,OXIDATIVE coupling ,CARBONYLATION ,FUNCTIONAL groups ,OXIDATIVE addition - Abstract
The nickel‐catalyzed three‐component reductive carbonylation of alkyl halides, aryl halides, and ethyl chloroformate is described. Ethyl chloroformate is utilized as a safe and readily available source of CO in this multi‐component protocol, providing an efficient and practical alternative for the synthesis of aryl‐alkyl ketones. The reaction exhibits a wide substrate scope and good functional group compatibility. Experimental and DFT mechanistic studies highlight the complexity of the cross‐electrophile coupling and provide insight into the sequence of the three consecutive oxidative additions of aryl halide, chloroformate, and alkyl halide. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
49. Fluorescence or Phosphorescence? The Metallic Composition of the Nanocluster Kernel Does Matter.
- Author
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Zhu, Chen, Xin, Junsheng, Li, Jing, Li, Hao, Kang, Xi, Pei, Yong, and Zhu, Manzhou
- Subjects
- *
FLUORESCENCE , *PHOTOLUMINESCENCE , *PHOSPHORESCENCE , *PHOSPHORESCENCE spectroscopy , *NANOSTRUCTURED materials , *ELECTRONS , *ALLOYS - Abstract
It remains challenging to manipulate the nature of photoluminescence as either fluorescence or phosphorescence for a correlated cluster series. In this work, two correlated nanoclusters, Au5Ag11(SR)8(DPPOE)2 and Pt1Ag16(SR)8(DPPOE)2 with comparable structure features, were synthesized and structurally determined. These two alloy nanoclusters displayed distinct photoluminescent nature—the Au5Ag11 nanocluster is fluorescent, whereas the Pt1Ag16 nanocluster is phosphorescent. The decay processes of the excited electrons in these two nanoclusters have been explicitly mapped out by both experimental and theoretical approaches, disclosing the mechanisms of their fluorescence and phosphorescence. Specifically, the metallic compositions of the nanocluster kernels mattered in determining their photoluminescent nature. The results herein provide an intriguing nanomodel that enables us to grasp the origin of photoluminescence at the atomic level, which further paves the way for fabricating novel nanoclusters or cluster‐based nanomaterials with customized photophysical properties. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
50. Asymmetric Radical Cyclization of Alkenes by Stereospecific Homolytic Substitution of Sulfinamides.
- Author
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Chen, Yasu, Wu, Xinxin, Yang, Shan, and Zhu, Chen
- Subjects
SULFINAMIDES ,RING formation (Chemistry) ,ALKENES ,FUNCTIONAL groups ,ASYMMETRIC synthesis - Abstract
We report a novel asymmetric radical cyclization of alkenes via stereospecific homolytic substitution of sulfinamides. This reaction produces a variety of cyclic sulfinamides with excellent stereocontrol. The protocol features broad functional group tolerance, high product diversity, and easy accessibility to feedstocks, and outlines a new pathway for the synthesis of chiral cyclic sulfinamides. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
Catalog
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