1. Genetics of denatonium‐responsive bitter receptors in aspirin‐exacerbated respiratory disease.
- Author
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Douglas, Jennifer E., Lin, Cailu, Mansfield, Corrine J., Bell, Katherine, Salmon, Mandy K., Kohanski, Michael A., Adappa, Nithin D., Palmer, James N., Bosso, John V., Reed, Danielle R., and Cohen, Noam A.
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GENETICS , *RESPIRATORY diseases , *TASTE disorders , *NASAL polyps , *BITTERNESS (Taste) , *TASTE perception , *UMAMI (Taste) - Abstract
AERD subjects demonstrated increased sensitivity to DB ( I p i < 0.01) and sucrose ( I p i < 0.01) compared with CRSsNP, while CRSsNP subjects demonstrated a reduced sensitivity to DB ( I p i < 0.05) and sucrose ( I p i < 0.05) compared with controls (Figure 1). It was anticipated that in AERD, unique genetic polymorphisms in DB-responsive T2Rs may result in upregulation of the receptors and resulting type-2 inflammation. Keywords: aspirin-exacerbated respiratory disease; bitter; chronic rhinosinusitis; gene; open array; sensory; taste EN aspirin-exacerbated respiratory disease bitter chronic rhinosinusitis gene open array sensory taste 269 272 4 02/21/23 20230301 NES 230301 INTRODUCTION Chronic rhinosinusitis (CRS), a disease of long-standing sinonasal inflammation, is divided into two phenotypes: CRS with and without nasal polyposis (CRSwNP, CRSsNP). [Extracted from the article]
- Published
- 2023
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