33 results on '"Jiao, Yao"'
Search Results
2. Stevioside reduces inflammation in periodontitis by changing the oral bacterial composition and inhibiting P. gingivalis in mice
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Han, Wenrui, Jiao, Yao, Mi, Sicong, Han, Shu, Xu, Junji, Li, Song, Liu, Yi, and Guo, Lijia
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- 2023
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3. The safety of digestive tract cancer surgery during COVID-19: A living systematic review and meta-analysis
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Qiu-xiang Wang, Juan Wang, Rui-ke Wu, Yi-lin Li, Cheng-jiao Yao, Feng-jiao Xie, Qin Xiong, and Pei-min Feng
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COVID-19 pandemic ,digestive tract cancer ,meta-Analysis ,Surgery ,RD1-811 - Abstract
Surgery is the primary curative treatment of solid cancers. However, its safety has been compromised by the outbreak of COVID-19. Therefore, it is necessary to evaluate the safety of digestive tract cancer surgery in the context of COVID-19. We used the Review Manager software (v.5.4) and Stata software (version 16.0) for meta-analysis and statistical analysis. Sixteen retrospective studies involving 17,077 patients met the inclusion criteria. The data indicates that performing digestive tract cancer surgery during the COVID-19 pandemic led to increased blood loss(MD = -11.31, 95%CI:-21.43 to −1.20, P = 0.03), but did not increase postoperative complications(OR = 1.03, 95%CI:0.78 to1.35, P = 0 0.86), anastomotic leakage (OR = 0.96, 95%CI:0.52 to1.77, P = 0 0.89), postoperative mortality (OR = 0.65, 95%CI:0.40 to1.07, P = 0 0.09), number of transfusions (OR = 0.74, 95%CI:0.30 to 1.80, P = 0.51), number of patients requiring ICU care(OR = 1.37, 95%CI:0.90 to 2.07, P = 0.14), postoperative 30-d readmission (OR = 0.94, 95%CI:0.82 to 1.07, P = 0 0.33), total hospital stay (MD = 0.11, 95%CI:-2.37 to 2.59, P = 0.93), preoperative waiting time(MD = − 0.78, 95%CI:-2.34 to 0.79, P = 0.33), postoperative hospital stay(MD = − 0.44, 95%CI:-1.61 to 0.74, P = 0.47), total operation time(MD = -12.99, 95%CI:-28.00 to 2.02, P = 0.09) and postoperative ICU stay (MD = − 0.02, 95%CI:-0.62 to 0.57, P = 0.94). Digestive tract cancer surgery can be safely performed during the COVID-19.
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- 2023
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4. Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease
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Qian Yan, Shasha Liu, Yang Sun, Chen Chen, Songwei Yang, Meiyu Lin, Junpeng Long, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, Naihong Chen, and Yantao Yang
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Cardiovascular disease ,Oxidative stress ,Herb monomer ,Antioxidative ,Medicine - Abstract
Abstract Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis (AS), and myocardial infarction (MI). Oxidative stress (OS) plays a crucial role in the pathogenesis and advancement of CVDs, highlighting its significance as a contributing factor. Maintaining an equilibrium between reactive oxygen species (ROS) and antioxidant systems not only aids in mitigating oxidative stress but also confers protective benefits on cardiac health. Herbal monomers can inhibit OS in CVDs by activating multiple signaling pathways, such as increasing the activity of endogenous antioxidant systems and decreasing the level of ROS expression. Given the actions of herbal monomers to significantly protect the normal function of the heart and reduce the damage caused by OS to the organism. Hence, it is imperative to recognize the significance of herbal monomers as prospective therapeutic interventions for mitigating oxidative damage in CVDs. This paper aims to comprehensively review the origins and mechanisms underlying OS, elucidate the intricate association between CVDs and OS, and explore the therapeutic potential of antioxidant treatment utilizing herbal monomers. Furthermore, particular emphasis will be placed on examining the cardioprotective effects of herbal monomers by evaluating their impact on cardiac signaling pathways subsequent to treatment. Graphical Abstract
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- 2023
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5. Targeting pyroptosis as a preventive and therapeutic approach for stroke
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Junpeng Long, Yang Sun, Shasha Liu, Songwei Yang, Chen Chen, Zhao Zhang, Shifeng Chu, Yantao Yang, Gang Pei, Meiyu Lin, Qian Yan, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, and Naihong Chen
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Stroke has caused tremendous social stress worldwide, yet despite decades of research and development of new stroke drugs, most have failed and rt-PA (Recombinant tissue plasminogen activator) is still the accepted treatment for ischemic stroke. the complexity of the stroke mechanism has led to unsatisfactory efficacy of most drugs in clinical trials, indicating that there are still many gaps in our understanding of stroke. Pyroptosis is a programmed cell death (PCD) with inflammatory properties and are thought to be closely associated with stroke. Pyroptosis is regulated by the GSDMD of the gasdermin family, which when cleaved by Caspase-1/Caspase-11 into N-GSDMD with pore-forming activity can bind to the plasma membrane to form small 10–20 nm pores, which would allow the release of inflammatory factors IL-18 and IL-1β before cell rupture, greatly exacerbating the inflammatory response. The pyroptosis occurs mainly in the border zone of cerebral infarction, and glial cells, neuronal cells and brain microvascular endothelial cells (BMECs) all undergo pyroptosis after stroke, which largely exacerbates the breakdown of the blood-brain barrier (BBB) and thus aggravates brain injury. Therefore, pyroptosis may be a good direction for the treatment of stroke. In this review, we focus on the latest mechanisms of action of pyroptosis and the process by which pyroptosis regulates stroke development. We also suggest potential therapeutic stroke drugs that target the pyroptosis pathway, providing additional therapeutic strategies for the clinical management of stroke. The role of pyroptosis after stroke. After stroke, microglia first rush to the damaged area and polarize into M1 and M2 types. Under the influence of various stimuli, microglia undergo pyroptosis, release pro-inflammatory factors, and are converted to the M1 type; astrocytes and neuronal cells also undergo pyroptosis under the stimulation of various pro-inflammatory factors, leading to astrocyte death due to increased osmotic pressure in the membrane, resulting in water absorption and swelling until rupture. BMECs, the main structural component of the BBB, also undergo pyroptosis when stimulated by pro-inflammatory factors released from microglia and astrocytes, leading to the destruction of the structural integrity of the BBB, ultimately causing more severe brain damage. In addition, GSDMD in neutrophils mainly mediate the release of NETs rather than pyroptosis, which also aggravates brain injury. IL-10=interleukin-10; TGF-β = transforming growth factor-β; IL-18=interleukin-18; IL-1β = interleukin-1β; TNF-α = tumor necrosis factor-α; iNOS=induced nitrogen monoxide synthase; MMPs=Matrix metalloproteinases; GSDMD = gasdermin D; BMECs=brain microvascular endothelial cells; BBB = blood-brain barrier.
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- 2023
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6. The mechanism of programmed death and endoplasmic reticulum stress in pulmonary hypertension
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Yang Sun, Shasha Liu, Chen Chen, Songwei Yang, Gang Pei, Meiyu Lin, Ting Wang, Junpeng Long, Qian Yan, Jiao Yao, Yuting Lin, Fan Yi, Lei Meng, Yong Tan, Qidi Ai, Naihong Chen, and Yantao Yang
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Pulmonary hypertension (PH) was a cardiovascular disease with high morbidity and mortality. PH was a chronic disease with complicated pathogenesis and uncontrollable factors. PH was divided into five groups according to its pathogenesis and clinical manifestations. Although the treatment and diagnosis of PH has made great progress in the past ten years. However, the diagnosis and prognosis of the PAH had a great contrast, which was not conducive to the diagnosis and treatment of PH. If not treated properly, it will lead to right ventricular failure or even death. Therefore, it was necessary to explore the pathogenesis of PH. The problem we urgently need to solve was to find and develop drugs for the treatment of PH. We reviewed the PH articles in the past 10 years or so as well as systematically summarized the recent advance. We summarized the latest research on the key regulatory factors (pyroptosis, apoptosis, necroptosis, ferroptosis, and endoplasmic reticulum stress) involved in PH. To provide theoretical basis and basis for finding new therapeutic targets and research directions of PH.
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- 2023
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7. Gut dysbacteriosis attenuates resistance to Mycobacterium bovis infection by decreasing cyclooxygenase 2 to inhibit endoplasmic reticulum stress
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Haoran Wang, Jiao Yao, Yulan Chen, Yuanzhi Wang, Yiduo Liu, Yi Liao, Zhengmin Liang, Yu hui Dong, Mengjin Qu, Xin Ge, and Xiangmei Zhou
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Gut dysbacteriosis ,cyclooxygenase 2 ,Mycobacterium bovis ,endoplasmic reticulum stress ,apoptosis ,faecal transplant ,Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
The role of gut microbiota has been described as an important influencer of the immune system. Gut-lung axis is critical in the prevention of mycobacterium infection, but the specific mechanism, by which dysbiosis affects tuberculosis, has not been reported. In this study, we attempted to provide more information on how the gut-lung axis contributes to Mycobacterium bovis (M. bovis) infection. Mice are pre-treated with broad-spectrum antibiotics cocktail (Abx) to induce gut dysbiosis. Interestingly, dysbiosis of microbes showed a significant increase in the bacterial burden in the lungs and inhibited the level of COX-2. After faecal transplantation, cyclooxygenase 2 (COX-2) expression was restored and the inflammatory lesion in the lungs was reduced. Further research found that the deficiency of COX-2 inhibited endoplasmic reticulum stress (ER stress). This mechanism was completed by COX-2 interaction with BIP. Moreover, we found a positive feedback mechanism by which blocking ER stress could reduce COX-2 levels by the NF-κB pathway. Taken together, we reveal for the first time gut dysbacteriosis exacerbates M. bovis disease by limiting the COX-2/ER stress pathway. The finding strengthens the foundation of gut microbiota-targeted therapy for tuberculosis treatment.
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- 2022
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8. CFP10–loaded PLGA nanoparticles as a booster vaccine confer protective immunity against Mycobacterium bovis
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Zhengmin Liang, Miaoxuan Li, Jiamin Ni, Tariq Hussain, Jiao Yao, Yinjuan Song, Yiduo Liu, Haoran Wang, and Xiangmei Zhou
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plga ,nanoparticles ,cfp10 ,mycobacterium bovis ,mucosal immunization ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Introduction: The limited efficacy of BCG (bacillus Calmette–Guérin) urgently requires new effective vaccination approaches for the control of tuberculosis. Poly lactic-co-glycolic acid (PLGA) is a prevalent drug delivery system. However, the effect of PLGA-based nanoparticles (NPs) against tuberculosis for the induction of mucosal immune response is no fully elucidated. In this study, we hypothesized that intranasal immunization with culture filtrate protein-10 (CFP10)-loaded PLGA NPs (CFP10-NPs) could boost the protective immunity of BCG against Mycobacterium bovis in mice. Methods: The recombinant protein CFP10 was encapsulated with PLGA NPs to prepare CFP10-NPs by the classical water–oil-water solvent-evaporation method. Then, the immunoregulatory effects of CFP10-NPs on macrophages in vitro and on BCG-immunized mice in vivo were investigated. Results: We used spherical CFP10-NPs with a negatively charged surface (zeta-potential −28.5 ± 1.7 mV) having a particle size of 281.7 ± 28.5 nm in diameter. Notably, CFP10-NPs significantly enhanced the secretion of tumor necrosis factor α (TNF-α) and interleukin (IL)-1β in J774A.1 macrophages. Moreover, mucosal immunization with CFP10-NPs significantly increased TNF-α and IL-1β production in serum, and immunoglobulin A (IgA) secretion in bronchoalveolar lavage fluid (BALF), and promoted the secretion of CFP10-specific interferon-γ (IFN-γ) in splenocytes of mice. Furthermore, CFP10-NPs immunization significantly reduced the inflammatory area and bacterial load in lung tissues at 3-week post-M. bovis challenge. Conclusion: CFP10-NPs markedly improve the immunogenicity and protective efficacy of BCG. Our findings explore the potential of the airway mucosal vaccine based on PLGA NPs as a vehicle for targeted lung delivery.
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- 2022
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9. Advances in the Study of Extracellular Vesicles for Bone Regeneration
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Jiao, Yao, primary, Liu, Yitong, additional, Du, Juan, additional, Xu, Junji, additional, Luo, Zhenhua, additional, Liu, Yi, additional, and Guo, Lijia, additional
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- 2024
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10. Sodium butyrate inhibits osteogenesis in human periodontal ligament stem cells by suppressing smad1 expression
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Hou, Jingyi, Xu, Junji, Liu, Yi, Zhang, Haiping, Wang, Sihan, Jiao, Yao, Guo, Lijia, and Li, Song
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- 2022
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11. Coordination of EZH2 and SOX2 specifies human neural fate decision
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Yuan Zhao, Tianyu Wang, Yanqi Zhang, Liang Shi, Cong Zhang, Jingyuan Zhang, Jiao Yao, Qianyu Chen, Xiaofen Zhong, Yanxing Wei, Yongli Shan, and Guangjin Pan
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Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Polycomb repressive complexes (PRCs) are essential in mouse gastrulation and specify neural ectoderm in human embryonic stem cells (hESCs), but the underlying molecular basis remains unclear. Here in this study, by employing an array of different approaches, such as gene knock-out, RNA-seq, ChIP-seq, et al., we uncover that EZH2, an important PRC factor, specifies the normal neural fate decision through repressing the competing meso/endoderm program. EZH2−/− hESCs show an aberrant re-activation of meso/endoderm genes during neural induction. At the molecular level, EZH2 represses meso/endoderm genes while SOX2 activates the neural genes to coordinately specify the normal neural fate. Moreover, EZH2 also supports the proliferation of human neural progenitor cells (NPCs) through repressing the aberrant expression of meso/endoderm program during culture. Together, our findings uncover the coordination of epigenetic regulators such as EZH2 and lineage factors like SOX2 in normal neural fate decision.
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- 2021
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12. The charge localization deteriorating the thermoelectric properties: The case of kiddcreekite-type Cu6WSnSe8
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Jiang, Yumei, Weng, Tianyao, Lin, Chen, Jiao, Yao, Guo, Kai, Wang, Da, Dong, Cheng, Zhang, Jiye, and Luo, Jun
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- 2021
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13. A Review of Research on the Association between Neuron–Astrocyte Signaling Processes and Depressive Symptoms
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Jiao Yao, Cong Chen, Yi Guo, Yantao Yang, Xinya Liu, Shifeng Chu, Qidi Ai, Zhao Zhang, Meiyu Lin, Songwei Yang, and Naihong Chen
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depression ,neurons ,astrocytes ,astrocyte–neuron interactions ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Depression is a mental illness that has a serious negative impact on physical and mental health. The pathophysiology of depression is still unknown, and therapeutic medications have drawbacks, such as poor effectiveness, strong dependence, adverse drug withdrawal symptoms, and harmful side effects. Therefore, the primary purpose of contemporary research is to understand the exact pathophysiology of depression. The connection between astrocytes, neurons, and their interactions with depression has recently become the focus of great research interest. This review summarizes the pathological changes of neurons and astrocytes, and their interactions in depression, including the alterations of mid-spiny neurons and pyramidal neurons, the alterations of astrocyte-related biomarkers, and the alterations of gliotransmitters between astrocytes and neurons. In addition to providing the subjects of this research and suggestions for the pathogenesis and treatment techniques of depression, the intention of this article is to more clearly identify links between neuronal–astrocyte signaling processes and depressive symptoms.
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- 2023
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14. Comprehensive Evaluation of Operational Efficiency of Intersections in Arterial Considering Pedestrians Yield Rule
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Lei Chen, Junjie Li, Yuhang Li, and Jiao Yao
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Transportation engineering ,TA1001-1280 ,Transportation and communications ,HE1-9990 - Abstract
Yield to pedestrians has become a new trend of civilized transportation in the metropolis. In order to evaluate the influence of yield behavior on the comprehensive operation efficiency of signalized intersections in arterial, the efficiency of the subject who gives way and the subject who is given up in the process of yielding to pedestrians was considered in this study, and the comprehensive operation evaluation of intersection in arterial was given. First, based on the rule of pedestrians yield, the concept of a safe headway gap of pedestrians was introduced in the process of conflict analysis of traffic flows at the intersection, and 3 situations were discussed, which are no yield, yield to 1 flow and 2 flows, to calculate the departure rate of traffic flow at the intersection. Furthermore, models of 3 evaluation indices were established, which are number of people passing per unit time, average delay per people, and average yield number per people at intersection. Moreover, the entropy weight method was taken to decide the weight of these 3 indices, and to calculate the comprehensive efficiency evaluation of intersection operation, with the standardized matrix. Finally, case study work was carried out to evaluate the comprehensive efficiency of 4 types of intersections in arterial considering pedestrians yield rule, which is the intersection between arterial and arterial (IAA), intersection between arterial and subarterial (IAS), intersection with one-time (IAA-1, IAS-1), and two-time (IAA-2, IAS-2) crossing of pedestrians. The relevant results show that the impact of an increase in the number of pedestrians on the combined efficiency of arterial intersections can vary dramatically in different scenarios. Therefore, in the implementation process of “yielding to pedestrians,” the flow fluctuation characteristics and channelization of each intersection should be taken into account, and the corresponding phase changes should be based on pedestrian and vehicle volumes to improve the efficiency of all parts, such as pedestrians and drivers.
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- 2022
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15. Enhanced photo-degradation of pollutants in three dimensions by rGO/Bi12O15Cl6/InVO4: LED-light photocatalytic performance and mechanism investigation
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Jiao Yao, Liying Huang, Yeping Li, Menghao Zhu, Shuai Liu, Shuangxiu Shu, Lijing Huang, and Xiaoya Wu
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Process Chemistry and Technology ,Materials Chemistry ,Ceramics and Composites ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2023
16. New Therapeutic Approaches to and Mechanisms of Ginsenoside Rg1 against Neurological Diseases
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Yang Sun, Yantao Yang, Shasha Liu, Songwei Yang, Chen Chen, Meiyu Lin, Qi Zeng, Junpeng Long, Jiao Yao, Fan Yi, Lei Meng, Qidi Ai, and Naihong Chen
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ginsenoside ,Rg1 ,inflammation ,oxidative stress ,Cytology ,QH573-671 - Abstract
Neurological diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury, depression and, stress, have high incidence and morbidity and often lead to disability. However, there is no particularly effective medication against them. Therefore, finding drugs with a suitable efficacy, low toxicity and manageable effects to improve the quality of life of patients is an urgent problem. Ginsenoside Rg1 (Rg1) is the main active component of ginseng and has a variety of pharmacological effects. In this review, we focused on the therapeutic potential of Rg1 for improving neurological diseases. We introduce the mechanisms of Ginsenoside Rg1 in neurological diseases, including apoptosis, neuroinflammation, the microRNA (miRNA) family, the mitogen-activated protein kinase (MAPK) family, oxidative stress, nuclear factor-κB (NF-κB), and learning and memory of Rg1 in neurological diseases. In addition, Rg1 can also improve neurological diseases through the interaction of different signal pathways. The purpose of this review is to explore more in-depth ideas for the clinical treatment of neurological diseases (including PD, AD, HD, stroke, cerebral infarction, ischemia–reperfusion injury, depression, and stress). Therefore, Rg1 is expected to become a new therapeutic method for the clinical treatment of neurological diseases.
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- 2022
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17. Construction of a novel double S-scheme structure WO3/g-C3N4/BiOI: Enhanced photocatalytic performance for antibacterial activity
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Yeping Li, Shuangxiu Shu, Liying Huang, Jiawei Liu, Juan Liu, Jiao Yao, Shuai Liu, Menghao Zhu, and Lijing Huang
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Biomaterials ,Colloid and Surface Chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2023
18. Facile synthesizing Z-scheme Bi12O15Cl6/InVO4 heterojunction to effectively degrade pollutants and antibacterial under light-emitting diode light
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Jiao Yao, Liying Huang, Yeping Li, Jiawei Liu, Juan Liu, Shuangxiu Shu, Lijing Huang, and Zijin Zhang
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Biomaterials ,Colloid and Surface Chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2022
19. Constructing an S-scheme CuBi2O4/Bi4O5I2 heterojunction for light emitting diode-driven pollutant degradation and bacterial inactivation
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Jiawei Liu, Liying Huang, Yeping Li, Jiao Yao, Shuangxiu Shu, Lijing Huang, Yanhua Song, and Qiwen Tian
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Biomaterials ,Colloid and Surface Chemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Published
- 2022
20. Two-Level Programming Model Based on Cooperative Operation Study of Stakeholders in Hazardous Chemical Storage
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Jiao Yao, Beibei Xie, Xiurong Wu, and Cong Zhang
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Renewable Energy, Sustainability and the Environment ,hazardous chemical warehousing ,two-level programming model ,stakeholder ,cooperative operation ,penalty coefficient ,improved adaptive particle algorithm ,Geography, Planning and Development ,Building and Construction ,Management, Monitoring, Policy and Law - Abstract
Due to the uncertainty of risk occurrence and the severity of accident consequences in the process of hazardous chemical storage, there are many stakeholders involved in the management and supervision of hazardous chemical storage, and their interest appeals are different. On the basis of ensuring storage safety, in order to balance the interests of stakeholders and achieve cooperative operation, a two-level programming model considering the maximization of social welfare and the interests of warehousing enterprises was proposed. First, the upper model mainly refers to the regulatory department represented by the government, including the daily supervision cost, risk loss cost, risk compensation cost, and penalty coefficient formulated by combining various indicators. In the lower model, the comprehensive risk level of the warehouse is determined by the warehouse enterprise. Based on this, the supervision coefficient is determined. Combined with the punishment coefficient, the warehousing operation cost, warehousing supervision cost, and the punishment cost when the accident occurs under different risk levels are determined. The relevant case analysis shows that, compared with the evolutionary game model, the social supervision cost of the upper level and the enterprise cost of the lower level can be reduced by 0.49% and 30.43% respectively. Compared with the traditional improved particle swarm optimization algorithm, the proposed algorithm can reduce the supervision cost of the upper society and the lower enterprise by 0.11% and 7.05%, respectively, thus achieving a better supervision effect at a relatively low cost.
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- 2023
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21. An Unscented Kalman Filter-Based Method for Reconstructing Vehicle Trajectories at Signalized Intersections
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Jiantao Mu, Yin Han, Cheng Zhang, Jiao Yao, and Jing Zhao
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Transportation engineering ,Economics and Econometrics ,TA1001-1280 ,Article Subject ,Strategy and Management ,Mechanical Engineering ,Automotive Engineering ,Transportation and communications ,HE1-9990 ,Computer Science Applications - Abstract
On-board data of detected vehicles play a critical role in the management of urban road traffic operation and the estimation of traffic status. Unfortunately, due to limitations of technology and privacy issues, the sampling frequency of the detected vehicle data is low and the coverage is also limited. Continuous vehicle trajectories cannot be obtained. To overcome the above problems, this paper proposes an unscented Kalman filter (UKF)-based method to reconstruct the trajectories at signalized intersections using sparse probe data of vehicles. We first divide the intersection into multiple road sections and use a quadratic programming problem to estimate the travel time of each section. The weight of each initial possible trajectory is calculated separately, and the trajectory is updated using the unscented Kalman filter (UKF); then, the trajectory between two updates is also obtained accordingly. Finally, the method is applied to the actual scenario provided by the NGSIM data and compared with the real trajectory. The mean absolute error (MAE) is adopted to evaluate the accuracy of the proposed trajectory reconstruction. Sensitivity analysis is provided in order to provide the requirement of sampling frequency to obtain highly accurate reconstructed vehicle trajectories under this method. The results demonstrate the applicability of the technique to the signalized intersection. Therefore, the method enables us to obtain richer and more accurate trajectory data information, providing a strong prior basis for future urban road traffic management and scholars using trajectory data for various studies.
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- 2021
22. Prevention Effects of Chain Management on Pressure Ulcers of Hospitalized Patients
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Jiao Yao, Jie Zhao, Tao Chen, and Xuehui Zeng
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Pressure Ulcer ,Medicine (General) ,Patients ,Article Subject ,Biomedical Engineering ,Health Informatics ,R5-920 ,Patient Satisfaction ,Medical technology ,Humans ,Surgery ,R855-855.5 ,Research Article ,Biotechnology - Abstract
The study focused on the preventive effects of the chain management model on pressure ulcers in the operating room. Sqoop big data collection module is used to collect patient information from various hospital information systems in a distributed manner. The data were from the clinical data center of the Zhongshan Hospital Xiamen University General Hospital, and 268 patients were selected as the research subjects. A chain management model is constructed, concerning the preventive measures, the management of each link, the perioperative pressure ulcer management, and the reporting of pressure ulcers. Then, the two groups were compared for the SAS and SDS scores before and after nursing, the pressure ulcer sites, pressure ulcer reporting rate, pressure ulcer staging, and nursing satisfaction. The results show that it is not that more collection modules will lead to better cluster performance and that the execution delay is caused by MapReduce requiring the JAVA virtual machine, and after reaching a certain point, the increase in the number of tasks will slow down the process, and as data size increases, DataNote has an expanded capability to analyze data. After nursing treatment, the SAS and SDS scores of the two groups of patients were significantly lower than before treatment ( P < 0.05 ). The pressure ulcers were mainly distributed in the forehead, mandible, cheeks, front chest, and knees in the two groups, and the difference between the two groups was statistically significant ( P < 0.05 ). The total satisfaction of the observation group was 93.28%, and the total satisfaction of the control group was 92.54%. The patients’ satisfaction with the chain management model was higher than that of conventional nursing.
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- 2021
23. Herbal Medicine Hewei Jiangni Decoction Is Noninferior to Oral Omeprazole for the Treatment of Nonerosive Gastroesophageal Reflux Disease: A Randomized, Double-Blind, and Double-Dummy Controlled Trail
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Li, Feng, primary, Yuan, Yali, additional, Wu, Di, additional, Li, Junxiang, additional, Han, Haixiao, additional, Li, Xiaohong, additional, Hu, Liming, additional, Chen, Runhua, additional, Yao, Yupu, additional, Jiao, Yao, additional, Chen, Huihui, additional, Mao, Tangyou, additional, and Xie, Chune, additional
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- 2022
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24. Construction of a novel double S-scheme structure WO
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Yeping, Li, Shuangxiu, Shu, Liying, Huang, Jiawei, Liu, Juan, Liu, Jiao, Yao, Shuai, Liu, Menghao, Zhu, and Lijing, Huang
- Abstract
In recent years, the threat to human health from bacteria in wastewater has attracted attention, and photocatalytic technology has emerged as a promising strategy for inactivating bacteria in water. Therefore, it is of great research value to develop a novel high-efficiency photocatalytic system with the visible light response. We successfully designed a double S-scheme heterojunction composite WO
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- 2022
25. Fabrication of n-p β-Bi
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Shuangxiu, Shu, Hao, Wang, Yeping, Li, Jiawei, Liu, Juan, Liu, Jiao, Yao, Shuai, Liu, Menghao, Zhu, and Lijing, Huang
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Staphylococcus aureus ,Light ,Escherichia coli ,Bismuth ,Catalysis ,Anti-Bacterial Agents - Abstract
A novel n-p β-Bi
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- 2022
26. Evaluation and Analysis of a Method to Real-Name Check Train Tickets during the COVID-19 Pandemic
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Tang Qingyun, Jiaping He, and Jiao Yao
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050210 logistics & transportation ,Article Subject ,Operations research ,Computer science ,business.industry ,Download ,05 social sciences ,Warranty ,Permission ,Track (rail transport) ,Weighting ,Modeling and Simulation ,Public transport ,0502 economics and business ,Ticket ,QA1-939 ,Train ,business ,Mathematics ,050203 business & management - Abstract
COVID-19 has swept the world for more than one year. Public transport, especially railway passenger transport for long distance and extensive areas, is the most potential risk source of the pandemic. In railway passenger transport, real-name train ticket check can effectively track the propagation path of the pandemic, which is of most significance for spread prevention of COVID-19. In this study, the evaluation index system of real-name check of ticket in trains was first established, in which 22 indexes in 4 levels were included, and their weights were determined by the Method of Kantiray Weighting. Furthermore, a comprehensive evaluation model of real-name system check was proposed, in which normalized work of different indexes was done, and key factors affecting the evaluation were founded. Finally, typical data of 8 trains check were collected, and from the evaluation analysis, we can find out that most factors affecting results of real-name ticket check are attendant management, train organization level, train service, and real-name ticket check proportion, based on which corresponding countermeasures and suggestions are given oriented to short-, medium-, and long-distance trains, respectively, all of which can reduce the risk of pandemic propagation in railway system. [ABSTRACT FROM AUTHOR] Copyright of Discrete Dynamics in Nature & Society is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
27. SoxC is Required for Ecdysteroid Induction of Neuropeptide Genes During Insect Eclosion
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Luo, Guang-Hua, primary, Chen, Xi-En, additional, Jiao, Yao-Yu, additional, Zhu, Guan-Heng, additional, Zhang, Ru, additional, Dhandapani, Ramesh Kumar, additional, Fang, Ji-Chao, additional, and Palli, Subba Reddy, additional
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- 2022
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28. Fabrication of n-p β-Bi2O3@BiOI core/shell photocatalytic heterostructure for the removal of bacteria and bisphenol A under LED light
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Shuangxiu Shu, Hao Wang, Yeping Li, Jiawei Liu, Juan Liu, Jiao Yao, Shuai Liu, Menghao Zhu, and Lijing Huang
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Colloid and Surface Chemistry ,Surfaces and Interfaces ,General Medicine ,Physical and Theoretical Chemistry ,Biotechnology - Published
- 2023
29. Study on Freeway Congestion Propagation in Foggy Environment Based on CA-SIR Model
- Author
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Jiao Yao, Jiaping He, Yujie Bao, Jiayang Li, and Yin Han
- Subjects
Renewable Energy, Sustainability and the Environment ,Geography, Planning and Development ,traffic engineering ,congestion propagation ,foggy environment ,cellular automata epidemic (CA-SIR) model ,freeway ,Building and Construction ,Management, Monitoring, Policy and Law - Abstract
The visibility in a foggy environment has a significant impact on driver behavior and traffic flow status, especially for whole closed highways with long distances between entrances and exits. Foggy days are very likely to cause congestion and even secondary traffic accidents, which seriously affect the reliability of freeway operation. In order to explore the influence of a fog environment on freeway traffic jams, firstly, this paper was based on the analysis of the impact of visibility on foggy days. Light fog, medium fog and heavy fog were classified as one scenario, while dense foggy weather was set separately as an extreme scenario without considering lane change. Furthermore, it used the SIR model of infectious disease for reference, and combined with the cellular automata (CA) model, the car-following model and lane-changing rules in different scenarios were set based on safe driving distance and speed for two scenarios. Finally, the key parameters of CA-SIR were calibrated, such as congestion propagation, recovery probability, vehicle braking, and lane-changing probability. The simulation analysis showed that with the decrease in visibility and vehicle speed, the phenomenon of congestion propagation was more prominent, but the causes of queuing phenomenon were different. A low speed limit was the main reason for traffic jams in the light fog condition. In the medium fog condition, the frequency of traffic jams was related to the random braking probability of the visibility. In heavy fog conditions, the congestion area gradually moved upstream with the passage of time. Moreover, in the dense fog condition, the congested area gradually moved upstream with the passage of time; however, vehicles were more likely to accompany each other, and the congested area traveled downstream synchronously with the passage of time and did not dissipate easily. Therefore, in a foggy environment, the best speed limit should be better established under different visibilities, the flow of highway traffic should be strictly controlled if necessary, and in worse situations than high-density traffic in low visibility, to avoid the spread of congestion, the intermittent release of different lanes is suggested to be implemented.
- Published
- 2022
30. Characteristics of Gut Microbiota in Diarrhea-predominant Irritable Bowel Syndrome of Han Nationality in Southwest China
- Author
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Tinglin Li, Yilin Li, Peimin Feng, Chunrong Yang, Cheng-Jiao Yao, Qin Xiong, Li-Hong Luo, and Fengjiao Xie
- Subjects
medicine.medical_specialty ,biology ,business.industry ,Gut flora ,medicine.disease ,biology.organism_classification ,digestive system ,Gastroenterology ,Diarrhea ,Internal medicine ,Medicine ,medicine.symptom ,business ,China ,Han nationality ,Irritable bowel syndrome - Abstract
Backgroud To study of gut microbiota in IBS-D of Han nationality in Southwest China, explore its relationship with environmental factors and differential expression function of gut microbiota in patients. Methods 120 cases of IBS-D group and 63 cases of HCs group were recruited, baseline data such as age, height, weight, monthly income, work intensity, eating habits and exercise were collected. HAMA and HAMD scores were performed on the two groups. IBS-D group was scored with IBS-SSS and IBS-QOL, and the differences in gastrointestinal symptoms, mental and psychological status and quality of life were compared. The laboratory tests were performed such as blood routine and liver function. Fresh feces of the two groups were collected for 16S rDNA sequencing. Then analyze the differences of gut microbiota between the two groups, and look for typical biomarkers of each. According to the dominant species and differentially expressed species at different classification levels, FAPROTAX was used to predict the functional differences of gut microbiota between the two groups. Taking the above scores and laboratory tests as environmental factors, spearman correlation analysis was conducted at the phylum level to explore the impact of environmental factors on the occurrence and development of gut microbiota and IBS-D. Results IBS-D patients are mostly concentrated in low-medium income people with medium-high labor intensity. The sleep time, exercise time, intake of vegetables and fruits of IBS-D are significantly lower than those of HCs, and the proportion of IBS-D who like to eat pepper is significantly higher than those of HCs. The scores of HAMA and HAMD, Urea nitrogen, AST, ALT , GGT in IBS-D were significantly higher than those in HCs.The richness of gut microbiota in IBS-D was significantly lower than that in HCs, but not diversity and eveness. The beta diversity index of gut microbiota community was significantly different between the two groups. The biomarkers of IBS-D were Prevotella, Clostridiales and Roseburia, the biomarkers of HCs were Veillonellaceae, Bacteroides-coprocola, Bifidobacteriales, Bifidobacteriumde, etc. The functions of gut microbiota in IBS-D were significantly up-regulated in cellulolysi, xylanolysis, and significantly down-regulated in fermentation, methanogenesis, nitrite_ammonification, nitrate_reduction. Correlation analysis showed that multiple intestinal microorganisms were closely related to HAMA, IBS-SSS, IBS-QOL, inflammatory indexes and liver enzymes. Conclusion There are significant differences in richness of gut microbiota, flora structure and flora function between IBS-D and HCs in Southwest China. These differences may be closely related to environmental factors such as eating habits, living habits and mental and psychological factors.The trial was registered and approved in China Clinical Trial Registry (Registration No.ChiCTR2100045751)
- Published
- 2021
31. Coordination of EZH2 and SOX2 specifies human neural fate decision
- Author
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Yanqi Zhang, Qianyu Chen, Jiao Yao, Yongli Shan, Guangjin Pan, Liang Shi, Tianyu Wang, Jingyuan Zhang, Yanxing Wei, Yuan Zhao, Xiaofen Zhong, and Cong Zhang
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Medicine (General) ,Neuroectoderm ,QH301-705.5 ,fungi ,Cell Biology ,macromolecular substances ,Biology ,Embryonic stem cell ,Neural stem cell ,Cell biology ,Gastrulation ,R5-920 ,medicine.anatomical_structure ,SOX2 ,embryonic structures ,medicine ,Biology (General) ,Stem cell ,Endoderm ,Neural development ,Developmental Biology ,Research Article - Abstract
Polycomb repressive complexes (PRCs) are essential in mouse gastrulation and specify neural ectoderm in human embryonic stem cells (hESCs), but the underlying molecular basis remains unclear. Here in this study, by employing an array of different approaches, such as gene knock-out, RNA-seq, ChIP-seq, et al., we uncover that EZH2, an important PRC factor, specifies the normal neural fate decision through repressing the competing meso/endoderm program. EZH2−/− hESCs show an aberrant re-activation of meso/endoderm genes during neural induction. At the molecular level, EZH2 represses meso/endoderm genes while SOX2 activates the neural genes to coordinately specify the normal neural fate. Moreover, EZH2 also supports the proliferation of human neural progenitor cells (NPCs) through repressing the aberrant expression of meso/endoderm program during culture. Together, our findings uncover the coordination of epigenetic regulators such as EZH2 and lineage factors like SOX2 in normal neural fate decision. Supplementary Information The online version contains supplementary material available at 10.1186/s13619-021-00092-6.
- Published
- 2021
32. Construction of Z-scheme Bi12O15Cl6/SnO2−x heterojunction for enhanced photocatalytic degradation of dyes and antibiosis
- Author
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Liying Huang, Jiao Yao, Lei Yang, Jiawei Liu, Juan Liu, Shuangxiu Shu, Mingqing Hua, Yanhua Song, and Hongxiang Zhu
- Subjects
Mechanics of Materials ,Mechanical Engineering ,Materials Chemistry ,Metals and Alloys - Published
- 2022
33. Social Force Model-Based Safety Evaluation of Intersections in Arterials Considering the Pedestrian Yield Rule
- Author
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Jiao Yao, Jiaping He, and Li Yuhang
- Subjects
acceleration interference ,pedestrian yield rule ,traffic engineering ,Health, Toxicology and Mutagenesis ,social force model ,Walking ,Pedestrian ,Pedestrian crossing ,Article ,Transport engineering ,Signal lamp ,Humans ,Computer Simulation ,Cities ,Pedestrians ,computer.programming_language ,business.industry ,Accidents, Traffic ,Public Health, Environmental and Occupational Health ,safety evaluation ,safety degree of pedestrian crossing ,VisSim ,Traffic engineering ,Trajectory ,Social force model ,Medicine ,Safety ,business ,computer ,Intersection (aeronautics) - Abstract
To enhance the safety of pedestrians crossing the street, a series of new regulations regarding pedestrian yield has been proposed and widely implemented across cities. In this study, we first made some improvements to the social force model, in which pedestrian crossing at the intersection, drivers’ psychology of giving way, vehicle yield to pedestrians, vehicle yield in different directions, the influence of pedestrians crossing boundaries, and signal lamp groups on pedestrian behavior were considered. Furthermore, pedestrian crossing and vehicle yield safety models were established, based on which the comprehensive safety evaluation model of intersections in arterials was established, in which two indices—(1) the safety degree of pedestrian crossings and (2) vehicle acceleration interference—were combined with the entropy weight method. Finally, four types of intersections in arterials were studied using a simulation: the intersections between different levels of arterials, and intersections with one-time and two-times pedestrian crossings. Moreover, safety evaluation and analysis of those intersections, considering the rule of pedestrian yield, were conducted combined with the trajectory data from the VISSIM simulation. The relevant results showed that for pedestrians crossing the street, the pedestrian safety of two-time crossing is significantly higher than that of one-time crossing, and compared with the arterial, the pedestrian crossing distance of the sub-arterial is shorter, and the pedestrian perception is safer. Moreover, due to the herd psychology effect, the increase in pedestrian flow volume improves the safety perception of pedestrians at the intersection.
- Published
- 2021
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