49 results on '"Spring, David R."'
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2. Towards the Targeted Protein Degradation of PRMT1
3. Tuneable thiol exchange linkers for traceless drug release applications in prodrugs and ADCs.
4. CK2 Inhibitors Targeting Inside and Outside the Catalytic Box
5. Unlocking Amides: A General Method for the Self‐Immolative Release of Amide‐Containing Molecules
6. Site-selective peptide functionalisation mediated via vinyl-triazine linchpins
7. Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution
8. Photoredox C(2)-Arylation of Indole- and Tryptophan-Containing Biomolecules.
9. Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes
10. Energetics of lipid transport by the ABC transporter MsbA is lipid dependent
11. Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late‐Stage Functionalisation
12. A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase.
13. A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction.
14. Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance
15. Selective inhibitors of the Aurora A-TPX2 protein-protein interaction exhibit in vivo efficacy as targeted anti-mitotic agents
16. A Recombinant Approach For Stapled Peptide Discovery Yields Inhibitors of the RAD51 Recombinase
17. The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance
18. Front Cover: Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance (ChemMedChem 2/2023)
19. Identification of macrocyclic peptides which activate bacterial cylindrical proteases
20. Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy
21. Peroxide-cleavable linkers for antibody–drug conjugates
22. Disulfide re-bridging reagents for single-payload antibody-drug conjugates
23. A cell-active peptide targeting the Nrf2/Keap1 protein-protein interaction
24. Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability
25. LGR5 targeting molecules as therapeutic agents for multiple cancer types
26. Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy.
27. Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI‐001 in in vitro Models of Prostate Cancer Drug Resistance.
28. A unified in vitro to in vivo fluorescence lifetime screening platform yields amyloid β aggregation inhibitors
29. Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy
30. Non-internalising antibody–drug conjugates
31. Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability
32. All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading
33. Development of small cyclic peptides targeting the CK2α/β interface
34. Correction: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions
35. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
36. Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5–6-mer) Peptides
37. Identification of macrocyclic peptides which activate bacterial cylindrical proteasesElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00136a
38. Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy.
39. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of actionElectronic supplementary information (ESI) available: All data supporting this study are included in the paper and provided as ESI accompanying this paper at the journal's website. See DOI: https://doi.org/10.1039/d2md00161f
40. Selective Aurora A-TPX2 Interaction Inhibitors Have In VivoEfficacy as Targeted Antimitotic Agents
41. The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance
42. Identification of macrocyclic peptides which activate bacterial cylindrical proteases
43. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
44. All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading
45. Energetics of lipid transport by the ABC transporter MsbA is lipid dependent
46. Unlocking Amides: A General Method for the Self-Immolative Release of Amide-Containing Molecules.
47. Red-light modulated ortho -chloro azobenzene photoswitch for peptide stapling via aromatic substitution.
48. Tryptophan in Multicomponent Petasis Reactions for Peptide Stapling and Late-Stage Functionalisation.
49. Synthesis of sp 3 -rich heterocyclic frameworks by a divergent synthesis strategy.
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