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Your search keyword '"Tseng, Wen-Ko"' showing total 5 results
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5 results on '"Tseng, Wen-Ko"'

3. The tumour/normal tissue ratio of Keap1 protein is a predictor for lymphovascular invasion in colorectal cancer: a correlation study between the Nrf2 and KRas pathways

Author

Chang, Liang-Che, Fan, Chung-Wei, Tseng, Wen-Ko, Chen, Jim-Ray, and Hua, Chung-Ching

Abstract

Oxidative stress has impacts on the KRas and Nrf2/Keap1 pathways, which have multiple interactions with each other and play important roles in colorectal cancer (CRC). This study investigated the expressions of proteins in the KRas and Nrf2/Keap1 pathways and their associations with clinicopathological features in CRC. The protein levels of Nrf2, Keap1, Bach1, p62, HO1, KRas, Erk, Raf1 and PI3K in both the tumour and normal tissues of 60 CRC subjects were determined by Western blot and their T/N (tumour/normal tissue) ratios were correlated with clinicopathological features. The T/N ratios of proteins in the KRas and Nrf2/Keap1 pathways had correlation patterns and proximity profiles in cluster dendrograms different in CRC with different status of lymphovascular invasion (LVI) or lymph node/distant metastases. The Keap1 protein T/N ratio was a significant predictor (odd ratio: 2.24; 95% confidence interval: 1.26 − 4.38) of LVI, which in turn predicted metastases (11.0; 3.49 − 39.8). The interactions between the KRas and Nrf2/Keap1 pathways may be affected differently by LVI and metastases, and the protein T/N ratio of Keap1 may be helpful for predicting LVI in CRC.

Published
2022
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5. Pretreatment Nutrition-Inflammation Biomarkers Correlated with Differential Cytokine Profiles in Taiwanese Patients with Colorectal Cancer.

Author

Yu, Yen-Lin, Tseng, Wen-Ko, Fan, Chung-Wei, Chang, Pei-Hung, Kuo, Hsuan-Chih, Pan, Yi-Ping, and Yeh, Kun-Yun

Subjects
*CYTOKINES, *BIOMARKERS, *INTERLEUKINS, *C-reactive protein, *TRANSFORMING growth factors-beta, *STATISTICAL significance, *STATISTICS, *INFLAMMATION, *MULTIVARIATE analysis, *RETROSPECTIVE studies, *COLORECTAL cancer, *CANCER patients, *NEUTROPHIL lymphocyte ratio, *TUMOR necrosis factors, *MEDICAL records, *SURVIVAL analysis (Biometry), *DESCRIPTIVE statistics, *RESEARCH funding, *INFLAMMATORY mediators, *LOGISTIC regression analysis, *BODY mass index, *STATISTICAL correlation, *DATA analysis software, *PROPORTIONAL hazards models
Abstract

Systemic inflammation plays a pivotal role in colorectal cancer (CRC) development. Two hallmarks reflect the severity of inflammation—circulating cytokines and nutrition-inflammation biomarkers (NIBs); however, their interplay has not been fully investigated. In total, 128 CRC patients were included. Ten circulating cytokines (TNF-α, TGF-β, IFN-γ, IL-1β, IL-4, IL-6, IL-10, IL-12, IL-13, and IL-23) and NIBs were analyzed. The relationship between cytokines, NIBs, clinicopathological variables, and overall survival (OS) was assessed using univariate and multivariate analyses. Three NIBs (CRP-to-albumin ratio [CAR]), neutrophil-to-lymphocyte ratio [NLR]), and prognostic nutritional index [PNI]) were associated with OS in univariate analysis; however, CAR was better for OS prediction in multivariate analysis (P = 0.015). None of the serum cytokines analyzed showed a significant association with OS. High CAR (≥0.25) and high IL-10 (≥76.6 pg/mL), high NLR (≥8.2) and high IL-23 (≥51.2 pg/mL), and high PNI (≥42.4) and high IL-1β (≥14.3 pg/mL) values were correlated. CAR, NLR, and PNI were not correlated with each other, whereas circulating cytokines were closely interrelated. High CAR was an independent predictor of poor OS in patients with CRC. Different NIBs have unique cytokine profiles, but show no correlation with each other. There is a close association among the circulating cytokines. [ABSTRACT FROM AUTHOR]

Published
2022
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