Search

Your search keyword '"Karberg, Kirsten"' showing total 35 results
Start Over Author "Karberg, Kirsten" Publication Year Range Last 3 years
35 results on '"Karberg, Kirsten"'

1. Analysis of the shorter drug survival times for Janus kinase inhibitors and interleukin-17 inhibitors compared with tumor necrosis factor inhibitors in a real-world cohort of axial spondyloarthritis patients - a retrospective analysis from the RHADAR network

Author

Strunz, Patrick-Pascal, Englbrecht, Matthias, Risser, Linus Maximilian, Witte, Torsten, Froehlich, Matthias, Schmalzing, Marc, Gernert, Michael, Schmieder, Astrid, Bartz-Bazzanella, Peter, von der Decken, Cay, Karberg, Kirsten, Gauler, Georg, Wurth, Patrick, Späthling-Mestekemper, Susanna, Kuhn, Christoph, Vorbrüggen, Wolfgang, Heck, Johannes, Welcker, Martin, and Kleinert, Stefan

Published
2024
Full Text
View/download PDF

2. Aktuelle Zahlen zur rheumatologischen Versorgung – Jahresbericht aus der Kerndokumentation der regionalen kooperativen Rheumazentren

Author

Albrecht, Katinka, Thiele, Katja, Alexander, Tobias, Aringer, Martin, Eidner, Thorsten, Henes, Jörg, Hoese, Guido, Karberg, Kirsten, Kiltz, Uta, Krause, Andreas, Ochs, Wolfgang, Richter, Jutta G, Späthling-Mestekemper, Susanna, Steinmüller, Mirko, Wassenberg, Siegfried, Strangfeld, Anja, and Callhoff, Johanna

Published
2024
Full Text
View/download PDF

3. Radiographic and non-radiographic axial spondyloarthritis are not routinely distinguished in everyday clinical care: an analysis of real-world data from rheumatology practices

Author

Kleinert, Stefan, Schuch, Florian, Rapp, Praxedis, Ronneberger, Monika, Wendler, Joerg, Sternad, Patrizia, Popp, Florian, Bartz-Bazzanella, Peter, von der Decken, Cay, Karberg, Kirsten, Gauler, Georg, Wurth, Patrick, Späthling-Mestekemper, Susanna, Kuhn, Christoph, Vorbrüggen, Wolfgang, and Welcker, Martin

Published
2024
Full Text
View/download PDF

6. Abatacept inhibits inflammation and onset of rheumatoid arthritis in individuals at high risk (ARIAA): a randomised, international, multicentre, double-blind, placebo-controlled trial

Author

Rech, Juergen, Tascilar, Koray, Hagen, Melanie, Kleyer, Arnd, Manger, Bernhard, Schoenau, Verena, Hueber, Axel J, Kleinert, Stefan, Baraliakos, Xenofon, Braun, Jürgen, Kiltz, Uta, Fleck, Martin, Rubbert-Roth, Andrea, Kofler, David M, Behrens, Frank, Feuchtenberger, Martin, Zaenker, Michael, Voll, Reinhard, Venhoff, Nils, Thiel, Jens, Glaser, Cornelia, Feist, Eugen, Burmester, Gerd R, Karberg, Kirsten, Strunk, Johannes, Cañete, Juan D, Senolt, Ladislav, Filkova, Maria, Naredo, Esperanza, Largo, Raquel, Krönke, Gerhard, D'Agostino, Maria-Antonietta, Østergaard, Mikkel, and Schett, Georg

Published
2024
Full Text
View/download PDF

8. Drug survival superiority of tumor necrosis factor inhibitors and interleukin-17 inhibitors over Janus kinase inhibitors and interleukin-12/23 inhibitors in German psoriatic arthritis outpatients: retrospective analysis of the RHADAR database

Author

Strunz, Patrick-Pascal, primary, Englbrecht, Matthias, additional, Risser, Linus Maximilian, additional, Witte, Torsten, additional, Froehlich, Matthias, additional, Schmalzing, Marc, additional, Gernert, Michael, additional, Schmieder, Astrid, additional, Bartz-Bazzanella, Peter, additional, von der Decken, Cay, additional, Karberg, Kirsten, additional, Gauler, Georg, additional, Wurth, Patrick, additional, Späthling-Mestekemper, Susanna, additional, Kuhn, Christoph, additional, Vorbrüggen, Wolfgang, additional, Heck, Johannes, additional, Welcker, Martin, additional, and Kleinert, Stefan, additional

Published
2024
Full Text
View/download PDF

9. Current data on rheumatological care: annual report from the National database (NDB) of the regional collaborative arthritis centres in Germany

Author

Albrecht, Katinka, primary, Thiele, Katja, additional, Alexander, Tobias, additional, Aringer, Martin, additional, Eidner, Thorsten, additional, Henes, Jörg, additional, Hoese, Guido, additional, Karberg, Kirsten, additional, Kiltz, Uta, additional, Krause, Andreas, additional, Ochs, Wolfgang, additional, Richter, Jutta G, additional, Späthling-Mestekemper, Susanna, additional, Steinmüller, Mirko, additional, Wassenberg, Siegfried, additional, Strangfeld, Anja, additional, and Callhoff, Johanna, additional

Published
2024
Full Text
View/download PDF

10. Rheuma-VOR study: optimising healthcare of rheumatic diseases by multiprofessional coordinating centres

Author

Dreher, Matthias, primary, Witte, Torsten, additional, Hoeper, Kirsten, additional, Assmann, Gunter, additional, Proft, Fabian, additional, Poddubnyy, Denis, additional, Murawski, Niels, additional, Triantafyllias, Konstantinos, additional, Grodd, Marlon, additional, Graf, Erika, additional, Fichtner, Urs A, additional, Binder, Harald, additional, Zeidler, Jan, additional, Hoeper, Juliana Rachel, additional, Callhoff, Johanna, additional, Karberg, Kirsten, additional, Trautwein, Anna, additional, Tibyampansha, Dativa, additional, Wojnowski, Leszek, additional, Schmidt, Reinhold E, additional, and Schwarting, Andreas, additional

Published
2023
Full Text
View/download PDF

11. Radiographic and non-radiographic axial spondyloarthritis are not routinely distinguished in everyday clinical care: an analysis of real-world data from rheumatology practices

Author

Kleinert, Stefan, primary, Schuch, Florian, additional, Rapp, Praxedis, additional, Ronneberger, Monika, additional, Wendler, Joerg, additional, Sternad, Patrizia, additional, Popp, Florian, additional, Bartz-Bazzanella, Peter, additional, von der Decken, Cay, additional, Karberg, Kirsten, additional, Gauler, Georg, additional, Wurth, Patrick, additional, Späthling-Mestekemper, Susanna, additional, Kuhn, Christoph, additional, Vorbrüggen, Wolfgang, additional, and Welcker, Martin, additional

Published
2023
Full Text
View/download PDF

12. Rheuma- VOR study: optimising healthcare of rheumatic diseases by multiprofessional coordinating centres.

Author

Dreher, Matthias, Witte, Torsten, Hoeper, Kirsten, Assmann, Gunter, Proft, Fabian, Poddubnyy, Denis, Murawski, Niels, Triantafyllias, Konstantinos, Grodd, Marlon, Graf, Erika, Fichtner, Urs A., Binder, Harald, Zeidler, Jan, Hoeper, Juliana Rachel, Callhoff, Johanna, Karberg, Kirsten, Trautwein, Anna, Tibyampansha, Dativa, Wojnowski, Leszek, and Schmidt, Reinhold E.

Published
2024
Full Text
View/download PDF

13. Eine Applikation für die rheumatologische Versorgung: RheCORD

Author

Welcker, Martin, additional, Klennert, Michael, additional, Aries, Peer, additional, Bartz-Bazzanella, Peter, additional, Von der Decken, Cay, additional, Engelbrecht, Matthias, additional, Gauler, Georg, additional, Hornig, Johannes, additional, Karberg, Kirsten, additional, Kuhn, Christoph, additional, Schuch, Florian, additional, Späthling-Mestekemper, Susanna, additional, Vorbrüggen, Wolfgang, additional, Wurth, Patrick, additional, Muth, Theresia, additional, Froschauer-Häfele, Sonja, additional, Mühlensiepen, Felix, additional, Popp, Florian, additional, Burigk, Kristin, additional, Kladny, Heike, additional, and Kleinert, Stefan, additional

Published
2023
Full Text
View/download PDF

15. Standardpräsentation 2021

Author

Thiele, Katja, Albrecht, Katinka, Alexander, Tobias, Aringer, Martin, Eidner, Thorsten, Henes, Jörg, Hoese, Guido, Karberg, Kirsten, Kiltz, Uta, Krause, Andreas, Ochs, Wolfgang, Richter, Jutta G., Wassenberg, Siegfried, Kopplin, Nina, Callhoff, Johanna, and Deutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz-Gemeinschaft

Subjects
rheumatologische Versorgung, rheumatoide Arthritis, Systemischer Lupus Erythematosus, axiale Spondyloarthritis, Kollagenosen, Vaskulitiden, Psoriasis-Arthritis, entzündlich-rheumatische Erkrankungen, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::614 Inzidenz und Prävention von Krankheiten
Abstract

Dargestellt sind die Ergebnisse der Kerndokumentation der regionalen kooperativen Rheumazentren des Jahres 2021. Es gibt Angaben zur Krankheitsaktivität, Medikation und nicht-medikamentöser Behandlung. Viele Patient:innen-berichtete Angaben zur Funktionskapazität, dem Krankheitseinfluss, depressiven Symptomen und weitere sind angegeben.

Published
2023
Full Text
View/download PDF

16. Impairment in cognitive function in patients with axial spondyloarthritis and psoriatic arthritis

Author

Kleinert, Stefan, primary, Schuch, Florian, additional, Rapp, Praxedis, additional, Ronneberger, Monika, additional, Wendler, Joerg, additional, Sternad, Patrizia, additional, Popp, Florian, additional, Bartz-Bazzanella, Peter, additional, von der Decken, Cay, additional, Karberg, Kirsten, additional, Gauler, Georg, additional, Wurth, Patrick, additional, Späthling-Mestekemper, Susanna, additional, Kuhn, Christoph, additional, Englbrecht, Matthias, additional, Vorbrüggen, Wolfgang, additional, Adler, Georg, additional, and Welcker, Martin, additional

Published
2022
Full Text
View/download PDF

17. Evaluation of the Disease Activity index for PSoriatic Arthritis (DAPSA) with a quick quantitative C reactive protein assay (Q-DAPSA) in patients with psoriatic arthritis: a prospective multicentre cross-sectional study

Author

Proft, Fabian, primary, Schally, Julia, additional, Brandt, Henning Christian, additional, Brandt-Juergens, Jan, additional, Burmester, Gerd Rüdiger, additional, Haibel, Hildrun, additional, Käding, Henriette, additional, Karberg, Kirsten, additional, Lüders, Susanne, additional, Muche, Burkhard, additional, Protopopov, Mikhail, additional, Rademacher, Judith, additional, Rios Rodriguez, Valeria, additional, Torgutalp, Murat, additional, Verba, Maryna, additional, Zinke, Silke, additional, and Poddubnyy, Denis, additional

Published
2022
Full Text
View/download PDF

18. Die 'ARIAA-Studie' – Abatacept verzögert den Übergang in eine RA bei at-risk-Patienten – klinische Ergebnisse zu Monat 18 der internationalen, randomisiert, placebo kontrollierten Studie

Author

Rech, Jürgen, Kleyer, Arnd, Ostergaard, Mikkel, Feuchtenberger, Martin, Hagen, Melanie, Valor Mendez, Larissa, Koray, Tascilar, Kroenke, Gerhard, Schönau, Verena, Kleinert, Stefan, Baraliakos, Xenofon, Braun, Jürgen, Fleck, Martin, Rubbert-Roth, Andrea, Behrens, Frank, Zaenker, Michael, Kofler, David M., Simon, David, Glaser, Cornelia, Hueber, Axel, Voll, Reinhard, Feist, Eugen, Burmester, Gerd-Rüdiger, Karberg, Kirsten, Strunk, Johannes, Cañete, Juan de Dios, Šenolt, Ladislav, Naredo, Esperanza, and Schett, Georg

Subjects
Medicine and health
Abstract

Einleitung: Der Entwicklung einer klinisch manifesten rheumatoiden Arthritis (RA) geht eine präklinische Phase der Autoimmunität voraus. Diese Autoimmunphase ist durch das Vorhandensein von antimodifizierten Proteinantikörpern (AMPA) gekennzeichnet. Ein Teil dieser Individuen at-risk [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
Full Text
View/download PDF

19. B cell characteristics and total numbers predict SARS-CoV-2 vaccination response among patients treated with rituximab

Author

Stefanski, Ana-Luisa, Rincon-Arevalo, Hector, Schrezenmeier, Eva, Karberg, Kirsten, Szelinski, Franziska, Ritter, Jacob, Schrezenmeier, Hubert, Chen, Yidan, Burmester, Gerd-Rüdiger, Lino, Andreia C., and Dörner, Thomas

Subjects
Medicine and health
Abstract

Introduction: Patients with autoimmune inflammatory rheumatic diseases (AIRD) receiving rituximab (RTX) therapy are at higher risk for poor COVID-19 outcomes [ref:1] and show substantially impaired anti-SARS-CoV-2 vaccine responses [ref:2]. Thus, the ability to further define and [for full text, please go to the a.m. URL]

Published
2022
Full Text
View/download PDF

20. Persistent but atypical germinal center reaction among 3rd SARS-CoV-2 vaccination after rituximab exposure

Author

Stefanski, Ana-Luisa, primary, Rincon-Arevalo, Hector, additional, Schrezenmeier, Eva, additional, Karberg, Kirsten, additional, Szelinski, Franziska, additional, Ritter, Jacob, additional, Chen, Yidan, additional, Meisel, Christian, additional, Jahrsdörfer, Bernd, additional, Ludwig, Carolin, additional, Schrezenmeier, Hubert, additional, Lino, Andreia C., additional, and Dörner, Thomas, additional

Published
2022
Full Text
View/download PDF

21. Is the Rheumatoid Arthritis Impact of Disease (RAID) score a meaningful instrument for other inflammatory rheumatic diseases? A cross-sectional analysis of data from the German National Database

Author

Thiele, Katja, primary, Albrecht, Katinka, additional, Zink, Angela, additional, Aringer, Martin, additional, Karberg, Kirsten, additional, Späthling-Mestekemper, Susanna, additional, von Hinüber, Ulrich, additional, and Callhoff, Johanna, additional

Published
2022
Full Text
View/download PDF

22. B Cell Characteristics at Baseline Predict Vaccination Response in RTX Treated Patients

Author

Stefanski, Ana-Luisa, primary, Rincon-Arevalo, Hector, additional, Schrezenmeier, Eva, additional, Karberg, Kirsten, additional, Szelinski, Franziska, additional, Ritter, Jacob, additional, Chen, Yidan, additional, Jahrsdörfer, Bernd, additional, Ludwig, Carolin, additional, Schrezenmeier, Hubert, additional, Lino, Andreia C., additional, and Dörner, Thomas, additional

Published
2022
Full Text
View/download PDF

23. B Cell Numbers Predict Humoral and Cellular Response Upon SARS – CoV ‐2 Vaccination Among Patients Treated With Rituximab

Author

Stefanski, Ana‐Luisa, primary, Rincon‐Arevalo, Hector, additional, Schrezenmeier, Eva, additional, Karberg, Kirsten, additional, Szelinski, Franziska, additional, Ritter, Jacob, additional, Jahrsdörfer, Bernd, additional, Schrezenmeier, Hubert, additional, Ludwig, Carolin, additional, Sattler, Arne, additional, Kotsch, Katja, additional, Chen, Yidan, additional, Claußnitzer, Anne, additional, Haibel, Hildrun, additional, Proft, Fabian, additional, Guerra, Gabriela, additional, Durek, Pawel, additional, Heinrich, Frederik, additional, Ferreira‐Gomes, Marta, additional, Burmester, Gerd R., additional, Radbruch, Andreas, additional, Mashreghi, Mir‐Farzin, additional, Lino, Andreia C., additional, and Dörner, Thomas, additional

Published
2022
Full Text
View/download PDF

24. sj-docx-1-tab-10.1177_1759720X221085951 – Supplemental material for Validation of the ASDAS with a quick quantitative CRP assay (ASDAS-Q) in patients with axial SpA: a prospective multicentre cross-sectional study

Author

Proft, Fabian, Schally, Julia, Brandt, Henning Christian, Brandt-Juergens, Jan, Rüdiger Burmester, Gerd, Haibel, Hildrun, Käding, Henriette, Karberg, Kirsten, Lüders, Susanne, Muche, Burkhard, Protopopov, Mikhail, Rademacher, Judith, Rios Rodriguez, Valeria, Torgutalp, Murat, Verba, Maryna, Zinke, Silke, and Poddubnyy, Denis

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-docx-1-tab-10.1177_1759720X221085951 for Validation of the ASDAS with a quick quantitative CRP assay (ASDAS-Q) in patients with axial SpA: a prospective multicentre cross-sectional study by Fabian Proft, Julia Schally, Henning Christian Brandt, Jan Brandt-Juergens, Gerd Rüdiger Burmester, Hildrun Haibel, Henriette Käding, Kirsten Karberg, Susanne Lüders, Burkhard Muche, Mikhail Protopopov, Judith Rademacher, Valeria Rios Rodriguez, Murat Torgutalp, Maryna Verba, Silke Zinke and Denis Poddubnyy in Therapeutic Advances in Musculoskeletal Disease

Published
2022
Full Text
View/download PDF

25. sj-docx-1-tab-10.1177_1759720X221114107 – Supplemental material for Validation of the Simplified Disease Activity Index (SDAI) with a quick quantitative C-reactive protein assay (SDAI-Q) in patients with rheumatoid arthritis: a prospective multicenter cross-sectional study

Author

Schally, Julia, Brandt, Henning Christian, Brandt-Jürgens, Jan, Burmester, Gerd R., Haibel, Hildrun, Käding, Henriette, Karberg, Kirsten, Lüders, Susanne, Muche, Burkhard, Protopopov, Mikhail, Rios Rodriguez, Valeria, Torgutalp, Murat, Verba, Maryna, Zinke, Silke, Poddubnyy, Denis, and Proft, Fabian

Subjects
FOS: Clinical medicine, 110604 Sports Medicine, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 110314 Orthopaedics
Abstract

Supplemental material, sj-docx-1-tab-10.1177_1759720X221114107 for Validation of the Simplified Disease Activity Index (SDAI) with a quick quantitative C-reactive protein assay (SDAI-Q) in patients with rheumatoid arthritis: a prospective multicenter cross-sectional study by Julia Schally, Henning Christian Brandt, Jan Brandt-Jürgens, Gerd R. Burmester, Hildrun Haibel, Henriette Käding, Kirsten Karberg, Susanne Lüders, Burkhard Muche, Mikhail Protopopov, Valeria Rios Rodriguez, Murat Torgutalp, Maryna Verba, Silke Zinke, Denis Poddubnyy and Fabian Proft in Therapeutic Advances in Musculoskeletal Disease

Published
2022
Full Text
View/download PDF

26. Validation of the ASDAS with a quick quantitative CRP assay (ASDAS-Q) in patients with axial SpA: a prospective multicentre cross-sectional study

Author

Proft, Fabian, primary, Schally, Julia, additional, Brandt, Henning Christian, additional, Brandt-Juergens, Jan, additional, Rüdiger Burmester, Gerd, additional, Haibel, Hildrun, additional, Käding, Henriette, additional, Karberg, Kirsten, additional, Lüders, Susanne, additional, Muche, Burkhard, additional, Protopopov, Mikhail, additional, Rademacher, Judith, additional, Rios Rodriguez, Valeria, additional, Torgutalp, Murat, additional, Verba, Maryna, additional, Zinke, Silke, additional, and Poddubnyy, Denis, additional

Published
2022
Full Text
View/download PDF

27. Validation of the Simplified Disease Activity Index (SDAI) with a quick quantitative C-reactive protein assay (SDAI-Q) in patients with rheumatoid arthritis: a prospective multicenter cross-sectional study

Author

Schally, Julia, primary, Brandt, Henning Christian, additional, Brandt-Jürgens, Jan, additional, Burmester, Gerd R., additional, Haibel, Hildrun, additional, Käding, Henriette, additional, Karberg, Kirsten, additional, Lüders, Susanne, additional, Muche, Burkhard, additional, Protopopov, Mikhail, additional, Rios Rodriguez, Valeria, additional, Torgutalp, Murat, additional, Verba, Maryna, additional, Zinke, Silke, additional, Poddubnyy, Denis, additional, and Proft, Fabian, additional

Published
2022
Full Text
View/download PDF

28. B Cell Characteristics at Baseline Predict Vaccination Response in RTX Treated Patients

Author

Stefanski, Ana-Luisa, Rincon-Arevalo, Hector, Schrezenmeier, Eva, Karberg, Kirsten, Szelinski, Franziska, Ritter, Jacob, Chen, Yidan, Jahrsdörfer, Bernd, Ludwig, Carolin, Schrezenmeier, Hubert, Lino, Andreia C., and Dörner, Thomas

Subjects
SARS-CoV-2, Immunology, Vaccination, B-cells, COVID-19, prediction, Arthritis, Rheumatoid, Immunoglobulin G, Immunology and Allergy, SARS – CoV – 2, Humans, RTX (rituximab), Rituximab, 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
Abstract

Background: Vaccination is considered as most efficient strategy in controlling SARS-CoV-2 pandemic spread. Nevertheless, patients with autoimmune inflammatory rheumatic diseases receiving rituximab (RTX) are at increased risk to fail humoral and cellular responses upon vaccination. The ability to predict vaccination responses is essential to guide adequate safety and optimal protection in these patients. Methods: B- and T- cell data before vaccination were evaluated for characteristics predicting vaccine responses in altogether 15 patients with autoimmune inflammatory rheumatic diseases receiving RTX. Eleven patients with rheumatoid arthritis (RA) on other therapies, 11 kidney transplant recipients (KTR) on regular immunosuppression and 15 healthy controls (HC) served as controls. A multidimensional analysis of B cell subsets via UMAP algorithm and a correlation matrix were performed in order to identify predictive markers of response in patients under RTX therapy. Results: Significant differences regarding absolute B cell counts and specific subset distribution pattern between the groups were identified at baseline. In this context, the majority of B cells from vaccination responders of the RTX group (RTX IgG+) were naïve and transitional B cells, whereas vaccination non-responders (RTX IgG-) carried preferentially plasmablasts and double negative (CD27-IgD-) B cells. Moreover, there was a positive correlation between neutralizing antibodies and B cells expressing HLA-DR and CXCR5 as well as an inverse correlation with CD95 expression and CD21low expression by B cells among vaccination responders. Summary: Substantial repopulation of the naïve B cell compartment after RTX therapy appeared to be essential for an adequate vaccination response, which seem to require the additional capability of antigen presentation and germinal center formation. Moreover, expression of exhaustion markers represent negative predictors of vaccination responses.

Published
2021

29. Prevalence of Depressive Symptoms in Patients With Psoriatic Arthritis: Have Numbers Changed During the COVID-19 Pandemic?

Author

Englbrecht, Matthias, primary, Bartz-Bazzanella, Peter, additional, von der Decken, Cay, additional, Gauler, Georg, additional, Wurth, Patrick, additional, Aries, Peer, additional, Karberg, Kirsten, additional, Kuhn, Christoph, additional, Schuch, Florian, additional, Späthling-Mestekemper, Susanna, additional, Vorbrüggen, Wolfgang, additional, Wendler, Jörg, additional, Welcker, Martin, additional, and Kleinert, Stefan, additional

Published
2021
Full Text
View/download PDF

30. Ist der RAID für entzündlich-rheumatische Erkrankungen ein aussagekräftiges Instrument?

Author

Thiele, Katja, Albrecht, Katinka, Zink, Angela, Aringer, Martin, Karberg, Kirsten, Späthling-Mestekemper, Susanna, Von Hinüber, Ulrich, and Callhoff, Johanna

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Einleitung: Der RAID (rheumatoid arthritis impact of disease score) ist ein patientenberichtetes Instrument, das die Auswirkungen der rheumatoiden Arthritis (RA) auf die Lebensqualität der Patienten abbildet und zugleich Hinweise auf die Krankheitsaktivität aus Patientensicht gibt [ref:1].[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Rheumatologiekongress 2021, 49. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 35. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), Wissenschaftliche Herbsttagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Published
2021

31. Persistent but atypical germinal center reaction among 3rd SARS-CoV-2 vaccination after rituximab exposure.

Author

Stefanski, Ana-Luisa, Rincon-Arevalo, Hector, Schrezenmeier, Eva, Karberg, Kirsten, Szelinski, Franziska, Ritter, Jacob, Yidan Chen, Meisel, Christian, Jahrsdörfer, Bernd, Ludwig, Carolin, Schrezenmeier, Hubert, Lino, Andreia C., and Dörner, Thomas

Subjects
GERMINAL centers, IMMUNOLOGIC memory, RITUXIMAB, VACCINATION, PLASMA cells, HYPERCOAGULATION disorders
Abstract

Background: Durable vaccine-mediated immunity relies on the generation of long-lived plasma cells and memory B cells (MBCs), differentiating upon germinal center (GC) reactions. SARS-CoV-2 mRNA vaccination induces a strong GC response in healthy volunteers (HC), but limited data is available about response longevity upon rituximab treatment. Methods: We evaluated humoral and cellular responses upon 3rd vaccination in seven patients with rheumatoid arthritis (RA) who initially mounted anti-spike SARS-CoV-2 IgG antibodies after primary 2x vaccination and got re-exposed to rituximab (RTX) 1-2 months after the second vaccination. Ten patients with RA on other therapies and ten HC represented the control groups. As control for known long-lived induced immunity, we analyzed humoral and cellular tetanus toxoid (TT) immune responses in steady-state. Results: After 3rd vaccination, 5/7 seroconverted RTX patients revealed lower anti-SARS-CoV-2 IgG levels but similar neutralizing capacity compared with HC. Antibody levels after 3rd vaccination correlated with values after 2nd vaccination. Despite significant reduction of circulating total and antigenspecific B cells in RTX re-exposed patients, we observed the induction of IgG+ MBCs upon 3rd vaccination. Notably, only RTX treated patients revealed a high amount of IgA+ MBCs before and IgA+ plasmablasts after 3rd vaccination. IgA+ B cells were not part of the steady state TT+ B cell pool. TNF-secretion and generation of effector memory CD4 spike-specific T cells were significantly boosted upon 3rd vaccination. Summary: On the basis of pre-existing affinity matured MBCs within primary immunisation, RTX re-exposed patients revealed a persistent but atypical GC immune response accompanied by boosted spike-specific memory CD4 T cells upon SARS-CoV-2 recall vaccination. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

33. BENEFITS FROM a Plant-Based Diet, Intermittent Fasting and Aspects of Ayurvedic Nutrition IN Rheumatoid Arthritis – a Case Report

Author

Hartmann, Anika M., Karberg, Kirsten, and Kessler, Christian S.

Abstract

Rheumatoid arthritis (RA) is one of the most common rheumatologic diseases worldwide causing high morbidity and mortality and a high socioeconomic burden. Current medications offer several therapeutic options. Additionally, increasing evidence endorses the positive influence of certain diets on the disease activity in RA.

Published
2023
Full Text
View/download PDF

34. [With RheMIT rheumatology centers can participate in the German national database-Expansion of the long-term rheumatological documentation].

Author

Callhoff J, Feuchtenberger M, Karberg K, Kiltz U, Aringer M, Baraliakos X, Muth T, Regierer AC, Richter JG, Thiele K, Zinke S, and Albrecht K

Subjects
Humans, Databases, Factual, Berlin, Documentation, Germany, Rheumatology, Rheumatic Diseases diagnosis, Rheumatic Diseases epidemiology, Rheumatic Diseases therapy
Abstract

The national database (NDB) of the German regional collaborative rheumatology centers was switched to the RheMIT documentation software last year. Rheumatology centers that already use RheMIT for care contracts or other research projects can therefore use the software to also participate in the NDB. Experiences from a hospital, a medical care center and a specialist practice show how the changeover to RheMIT from an existing documentation system or a new participation in the NDB with RheMIT can be implemented. The NDB team at the German Rheumatism Research Center in Berlin (DRFZ) welcomes new participating rheumatology centers., (© 2023. The Author(s).)

Published
2023
Full Text
View/download PDF

35. Persistent but atypical germinal center reaction among 3 rd SARS-CoV-2 vaccination after rituximab exposure.

Author

Stefanski AL, Rincon-Arevalo H, Schrezenmeier E, Karberg K, Szelinski F, Ritter J, Chen Y, Meisel C, Jahrsdörfer B, Ludwig C, Schrezenmeier H, Lino AC, and Dörner T

Subjects
Antibodies, Viral, COVID-19 Vaccines, Germinal Center, Humans, Immunoglobulin A, Immunoglobulin G, Rituximab, SARS-CoV-2, Vaccination, Arthritis, Rheumatoid, COVID-19
Abstract

Background: Durable vaccine-mediated immunity relies on the generation of long-lived plasma cells and memory B cells (MBCs), differentiating upon germinal center (GC) reactions. SARS-CoV-2 mRNA vaccination induces a strong GC response in healthy volunteers (HC), but limited data is available about response longevity upon rituximab treatment., Methods: We evaluated humoral and cellular responses upon 3rd vaccination in seven patients with rheumatoid arthritis (RA) who initially mounted anti-spike SARS-CoV-2 IgG antibodies after primary 2x vaccination and got re-exposed to rituximab (RTX) 1-2 months after the second vaccination. Ten patients with RA on other therapies and ten HC represented the control groups. As control for known long-lived induced immunity, we analyzed humoral and cellular tetanus toxoid (TT) immune responses in steady-state., Results: After 3 rd vaccination, 5/7 seroconverted RTX patients revealed lower anti-SARS-CoV-2 IgG levels but similar neutralizing capacity compared with HC. Antibody levels after 3rd vaccination correlated with values after 2nd vaccination. Despite significant reduction of circulating total and antigen-specific B cells in RTX re-exposed patients, we observed the induction of IgG+ MBCs upon 3 rd vaccination. Notably, only RTX treated patients revealed a high amount of IgA+ MBCs before and IgA+ plasmablasts after 3 rd vaccination. IgA+ B cells were not part of the steady state TT+ B cell pool. TNF-secretion and generation of effector memory CD4 spike-specific T cells were significantly boosted upon 3 rd vaccination., Summary: On the basis of pre-existing affinity matured MBCs within primary immunisation, RTX re-exposed patients revealed a persistent but atypical GC immune response accompanied by boosted spike-specific memory CD4 T cells upon SARS-CoV-2 recall vaccination., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Stefanski, Rincon-Arevalo, Schrezenmeier, Karberg, Szelinski, Ritter, Chen, Meisel, Jahrsdörfer, Ludwig, Schrezenmeier, Lino and Dörner.)

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results