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3. A description of the management and outcomes of infants with short bowel syndrome in a South African context.

Author

Wagener, M.

Subjects
*SHORT bowel syndrome, *SURGICAL complications, *HUMAN abnormalities, *ODDS ratio, *VOLVULUS
Abstract

Background. Intestinal failure because of congenital or acquired massive bowel loss is an extremely difficult problem to manage and has traditionally been associated with a very poor outcome. Objective. To describe the current management of short bowel syndrome (SBS) and the factors associated with survival and achievement of enteral autonomy in a South African context. Methods. A retrospective chart review of children managed with intestinal failure due to SBS was conducted at Inkosi Albert Luthuli Central Hospital, South Africa, from November 2015 to February 2023. Results. A total of 22 patients with intestinal failure were managed during the study period. The diagnoses included: type 4 jejunal atresia with 3b component (n=5; 22.7%); type 3b jejunal atresia (n=5; 22.7%); type 4 jejunal atresia without 3b component (n=3; 13.6%) and malrotation with volvulus (n=3; 13.6%). One patient each had necrotising enterocolits, gastroschisis with atresia, intussusception, type 1, jejunal atresia with volvulus, type 3a jejunal atresia and volvulus around an ileostomy. The median bowel length was 36.5 cm and average length of stay was 122 days. Enteral autonomy was achieved in 10 patients (45%) and survival in 9 patients (41%). Surgical complication requiring early re-operation (odds ratio 18) and bowel length =20 cm were associated with non-survival. Conclusion. A substantial proportion of children with intestinal failure can achieve enteral autonomy and survival in our context. The treatment process is, however, resource intensive. Avoiding early re-operation and bowel length >20 cm are associated with better survival. [ABSTRACT FROM AUTHOR]

Published
2024
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6. The ChatGPT Artificial Intelligence Chatbot: How Well Does It Answer Accounting Assessment Questions?

Author

Wood, DA, Achhpilia, MP, Adams, MT, Aghazadeh, S, Akinyele, K, Akpan, M, Allee, KD, Allen, AM, Almer, ED, Ames, D, Arity, V, Barr-Pulliam, D, Basoglu, KA, Belnap, A, Bentley, JW, Berg, T, Berglund, NR, Berry, E, Bhandari, A, Bhuyan, MNH, Black, PW, Blondeel, E, Bond, D, Bonrath, A, Borthick, AF, Boyle, ES, Bradford, M, Brandon, DM, Brazel, JF, Brockbank, BG, Burger, M, Byzalov, D, Cannon, JN, Caro, C, Carr, AH, Cathey, J, Cating, R, Charron, K, Chavez, S, Chen, J, Chen, JC, Chen, JW, Cheng, C, Cheng, X, Christensen, BE, Church, KS, Cicone, NJ, Constance, P, Cooper, LA, Correia, CL, Coyne, J, Cram, WA, Curtis, A, Daigle, RJ, Dannemiller, S, Davenport, SA, Dawson, GS, De Meyst, KJL, Dell, S, Demirkan, S, Denison, CA, Desai, H, DeSimone, S, Diehl, LM, Dimes, R, Dong, B, Donnelly, A, du Pon, A, Duan, HK, Duffey, A, Dunn, RT, Durkin, MP, Dzuranin, AC, Eberle, RM, Ege, MS, El Mahdy, D, Esplin, A, Eulerich, M, Everaert, P, Farah, N, Farish, L, Favere-Marchesi, M, Fayard, D, Filosa, JR, Ford, M, Franz, DR, Fulmer, BP, Fulmer, S, Furner, ZZ, Gantman, S, Garner, S, Garrett, J, Geng, X, Golden, J, Goldman, W, Gomez, J, Gooley, M, Granitto, SP, Green, KY, Greenman, CL, Gupta, G, Guymon, RN, Hale, K, Harper, CJ, Hartt, SA, Hawk, H, Hawkins, SR, Hawkins, EM, Hay, DC, Heinzelmann, R, Henderson, CD, Hendricks, BE, Heninger, WG, Hill, MS, Holden, N, Holderness, DK, Holt, TP, Hoopes, JL, Hsieh, S-F, Huang, F, Huang, H-W, Huang, T-C, Huels, BW, Hunter, K, Hurley, PJ, Inger, K, Islam, S, Ison, I, Issa, H, Jackson, AB, Jackson, SC, Janvrin, DJ, Jimenez, PD, Johanson, D, Judd, JS, Kawada, BS, Kelton, AS, Kern, S, Kerr, JN, Keune, MB, Kim, M, Knox, BD, Kogan, G, Kotb, A, Krane, R, Kremin, J, Krieg, KS, Kugel, J, Kulset, EM, Kuruppu, C, LaDuca, G, Lamberton, BA, Lamboy-Ruiz, MA, Lang, B, Larocque, SA, Larson, MP, Lawson, BP, Lawson, JG, Lee, L, Lenk, MM, Li-Kuehne, M, Liljegren, J, Lin, Y-H, Liu, W-P, Liu, Z, Lock, B, Long, JH, Loraas, T, Lowensohn, S, Loy, TR, Lyngstadaas, H, Maas, W, MacGregor, JE, Madsen, DØ, Malone, CL, Margolin, M, Marshall, ME, Martin, RM, Mpofu, CM, McCoy, C, McGuigan, NC, McSwain, DN, Meckfessel, MD, Mellon, MJ, Melton, OS, Mercado, JM, Mitsuda, S, Modugu, K, Moehrle, S, Chaghervand, AM, Moffitt, K, Moon, JS, Muehlmann, B, Murray, J, Mwaungulu, ES, Myers, N, Naegle, JC, Ndicu, MJ, Nelson, AS, Nguyen, AL, Niederkofler, T, Nikbakht, E, O'Brien, AD, Ogunade, KM, O'Leary, D, Oler, MJ, Oler, DK, Olsen, KJ, Otalor, JI, Outlaw, KW, Ozlanski, ME, Parlier, J, Paterson, JS, Pearson, CA, Petersen, MJ, Petra, ST, Pickard, MD, Pickerd, J, Pinsker, R, Plante, C, Plečnik, JM, Price, RA, Quick, LA, Raedy, J, Raschke, R, Ravenscraft, J, Richardson, V, Rixom, BA, Robertson, JF, Rock, I, Romney, MA, Rozario, A, Ruff, MF, Rupley, K, Saeedi, A, Saiewitz, A, Salzsieder, LW, Sarkar, S, Saulls, M, Scanlan, TA, Schaefer, TJ, Schaupp, D, Schneider, GP, Seebeck, A, Sellers, RD, Seto, SC, Sevel, R-L, Shan, Y, Sherwood, MG, Singorahardjo, M, Skaftadottir, HK, Skomra, J, Smith, JL, Smith, DO, Smith, J, Snow, MC, Sommerfeldt, RD, Sorensen, KB, Sorensen, TL, Spieler, AC, Stallings, MA, Stallings, L, Stancill, A, Stanley, JD, Stefaniak, CM, Stephens, NM, Stewart, BW, Stratopoulos, TC, Street, DA, Subedi, M, Summers, SL, Sundkvist, CH, Synn, C, Tadesse, A, Tapis, GP, Tassin, K, Taylor, S, Teal, M, Teeter, R, Tharapos, M, Theis, JC, Thomas, J, Thompson, KS, Thornock, TA, Tietz, W, Travalent, AM, Trinkle, BS, Truelson, JM, Turner, MC, Vagner, B, Vakilzadeh, H, van der Geest, J, van Pelt, V, Vandervelde, SD, Vega, J, Vera-Muñoz, S, Villanueva, B, Vincent, NE, Wagener, M, Walton, S, Warne, RC, Watanabe, OV, Watson, D, Watson, MW, Weber, J, Weirich, T, West, AN, Wilford, AL, Wilson, AB, Winrow, B, Winrow, T, Winrow, TS, Wiseman, D, Witte, AL, Wood, BD, Wood, J, Woolley, D, Wright, NS, Wu, J, Xiong, X, Yatsenko, D, Yazzie, CE, Young, GM, Zhang, C, Zimmerman, AB, Zoet, E, Wood, DA, Achhpilia, MP, Adams, MT, Aghazadeh, S, Akinyele, K, Akpan, M, Allee, KD, Allen, AM, Almer, ED, Ames, D, Arity, V, Barr-Pulliam, D, Basoglu, KA, Belnap, A, Bentley, JW, Berg, T, Berglund, NR, Berry, E, Bhandari, A, Bhuyan, MNH, Black, PW, Blondeel, E, Bond, D, Bonrath, A, Borthick, AF, Boyle, ES, Bradford, M, Brandon, DM, Brazel, JF, Brockbank, BG, Burger, M, Byzalov, D, Cannon, JN, Caro, C, Carr, AH, Cathey, J, Cating, R, Charron, K, Chavez, S, Chen, J, Chen, JC, Chen, JW, Cheng, C, Cheng, X, Christensen, BE, Church, KS, Cicone, NJ, Constance, P, Cooper, LA, Correia, CL, Coyne, J, Cram, WA, Curtis, A, Daigle, RJ, Dannemiller, S, Davenport, SA, Dawson, GS, De Meyst, KJL, Dell, S, Demirkan, S, Denison, CA, Desai, H, DeSimone, S, Diehl, LM, Dimes, R, Dong, B, Donnelly, A, du Pon, A, Duan, HK, Duffey, A, Dunn, RT, Durkin, MP, Dzuranin, AC, Eberle, RM, Ege, MS, El Mahdy, D, Esplin, A, Eulerich, M, Everaert, P, Farah, N, Farish, L, Favere-Marchesi, M, Fayard, D, Filosa, JR, Ford, M, Franz, DR, Fulmer, BP, Fulmer, S, Furner, ZZ, Gantman, S, Garner, S, Garrett, J, Geng, X, Golden, J, Goldman, W, Gomez, J, Gooley, M, Granitto, SP, Green, KY, Greenman, CL, Gupta, G, Guymon, RN, Hale, K, Harper, CJ, Hartt, SA, Hawk, H, Hawkins, SR, Hawkins, EM, Hay, DC, Heinzelmann, R, Henderson, CD, Hendricks, BE, Heninger, WG, Hill, MS, Holden, N, Holderness, DK, Holt, TP, Hoopes, JL, Hsieh, S-F, Huang, F, Huang, H-W, Huang, T-C, Huels, BW, Hunter, K, Hurley, PJ, Inger, K, Islam, S, Ison, I, Issa, H, Jackson, AB, Jackson, SC, Janvrin, DJ, Jimenez, PD, Johanson, D, Judd, JS, Kawada, BS, Kelton, AS, Kern, S, Kerr, JN, Keune, MB, Kim, M, Knox, BD, Kogan, G, Kotb, A, Krane, R, Kremin, J, Krieg, KS, Kugel, J, Kulset, EM, Kuruppu, C, LaDuca, G, Lamberton, BA, Lamboy-Ruiz, MA, Lang, B, Larocque, SA, Larson, MP, Lawson, BP, Lawson, JG, Lee, L, Lenk, MM, Li-Kuehne, M, Liljegren, J, Lin, Y-H, Liu, W-P, Liu, Z, Lock, B, Long, JH, Loraas, T, Lowensohn, S, Loy, TR, Lyngstadaas, H, Maas, W, MacGregor, JE, Madsen, DØ, Malone, CL, Margolin, M, Marshall, ME, Martin, RM, Mpofu, CM, McCoy, C, McGuigan, NC, McSwain, DN, Meckfessel, MD, Mellon, MJ, Melton, OS, Mercado, JM, Mitsuda, S, Modugu, K, Moehrle, S, Chaghervand, AM, Moffitt, K, Moon, JS, Muehlmann, B, Murray, J, Mwaungulu, ES, Myers, N, Naegle, JC, Ndicu, MJ, Nelson, AS, Nguyen, AL, Niederkofler, T, Nikbakht, E, O'Brien, AD, Ogunade, KM, O'Leary, D, Oler, MJ, Oler, DK, Olsen, KJ, Otalor, JI, Outlaw, KW, Ozlanski, ME, Parlier, J, Paterson, JS, Pearson, CA, Petersen, MJ, Petra, ST, Pickard, MD, Pickerd, J, Pinsker, R, Plante, C, Plečnik, JM, Price, RA, Quick, LA, Raedy, J, Raschke, R, Ravenscraft, J, Richardson, V, Rixom, BA, Robertson, JF, Rock, I, Romney, MA, Rozario, A, Ruff, MF, Rupley, K, Saeedi, A, Saiewitz, A, Salzsieder, LW, Sarkar, S, Saulls, M, Scanlan, TA, Schaefer, TJ, Schaupp, D, Schneider, GP, Seebeck, A, Sellers, RD, Seto, SC, Sevel, R-L, Shan, Y, Sherwood, MG, Singorahardjo, M, Skaftadottir, HK, Skomra, J, Smith, JL, Smith, DO, Smith, J, Snow, MC, Sommerfeldt, RD, Sorensen, KB, Sorensen, TL, Spieler, AC, Stallings, MA, Stallings, L, Stancill, A, Stanley, JD, Stefaniak, CM, Stephens, NM, Stewart, BW, Stratopoulos, TC, Street, DA, Subedi, M, Summers, SL, Sundkvist, CH, Synn, C, Tadesse, A, Tapis, GP, Tassin, K, Taylor, S, Teal, M, Teeter, R, Tharapos, M, Theis, JC, Thomas, J, Thompson, KS, Thornock, TA, Tietz, W, Travalent, AM, Trinkle, BS, Truelson, JM, Turner, MC, Vagner, B, Vakilzadeh, H, van der Geest, J, van Pelt, V, Vandervelde, SD, Vega, J, Vera-Muñoz, S, Villanueva, B, Vincent, NE, Wagener, M, Walton, S, Warne, RC, Watanabe, OV, Watson, D, Watson, MW, Weber, J, Weirich, T, West, AN, Wilford, AL, Wilson, AB, Winrow, B, Winrow, T, Winrow, TS, Wiseman, D, Witte, AL, Wood, BD, Wood, J, Woolley, D, Wright, NS, Wu, J, Xiong, X, Yatsenko, D, Yazzie, CE, Young, GM, Zhang, C, Zimmerman, AB, and Zoet, E

Abstract

ChatGPT, a language-learning model chatbot, has garnered considerable attention for its ability to respond to users’ questions. Using data from 14 countries and 186 institutions, we compare ChatGPT and student performance for 28,085 questions from accounting assessments and textbook test banks. As of January 2023, ChatGPT provides correct answers for 56.5 percent of questions and partially correct answers for an additional 9.4 percent of questions. When considering point values for questions, students significantly outperform ChatGPT with a 76.7 percent average on assessments compared to 47.5 percent for ChatGPT if no partial credit is awarded and 56.5 percent if partial credit is awarded. Still, ChatGPT performs better than the student average for 15.8 percent of assessments when we include partial credit. We provide evidence of how ChatGPT performs on different question types, accounting topics, class levels, open/closed assessments, and test bank questions. We also discuss implications for accounting education and research.

Published
2023

9. Global economic burden of unmet surgical need for appendicitis

Author

Reuter, Anna, Rogge, Lisa, Monahan, Mark, Kachapila, Mwayi, Morton, Dion G, Davies, Justine, Vollmer, Sebastian, A A Essam, Abd Elkhalek Sallam, Abd Elrahman Elshafay, Abd El-Rahman Hegazy Khedr, Abdalla Gamal Saad, Abdalla Gharib, Abdalla Kenibar, Abdallah Salah Elsherbiny, Abdalrahman Adel, Abdelaziz Abdelaal, Abdelaziz Osman Abdelaziz Elhendawy, Abdelfatah Hussein, Abdelkader Belkouchi, Abdelmalek Hrora, Abdelrahman Adelshone, Abdelrahman Alkammash, Abdelrahman Assal, Abdelrahman Geuoshy, Abdelrahman Haroun, Abdelrahman Mohammed, Abdelrahman Sayed, Abdelrahman Soliman, Abdelrhman Essam Elnemr, Abdelrhman Kz Darwish, Abdelrhman Osama Elsebaaye, Abdul Khalique, Abdul Rehman Alvi, Abdul Wahid Anwar, Abdulaziz Altwijri, Abdullah Al-Mallah, Abdullah Almoflihi, Abdullah Altamimi, Abdullah Daqeeq, Abdullah Dwydar, Abdullah Gouda, Abdullah Hashim, Abdulmalik Altaf, Abdulmalik Huwait, Abdulrahman Abdel-Aty, Abdulrahman M Altwigry, Abdulrahman Sheshe, Abdulrasheed A Nasir, AbdulRazzaq Oluwagbemiga Lawal, Abdulshafi Khaled Abdrabou, Abdurrahaman Sheshe, Abdussemiu Abdurrazzaaq, Abebe Bekele Zerihun, Abeer Al-Shammari, Abeer El Gendy, Abeer Esam, Abeer Marey, Abhishek Mittal, Abiboye Yifieyeh, Abid Bin Mahamood, Abidemi Adesuyi, Abouelatta Khairy Aly, Abrar Nawawi, Adam Gyedu, Ade Waterman, Adedapo Osinowo, Adedeji Fatuga, Adel Albiety, Adel B Hassanein, Adel Denewar, Adeleke Adekoya, Ademola Adebanjo, Ademola Adeyeye, Ademola Popoola, Adesina Adedeji, Adesoji O Ademuyiwa, Adesoji Tade, Adewale Adeniyi, Adewale O Adisa, Adham Tarek, Adomas Ladukas, Adrian F Palma, Afifatun Hasanah, Afizah Salleh, Afnan Abdelfatah, Afnan Altamimi, Afnan Altamini, Agazi Fitsum, Agboola Taiwo, Ahamed Hassan, Ahed Ghaben, Ahmad Abdel Fattah, Ahmad Abdel Razaq Al Rafati, Ahmad Aboelkassem Ibrahem, Ahmad Aldalaq, Ahmad Ali, Ahmad Almallah, Ahmad Alrifaie, Ahmad Ashour, Ahmad Bakr, Ahmad Bani-Sadar, Ahmad Bin Adnan, Ahmad Elbatahgy, Ahmad Faraz, Ahmad Gudal, Ahmad Hasan, Ahmad Khaled Sabe, Ahmad Khoja, Ahmad Nashaat, Ahmad Qaissieh, Ahmad Sabe, Ahmad Saber Sleem, Ahmad Sakr, Ahmad Shalabi, Ahmad Uzair Qureshi, Ahmed Aamer, Ahmed Abd El Galeel, Ahmed Abd Elmoen Elhusseiny, Ahmed Abd Elsameea, Ahmed Abdelkareem, Ahmed Abdelmotaleb Ghazy, Ahmed Abo El Magd, Ahmed Abo Elazayem, Ahmed Adamu, Ahmed Adel, Ahmed Afandy, Ahmed Ahmed, Ahmed Alghamdi, Ahmed Ali, Ahmed Al-Khatib, Ahmed Altibi, Ahmed Alzahrani, Ahmed Ata, Ahmed Badr, Ahmed Dahy, Ahmed Diab, Ahmed El Kashash, Ahmed El Kholy, Ahmed Elgaili Khalid Musa, Ahmed Elgebaly, Ahmed Elkelany, Ahmed Elkholy, Ahmed El-Sehily, Ahmed Essam, Ahmed Fahiem, Ahmed Farag, Ahmed Fawzy, Ahmed Fouad, Ahmed Gad, Ahmed Ghanem, Ahmed Gheith, Ahmed Gomaa, Ahmed Hafez El-Badri Kotb, Ahmed Hammad, Ahmed Hassan, Ahmed Hossam Eldin Fouad Rida, Ahmed Ismail, Ahmed Karim, Ahmed Khyrallh, Ahmed Lasheen, Ahmed M Rashed, Ahmed Magdy, Ahmed Mahmoud Abdelraouf, Ahmed Menshawy, Ahmed Meshref, Ahmed Mohamed Afifi, Ahmed Mohamed Ibrahim, Ahmed Mohameden, Ahmed Mohammed, Ahmed Mokhtar, Ahmed Mosad, Ahmed Moustafa, Ahmed Moustafa Saeed, Ahmed Negida, Ahmed Rabeih Mohammed, Ahmed Rabie Mohamed, Ahmed Ragab Nayel, Ahmed Ragab Soliman, Ahmed Raslan, Ahmed Raza, Ahmed Refaat, Ahmed Rslan, Ahmed Sabry, Ahmed Sabry El-Hamouly, Ahmed Safwan Marey, Ahmed Saidbadr, Ahmed Sakr, Ahmed Samir, Ahmed Shahine, Ahmed Sheta, Ahmed Soliman, Ahmed Tammam, Ahmed Tarek Abdelbaset Hassan, Ahmed W Shamsedine, Ahmed Zaki, Ahmed Zaki Eldeeb, Ahmed Zohair, Ahmedali M Kandil, Ahmedglal Elnagar, Ahsan Zil-E-Ali, Aijaz Jabbar, Ailsa Claire Snaith, Ainhoa Costas-Chavarri, Aiste Austraite, Ajayesh Mistry, Akin Olaolorun, Akinlabi E Ajao, Al Faifi Jubran, Ala Shamasneh, Alaa Abouelnasr, Alaa Al-Buhaisi, Alaa Bowabsak, Alaa El Jamassi, Alaa Elazab, Alaa Elhadad, Alaa Fergany, Alaa Habeebullah, Alaa Hassan, Alaa Shabkah, Alaa Shaheen, Alaba Adesina, Alan Baird, Alan Grant, Alasdair Ball, Alban Cacurri, Albert Mohale Mphatsoe, Alberto Realis Luc, Alejandro Matheu, Alejandro Munera, Alemayehu Ginbo Bedada, Alessandro Favero, Alessio Maniscalco, Alexander Canta Calua, Alexander J Fowler, Alexandra Gerosa, Alexandre Horobjowsky, Alexandre Venancio De Sousa, Alexia Farrugia, Alexis Pierre Arnaud, Alfio Alessandro Russo, Alfredo Gulielmi, Ali Ababneh, Ali Abo El Dahab, Ali Amin Ahmed Ata, Ali Khan Niazi, Ali Kiasat, Ali Mohamed Hammad, Ali Zardab, Ali Zeynel Abidin Balkan, Aliaa Gamal Toeema, Aliaa Sadek, Aliaksandr Filatau, Aliang Latif, Alibeth Andres Baquero Suarez, Alice Faure, Alice Niragire, Alina Robledo-Rabanal, Aline Broch, Alireza Hasheminia, Alisdair Macdonald, Aliyu Ndajiwo, Allan Novak, Alphonse Zeta Mutabazi, Alvaro Enrique Mendoza Beleño, Alvin Ee Zhiun Cheah, Aly Abd Elrazek, Aly Nasr, Aly Sanad, Alyaa Halim Elgendy, Alyne Daltri Lazzarini Cury, Amal Ibrahim, Amandine Martin, Amani Althwainy, Amany Abouzahra, Amany Eldosouky Mohammed, Amar Kourdouli, Amel Hashish, Amerdip Birring, Amgad Al Meligy, Amina Abdelhamid, Aminah Hanum Haji Abdul Majid, Aminu Mohammad, Amir Ait Kaci, Amira Atef Omar, Amira Elsawy, Amira Hassan Bekhet, Amira Reda, Amjad Abu Qumbos, Amjad Elmashala, Ammar Gado, Amna Mamdouh Mohamed, Amna Mohamed, Amoudtha Rasendran, Amr Ahmed Saleh, Amr Fadel, Amr Hasan, Amr Hassaan, Amr Hossameldin, Amr Muhammad Elkorashy, Amr Tarek Hafez, Amreen Faruq, Amro Aglan, Ana Cecilia Manchego Bautista, Ana Lucia Contreras-Vergara, Ana Maria Sandoval Barrantes, Ana Vega Carreiro De Freitas, Ana Vega Freitas, Anam Rashid, Anan Rady Abdelazeam, Anand Kirishnan, Anass Majbar, Anastasia Bamicha, Anastasios Stefanopoulos, Anders Thorell, Andre Das, Andre Dubois, Andre L Mihaljevic, Andre Navarro, Andrea Allegri, Andrea Armellini, Andrea Belli, Andrea Bondurri, Andrea Echevarria Rosas Moran, Andrea Natili, Andrea Ruzzenente, Andrea Simioni, Andreass Haloho, Andrei Tanase, Andrej Kolosov, Andrejus Subocius, Andrew G N Robertson, Andrew Kirby, Andrew Mcguigan, Andrew Spina, Andrey Litvin, Andrius Burmistrovas, Andrius Strazdas, Andy Arenas, Aneel Bhangu, Anele Rudzenskaite, Angel David Pérez Rojas, Angela Dell, Angelica Genoveva Vergara Mejia, Angeline Charles, Angelo Antoniozzi, Angelo Benevento, Angelos Tselos, Angham Solaiman El-Ma'doul, Anjana Sreedharan, Ankur Bhatnagar, Ann Kjellin, Anna Lasek, Anna Maffioli, Anna Powell, Anna Rinaldi, Anna Watts, Annalisa Lo Conte, Annamaria Bigaran, Annelisse Ashton, Annisa Dewi Fitriana Mukin, Antanas Gulbinas, Antanas Zadoroznas, Anthonius Santoso Rulie, Anthony Ajiboye, Anthony Avoka, Anthony Chuk-Him Lai, Anthony Davor, Anthony Sander, Antje Oosterkamp, Antoinette Bediako-Bowan, Antonella La Brocca, Antônio Leal, Antonio Nocito, Antonio Ramos-De La Medina, Antonio Taddei, Anwar Atiyeh, Anyomih Theophilus Teddy Kojo, Aoife Driscoll, Apar Shah, Apostolos Vlachogiorgos, April Camilla Roslani, Aram Abdelhaq, Arazzelly Del Pilar Paucar, Arcangelo Picciariello, Areej Tarek, Arezo Kanani, Ari Leppäniemi, Arianna Birindelli, Arij Ibrahim, Arjun Nesaratnam, Arlindawati Suyadi, Armando José Román Velásquez, Arnaud Bonnard, Arnav Agarwal, Aroub Alkaaki, Arturas Vaicius, Arvin Khamajeet, Arvo Reinsoo, Arwa Abouzaid, Arwa Elfarargy, Arwa Ibrahim, Arwa Mohamed, Asaf Kedar, Asdaq Ahmed, Ased Ali, Aseel Alnusairat, Aseel Hamarshi, Aseel Musleh, Ash Prabhudesai, Ashraf A Maghrabi, Ashraf Morsi, Ashrarur Rahman Mitul, Asmaa Abdelgelil, Asmaa Abdel-Rahman Al-Aarag, Asmaa Rezq, Asmaa Salah, Aspasia Papailia, Assmaa Badwy, Astrid Leusink, Ata Khan, Ataa Ahmed, Athanasia Bamicha, Athar Eysa, Athirah Zulkifli, Atif Mahdi, Attia Attia, Attia Mohamed Attia, Audrey Clarissa, Audrius Dulskas, Audrius Parseliunas, Augusto Zani, Aung Kyaw Tun, Aurel Mironescu, Aurel Sandu Mironescu, Aurelien Scalabre, Aurora Mariani, Aurore Haffreingue, Aurore Thollot, Ausrine Usaityte, Austė Skardžiukaitė, Awais Raza, Aya Abdel Fatah Ibraheem, Aya Aboarab, Aya Adel Elsharkawy, Aya El-Sawy, Aya Elwaey, Aya Firwana, Aya Hagar, Aya Hammad, Aya Mohamed Fathy, Aya Reda, Aya Yehia Ata, Ayah Hamdan, Ayat Hassaan, Ayman And Taher, Ayman Elwan, Ayman Nabawi, Ayman Salman, Ayman Shwky, Ayokunle Ogunyemi, Azher Herebat, Azmina Verjee, Babajide Adenekan, Babatunde Odeyemi, Badr Eldin Adel, Badreldin Adel Tawfik, Bahar Busra Ozkan, Bakeer Mohamed, Bakhtiar Nighat, Bandar Albeladi, Bárbara Málaga, Barbara Mijuskovic, Barbara Pereira Silvestre, Basant Kumar, Basem Sieda, Bashir Bello, Basim Alghamdi, Basma Magdy, Basma Mahmoud, Basmah Alhassan, Bassant Mowafy, Beatrice Brunoni, Beatrix Weber, Belen Sanchez, Ben Thompson, Benoît Parmentier, Bernard Limoges, Bernard Van Duren, Bernhard Wolf, Bertrand Dousset, Besmir Grizhja, Bettina Lieske, Betty Maillot, Billal Mansour, Bjorn Frisk, Bogdan Diaconescu, Bogdan-Valeriu Martian, Boris Marinkovic, Brendan Skelly, Brian Cameron, Britta Dedekind, Bruno Noukpozounkou, Bryon Frankie Hon Khi Chong, Bylapudi Seshu Kumar, Caio Vinícius Barroso de Lima, Calogero Iacono, Cameron Fairfield, Camila Sanchez Samaniego, Camilla Cona, Camilo Lopez-Arevalo, Caoimhe Normile, Caranj Venugopal, Carla Cecilia Ramã Rez Cabrera, Carla Pierina García Torres, Carlo Corbellini, Carlos Alejandro Arroyo Basto, Carlos Iván Pérez Velásquez, Carlos Morales, Carlos Nsengiyumva, Carlos Paz Galvez, Carmen Capito, Carmen Fernández, Carmina Diaz-Zorrilla, Carolina Guzmán Dueñas, Carolina Oliveira Felipe, Caroline Clifford, Caroluce K Musyoka, Catherine A Shaw, Cathy Magee, Cecile Muller, Cecilia Costa, Cecilia Tolg, Cecilia Wredberg, Celeste Del Basso, Céline Grosos, Cesar Augusto Azmitia Mendizabal, Cesar Miranda, Cesar Razuri, Cezar Ciubotaru, Chali Chibuye, Challine Alexandre, Charing Cheuk Ling Szeto, Charles Dally, Charlotte Jane Mcintyre, Chaymae Benyaiche, Chean Leung Chong, Chee Siong Wong, Cheewei Gan, Chelise Currow, Chelsea Deane, Cheng Chun Goh, Cherry Koh, Cheryl Ou Yong, Chetan Khatri, Chi Chung Foo, Chi Ying Jacquelyn Fok, Chia Kong, Chiara Ceriani, Chimwemwe Kwatiwani, Chingwan Yip, Chintya Tedjaatmadja, Choon Seng Chong, Chouikh Taieb, Choy Ling Tan, Chris Bode, Chris Lee, Christel Leanne Almanon, Christian Hinojosa, Christian Lari Coompson, Christin Schoewe, Christina Neophytou, Christina P Major, Christina Panteli, Christine Mizzi, Christoforos Ferousis, Christopher Bode, Christos Agalianos, Christos Anthoulakis, Christos Barkolias, Christos Dervenis, Chu-Ann Chai, Chui Yee Wong, Ciara Fahy, Cicilia Viany Evajelista, Cirugia De Emergencia, Ciskje Zarb, Citra Dewi Mohd Ali, Claire Sharpin, Clara Milagros Herrera Puma, Clare M Rees, Clare Morgan, Claudia Reali, Claudio Arcudi, Claudio Fermani, Claudio Gabriel Fermani, Clemens Nawara, Clement Onuoha, Clodagh Mangan, Colleen Sampson, Collins Nwokoro, Colombani Jean-Francois, Constantinos Marinos, Cornelius Mukuzunga, Corrado Bottini, Craig Gouldthorpe, Crislee Elizabeth Lopez, Cristina Fernandes, Crystal Yern Nee Chow, Cutting Edge Manipal, Dale Vimalachandran, Dalia Alkhabbaz, Dalia Hemeda, Damien Brown, Damir Ljuhar, Dan L Deckelbaum, Dana Jaradat, Danelo Du Plessis, Daniel Ardian Soeselo, Daniel Cox, Daniel Dabessa, Daniel Estuardo Marroquín Rodríguez, Daniel Hamill, Daniel Nel, Daniel Youssef, Daniela Magri, Daniele Angelieri, Daniele Gui, Danilo Herrera Cruz, Danjuma Sale, Dansou Gaspard Gbessi, Dario Andreotti, Darius Kazanavicius, Darragh McCullagh, David Mcnish, David Merlini, David Monterroso Cohen, Davide De Boni, Davide Rossi, Dayang Nita Abdul Aziz, D C Grobler, Debora Schivo, Deborah Chiesa, Deimante Mikuckyte, Deividas Dragatas, Demi Gray, Diaa Eldin Abdelazeem Amin Elsorogy, Diaa Moustafa Elbendary Elsawahly, Diaaaldin Zahran, Diana Duarte Cadogan, Diana Sanchez, Dickson Bandoh, Diego Alonso Romani Pozo, Diego Antezana, Diego Coletta, Diego Romani, Diego Sasia, Dietmar Öfner, Dieudonne Duhoranenayo, Dimitri Aristotle Raptis, Dimitrios Balalis, Dimitrios K Manatakis, Dimitrios Karousos, Dimitrios Korkolis, Dimitrios Kyziridis, Dimitrios Lytras, Dimitrios Papageorgiou, Dimitrios Sfougaris, Dimitris-Christos Zachariades, Dina Al-Marakby, Dina Faizatur Rahmah, Dina Gamal, Dina Tarek, Dineshwary Periasammy, Diogo Vinicius Dos Santos, Dion Morton, Diya Mirghani, Djifid Morel Seto, D M Cocker, Dmitri A Raptis, Dmitri Nepogodiev, Dmitri Raptis, Doaa Emadeldin, Doaa Gamil, Doaa Hasan, Doaa Hasanain, Doaa Maher Abdelrouf, Domenica Pata, Domingos Mapasse, Dominic Charles Marshall, Donal B O'Connor, Donatas Danys, Donatas Venskutonis, Dorota Radkowiak, Doug Bowley, Dovilè Majauskyté, Dulan Irusha Samaraweera, Durvesh Lacthman Jethwani, Dush Iyer, Dushyant Iyer, Dzianis Khokha, Dzmitry Paulouski, Ebenezer Takyi Atkins, Echaieb Anis, Edgar Domini, Edilberto Temoche, Eduardo Huaman, Edvard Grisin, Edvinas Dainius, Efeson Thomas, Egle Preckailaite, Ehab Alnawam, Ehab Mamdouh, Eirik Kjus Aahlin, Eirini Kefalidi, Ekow Mensah, Elaine Borg, Eldaa Prisca Refianti Sutanto, Eleanor Marks, Elena Goldin, Elena Muzio, Elena Vendramin, Elena Zdanyte Sruogiene, Eleonora Ciccioli, Elio Jovine, Elisa Francone, Elisabeth Jensen, Elissa Rifhan Mohd Basir, Elizabeth Snyder, Ella Teasdale, Elliot Akoto, Elodie Gaignard, Elodie Haraux, Elsa Robert, Elsayed Ali, Elsayed Gamaly, Emad Abdallah, Emad Al-Dakka, Emad Ali Ahmed, Emad Aljohani, Emad Mohamed Saeed Taha, Eman Abd Al Raouf, Eman Abdelmageed, Eman Abuqwaider, Eman Adel Sayma, Eman Elwy, Eman Emara, Eman Hashad, Eman Ibrahim, Eman Magdy, Eman Magdy Hegazy, Eman Mahmoud Abdulhakeem, Eman Mohamed Ibrahim, Eman Mohamed Morshedy, Eman Nofal, Eman Rashad, Eman Yahya Mansor, Emanuel Barrios, Emanuele Rausa, Emeka Nwabuoku, Emilia De Luca, Emilie Eyssartier, Emilio Dijan, Emma Blower, Emma Jurdell, Emma Upchurch, Emmanuel Acquah, Emmanuel Akatibo, Emmanuel Barrios, Emmy Runigamugabo, Enas Alaloul, Enas Alqahtani, Enoch Dagoe, Enoch Tackie, Eriberto Farinella, Eric Ackom, Eric Kofi Appiah, Erick Samuel Florez Farfan, Erik Hervieux, Erik Schadde, Erika Vicario, Erikas Laugzemys, Ernest Yemalin Stephane Ahounou, Eslam Elbanby, Eslam Ezzat, Esraa Abd 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Ferdy Iskandar, Fernanda Altoe, Fernanda Frade, Fernande Djivoh, Fernando Espinoza, Fernando Fernandez-Bueno, Fernando Tale, Ferry Fitriya Ayu Andika, Fidelis Jacklyn Adella, Filippo Di Franco, Finaritra Casimir Fleur Prudence Rahantasoa, Fitjerald Henry, Fitriana Nur Rahmawati, Florence Dedey, Florian Primavesi, Florin-Mihail Iordache, Fong Yee Lam, Foteini Koumpa, Francesca Steccanella, Francesco Pata, Francesco Riente, Francesco Ruben Giardino, Francesco Selvaggi, Francis Abantanga, Francis Dossou, Francisco Fujii, Francisco Regalado, Francois-Coridon Helene, Françoise Schmitt, Frank Enoch Gyamfi, Frank Owusu, Fred Alexander Naranjo Aristizã Bal, Fred Hodonou, Frederick Du Toit, Frederique Sauvat, Fredrik Wogensen, Frehun Ayele Asele, Fridiz Saravia, Gabriel Pardo, Gabriela Elisa Nita, Gaetano Gallo, Gaetano Luglio, Gaetano Tessera, Galaleldin Abdelazim, Gamal Shimy, Gandau Naa Barnabas, Garba Samson, Gareth Irwin, Gehad El Ashal, Gehad Samir El Sayed, Gehad Tawfik, Gemma Humm, Genoveffa Balducci, George Christian Manrique Sila, George Ihediwa, George Manrique Sila, Georges Azzie, Georgette Marie Camilleri, Georgios Gemenetzis, Georgios Gkiokas, Georgios Karabelias, Georgios Kyrou, Georgios Tzikos, Gerardo Perrotta, Gerfried Teufelberger, Germain Ahlonsou, German Minguez, Geta Maharaj, Gezim Galiqi, Ghada Elhoseny, Ghada Saied Nagy, Ghiath Al Saied, Ghina Shamim Shamsi, Giacomo Nastri, Giacomo Pata, Gianfranco Cocorullo, Gianluca Curletti, Gianluca Pagano, Gianluca Pellino, Gianmaria Confalonieri, Gianpiero Gravante, Giedrius Lauzikas, Giles Dawnay, Gintaras Simutis, Giorgio Vasquez, Giovanni Landolfo, Giovanni Lazzari, Giovanni Luca Lamanna, Giovanni Pascale, Giovanni Pesenti, Giovanni Sgroi, Giridhar H Devadasar, Gisele Moreira, Giuliano Borda-Luque, Giuseppe Clerico, Giuseppe Rotunno, Giuseppe Salamone, Giuseppe Sammarco, Gokhan Lap, Greg Padmore, Gregorio Tugnoli, Gregory Kouraklis, Greta Mclachlan, Greta Wood, Greta Žiubrytė, Guillaume Podevin, Guillermo Sanchez Rosenberg, Guo Liang Yong, Gurdeep Singh Mannu, Gurpreet Singh Banipal, Gustavo Miguel Machain Vega, Gustavo Peixoto Soares Miguel, Gustavo Pereira Fraga, Gustavo Recinos, Gustavo Rodolfo Pertersen Servin, Haaris A Shiwani, Hadeel Al-Farram, Hafiz Hakim, Hagar Zidan, Hager Abdul Aziz Amin, Hager Abdulaziz, Hager Ahmed El-Badawy, Hager Elwakil, Hager Tolba, Hagir Zain Elabdin, Haidar Hajeh, Hala Ahmed, Hala Saad, Halima Aliyu, Hamdi Ebdewi, Hamza Asumah, Hamza Waleed, Hanan Adel Saad, Haney Youssef, Hani Natalie, Hanna Royson, Hannah Anderson-Knight, Hannah Burns, Hannah S Thomas, Hans-Ivar Pahlsson, Harish Neelamraju Lakshmi, Harriet Jordan, Hasan Ismael Ibraheem, Hasan Ismael Ibraheem Al-Hameedi, Hasbi Maulana Arsyad, Hasnain Abbas Dharamshi, Hassan Ali Mostafa, Hatem El-Sheemy, Haya Tahboub, Hayam Ahmed, Hayden Kretzmann, Hayssam Rashwan, Haytham Abudeeb, Hazem Khaled, Hazmi Dwinanda Nurqistan, Heather Bougard, Heba Baraka, Heba Gamal, Heba Shaker, Hector Shibao Miyasato, Helen Mohan, Helen Woodward, Helena Franco, Helene Francois-Coridon, Helmut Alfredo Segovia Lohse, Hend Adel Gawad Shakshouk, Hend Kandil, Hend Mahmoud, Henri Kotobi, Henry Mendel, Henry Nnaj, Herlin Karismaningtyas, Herman Cruz, Hesham Magdy, Hesham Mohammed Bakry, Hian Ee Heng, Hildur Thorarinsdottir, Hisham Safa, Hisham Samih, Hogea Mircea, Hong Kong Sar, Hong Yee Wong, Hoong-Yin Chong, Hope Edem Kofi Kordorwu, Hope Glover-Addy, Horacio Paredes Decoud, Hosni Khairy Salem, Hossam Dawoud, Hossam Elfeki, Hossam Emadeldin, Houda Bachri, Hunain Shiwani, Hussein Ali, Hussein El-Kashef, Hussein Mohammed, Hussien Ahmed, Iason-Antonios Papaskarlatos, Ibrahem Abdelmotaleb, Ibrahim AbdelFattah, Ibrahim Alhabli, Ibrahim Al-Slaibi, Ibrahim AlYoussef, Ibrahim Elzayat, Ibrahim Elzayyat, Ibrahim N Alomar, Ibrahim Rakha, Ibrahim Raza, Ida Björklund, Idelso Vasquez, Ignas Rakita, Ihab Hassan, Ihdaa Adawi, Iloba Njokanma, Iman Elkadsh, Immacolata Iannone, Ingemar Havemann, Ioannis Kyriazanos, Ioannis Patoulias, Ioannis Valioulis, Ionasc Dan, Ionut Negoi, Ionut-Bogdan Diaconescu, Irene Montes, Irene Ortega-Vazquez, Isaac Amole, Isaac Bertuello, Isaac Hanley, Isam Bsisu, Islam Magdy El Sayed, Ismael Isaac Zelada Alvarez, Ismail Lawani, Israa Abdullah Aziz Al-Azraqi, Israa Adel, Israa Awad, Israa Qawasmi, Ivan Mendoza Restrepo, J Edward Fitzgerald, Jack Almy, Jacqueline Sheehan, Jaime Andres Montoya Botero, Jaime Herrera-Matta, Jakeline Restrepo, Jakov Mihanovic, James Adeniran, James Brown, James Davies, James Giles, James Glasbey, James Olivier, James Pape, James Richards, James Wheeler, James Yang, Jamie Shah, Janet Pagnozzi, Jannin Salcedo, Jasim Amin, Jason Brown, Javier Pastora, Javier Rosales, Jazmin Coronel, Jean Bréaud, Jean De La Croix Allen Ingabire, Jean-Baptiste Marret, Jean-Francois Colombani, Jean-François Lecompte, Jeffrey Dalli, Jehad Hassan Youssif, Jehad Meqbil, Jemina Onimowo, Jen Cornick, Jenifa Jeyakumar, Jennifer Nowers, Jennifer Rickard, Jennifer Skehan, Jerry Makama, Jesse Ron Swire Ting, Jessica Juliana Tan, Jessica Patricia Gonzales Stuva, Jessica Roth, Jessica Souza Luiz, Jia Hao Law, Jia Yng Siaw, Jian Er Saw, Jibran Abbasy, Jiheon Song, Jimy Harold Jara Quezada, Joachim Amoako, Joachim Wiborg, Joanna Swann, Jo-Anne Carreira, Joanne Edwards, Joe Vincent, Joel Kin Tan, Joe-Nat Clegg-Lamptey, Johanna Joosten, Johanna Nyberg, Johannes Kurt Schultz, Johannes Wiik Larsen, John Bondin, John F Camilleri-Brennan, John Jemuel V Mora, John Lee Y Allen, John Whitaker, Jolanta Gribauskaite, Jon Arne Søreide, Jon Kristian Narvestad, Jonathan Ajah, Jonathan Dakubo, Jonathan Heath, Jonathan R L Wild, Jonny Setiawan, Jorge Armando Chungui Bravo, Jorge Torres Cardozo, Jose Aguilar-Jimenez, Jose Andres Garcia-Marin, Jose Antonio Cabala Chiong, Jose Costa-Maia, José Hamasaki, José Luis Hamasaki Hamaguchi, Jose Luis Rodicio, Jose María Vergara Celis, José René Arévalo Azmitia, Joselyn Ye, Joseph Awuku-Asabre, Josephine Psaila, Joshua Luck, Joshua Michael Clements, Joyeta Razzaque, Juan Camilo Correa, Juan Carpio, Juan Gouws, Juan Jaime Herrera Matta, Juan Manuel Carmona, Juan Marcelo Delgado, Juana Kabba, Jubran J Al-Faifi, Julia Guasti Pinto Vianna, Julian Camilleri-Brennan, Juliana Menegussi, Julien Leroux, Julien Rod, Juliette Hascoet, Julio Jimenez, Junyeong Oh, Juozas Kutkevicius, Justas Kuliavas, Justas Žilinskas, Justin Chak Yiu Lam, Justus Lando, Ka Hin Gabriel Li, Ka Wai Leung, Kai Yin Lee, Kalangu Kabongo, Kalitha Pinnagoda, Kalon Hewage, Kamau Kinandu, Kamran Faisal Bhopal, Kandasami Palayan, Kareem Dabbour, Kareem Elshaer, Karen Bailey, Karim Hilal, Karl Bonavia, Karolis Lagunavicius, Karolis Varkalys, Kate Cross, Kate Yu-Ching Chang, Katharina Beate Reinisch, Katharine Whitehurst, Katherine Gash, Kathryn Chu, Kathryn Lee, Katie Connor, Katrin Gudlaugsdottir, Kaustuv Das, Kazeem Atobatele, K C Janardha, Kean Leong Koay, Keat-Seong Poh, Keiran David Clement, Keith Sammut, Keith Say Kwang Tan, Kenneth Aaniana, Kenneth Johnson, Kenneth Mealy, Kenneth Thorsen, Kenny Turpo Espinoza, Kent Pluke, Kestutis Strupas, Kevin C Conlon, Kevin Turpo Espinoza, Khaled Abozeid, Khaled Alhady, Khaled Aljboor, Khaled Dawood, Khaled Hesham Elbisomy, Khaled Ibrahim, Khaled Khattab, Khaled Naser El Deen, Khalid Mahmud, Khalid Qurie, Khalid Salah El-Dien, Khalil Abdul Bassit, Khaoula Boukhal, Khlood Ashour, Kholod Tarek Lasheen, Kholoud Abdelbadeai, Khurram Khan, Khuzaimah Zahid Syibrah, Kieran Atkinson, Kieran Ka Kei Li, Kirsten Lafferty, Kjetil Søreide, Knut Magne Augestad, Kolonia Konstantina, Konstantinos Farmakis, Konstantinos Gasteratos, Kornelija Maceviciute, Kpèmahouton René Keke, Kresimir Zamarin, Kristian Styles, Kristijonas Jasaitis, Kristijonas Jokubonis, Kristina Cassar, Kuet Jun Chung, Kuhaendran Gunaseelan, Kuok Chung Lee, Kurt Carabott, Kwabena Agbedinu, Kwaku Boakye-Yiadom, Kwame Maison, Kwasi Asare-Bediako, Kwasi Kusi, Kyaw Phyo Aung, Kylie Joan-Yi Szeto, Kyriakos Psarianos, Laimonas Uščinas, Lalith Asanka Jayasooriya Jayasooriya Arachchige, Lana Abusalem, Larissa Ines Páez Lopez, Lau Wen Liang Joel, Laura Gavagna, Laura Koskenvuo, Laura Lorenzon, Laura Luque, Laurent Fourcade, Lawal Abdullahi, Lawani Ismaïl, Lawrence Bongani Khulu, Layza-Alejandra Mercado Rodriguez, Lee Shi Yeo, Leif Israelsson, Lemuel Davies Bray, Lenin Peña, Leo Licari, Leonardo Solaini, Li Jing Yeang, Liam Henderson, Liam Richardson, Liana Roodt, Lillian Reza, Linas Urbanavicius, Linas Venclauskas, Linda Alvi Madrid Barrientos, Linda Andersson, Ling Wilson, Linn Nymo, Linnea Mauro, Liviu Iuliu Muntean, Liviu Muntean, Ljiljana Jeremic, Lofty-John Anyanwu, Lopna Ahmed Mohamed Ahmed, Lorena Fuentes-Rivera, Lorena Rodriguez, Lorena Solar García, Lorraine Sproule, Lotfy Eldamaty, Luai Jamal, Luana Ayres Da Silva, Lubna Sabeeh, Luc Hervé Samison, Luca Ansaloni, Luca Bortolasi, Luca Turati, Lucia Duinhouwer, Lucian Corneliu Vida, Lucile Fievet, Lucio Selvaggi, Ludwing Alexander Zeta Solis, Luen Shaun Chew, Luigi 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Mahmoud Warda, Mahmoud Zakaria, Mahmut Arif Yuksek, Mahnoor Javaid, Mahnuma Mahfuz Estee, Mai Ebidy, Mai Mohamed Ebidy, Mai Salama, Maíra Cassa Careta, Maja Marcus, Majd Dabboor, Majed Aboelella, Makafui Dayie, Makki Elsayed, Malcolm Falzon, Maleeha Hassan, Malin Sund, Man Fung Leung, Man Hon Andrew Yeung, Manar Abd-Elmawla, Manar Saeed, Mantas Drungilas, Mantas Jokubauskas, Mantas Vilčinskas, Manuel Francisco Roxas, Manuel Hache-Marliere, Manuel Lopez, Manuel Rodriguez Castro, Manuela Mendez, Manzoor Dar, Maram Abu-Toyour, Maram Salah, Marcelo O Higgins Roche, Marco Catani, Marco Maria Pascale, Marco Migliore, Mardelangel Zapata Ponze De Leon, Margaret O'Shea, Margarita Montrimaite, Margherita Notarnicola, Margub Hussain, Maria Clara Mendoza Arango, Maria Giovanna Grella, Maria Hjertberg, Maria Isabel Villegas Lanau, Maria Jesusa B Maño, Maria Lorena Aguilera, Maria Marta Modolo, Maria Mayasari, Maria Novella Ringressi, Maria Soledad Gonzales Montejo, Maria Soledad Merlo, Maria Utter, María Valcarcel-Saldaña, Maria-Lorena Aguilera-Arevalo, Mariam Darweesh, Mariam O Gad, Mariam Saad Aboul-Naga, Mariano Cesare Giglio, Mariastella Malavenda, Marie Carmela Lapitan, Marie Dione Parreno-Sacdalan, Marie Paul, Mariette Renaux-Petel, Marija Agius, Marilia Del Carmen Escalante Salas, Marilla Dickfos, Marina Luiza Pimenta, Mario Contreras Urquizu, Mario Corbellino, Mário Jacobe, Mario Lopez, Mario Pasini, Mario Trompetto, Marisa Leal, Marisol Manriquez-Reyes, Mariuca Popa, Mark Ian Hampton, Mark Sykes, Mark Wagener, Markus Zuber, Marte Bliksøen, Martha Glynn, Martin Jarmin, Martin Kyereh, Martina Perino, Martina Yusuf Shawky, Martinique Vella-Baldacchino, Marvin Vargas, Marwa Altarayra, Marwa Elashmawy, Marwa Elshobary, Marwa Hamdan, Marwa Sayed, Marwan Abubakr, Marwan Fahim, Marwan Shawki, Maryam Ali Khan, Maryna Shubianok, Mashael Al-Mousa, Masood Alghamdi, Masood Jawaid, Massiell Machaca, Massimiliano Dal Canto, Massimo Coletti, Matas Pažuskis, Matei Bratu, Matei Razvan Bratu, Mateusz Rubinkiewicz, Matteo Papandrea, Matteo Ripa, Mattew Ekow, Matthew Baldacchino, Matthew Billy, Matthew Young-Han Kim, Matthieu Peycelon, Matti Tolonen, Maureen Bezzina, Maurizio Foco, Mawaddah Alrajraji, Max Dénakpo, Max Rath, Mayaba Maimbo, Mazed Mohamed, Mazen Hassanain, Megan Turner, Mehmet Ali Yavuz, Mehmet Gumar, Mehmet Uluşahin, Melanie Castro Mollo, Melanie Zapata Ponze De Leon, Menatalla Salem, Mengistu Worku, Menna Tallah Ramadan, Mennaallah Hafez, Mennat-Allah Mustafa, Menold Archee P Redota, Meran Allam, Meric Mericliler, Merna Mostafa, Meryem Abbouch, Metwally Aboraya, Michael Amoah, Michael Cox, Michael Edye, Michael Gillespie, Michael Hanrahan, Michael Livingston, Michael Puttick, Michael Stoddart, Michael Van Niekerk, Michael Walsh, Michael Wilson, Michail Kontos, Michail Margaritis, Michał Janik, Micheal Ohene-Yeboah, Michela Monteleone, Michele Carlucci, Michele Sacco, Michelle Mccarthy, Midhun Mohan, Miguel Angel Paludi, Miguel Siguantay, Mihael Radic, Mihaela Vartic, Miklosh Bala, Milaksh Kumar Nirumal, Milan Radojkovic, Milica Nestorovic, Millika Ghetia, Mindaugas Kiudelis, Mircea Beuran, Mircea Hogea, Mirko Mangiapane, Mitchelle Solange De Fã Tima Linares Delgado, Moayad Othman, Mobolaji Oludara, Modise Zacharia Koto, Mohamad Baheeg, Mohamad Bakhaidar, Mohamad Jeffrey Bin Ismail, Mohamed A Abdelaziz, Mohamed A Amer, Mohamed A Baky Fahmy, Mohamed Abbas, Mohamed Abd El Slam, Mohamed Abdelaty, Mohamed Abdelaty Mohamed, Mohamed Abdelkhalek, Mohamed Abdelraheim, Mohamed Abozaid, Mohamed Abozed Abdullah, Mohamed Abuseif, Mohamed Adel Badenjki, Mohamed Ali Ghonaim, Mohamed Ali Mahmoud, Mohamed Ameen, Mohamed Ammar, Mohamed Asal, Mohamed Awad Elkarim Hamad Mohamed, Mohamed Dablouk, Mohamed El Halawany, Mohamed Elazoul, Mohamed Elbermawy, Mohamed Elfil, Mohamed Elsehimy, Mohamed Elzayat, Mohamed Etman, Mohamed F Zalabia, Mohamed Fares, Mohamed Fawzy Mahrous Badr, Mohamed Fouad Hamed, Mohamed Gadelkarim, Mohamed Ghoneem, Mohamed Gulamhussein, Mohamed Hafez, Mohamed Hashish, Mohamed Hassab Alnaby, Mohamed Husseini, Mohamed Ibrahim, Mohamed Ismail, Mohamed Karkeet, Mohamed Kelany, Mohamed Mabrouk, Mohamed Magdy, Mohamed Mahmoud, Mohamed Moamen Mohamed, Mohamed Moaty, Mohamed Mostafa, Mohamed Mustafa, Mohamed Nashat, Mohamed Nazir, Mohamed Reda Loaloa, Mohamed Rezal Abdul Aziz, Mohamed Sabry Ammar, Mohamed Salah, Mohamed Salah Elhelbawy, Mohamed Seisa, Mohamed Shaalan, Mohamed Sleem, Mohamed Sobhi Jabal, Mohamed Youssef, Mohamed Zidan, Mohamedraed Elshami, Mohammad Abdulkhalek Habeeb, Mohammad Aboraya, Mohammad Adawi, Mohammad Alherz, Mohammad Aliyu, Mohammad Elsayed Omar, Mohammad Ghannam, Mohammad Ghassan Alwafai, Mohammad Mohsin Arshad, Mohammad Rashid, Mohammadasim Amjad, Mohammed Alamoudi, Mohammed Alhendy, Mohammed AlRowais, Mohammed Alsaggaf, Mohammed Alzahrani, Mohammed Bukari, Mohammed Deputy, Mohammed Elgheriany, Mohammed Elsayed, Mohammed Elshaar, Mohammed Elsiddig, Mohammed Firdouse, Mohammed G Azizeldine, Mohammed Hanafy, Mohammed Ismail, Mohammed Kamal Ismail, Mohammed Mousa, Mohammed Mousa Salem, Mohammed Mustafa Hassan Mohammed, Mohammed Mustafa Mohammed, Mohammed Najjar, Mohammed Nasr, Mohammed Osman, Mohammed Osman Dablouk, Mohammed Saeed, Mohammed Saleh A Alghamdi, Mohammed Ubaid Alsaggaf, Mohammed Yahia Mohamed Aly, Mohannad Aledrisy, Mojolaoluwa Olugbemi, Mona Hamdy Madkor, Mona Hosh, Mona Rashad, Monica Bassem, Monique Moron Munhoz, Monty Khajanchi, Morgan Haines, Morvarid Ashtari, Mostada Samy, Mostafa Abdelkader, Mostafa Ahmed Bahaa Eldin, Mostafa Allam, Mostafa Gemeah, Mostafa Mahmoud Eid, Mostafa Qenawy, Mostafa Samy, Mostafa Seif, Mostafa Shalaby, Mousa Mustafa, Moustafa Ibrahim Mahmoud, Moustafa R Aboelsoud, Msafiri Kimaro, Muayad Ahmed Alfarsi, Muhamed M H Farhan-Alanie, Muhammad Adil, Muhammad Alkelani, Muhammad Amsyar Auni Lokman, Muhammad Bin Hasnan, Muhammad Daniyan, Muhammad El-Saied Ahmad Muhammad Gohar, Muhammad Fathi Waleed Omar, Muhammad Habib Ibrahim, Muhammad Mohsin Furqan, Muhammad Rashid Minhas Qadir, Muhammad Saqlain, Muhammad Shawqi, Muhammad Talha Butt, Muhammad Taqiyuddin Yahaya, Muhammad Waqar, Muhammed Masood Riaz, Muhammed Talaat, Muhtarima Haque, Muna Rommaneh, Murad Aljiffry, Murat Karakahya, Musah Yakubu, Muslimat Alada, Mustafa Farhad, Mustafa Mohammed Taher, Muthukumaran Rangarajan, Muwaffaq Mezeil Telfah, Myint Tun, Myranda Attard, Nada Ahmed Reda Elsayed, Nada El-Sagheer, Nada Elzahed, Nada Mohamed Bekhet, Nader Abd El Hamid, Nadia Khalid Abd El-Latif, Nadia Ortiz, Nadin Elsayed, Nadya Johanna, Nahilia Carrasco, Najwa Nadeem, Naomi J Wright, Napoleon Mendez, Narimantas E Samalavicius, Nashat Ghandora, Nasir Bustangi, Natale Di Martino, Natalie Blencowe, Natalie Redgrave, Nathalie Botto, Nathania Sutandi, Nawal Sadig, Nazmie Kariem, Nebil Behar, Nebiyou Seyoum Abebe, Nebyou Seyoum, Nebyou Seyoum Abebe, Neel Gobin, Neel Limaye, Neerav Aruldas, Nehal Yosri Elsayed Abdel-Wahab, Neil Smart, Nelson Manuel Urbina Rojas, Nelson Msiska, Nerijus Kaselis, Nermeen Soubhy El-Shahat, Nermin M Badwi, Nermin Mohamed Badwi, Nesma Elfouly, Nicholas Phillips, Nichole Starr, Nicola Chetta, Nicola Zanini, Nicolas Henric, Nicole D'aguzan, Nicole Grech, Nicoleta Panait, Nicoletta Leone, Nicolò Falco, Nidhi Gyanchandani, Nigel J Hall, Nihaal Shaikh, Niiarmah Adu-Aryee, Nik Azim Nik Abdullah, Nik Ritza Kosai, Nikica Pezelj, Nikki Green, Nikolaos Gouvas, Nikolaos Ivros, Nikolaos Mitroudis, Nikolaos Nikoloudis, Nikolaos Zampitis, Nithya Niranjan, Niveshni Maistry, Noha Abdullah, Noha Abdullah Soliman, Noha Maraie, Noha Wael, Nohad Osman, Noman Shahzad, Nora Abdul Aziz, Norah Al Subaie, Noran Abdel-Hameed, Noran Halim El Gendy, Norbert Uzabumwana, Norberto Herrera, Norma Depalma, Nosisa Sishuba, Nouf Akeel, Noura A Attallah, Nourhan Adam, Nourhan Anwar, Nourhan Elsabbagh, Nourhan Medhat Elhadary, Nourhan Mesbah, Nourhan Semeda, Nourhan Soliman, Novia Adhitama, Nowrin F Aman, Nuno Muralha, Nur Zulaika Riswan, 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Pandi Eduard, Panu Mentula, Paola Salusso, Paola Violi, Paolino De Marco, Paolo Aonzo, Paolo Silvani, Paolo Ubiali, Patrizio Mao, Paul Kielty, Paul Sutton, Paul Ugalde, Paul Witherspoon, Paul Wondoh, Pauline Gastaldi, Paulius Karumnas, Paulius Kondrotas, Paulo Alves Bezerra Morais, Pedro Angel Toribio Orbegozo, Peep Talving, Pei Ying Koh, Per Weber, Per-Olof Lundgren, Peter Deutschmann, Peter Labib, Peter Wiel Monrad-Hansen, Petras Višinskas, Phebe Anggita Gultom, Philip Alexander, Philip Choi, Philip Mshelbwala, Philip Taah Amoako, Philippe Buisson, Phoebe De Bono, Phumudzo Ndwambi, Pier Paolo Grandinetti, Piergiorgio Danelli, Pierpaolo Sileri, Pietra Ligure, Pietro Mingrone, Pigeneswaren Yoganathan, Piotr Major, Poddevin Francois, Povilas Ignatavicius, Povilas Mazrimas, Prasad Pitigala Arachchi, Pratik Jain, Prince Kwakyeafriyie, Prisca A L Har, Pui Xin Chin, Puneet Malik, Puyearashid Nashidengo, Qinyang Liu, Quentin Alimi, Quentin Ballouhey, Quinn Ellison, R Goh Ern Tze, Rachel 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Abdelrouf, Doaa, Pata, Domenica, Mapasse, Domingo, Charles Marshall, Dominic, B O'Connor, Donal, Danys, Donata, Venskutonis, Donata, Radkowiak, Dorota, Bowley, Doug, Majauskyté, Dovilè, Irusha Samaraweera, Dulan, Lacthman Jethwani, Durvesh, Iyer, Dush, Iyer, Dushyant, Khokha, Dziani, Paulouski, Dzmitry, Takyi Atkins, Ebenezer, Anis, Echaieb, Domini, Edgar, Temoche, Edilberto, Huaman, Eduardo, Grisin, Edvard, Dainius, Edvina, Thomas, Efeson, Preckailaite, Egle, Alnawam, Ehab, Mamdouh, Ehab, Kjus Aahlin, Eirik, Kefalidi, Eirini, Mensah, Ekow, Borg, Elaine, Prisca Refianti Sutanto, Eldaa, Marks, Eleanor, Goldin, Elena, Muzio, Elena, Vendramin, Elena, Zdanyte Sruogiene, Elena, Ciccioli, Eleonora, Jovine, Elio, Francone, Elisa, Jensen, Elisabeth, Rifhan Mohd Basir, Elissa, Snyder, Elizabeth, Teasdale, Ella, Akoto, Elliot, Gaignard, Elodie, Haraux, Elodie, Robert, Elsa, Ali, Elsayed, Gamaly, Elsayed, Abdallah, Emad, Al-Dakka, Emad, Ali Ahmed, Emad, Aljohani, Emad, Mohamed Saeed Taha, Emad, 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Tuan, Sholadoye, Tunde, Mak, Twc, Rouse, Tyler, Chen, Tzu-Ling, Muddebihal, Uday, Karabacak, Ufuk, Gunnarsson, Ulf, Gustafsson, Ulf, Muktar, Umar, Tedeschi, Umberto, Salma, Umme, Hantour, Usama, Alamoudi, Uthman, Jotautas, Valdemara, Parent, Valentine, Dina Palomino Castillo, Vanessa, Msosa, Vanessa, Guglielmo, Vania, Silvestri, Vania, Despotidis, Vasileio, Kalles, Vasileio, Soulou, Vasiliki, Kalles, Vassili, Shatkar, Veereanna, Barendegere, Venerand, Grassi, Veronica, Lazzari, Veronica, Jennings, Vicky, Dassah, Victor, Etwire, Victor, Kong, Victor, Manuel Quintero Riaza, Victor, Nwinee, Victor, K Proctor, Victoria, Upadhyaya, Vijaid, Gadhvi, Vijay, Ambrozeviciute, Viktorija, Nevieraite, Viktorija, Sallinen, Ville, Thanusan, Vimalakanthan, Jonas Banaitis, Vinca, Beisa, Virgiliju, Sollazzo, Viviana, Graffieille, Vivien, Jean Paul Nsengimana, Vizir, Khokha, Vladimir, Thanh Hien Le, Vu, Gaižauskas, Vytauta, Lipnickas, Vytauta, Anwer, Wahid, Cheong Soon, Wai, Him Lam, Wai, Ndegwa, Wairimu, 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Esthefany Alejos Bermúdez, Ysabel, Cengiz, Yücel, Hong Eric Cheung, Yuk, Altinel, Yuksel, Kok Ng, Yung, Macchitella, Yuri, Aigrain, Yve, Mikwar, Zaher, Jaffry, Zahra, Ali Khan, Zain, Iftikhar, Zainab, M Elsayed, Zaynab, Zhang, Zhongtao, Hao Sam, Zi, Urniežius, Zigmanta, Dambrauskas, Zilvina, Bentounsi, Zineb, Tverskis, Zygimantas, Reuter A., Rogge L., Monahan M., Kachapila M., Morton D.G., Davies J., Vollmer S., Essam A.A., Sallam A.E., Elshafay A.E., Khedr A.E.-R.H., Saad A.G., Gharib A., Kenibar A., Elsherbiny A.S., Adel A., Abdelaal A., Elhendawy A.O.A., Hussein A., Belkouchi A., Hrora A., Adelshone A., Alkammash A., Assal A., Geuoshy A., Haroun A., Mohammed A., Sayed A., Soliman A., Elnemr A.E., Darwish A.K.Z., Elsebaaye A.O., Khalique A., Alvi A.R., Anwar A.W., Altwijri A., Al-Mallah A., Almoflihi A., Altamimi A., Daqeeq A., Dwydar A., Gouda A., Hashim A., Altaf A., Huwait A., Abdel-Aty A., Altwigry A.M., Sheshe A., Nasir A.A., Lawal A.O., Abdrabou A.K., Abdurrazzaaq A., Zerihun A.B., Al-Shammari A., Gendy A.E., Esam A., Marey A., Mittal A., Yifieyeh A., Bin Mahamood A., Adesuyi A., Aly A.K., Nawawi A., Gyedu A., Waterman A., Osinowo A., Fatuga A., Albiety A., Hassanein A.B., Denewar A., Adekoya A., Adebanjo A., Adeyeye A., Popoola A., Adedeji A., Ademuyiwa A.O., Tade A., Adeniyi A., Adisa A.O., Tarek A., Ladukas A., Palma A.F., Hasanah A., Salleh A., Abdelfatah A., Altamini A., Fitsum A., Taiwo A., Hassan A., Ghaben A., Fattah A.A., Al Rafati A.A.R., Ibrahem A.A., Aldalaq A., Ali A., Almallah A., Alrifaie A., Ashour A., Bakr A., Bani-Sadar A., Bin Adnan A., Elbatahgy A., Faraz A., Gudal A., Hasan A., Sabe A.K., Khoja A., Nashaat A., Qaissieh A., Sabe A., Sleem A.S., Sakr A., Shalabi A., Qureshi A.U., Aamer A., El Galeel A.A., Elhusseiny A.A.E., Elsameea A.A., Abdelkareem A., Ghazy A.A., El Magd A.A., Elazayem A.A., Adamu A., Afandy A., Ahmed A., Alghamdi A., Al-Khatib A., Altibi A., Alzahrani A., Ata A., Badr A., Dahy A., Diab A., Kashash A.E., Kholy A.E., Musa A.E.K., Elgebaly A., Elkelany A., Elkholy A., El-Sehily A., Essam A., Fahiem A., Farag A., Fawzy A., Fouad A., Gad A., Ghanem A., Gheith A., Gomaa A., El-Badri Kotb A.H., Hammad A., Rida A.H.E.F., Ismail A., Karim A., Khyrallh A., Lasheen A., Rashed A.M., Magdy A., Abdelraouf A.M., Menshawy A., Meshref A., Afifi A.M., Ibrahim A.M., Mohameden A., Mokhtar A., Mosad A., Moustafa A., Saeed A.M., Negida A., Mohammed A.R., Mohamed A.R., Nayel A.R., Soliman A.R., Raslan A., Raza A., Refaat A., Rslan A., Sabry A., El-Hamouly A.S., Marey A.S., Saidbadr A., Samir A., Shahine A., Sheta A., Tammam A., Hassan A.T.A., Shamsedine A.W., Zaki A., Eldeeb A.Z., Zohair A., Kandil A.M., Elnagar A., Zil-E-Ali A., Jabbar A., Snaith A.C., Costas-Chavarri A., Austraite A., Mistry A., Olaolorun A., Ajao A.E., Jubran A.F., Shamasneh A., Abouelnasr A., Al-Buhaisi A., Bowabsak A., Jamassi A.E., Elazab A., Elhadad A., Fergany A., Habeebullah A., Shabkah A., Shaheen A., Adesina A., Baird A., Grant A., Ball A., Cacurri A., Mphatsoe A.M., Luc A.R., Matheu A., Munera A., Bedada A.G., Favero A., Maniscalco A., Calua A.C., Fowler A.J., Gerosa A., Horobjowsky A., De Sousa A.V., Farrugia A., Arnaud A.P., Russo A.A., Gulielmi A., Ababneh A., El Dahab A.A., Ata A.A.A., Niazi A.K., Kiasat A., Hammad A.M., Zardab A., Balkan A.Z.A., Toeema A.G., Sadek A., Filatau A., Latif A., Suarez A.A.B., Faure A., Niragire A., Robledo-Rabanal A., Broch A., Hasheminia A., Macdonald A., Ndajiwo A., Novak A., Mutabazi A.Z., Beleno A.E.M., Cheah A.E.Z., Elrazek A.A., Nasr A., Sanad A., Elgendy A.H., Cury A.D.L., Ibrahim A., Martin A., Althwainy A., Abouzahra A., Mohammed A.E., Kourdouli A., Hashish A., Birring A., Al Meligy A., Abdelhamid A., Majid A.H.H.A., Mohammad A., Kaci A.A., Omar A.A., Elsawy A., Bekhet A.H., Reda A., Qumbos A.A., Elmashala A., Gado A., Mohamed A.M., Mohamed A., Rasendran A., Saleh A.A., Fadel A., Hassaan A., Hossameldin A., Elkorashy A.M., Hafez A.T., Faruq A., Aglan A., Bautista A.C.M., Contreras-Vergara A.L., Barrantes A.M.S., De Freitas A.V.C., Freitas A.V., Rashid A., Abdelazeam A.R., Kirishnan A., Majbar A., Bamicha A., Stefanopoulos A., Thorell A., Das A., Dubois A., Mihaljevic A.L., Navarro A., Allegri A., Armellini A., Belli A., Bondurri A., Moran A.E.R., Natili A., Ruzzenente A., Simioni A., Haloho A., Tanase A., Kolosov A., Subocius A., Robertson A.G.N., Kirby A., McGuigan A., Spina A., Litvin A., Burmistrovas A., Strazdas A., Arenas A., Bhangu A., Rudzenskaite A., Rojas A.D.P., Dell A., Mejia A.G.V., Charles A., Antoniozzi A., Benevento A., Tselos A., El-Ma'doul A.S., Sreedharan A., Bhatnagar A., Kjellin A., Lasek A., Maffioli A., Powell A., Rinaldi A., Watts A., lo Conte A., Bigaran A., Ashton A., Mukin A.D.F., Gulbinas A., Zadoroznas A., Rulie A.S., Ajiboye A., Avoka A., Lai A.C.-H., Davor A., Sander A., Oosterkamp A., Bediako-Bowan A., Brocca A.L., Leal A., Nocito A., La Medina A.R.-D., Taddei A., Atiyeh A., Kojo A.T.T., Driscoll A., Shah A., Vlachogiorgos A., Roslani A.C., Abdelhaq A., del Pilar Paucar A., Picciariello A., Kanani A., Leppaniemi A., Birindelli A., Nesaratnam A., Suyadi A., Velasquez A.J.R., Bonnard A., Agarwal A., Alkaaki A., Vaicius A., Khamajeet A., Reinsoo A., Abouzaid A., Elfarargy A., Kedar A., Alnusairat A., Hamarshi A., Musleh A., Prabhudesai A., Maghrabi A.A., Morsi A., Mitul A.R., Abdelgelil A., Al-Aarag A.A.-R., Rezq A., Salah A., Papailia A., Badwy A., Leusink A., Khan A., Eysa A., Zulkifli A., Mahdi A., Attia A., Attia A.M., Clarissa A., Dulskas A., Parseliunas A., Zani A., Tun A.K., Mironescu A., Mironescu A.S., Scalabre A., Mariani A., Haffreingue A., Thollot A., Usaityte A., Skardziukaite A., Ibraheem A.A.F., Aboarab A., Elsharkawy A.A., El-Sawy A., Elwaey A., Firwana A., Hagar A., Fathy A.M., Ata A.Y., Hamdan A., Taher A.A., Elwan A., Nabawi A., Salman A., Shwky A., Ogunyemi A., Herebat A., Verjee A., Adenekan B., Odeyemi B., Adel B.E., Tawfik B.A., Ozkan B.B., Mohamed B., Nighat B., Albeladi B., Malaga B., Mijuskovic B., Silvestre B.P., Kumar B., Sieda B., Bello B., Alghamdi B., Magdy B., Mahmoud B., Alhassan B., Mowafy B., Brunoni B., Weber B., Sanchez B., Thompson B., Parmentier B., Limoges B., Van Duren B., Wolf B., Dousset B., Grizhja B., Lieske B., Maillot B., Mansour B., Frisk B., Diaconescu B., Martian B.-V., Marinkovic B., Skelly B., Cameron B., Dedekind B., Noukpozounkou B., Chong B.F.H.K., Kumar B.S., de Lima C.V.B., Iacono C., Fairfield C., Samaniego C.S., Cona C., Lopez-Arevalo C., Normile C., Venugopal C., Cabrera C.C.R., Torres C.P.G., Corbellini C., Basto C.A.A., Velasquez C.I.P., Morales C., Nsengiyumva C., Galvez C.P., Capito C., Fernandez C., Diaz-Zorrilla C., Duenas C.G., Felipe C.O., Clifford C., Musyoka C.K., Shaw C.A., Magee C., Muller C., Costa C., Tolg C., Wredberg C., Del Basso C., Grosos C., Mendizabal C.A.A., Miranda C., Razuri C., Ciubotaru C., Chibuye C., Alexandre C., Szeto C.C.L., Dally C., McIntyre C.J., Benyaiche C., Chong C.L., Wong C.S., Gan C., Currow C., Deane C., Goh C.C., Koh C., Yong C.O., Khatri C., Foo C.C., Fok C.Y.J., Kong C., Ceriani C., Kwatiwani C., Yip C., Tedjaatmadja C., Chong C.S., Taieb C., Tan C.L., Bode C., Lee C., Almanon C.L., Hinojosa C., Coompson C.L., Schoewe C., Neophytou C., Major C.P., Panteli C., Mizzi C., Ferousis C., Agalianos C., Anthoulakis C., Barkolias C., Dervenis C., Chai C.-A., Wong C.Y., Fahy C., Evajelista C.V., De Emergencia C., Zarb C., Ali C.D.M., Sharpin C., Puma C.M.H., Rees C.M., Morgan C., Reali C., Arcudi C., Fermani C., Fermani C.G., Nawara C., Onuoha C., Mangan C., Sampson C., Nwokoro C., Jean-Francois C., Marinos C., Mukuzunga C., Bottini C., Gouldthorpe C., Lopez C.E., Fernandes C., Chow C.Y.N., Manipal C.E., Vimalachandran D., Alkhabbaz D., Hemeda D., Brown D., Ljuhar D., Deckelbaum D.L., Jaradat D., Du Plessis D., Soeselo D.A., Cox D., Dabessa D., Rodriguez D.E.M., Hamill D., Nel D., Youssef D., Magri D., Angelieri D., Gui D., Cruz D.H., Sale D., Gbessi D.G., Andreotti D., Kazanavicius D., McCullagh D., McNish D., Merlini D., Cohen D.M., De Boni D., Rossi D., Aziz D.N.A., Grobler D.C., Schivo D., Chiesa D., Mikuckyte D., Dragatas D., Gray D., Elsorogy D.E.A.A., Elsawahly D.M.E., Zahran D., Cadogan D.D., Sanchez D., Bandoh D., Pozo D.A.R., Antezana D., Coletta D., Romani D., Sasia D., Ofner D., Duhoranenayo D., Raptis D.A., Balalis D., Manatakis D.K., Karousos D., Korkolis D., Kyziridis D., Lytras D., Papageorgiou D., Sfougaris D., Zachariades D.-C., Al-Marakby D., Rahmah D.F., Gamal D., Tarek D., Periasammy D., dos Santos D.V., Morton D., Mirghani D., Seto D.M., Cocker D.M., Nepogodiev D., Raptis D., Emadeldin D., Gamil D., Hasan D., Hasanain D., Abdelrouf D.M., Pata D., Mapasse D., Marshall D.C., O'Connor D.B., Danys D., Venskutonis D., Radkowiak D., Bowley D., Majauskyte D., Samaraweera D.I., Jethwani D.L., Iyer D., Khokha D., Paulouski D., Atkins E.T., Anis E., Domini E., Temoche E., Huaman E., Grisin E., Dainius E., Thomas E., Preckailaite E., Alnawam E., Mamdouh E., Aahlin E.K., Kefalidi E., Mensah E., Borg E., Sutanto E.P.R., Marks E., Goldin E., Muzio E., Vendramin E., Sruogiene E.Z., Ciccioli E., Jovine E., Francone E., Jensen E., Basir E.R.M., Snyder E., Teasdale E., Akoto E., Gaignard E., Haraux E., Robert E., Ali E., Gamaly E., Abdallah E., Al-Dakka E., Ahmed E.A., Aljohani E., Taha E.M.S., Al Raouf E.A., Abdelmageed E., Abuqwaider E., Sayma E.A., Elwy E., Emara E., Hashad E., Ibrahim E., Magdy E., Hegazy E.M., Abdulhakeem E.M., Ibrahim E.M., Morshedy E.M., Nofal E., Rashad E., Mansor E.Y., Barrios E., Rausa E., Nwabuoku E., De Luca E., Eyssartier E., Dijan E., Blower E., Jurdell E., Upchurch E., Acquah E., Akatibo E., Runigamugabo E., Alaloul E., Alqahtani E., Dagoe E., Tackie E., Farinella E., Ackom E., Appiah E.K., Farfan E.S.F., Hervieux E., Schadde E., Vicario E., Laugzemys E., Ahounou E.Y.S., Elbanby E., Ezzat E., Elkhalek E.A., Kasem E.A., Eldeen E.A., El-Gizawy E., Elhalawany E., El-Taher E., Gamal E., Ghanem E., Kasem E., Elbanby E.S., Zakaria E., Hany E., Courboin E., Lee E.X., Macdonald E., Niyirera E., Grasset E., Morandi E., Panieri E., Borin E., Voulgaris E., Slapelyte E., Woin E., Macdermid E., Harrison E.M., Khalifah E., Veronese E., Deichsel F., Aquilino F., Sabour F.A., Idris F., Leong F.Q.H., Rasoaherinomenjanahary F., Ali F.M., Iftekhar F., Sayed F., Balogun F., Al Bastawis F., Asi F., Nada F., Elzowawi F., El-Salam F.A., Sroor F., Baluch F., Elgendy F.I., Elkady F., Ntirenganya F., Elsherif F.A., Mohamed F., Al Barrawi F.E., Noor F., Bianco F., Falaschi F., Coccolini F., Zheng F., Zapata F., Alakaloko F., Lee F., Chai F.Y., Iskandar F., Altoe F., Frade F., Djivoh F., Espinoza F., Fernandez-Bueno F., Tale F., Andika F.F.A., Adella F.J., Di Franco F., Rahantasoa F.C.F.P., Henry F., Rahmawati F.N., Dedey F., Primavesi F., Iordache F.-M., Lam F.Y., Koumpa F., Steccanella F., Pata F., Riente F., Giardino F.R., Selvaggi F., Abantanga F., Dossou F., Fujii F., Regalado F., Helene F.-C., Schmitt F., Gyamfi F.E., Owusu F., Aristizabal F.A.N., Hodonou F., Du Toit F., Sauvat F., Wogensen F., Asele F.A., Saravia F., Pardo G., Nita G.E., Gallo G., Luglio G., Tessera G., Abdelazim G., Shimy G., Barnabas G.N., Samson G., Irwin G., El Ashal G., El Sayed G.S., Tawfik G., Humm G., Balducci G., Sila G.C.M., Ihediwa G., Sila G.M., Azzie G., Camilleri G.M., Gemenetzis G., Gkiokas G., Karabelias G., Kyrou G., Tzikos G., Perrotta G., Teufelberger G., Ahlonsou G., Minguez G., Maharaj G., Galiqi G., Elhoseny G., Nagy G.S., Al Saied G., Shamsi G.S., Nastri G., Pata G., Cocorullo G., Curletti G., Pagano G., Pellino G., Confalonieri G., Gravante G., Lauzikas G., Dawnay G., Simutis G., Vasquez G., Landolfo G., Lazzari G., Lamanna G.L., Pascale G., Pesenti G., Sgroi G., Devadasar G.H., Moreira G., Borda-Luque G., Clerico G., Rotunno G., Salamone G., Sammarco G., Lap G., Padmore G., Tugnoli G., Kouraklis G., McLachlan G., Wood G., Ziubryte G., Podevin G., Rosenberg G.S., Yong G.L., Mannu G.S., Banipal G.S., Vega G.M.M., Miguel G.P.S., Fraga G.P., Recinos G., Servin G.R.P., Shiwani H.A., Al-Farram H., Hakim H., Zidan H., Amin H.A.A., Abdulaziz H., El-Badawy H.A., Elwakil H., Tolba H., Elabdin H.Z., Hajeh H., Ahmed H., Saad H., Aliyu H., Ebdewi H., Asumah H., Waleed H., Saad H.A., Youssef H., Natalie H., Royson H., Anderson-Knight H., Burns H., Thomas H.S., Pahlsson H.-I., Lakshmi H.N., Jordan H., Ibraheem H.I., Al-Hameedi H.I.I., Arsyad H.M., Dharamshi H.A., Mostafa H.A., El-Sheemy H., Tahboub H., Kretzmann H., Rashwan H., Abudeeb H., Khaled H., Nurqistan H.D., Bougard H., Baraka H., Gamal H., Shaker H., Miyasato H.S., Mohan H., Woodward H., Franco H., Francois-Coridon H., Lohse H.A.S., Shakshouk H.A.G., Kandil H., Mahmoud H., Kotobi H., Mendel H., Nnaj H., Karismaningtyas H., Cruz H., Magdy H., Bakry H.M., Heng H.E., Thorarinsdottir H., Safa H., Samih H., Mircea H., Sar H.K., Wong H.Y., Chong H.-Y., Kordorwu H.E.K., Glover-Addy H., Decoud H.P., Salem 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J., Oh J., Kutkevicius J., Kuliavas J., Zilinskas J., Lam J.C.Y., Lando J., Li K.H.G., Leung K.W., Lee K.Y., Kabongo K., Pinnagoda K., Hewage K., Kinandu K., Bhopal K.F., Palayan K., Dabbour K., Elshaer K., Bailey K., Hilal K., Bonavia K., Lagunavicius K., Varkalys K., Cross K., Chang K.Y.-C., Reinisch K.B., Whitehurst K., Gash K., Chu K., Lee K., Connor K., Gudlaugsdottir K., Das K., Atobatele K., Janardha K.C., Koay K.L., Poh K.-S., Clement K.D., Sammut K., Tan K.S.K., Aaniana K., Johnson K., Mealy K., Thorsen K., Espinoza K.T., Pluke K., Strupas K., Conlon K.C., Abozeid K., Alhady K., Aljboor K., Dawood K., Elbisomy K.H., Ibrahim K., Khattab K., El Deen K.N., Mahmud K., Qurie K., El-Dien K.S., Bassit K.A., Boukhal K., Ashour K., Lasheen K.T., Abdelbadeai K., Khan K., Syibrah K.Z., Atkinson K., Li K.K.K., Lafferty K., Soreide K., Augestad K.M., Konstantina K., Farmakis K., Gasteratos K., Maceviciute K., Keke K.R., Zamarin K., Styles K., Jasaitis K., Jokubonis K., Cassar K., Chung K.J., Gunaseelan K., Lee K.C., Carabott K., Agbedinu K., Boakye-Yiadom K., Maison K., Asare-Bediako K., Kusi K., Aung K.P., Szeto K.J.-Y., Psarianos K., Uscinas L., Arachchige L.A.J.J., Abusalem L., Lopez L.I.P., Joel L.W.L., Gavagna L., Koskenvuo L., Lorenzon L., Luque L., Fourcade L., Abdullahi L., Ismail L., Khulu L.B., Rodriguez L.-A.M., Yeo L.S., Israelsson L., Bray L.D., Pena L., Licari L., Solaini L., Yeang L.J., Henderson L., Richardson L., Roodt L., Reza L., Urbanavicius L., Venclauskas L., Barrientos L.A.M., Andersson L., Wilson L., Nymo L., Mauro L., Muntean L.I., Muntean L., Jeremic L., Anyanwu L.-J., Ahmed L.A.M., Fuentes-Rivera L., Rodriguez L., Garcia L.S., Sproule L., Eldamaty L., Jamal L., Da Silva L.A., Sabeeh L., Samison L.H., Ansaloni L., Bortolasi L., Turati L., Duinhouwer L., Vida L.C., Fievet L., Selvaggi L., Solis L.A.Z., Chew L.S., Bonavina L., Bucci L., Cloro L.M., Laufer L.A.V., Barneo L., Florez L.J.G., Helguero-Santin L.M., Barreda L.M.A., Tale L., Giavarini L., De Castro Segundo L.C.B., Tatagiba L.S., Eisner L., Mata L.P.S., Vermaas M., Amoako-Boateng M., Dziak M.W., Jha M., Gimzewska M., Gran M., O'neill M., Mitroudi M., Boijsen M., Al-Faqawi M., Elmasry M., Hamad M.G.M., Nasr M., Tata M.D., Essam M., Farahat M.M., Elnajjar M.A., Abdelshafy M., Abdelshakour M., Abdulgawad M., Abozyed M.A.F., Alrahawy M., Amreia M., Badawy M., Eldafrawy M., Elfiky M., Maher M.E., Elkhadrawi M., Moghazy M.E., Gomah M., Saad M.M., Metwally M.M., Morsi M., Saad M., Saami M., Salama M., Salma M., Shalaby M., Warda M., Zakaria M., Yuksek M.A., Javaid M., Estee M.M., Ebidy M., Ebidy M.M., Careta M.C., Marcus M., Dabboor M., Aboelella M., Dayie M., Elsayed M., Falzon M., Hassan M., Sund M., Leung M.F., Yeung M.H.A., Abd-Elmawla M., Saeed M., Drungilas M., Jokubauskas M., Vilcinskas M., Roxas M.F., Hache-Marliere M., Lopez M., Castro M.R., Mendez M., Dar M., Abu-Toyour M., Salah M., Higgins Roche M.O., Catani M., Pascale M.M., Migliore M., De Leon M.Z.P., O'Shea M., Montrimaite M., Notarnicola M., Hussain M., Arango M.C.M., Grella M.G., Hjertberg M., Lanau M.I.V., Mano M.J.B., Aguilera M.L., Modolo M.M., Mayasari M., Ringressi M.N., Montejo M.S.G., Merlo M.S., Utter M., Valcarcel-Saldana M., Aguilera-Arevalo M.-L., Darweesh M., Gad M.O., Aboul-Naga M.S., Giglio M.C., Malavenda M., Lapitan M.C., Parreno-Sacdalan M.D., Paul M., Renaux-Petel M., Agius M., Del Carmen Escalante Salas M., Dickfos M., Pimenta M.L., Urquizu M.C., Corbellino M., Jacobe M., Pasini M., Trompetto M., Leal M., Manriquez-Reyes M., Popa M., Hampton M.I., Sykes M., Wagener M., Zuber M., Bliksoen M., Glynn M., Jarmin M., Kyereh M., Perino M., Shawky M.Y., Vella-Baldacchino M., Vargas M., Altarayra M., Elashmawy M., Elshobary M., Hamdan M., Sayed M., Abubakr M., Fahim M., Shawki M., Khan M.A., Shubianok M., Al-Mousa M., Alghamdi M., Jawaid M., Machaca M., Dal Canto M., Coletti M., Pazuskis M., Bratu M., Bratu M.R., Rubinkiewicz M., Papandrea M., Ripa M., Ekow M., Baldacchino M., Billy M., Kim M.Y.-H., Peycelon M., Tolonen M., Bezzina M., Foco M., Alrajraji M., Denakpo M., Rath M., Maimbo M., Mohamed M., Hassanain M., Turner M., Yavuz M.A., Gumar M., Ulusahin M., Mollo M.C., Salem M., Worku M., Ramadan M.T., Hafez M., Mustafa M.-A., Redota M.A.P., Allam M., Mericliler M., Mostafa M., Abbouch M., Aboraya M., Amoah M., Cox M., Edye M., Gillespie M., Hanrahan M., Livingston M., Puttick M., Stoddart M., Van Niekerk M., Walsh M., Wilson M., Kontos M., Margaritis M., Janik M., Ohene-Yeboah M., Monteleone M., Carlucci M., Sacco M., McCarthy M., Mohan M., Paludi M.A., Siguantay M., Radic M., Vartic M., Bala M., Nirumal M.K., Radojkovic M., Nestorovic M., Ghetia M., Kiudelis M., Beuran M., Hogea M., Mangiapane M., De Fa Tima Linares Delgado M.S., Othman M., Oludara M., Koto M.Z., Baheeg M., Bakhaidar M., Bin Ismail M.J., Abdelaziz M.A., Amer M.A., Baky Fahmy M.A., Abbas M., El Slam M.A., Abdelaty M., Mohamed M.A., Abdelkhalek M., Abdelraheim M., Abozaid M., Abdullah M.A., Abuseif M., Badenjki M.A., Ghonaim M.A., Mahmoud M.A., Ameen M., Ammar M., Asal M., Mohamed M.A.E.H., Dablouk M., El Halawany M., Elazoul M., Elbermawy M., Elfil M., Elsehimy M., Elzayat M., Etman M., Zalabia M.F., Fares M., Badr M.F.M., Hamed M.F., Gadelkarim M., Ghoneem M., Gulamhussein M., Hashish M., Alnaby M.H., Husseini M., Ibrahim M., Ismail M., Karkeet M., Kelany M., Mabrouk M., Magdy M., Mahmoud M., Mohamed M.M., Moaty M., Mustafa M., Nashat M., Nazir M., Loaloa M.R., Aziz M.R.A., Ammar M.S., Elhelbawy M.S., Seisa M., Shaalan M., Sleem M., Jabal M.S., Youssef M., Zidan M., Elshami M., Habeeb M.A., Adawi M., Alherz M., Aliyu M., Omar M.E., Ghannam M., Alwafai M.G., Arshad M.M., Rashid M., Amjad M., Alamoudi M., Alhendy M., AlRowais M., Alsaggaf M., Alzahrani M., Bukari M., Deputy M., Elgheriany M., Elshaar M., Elsiddig M., Firdouse M., Azizeldine M.G., Hanafy M., Ismail M.K., Mousa M., Salem M.M., Mohammed M.M.H., Mohammed M.M., Najjar M., Osman M., Dablouk 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P., Mingrone P., Yoganathan P., Major P., Francois P., Ignatavicius P., Mazrimas P., Arachchi P.P., Jain P., Kwakyeafriyie P., Har P.A.L., Chin P.X., Malik P., Nashidengo P., Liu Q., Alimi Q., Ballouhey Q., Ellison Q., Tze R.G.E., King R., Moore R., Amandito R., Dorani R.M.N.R., Araujo R., Soley R., Roszkowski R., Galleano R., Narayanan R., Herikstad R., Kamil R., Satoskar R., Kabariti R., Staerkle R.F., Nataraja R., Oumer R., Shaker R., Jonnalagadda R., Jaramillo R.A., Cardozo R.A.M., Mamdouh R., Saadeh R., Rodriguez-Uria R., Claire R., Abdelhamed R., Bratu R.-M., Zilinskiene R., Bennai R.M., Alyahya R., Fakher R., Husseiny R., Khreishi R., Balila R.M.H., Elashry R., El-Din R.A., Alshareef R., Saad R., Melo R., D'cruz R., Rajan R., Karim R., Velasquez R., Gilbert R., Lilford R., Opoku-Agyeman R., Spence R., Gilbert R.W., Hagan R., Alyami R., Ots R., Rakauskas R., Khan R., George R., Karlo R., Kerley R., McIntyre R., Morton R., Parker R., Tyler R., Bugeja R., Tutino R., Villa R., 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Elhadry S., Hussein S., Mahmoud S., Talukder S., Shaharuddin S., El-Din S.A., Aql S., Torres S.G., Aliyu S., Karandikar S., Koh S., Mohamed S.R., Elsheikh S., Shehata S., Tariq S., Gamal S., Elkholy S.S., Gaafar S., Tewari S., Dindyal S., Tharmalingam S., El Mesery S., Ymeri S., Nadkarni S., Ayyar S., Kong S.N., Teo S.Y., Gokani S., Lim S.Y., Holte S., Basilico S., Boni S., De Franciscis S., Gosling S.G., Gosling S., Ng S., Stock S., Juciute S., Kasputyte S., Conci S., Sandler S., Targa S., Yam S.Y., Asilah S.M.D., Kamarulzamil S.N.A., Sivaganesh S., Suleiman S.I., Chung S., Elsobky S., Mouttalib S., Abushamleh S., Elmihy S., Ahmed S.M., Turkustani S., Hmila S., Africa S., Pai S., Bhat S., Prasad S.S., Paul S., Parasyris S., Botes S., Breitenstein S., Zammit S., Berti S., Cucumazzo S., Basso S.M.M., Roncali S., Kim S.B., Saar S., Kwok S.H.-W., Van Straten S., Dias S., Chapman S.J., Kache S., McAleer S., Knight S.R., Tabiri S., Petrikenas S., Fergusson S.J., Parpoudi S., Germanos S., Roy S., Suresh S., Burger S., Baba S., Almuallem S., Kim S.-H., Das S., Bahar S., Aviles S., Limache S., Mathew S.W., Durand S.Y.A., Brincat S.D., Kruspi S., Ali S.A.W.E.W., Naqvi S.A., ul Razi S.A., Lemaire S.B., Mochet S., Rekhis S., Widiastini T.A., Ngwa T.E., Yusufali T., Al-Taher T., Yaseen T.M., Yaseen T., Naqvi T., Lawal T.A., Lawal T., Arulampalam T., Gala T., Kumar T., Grima T., Ezzat T., Razek T., Idress T., Kanta T.H., Shachykava T., Khan T., Ali T.H.A., Fautz T., Worku T., Nouh T., Pugliesi T.B., Dimech T., Tembo T., Xerri T., Pezas T., Theodosopoulos T., Giuriato T.F., Alihonou T., Feidantsis T., Fozard T., Weiser T.G., Drake T.M., Olajide T.O., Pinkney T., Prudhomme T., Sherman T., Moe T.T., Alzayat T., Hettiarachchi T.S., Lee T.S.B., White T., Gaarder T., Schuetz T., Tolotra T.E.C., Cecilia T., Malik T.A.M., Arthur T., Hall T.F., Abaliksta T., Jankus T., Poskus T., Bocchetti T., Campagnaro T., Fontana T., Mak T., Khafagy T., Veen T., Wold T.B., Chan T.-Y.K., Mat T.N.T., Sholadoye T., Mak T.W.C., Rouse T., Chen T.-L., Muddebihal U., Karabacak U., Gunnarsson U., Gustafsson U., Muktar U., Tedeschi U., Salma U., Hantour U., Alamoudi U., Jotautas V., Parent V., Castillo V.D.P., Msosa V., Guglielmo V., Silvestri V., Despotidis V., Kalles V., Soulou V., Shatkar V., Barendegere V., Grassi V., Lazzari V., Jennings V., Dassah V., Etwire V., Kong V., Riaza V.M.Q., Nwinee V., Proctor V.K., Upadhyaya V., Gadhvi V., Ambrozeviciute V., Nevieraite V., Sallinen V., Thanusan V., Banaitis V.J., Beisa V., Sollazzo V., Graffieille V., Nsengimana V.J.P., Khokha V., Le V.T.H., Gaizauskas V., Lipnickas V., Anwer W., Soon W.C., Lam W.H., Ndegwa W., Thabet W., Adham W., Forno W., Panez W.R., Nasir W.N.A.W.M., Senanayake W.S.M.K.J., Hamsho W., Dar W., Alhazmi W., Guo W., Ho W., Dao W., Aguilar W.L.M., Goh W., Jeo W.S., Pino W., Appeadu-Mensah W., Beasley W., Bonney W., Hutch W., Lossius W.J., Milligan W., Ticona W.A., Li W.S., Chachulski W., Delforge X., Rodriguez X., Low X., Chan X.W., Neo Y.T., Souaibou Y.I., Ukwenya Y., Salama Y., Rajjoub Y., Ibrahim Y., Abd-Elrasoul Y., Elfouly Y., Hegazy Y., Soliman Y., El Salam Y.A., Tan Y.W., Zakaria Y., Reddy Y., Tan Y.K., Mok Y.T., Cheong Y.J., Gan Y.Y., Der Y., Mogan Y.P., Allam Y., Asar Y.H., Tew Y.Y., Abuowda Y., Shoura Y.E., Bermudez Y.E.A., Cengiz Y., Cheung Y.H.E., Altinel Y., Ng Y.K., Macchitella Y., Aigrain Y., Mikwar Z., Jaffry Z., Khan Z.A., Iftikhar Z., Elsayed Z.M., Zhang Z., Sam Z.H., Urniezius Z., Dambrauskas Z., Bentounsi Z., and Tverskis Z.

Subjects
surgical unmetneed, no keywords listed, appendicitis, global surgery, Financial Stress, Health Care Costs, Appendicitis, Financial Stre, Health Care Cost, Cost of Illness, Humans, appendicitis,economic burden, surgery, Surgery, Appendiciti, Human
Abstract

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and $73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and $75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially.

Published
2022

10. [Pediatric guidelines for coeliac disease: Treatment and follow-up].

Author

Ortiz G, Mora M, Toca MDC, Orsi M, Furnes R, Litwin N, Wagener M, Guzmán L, Bastianelli C, Martín G, Guouman A, Cóccolo S, Botero A, Ursino F, Menéndez L, Oviedo A, Kahane V, García de Dávila MT, González J, Sosa P, and Levy L

Abstract

The goal of the treatment is to relieve symptoms, achieve duodenal mucosal healing, avoid long term complications, and ensure children´s appropriate growth, for which it´s necessary to follow a lifelong, nutritionally complete and healthy gluten free diet (GFD). The Celiac Disease Working Group of the Gastroenterology Committee of the Sociedad Argentina de Pediatría developed this guide based on expert consensus, aimed at gastroenterologists, pediatricians and primary care physicians with the objective of updating the following topics: Treatment. Definition of gluten free food. Nutritional approach to children with celiac disease. Clinical, nutritional aspects and laboratory tests that should be monitored at initial controls. The importance of follow up visits, their frequency, which professionals should make up the monitoring team and what should be assessed. How to assess adherence to the GFD and other recommendations., (Sociedad Argentina de Pediatría)

Published
2024
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11. Comparison of invasive and non-invasive gradients before and after TAVI and their implications on clinical outcomes.

Author

Pfenniger A, Stolte T, Reichl JJ, Leibundgut G, Wagener M, Kaiser C, Boeddinghaus J, Mahfoud F, and Nestelberger T

Abstract

Transcatheter aortic valve implantation (TAVI) is recommended for treatment of high-risk aortic stenosis patients. While measuring mean transaortic valve gradient (MG) is crucial in evaluating procedural success, echocardiographic measurements often overestimate direct invasive measurements. This study aimed to examine the discordance between echocardiographic and invasive MGs in TAVI patients and assess their prognostic value on long-term outcomes. This prospective registry included consecutive TAVI patients at a tertiary university hospital. Transthoracic or transoesophageal echocardiography was performed pre-TAVI, at discharge, 1 month, 1, and 5 years with invasive MG measurements obtained peri-procedurally. The primary endpoints were 5-year all-cause mortality and major adverse cardiac events. Among 1353 patients from 2011 to 2023, non-invasive MGs exceeded invasive MGs pre- and post-implantation (43 [36, 52] mmHg vs. 40 [30, 50] mmHg, p < 0.001; 9 [6, 12] mmHg vs. 4 [2, 7] mmHg, p < 0.001) Pre-procedural MGs correlated better than post-procedural MGs (r = 0.70, p < 0.001 vs. r = 0.23, p < 0.001), particularly in self-expandable valves and smaller sinus of Valsalva diameter (SOVd) (r = 0.33, p < 0.001; r = 0.46, p < 0.001 vs R = 0.06, p = 0.701). Non-invasive MG remained stable from discharge (9 [6, 12] mmHg) to 5 years (9 [7, 12] mmHg). While structural valve deterioration and patient-prosthesis mismatch showed no impact, extreme invasive MGs (< 3 or > 6 mmHg) predicted worse outcomes (mortality hazard: 1.25 [1.06, 1.88] and 0.85 [0.8, 0.95], respectively), unlike non-invasive measurements. In conclusion, invasive as compared with non-invasive MGs correlated better before than after valve implantation, whereas invasive MGs were always lower than non-invasive MGs. Lower invasive MGs after TAVI appeared to be associated with favourable long-term outcomes., (© 2024. The Author(s).)

Published
2024
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12. [Pediatric coeliac disease: Clinical features and diagnostic process].

Author

Ortiz G, Toca MDC, Mora M, Orsi M, Furnes R, Litwin N, Wagener M, Guzmán L, Bastianelli C, Martin G, Guouman A, Coccolo S, Botero A, Ursino F, Menéndez L, Oviedo A, Kahane V, García de Dávila MT, González J, Sosa P, and Levy L

Abstract

Celiac disease is a chronic condition that affects approximately 1% of the world's population, becoming a public health problem. The numerous publications and international guides published in recent years make it necessary to update aspects related to its diagnosis. Highly sensitive and specific serological determinations have allowed the identification of the clinical polymorphism. The Celiac Disease Working Group of the Gastroenterology Committee of the Sociedad Argentina de Pediatría. developed this consensus based on the opinion of experts, aimed at pediatricians, updating the following topics: definition, classification of clinical forms, recommended serological determinations, indication for duodenal biopsies, histopathological classification, usefulness of genetic study., (Sociedad Argentina de Pediatría.)

Published
2024
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13. TAVI with the ACURATE neo2 in severe bicuspid aortic valve stenosis: the Neo2 BAV Registry.

Author

Ruck A, Kim WK, Del Sole PA, Wagener M, McInerney A, Yacoub MS, Hasabo EA, Ayhan C, Elzomor H, Neiroukh D, Amir A, Saleh N, Settergren M, Lindler R, Verouhis D, Sossalla S, Renker M, Montorfano M, Bellini B, Suarez XC, Del Olmo VV, De Marco F, Biroli M, Mollmann H, Enno EC, Tarantini G, Fabris T, Ielasi A, Costa G, Barbanti M, Soliman O, and Mylotte D

Abstract

Background: The ACURATE neo2 is a contemporary transcatheter aortic valve implantation (TAVI) system approved for the treatment of severe aortic stenosis in Europe. The ACURATE neo2 has not been evaluated in bicuspid aortic valve (BAV) stenosis., Aims: We sought to evaluate the safety and efficacy of ACURATE neo2 in patients with BAV stenosis., Methods: We retrospectively analysed consecutive severe BAV stenosis patients undergoing TAVI with ACURATE neo2 at 10 European centres. Imaging data from preprocedural multislice computed tomography, pre- and postprocedural echocardiography, and procedural cinefluoroscopy were evaluated by a core laboratory. Valve Academic Research Consortium 3 (VARC-3)-defined 30-day procedure safety and efficacy were the primary endpoints. Adverse events were site-reported according to VARC-3 criteria., Results: Among 181 patients with BAV stenosis treated with the ACURATE neo2, the mean age was 77.5±7.2 years, 58.0% were female, and the Society of Thoracic Surgeons Predicted Risk of Mortality (STS-PROM) score was 2.3% (1.6-3.7%). Most procedures were transfemoral, and predilatation was performed in all cases. A second valve was required in 4 cases (2.2%). VARC-3-defined technical success was 95.6%. The primary endpoints of device success and early safety occurred in 90.6% and 82.3%, respectively. At 30 days, cardiovascular death occurred in 2.2% (N=4) and stroke in 1.6% (N=3). Core laboratory-adjudicated echocardiography reported an effective orifice area of 2.0 (1.7-2.5) cm 2 and a mean transvalvular gradient of 6.5 (4.6-9.0) mmHg. Half of all cases (51.2%) had no paravalvular leak, while moderate leak occurred in 4.3%. A new permanent pacemaker was required in 11 patients (6.5%)., Conclusions: The ACURATE neo2 demonstrated favourable clinical outcomes and bioprosthetic valve performance at 30 days in selected patients with severe BAV stenosis.

Published
2024
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14. Does renal denervation require cardiovascular outcome-driven data?

Author

Haider SA, Wagener M, Iqbal T, Shahzad S, Del Sole PA, Leahy N, Murphy D, Sharif R, Ullah I, and Sharif F

Subjects
Humans, Cardiovascular Diseases, Blood Pressure physiology, Sympathectomy methods, Treatment Outcome, Denervation methods, Randomized Controlled Trials as Topic, Kidney innervation, Hypertension surgery, Hypertension drug therapy
Abstract

Hypertension is a major driver of cardiovascular disease with a prevalence of 32-34% in adults worldwide. This poses a formidable unmet challenge for healthcare systems, highlighting the need for enhanced treatment strategies. Since 2017, eight major sham-controlled randomised controlled trials have examined the effectiveness and safety of renal denervation (RDN) as therapy for BP control. Although most trials demonstrated a reduction in systolic 24-hour/daytime ambulatory BP compared to control groups, open to discussion is whether major adverse cardiovascular events (MACE)-driven RDN trials are necessary or whether the proof of BP reduction as a surrogate for better cardiovascular outcomes is sufficient. We conducted an analysis of the statistical methods used in various trials to assess endpoint definitions and determine the necessity for MACE-driven outcome data. Such comprehensive analysis provides further evidence to confidently conclude that RDN significantly reduces blood pressure compared to sham controls. Importantly, this enables the interpolation of RDN trial endpoints with other studies that report on outcome data, such as pharmacological trials which demonstrate a significant reduction in MACE risk with a decrease in BP. Moreover, limitations associated with directly evaluating outcome data further support the use of BP as a surrogate endpoint. For example, conducting lengthier trials with larger numbers of participants to ensure robust statistical power presents a substantial challenge to evaluating outcome data. Thus, in light of the crucial need to tackle hypertension, there are notable advantages of considering BP as a surrogate for outcome data., (© 2024. The Author(s).)

Published
2024
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15. Features and Limitations of Robotically Assisted Percutaneous Coronary Intervention (R-PCI): A Systematic Review of R-PCI.

Author

Wagener M, Onuma Y, Sharif R, Coen E, Wijns W, and Sharif F

Abstract

Background: Ischaemic heart disease is one of the major drivers of cardiovascular death in Europe. Since the first percutaneous coronary intervention (PCI) in 1977, developments and innovations in cardiology have made PCI the treatment of choice for stenotic coronary artery disease. To address the occupational hazards related to chronic exposure to radiation and wear and tear from heavy lead-based radioprotective aprons, the concept of robotically assisted PCI (R-PCI) was introduced in 2005. Aim: To explore the features and limitations of R-PCI, we first discuss the concept and evolution of R-PCI platforms and then systematically review the available clinical data. Methods: A systematic review has been performed across the Pubmed, Embase and Cochrane databases in order to assess the efficacy and safety of R-PCI. Secondary endpoints, such as operator and patient exposure to radiation, contrast volume used and procedural time, were assessed when available. Results: In selected patients, R-PCI provides high technical and clinical success rates, ranging from 81 to 98.8% and from 93.3 to 100%, respectively. In-hospital and 1-year MACE rates ranged from 0 to 10.4% and 4.8 to 10.5%, respectively. R-PCI is able to significantly reduce the operator's exposure to radiation. Further research analysing the patient's and cath lab staff's exposure to radiation is needed. Therapy escalation with R-PCI seems to be limited to complex lesions. R-PCI procedures add approximately 10 min to the procedural time. Conclusions: The efficacy and safety of R-PCI have been proven, and R-PCI is able to significantly reduce occupational hazards for the first operator. The lack of adoption in the community of interventional cardiologists may be explained by the fact that current generations of R-PCI platforms are limited by their incompatibility with advanced interventional devices and techniques needed for escalation in complex interventions.

Published
2024
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16. Two-Qubit Operations for Finite-Energy Gottesman-Kitaev-Preskill Encodings.

Author

Rojkov I, Röggla PM, Wagener M, Fontboté-Schmidt M, Welte S, Home J, and Reiter F

Abstract

We present techniques for performing two-qubit gates on Gottesman-Kitaev-Preskill (GKP) codes with finite energy, and find that operations designed for ideal infinite-energy codes create undesired entanglement when applied to physically realistic states. We demonstrate that this can be mitigated using recently developed local error-correction protocols, and evaluate the resulting performance. We also propose energy-conserving finite-energy gate implementations which largely avoid the need for further correction.

Published
2024
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17. Prognostic Impact of Left Ventricular Ejection Fraction Improvement after Transcatheter Aortic Valve Replacement.

Author

Reichl JJ, Stolte T, Tang S, Boeddinghaus J, Wagener M, Leibundgut G, Kaiser CA, and Nestelberger T

Abstract

Introduction : Transcatheter aortic valve replacement (TAVR) has become an efficient and safe alternative to surgical aortic valve replacement (SAVR). While severe aortic stenosis as well as severe aortic regurgitation (AR) are known to negatively impact left ventricular ejection fraction (LVEF), prior studies have shown that TAVR can lead to an improvement in LVEF. Thus far, little is known about the prognostic implication of LVEF improvement as a sole predictor of outcomes. Therefore, the aim of this study was to assess the prognostic impact of LVEF impairment before TAVR, as well as early LVEF improvement in patients undergoing TAVR. Materials and Methods : Patients undergoing TAVR in a large tertiary university hospital were consecutively included in a prospective registry. Transthoracic echocardiography (TTE) was performed at baseline, after 1 month and annually thereafter. Significant LVEF improvement was defined as a relative increase of ≥10% in LVEF at 30 days compared to baseline LVEF. The primary outcome was all-cause mortality at 1 year. Secondary outcomes were major adverse cardiovascular events (MACEs) including cardiovascular death, non-fatal myocardial infarction, stroke, bleeding and unplanned re-interventions of the aortic valve at 5 years. Results : Among 1655 patients who underwent TAVR between September 2011 and April 2024, the LVEF at baseline was available for 1556 patients. Of these, 1031 patients (66.2%) had preserved LVEF at baseline (LVEF ≥ 53%), whereas 303 patients (19.5%) had moderately reduced LVEF (40-52%) and 222 patients (14.3%) had severely reduced LVEF (<40%). Out of the patients with impaired LVEF, 155 (40.4%) patients showed a significant improvement in LVEF ≥10% after 30 days, while 229 (60.6%) patients showed no significant LVEF improvement (<10%). Patients with preserved LVEF at baseline had significantly better mortality outcomes than those with severely reduced LVEF ( p < 0.001). LVEF improvement was associated with a survival benefit after 1 year ( p = 0.009, HR 2.68, 0.95 CI 1.23-5.85) which diminished after 5 years ( p = 0.058), but patients with LVEF improvement showed lower MACE rates at 5 years ( p < 0.001). Conclusions : Preserved LVEF before TAVR is an independent predictor for improved outcomes. Additionally, early improvement in LVEF is associated with beneficial outcomes in patients undergoing TAVR.

Published
2024
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18. Chimneys and Basilicas: Do We Have White Smoke?

Author

Mylotte D and Wagener M

Subjects
Humans, Aortic Valve surgery, Prosthesis Design, Treatment Outcome, Aortic Valve Stenosis surgery, Heart Valve Prosthesis, Transcatheter Aortic Valve Replacement
Abstract

Competing Interests: Funding Support and Author Disclosures Dr Mylotte is a consultant for Medtronic, Boston Scientific, and Microport. Dr Wagener has reported that he has no relationships relevant to the contents of this paper to disclose.

Published
2024
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19. The Impact of Cerebral Embolic Protection Devices on Characteristics and Outcomes of Stroke Complicating TAVR.

Author

Levi A, Linder M, Seiffert M, Witberg G, Pilgrim T, Tomii D, Barkan YT, Van Mieghem NM, Adrichem R, Codner P, Hildick-Smith D, Arunothayaraj S, Perl L, Finkelstein A, Loewenstein I, De Backer O, Barnea R, Tarantini G, Fovino LN, Vaknin-Assa H, Mylotte D, Wagener M, Webb JG, Akodad M, Colombo A, Mangieri A, Latib A, Kargoli F, Giannini F, Ielasi A, Søndergaard L, Aviram I, Lerman TT, Kheifets M, Auriel E, and Kornowski R

Subjects
Humans, Treatment Outcome, Risk Factors, Aortic Valve diagnostic imaging, Aortic Valve surgery, Transcatheter Aortic Valve Replacement, Ischemic Stroke etiology, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Aortic Valve Stenosis complications, Stroke diagnostic imaging, Stroke etiology, Stroke prevention & control, Embolic Protection Devices
Abstract

Background: Acute ischemic stroke remains a serious complication of transcatheter aortic valve replacement (TAVR). Cerebral embolic protection devices (CEPD) were developed to mitigate the risk of acute ischemic stroke complicating TAVR (AISCT). However, the existing body of evidence does not clearly support CEPD efficacy in AISCT prevention., Objectives: In a cohort of patients with AISCT, we aimed to compare the characteristics and outcomes of patients who have had unprotected TAVR (CEPD-) vs CEPD-protected TAVR (CEPD+)., Methods: Data were derived from an international multicenter registry focusing on AISCT. We included all patients who experienced ischemic stroke within 72 hours of TAVR. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS). Primary outcomes were neurologic disability status according to the modified Rankin Score at 30 days, and 6-month all-cause death. Propensity score matched analysis was used to control for differences between groups., Results: In 18,725 TAVR procedures, 416 AISCT (2.2%) within 72 hours were documented, of which 376 were in the CEPD- TAVR group and 40 in the CEPD+ TAVR group. Although the middle cerebral artery stroke rate was similar in both groups (29.7% CEPD- vs 33.3% CEPD+; P = 0.71), AISCT in the CEPD+ group was characterized by a lower rate of internal carotid artery occlusion (0% vs 4.7%) and higher rate of vertebrobasilar system strokes (15.4% vs 5.7%; P = 0.04). AISCT was severe (NIHSS ≥15) in 21.6% CEPD- and 23.3% CEPD+ AISCT (P = 0.20). Disabling stroke rates (modified Rankin Score >1 at 30 days) were 47.3% vs 42.5% (P = 0.62), and 6-month mortality was 31.3% vs 23.3% (P = 0.61), in the CEPD- and CEPD+ groups, respectively. In the propensity score matched cohort, disabling stroke rates were 56.5% vs 41.6% (P = 0.16), and 6-month mortality was 33% vs 19.5% (P = 0.35), in the CEPD- and CEPD+ groups, respectively., Conclusions: In a large cohort of patients with AISCT, the use of CEPD had little effect on stroke distribution, severity, and outcomes., Competing Interests: Funding Support and Author Disclosures Dr Seiffert has received speaker or advisory fees from Abbott Vascular, Abiomed, Amgen, AstraZeneca, Boston Scientific, Bristol Myers Squibb, Daiichi-Sankyo, Edwards Lifesciences, Inari Medical, Medtronic, Pfizer, Shockwave Medical, and Siemens Healthineers; and a research grant from Boston Scientific—all unrelated to the submitted work. Dr Pilgrim has received institutional research grants from Edwards Lifesciences, Boston Scientific, and Biotronik; and personal fees from Biotronik, Boston Scientific, Medtronic, Abbott, and Edwards Lifesciences. Dr Van Mieghem has received research grant support from Abbott Vascular, Boston Scientific, Medtronic, Edwards Lifesciences, Daiichi-Sankyo, and AstraZeneca, and advisory/consultancy/speaker fees from JenaValve, Anteris, Siemens, Pie Medical, Materialise, Amgen, Abbott Vascular, Boston Scientific, Medtronic, Daiichi-Sankyo, Teleflex, and PulseCath BV. Dr Perl is a consultant for Edwards Lifesciences. Dr De Backer has received research grants and consultant fees from Abbott and Boston Scientific. Dr Wagener has received educational support from Medtronic. Dr Webb has been a consultant to, and has received research funding from Edwards Lifesciences, Medtronic, and Boston Scientific. Dr Akodad has received research funding from Medtronic, Biotronik, MUSE Explore, and Federation Française de Cardiologie; and is a consultant for Medtronic and Edwards Lifesciences. Dr Mangieri has received an institutional research grant from Boston Scientific; and has served on a medical advisory board for Boston Scientific. Dr Latib has served on advisory boards for Medtronic and Abbott; and has been a consultant to Edwards Lifesciences. Dr Søndergaard is chief medical officer at Abbott Structural Heart; and has received consultant fees and/or institutional research funding from Abbott, Boston Scientific, Edwards Lifesciences, Medtronic, and SMT. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (Copyright © 2024 American College of Cardiology Foundation. All rights reserved.)

Published
2024
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20. The European Lead Factory: Results from a decade of collaborative, public-private, drug discovery programs.

Author

van Vlijmen H, Pannifer AD, Cochrane P, Basting D, Li VM, Engkvist O, Ortholand JY, Wagener M, Duffy J, Finsinger D, Davis J, van Helden SP, and de Vlieger JSB

Subjects
High-Throughput Screening Assays methods, Drug Industry, Universities, Small Molecule Libraries chemistry, Drug Discovery methods
Abstract

The European Lead Factory (ELF) is a consortium of universities and small and medium-sized enterprises (SMEs) dedicated to drug discovery, and the pharmaceutical industry. This unprecedented consortium provides high-throughput screening, triage, and hit validation, including to non-consortium members. The ELF library was created through a novel compound-sharing model between nine pharmaceutical companies and expanded through library synthesis by chemistry-specialized SMEs. The library has been screened against ∼270 different targets and 15 phenotypic assays, and hits have been developed to form the basis of patents and spin-off companies. Here, we review the outcome of screening campaigns of the ELF, including the performance and physicochemical properties of the library, identification of possible frequent hitter compounds, and the effectiveness of the compound-sharing model., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Published
2024
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21. Exploring Potential Referral Pathways for Renal Artery Denervation and Developing a Centre of Excellence in Ireland.

Author

Leahy N, Wagener M, Shahzad S, Murphy D, McMorrow A, Coen E, Sharif R, and Sharif F

Abstract

Arterial hypertension is one of the most significant and prevalent risk factors for cardiovascular disease. Despite widespread awareness of the condition, as well as a multitude of available antihypertensive drug classes, rates of uncontrolled hypertension remain high on a global scale. Frequently, poor compliance with anti-hypertensive medication plays a big role in patients' inability to attain adequate blood pressure control. In individuals with resistant and/or uncontrolled hypertension, renal denervation is an emerging device-based therapy that has shown to be efficacious and safe in reducing blood pressure in several sham controlled trials. Additionally, it represents a treatment option for patients intolerant to oral pharmacotherapy. University Hospital Galway has been performing renal denervation procedures over the past number of years within multicentre, international sham-controlled trials and registries. Representing a novel and emerging antihypertensive treatment option, sources of referral for renal denervation are diverse and multiple; thus, there is an unmet need for standardised referral structures in Ireland. Herein, we review current and developing referral pathways for renal denervation at our institution, and discuss streamlined patient management and requirements to establish a centre of excellence., Competing Interests: Competing InterestsMax Wagener has received educational support from Medtronic and Synapse Medical Sisk Healthcare. Faisal Sharif has received consultancy fees from Medtronic. Faisal Sharif has received research funding from Boston Scientific, Endotronix, and Medtronic. Niall Leahy, Shirjeel Shahzad, Darragh Murphy, Amy McMorrow, Eileen Coen, and Ruth Sharif have no conflicts of interest to declare., (© The Author(s) 2024.)

Published
2024
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22. Renal Denervation as a Complementary Treatment Option for Uncontrolled Arterial Hypertension: A Situation Assessment.

Author

Wagener M, Dolan E, Arnous S, Galvin J, Murphy AW, Casserly I, Eustace J, O'Connor S, McCreery C, Shand J, Wall C, Matiullah S, and Sharif F

Abstract

Uncontrolled arterial hypertension is a major global health issue. Catheter-based renal denervation has shown to lower blood pressure in sham-controlled trials and represents a device-based, complementary treatment option for hypertension. In this situation assessment, the authors, who are practicing experts in hypertension, nephrology, general practice and cardiology in the Republic of Ireland, discuss the current evidence base for the BP-lowering efficacy and safety of catheter-based renal denervation with different modalities. Although important questions remain regarding the identification of responders, and long-term efficacy and safety of the intervention, renal denervation has the potential to provide much-needed help to address hypertension and its adverse consequences. The therapeutic approach needs to be multidisciplinary and personalised to take into account the perspective of patients and healthcare professionals in a shared decision-making process.

Published
2023
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23. Improving the Evidence-Based Practice Skills of Entry-Level Physiotherapy Students through Educational Interventions: A Scoping Review of Literature.

Author

Boshnjaku A, Arnadottir SA, Pallot A, Wagener M, and Äijö M

Subjects
Humans, Educational Status, Evidence-Based Practice, Physical Therapy Modalities, Students, Learning
Abstract

Evidence-based practice (EBP) is an essential approach in healthcare, attracting growing interest among both practitioners and researchers. This scoping review aims to (1) systematically investigate the effectiveness of pedagogical methods used to facilitate learning of the EBP approach, and (2) explore the perceptions, experiences, and issues related to these learning methods. The overarching purpose is to identify the state of the art in pedagogical methods, instruments, influences, and barriers in teaching and learning EBP within entry-level physiotherapy education programs. This scoping review was conducted following PRISMA guidelines, with PubMed and Eric databases being searched for peer-reviewed original research articles using a combination of keywords. Excluding non-pertinent articles from the initial 465 identified, 12 were eligible for final inclusion (5 quantitative, 3 qualitative, and 4 mixed-methodology studies). A range of pedagogical methods and instruments for teaching EBP in physiotherapy education were detected, all of which having the capability to positively affect physiotherapy outcomes. Findings from this study support the significant influence that EBP exerts on the improving of the quality of teaching, together with the necessities that the involvement of EBP in physiotherapy education programs provide. Several barriers were identified, which should be taken into consideration when designing population-specific EBP strategies tailored to these particular needs.

Published
2023
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24. Feasibility and Safety of Same-Day Discharge Following Radiofrequency Renal Artery Sympathetic Denervation.

Author

Fezzi S, Gibson W, Wagener M, Murphy D, Coen E, Serruys PW, Onuma Y, and Sharif F

Subjects
Humans, Renal Artery, Feasibility Studies, Patient Discharge, Sympathectomy adverse effects, Kidney blood supply, Blood Pressure, Denervation, Sympathetic Nervous System surgery, Hypertension diagnosis, Hypertension surgery, Catheter Ablation adverse effects
Published
2023
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25. Predictors of Conduction Disturbances Requiring New Permanent Pacemaker Implantation following Transcatheter Aortic Valve Implantation Using the Evolut Series.

Author

Abdelshafy M, Elkoumy A, Elzomor H, Abdelghani M, Campbell R, Kennedy C, Kenny Gibson W, Fezzi S, Nolan P, Wagener M, Arsang-Jang S, Mohamed SK, Mostafa M, Shawky I, MacNeill B, McInerney A, Mylotte D, and Soliman O

Abstract

(1) Background: Conduction disturbance requiring a new permanent pacemaker (PPM) after transcatheter aortic valve implantation (TAVI) has traditionally been a common complication. New implantation techniques with self-expanding platforms have reportedly reduced the incidence of PPM. We sought to investigate the predictors of PPM at 30 days after TAVI using Evolut R/PRO/PRO+; (2) Methods: Consecutive patients who underwent TAVI with the Evolut platform between October 2019 and August 2022 at University Hospital Galway, Ireland, were included. Patients who had a prior PPM ( n = 10), valve-in-valve procedures ( n = 8) or received >1 valve during the index procedure ( n = 3) were excluded. Baseline clinical, electrocardiographic (ECG), echocardiographic and multislice computed tomography (MSCT) parameters were analyzed. Pre-TAVI MSCT analysis included membranous septum (MS) length, a semi-quantitative calcification analysis of the aortic valve leaflets, left ventricular outflow tract, and mitral annulus. Furthermore, the implantation depth (ID) was measured from the final aortography. Multivariate binary logistic analysis and receiver operating characteristic (ROC) curve analysis were used to identify independent predictors and the optimal MS and ID cutoff values to predict new PPM requirements, respectively; (3) Results: A total of 129 TAVI patients were included (age = 81.3 ± 5.3 years; 36% female; median EuroSCORE II 3.2 [2.0, 5.4]). Fifteen patients (11.6%) required PPM after 30 days. The patients requiring new PPM at 30 days were more likely to have a lower European System for Cardiac Operative Risk Evaluation II, increased prevalence of right bundle branch block (RBBB) at baseline ECG, have a higher mitral annular calcification severity and have a shorter MS on preprocedural MSCT analysis, and have a ID, as shown on the final aortogram. From the multivariate analysis, pre-TAVI RBBB, MS length, and ID were shown to be predictors of new PPM. An MS length of <2.85 mm (AUC = 0.85, 95%CI: (0.77, 0.93)) and ID of >3.99 mm (area under the curve (AUC) = 0.79, (95% confidence interval (CI): (0.68, 0.90)) were found to be the optimal cut-offs for predicting new PPM requirements; (4) Conclusions: Membranous septum length and implantation depth were found to be independent predictors of new PPM post-TAVI with the Evolut platform. Patient-specific implantation depth could be used to mitigate the requirement for new PPM.

Published
2023
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26. Clinical Outcomes in High-Gradient, Classical Low-Flow, Low-Gradient, and Paradoxical Low-Flow, Low-Gradient Aortic Stenosis After Transcatheter Aortic Valve Implantation: A Report From the SwissTAVI Registry.

Author

Wagener M, Reuthebuch O, Heg D, Tüller D, Ferrari E, Grünenfelder J, Huber C, Moarof I, Muller O, Nietlispach F, Noble S, Roffi M, Taramasso M, Templin C, Toggweiler S, Wenaweser P, Windecker S, Stortecky S, and Jeger R

Subjects
Humans, Aortic Valve diagnostic imaging, Aortic Valve surgery, Prospective Studies, Treatment Outcome, Retrospective Studies, Registries, Severity of Illness Index, Transcatheter Aortic Valve Replacement, Aortic Valve Stenosis
Abstract

Background In view of the rising global burden of severe symptomatic aortic stenosis, its early recognition and treatment is key. Although patients with classical low-flow, low-gradient (C-LFLG) aortic stenosis have higher rates of death after transcatheter aortic valve implantation (TAVI) when compared with patients with high-gradient (HG) aortic stenosis, there is conflicting evidence on the death rate in patients with severe paradoxical low-flow, low-gradient (P-LFLG) aortic stenosis. Therefore, we aimed to compare outcomes in real-world patients with severe HG, C-LFLG, and P-LFLG aortic stenosis undergoing TAVI. Methods and Results Clinical outcomes up to 5 years were addressed in the 3 groups of patients enrolled in the prospective, national, multicenter SwissTAVI registry. A total of 8914 patients undergoing TAVI at 15 heart valve centers in Switzerland were analyzed for the purpose of this study. We observed a significant difference in time to death at 1 year after TAVI, with the lowest observed in HG (8.8%) aortic stenosis, followed by P-LFLG (11.5%; hazard ratio [HR], 1.35 [95% CI, 1.16-1.56]; P <0.001) and C-LFLG (19.8%; HR, 1.93 [95% CI, 1.64-2.26]; P <0.001) aortic stenosis. Cardiovascular death showed similar differences between the groups. At 5 years, the all-cause death rate was 44.4% in HG, 52.1% in P-LFLG (HR, 1.35 [95% CI, 1.23-1.48]; P <0.001), and 62.8% in C-LFLG aortic stenosis (HR, 1.7 [95% CI, 1.54-1.88]; P <0.001). Conclusions Up to 5 years after TAVI, patients with P-LFLG have higher death rates than patients with HG aortic stenosis but lower death rates than patients with C-LFLG aortic stenosis.

Published
2023
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27. Real-world effectiveness of preemptive therapy (PET) for cytomegalovirus (CMV) disease prevention in CMV high-risk donor seropositive/recipient seronegative (D+R-) liver transplant recipients (LTxR).

Author

Doss KM, Kling CE, Heldman MR, Singh N, Wagener M, Rakita RM, Fisher CE, and Limaye AP

Subjects
Adult, Humans, Cytomegalovirus, Antiviral Agents therapeutic use, Retrospective Studies, Treatment Outcome, Positron-Emission Tomography adverse effects, Transplant Recipients, Ganciclovir therapeutic use, Liver Transplantation adverse effects, Cytomegalovirus Infections epidemiology, Cytomegalovirus Infections prevention & control, Cytomegalovirus Infections drug therapy
Abstract

Background: Despite superiority of preemptive therapy (PET) compared to universal prophylaxis for prevention of cytomegalovirus (CMV) disease in the CAPSIL randomized trial among CMV D+R- liver transplant recipients (LTxRs), real-world effectiveness may be lower because of logistical concerns about feasibility of PET., Methods: We retrospectively assessed PET as standard clinical care at a single transplant center among 50 consecutive adult CMV D+R- LTxRs undergoing a first liver transplant between 4/4/2019 and 5/18/2021 and compared outcomes and adherence to those randomized to PET in the CAPSIL study (N = 100). The primary outcome was CMV disease and secondary outcomes were biopsy-confirmed acute allograft rejection, retransplant, invasive fungal infections, and death, all assessed by 1-year post-transplant. Exploratory outcomes included virologic parameters and measures of adherence to protocol-specified CMV qPCR monitoring., Results: Baseline characteristics were similar between groups. The cumulative incidence of CMV disease at 1-year post-transplant was 4/50 (8%) versus 9/100 (9%) in the real-world and CAPSIL cohorts, respectively, p = 1.0. The rate of breakthrough CMV disease during the 100-day PET period was low (2/50 [4%]) and similar to the PET cohort from the CAPSIL study (3/100 [3%]).  All secondary and exploratory outcomes were not significantly different between the real-world and CAPSIL PET cohorts., Conclusions: In this first reported study of real-world PET, the feasibility and effectiveness for CMV disease prevention and for other clinical outcomes in CMV D+R- LTxRs were similar to those reported with PET in a clinical trial. Additional studies to confirm feasibility and generalizability in other settings are warranted., (© 2023 Wiley Periodicals LLC.)

Published
2023
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28. Fast calculation of scattering patterns using hypergeometric function algorithms.

Author

Wagener M and Förster S

Abstract

The scattering of light, X-rays, electrons or neutrons by matter is used widespread for structural characterization from atomic to macroscopic length scales. With the advent of high-brilliance beam sources and the development fast, large area pixelated detectors, scattering patterns are now acquired at unprecedented frame rates and frame sizes. The slow analysis of these scattering patterns has evolved into a severe bottleneck retarding scientific insight. Here we introduce an algorithm based on the use of hypergeometric functions providing gains in computational speed of up to 10 5 compared to present numerical integration algorithms. Hypergeometric functions provide analytical descriptions of geometrical shapes, can be rapidly computed as series and asymptotic expansions, and can be efficiently implemented in GPUs. The algorithm provides the necessary computational speed to calculate scattering patterns on timescales required for real-time experiment feedback, the analysis of large volumes of scattering data, and for the generation of training data sets for machine learning., (© 2023. The Author(s).)

Published
2023
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29. Trends in Coronary and Structural Heart Interventions in Switzerland over the Last 16 Years and Impact of COVID-19: Insights from the National Swiss PCI Survey.

Author

Wagener M, Boeddinghaus J, Gaemperli O, Räber L, Nietlispach F, Meier P, Muller O, Weilenmann D, and Jeger R

Abstract

Background: Considering the global burden of cardiovascular disease, we analysed trends in interventional coronary and structural procedures over the past 16 years (2005-2021), using continuous data from the Swiss national registry., Methods: Based on a standardised questionnaire, data on coronary and structural interventions in Switzerland were assessed by the Working Group Interventional Cardiology of the Swiss Society of Cardiology (SSC). Here, we analysed the trend of annually performed interventions from 2005 to 2021 in Switzerland and the impact of the COVID-19 pandemic., Results: We observed a constant increase in the total number of cases (including coronary angiographies (CA) and percutaneous coronary interventions (PCI)) from 36,436 cases in 2005 to 56,555 cases in 2021 (+55%). With 18 cases in 2007, TAVI procedures have increased to 2004 cases in 2021. During the early phase of the COVID-19 pandemic in 2020, a slight decrease in CAs and PCIs of 9.15% was observed. In contrast, we did not observe an impact of the COVID-19 pandemic on the number of no TAVI procedures. Most importantly, all cause in-hospital mortality for coronary interventions before and during the peak of the COVID-19 pandemic was comparable (1.4% vs. 1.3%)., Conclusion: Over a 16-year period, we observed an upward trend in diagnostic and therapeutic procedures for coronary as well as structural heart disease, with only a small short-term impact of the COVID-19 pandemic on interventions and a similar procedure-related in-hospital-mortality in Switzerland.

Published
2022
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30. Learning to rank Higgs boson candidates.

Author

Köppel M, Segner A, Wagener M, Pensel L, Karwath A, Schmitt C, and Kramer S

Abstract

In the extensive search for new physics, the precise measurement of the Higgs boson continues to play an important role. To this end, machine learning techniques have been recently applied to processes like the Higgs production via vector-boson fusion. In this paper, we propose to use algorithms for learning to rank, i.e., to rank events into a sorting order, first signal, then background, instead of algorithms for the classification into two classes, for this task. The fact that training is then performed on pairwise comparisons of signal and background events can effectively increase the amount of training data due to the quadratic number of possible combinations. This makes it robust to unbalanced data set scenarios and can improve the overall performance compared to pointwise models like the state-of-the-art boosted decision tree approach. In this work we compare our pairwise neural network algorithm, which is a combination of a convolutional neural network and the DirectRanker, with convolutional neural networks, multilayer perceptrons or boosted decision trees, which are commonly used algorithms in multiple Higgs production channels. Furthermore, we use so-called transfer learning techniques to improve overall performance on different data types., (© 2022. The Author(s).)

Published
2022
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31. Frequency multiplication by collective nanoscale spin-wave dynamics.

Author

Koerner C, Dreyer R, Wagener M, Liebing N, Bauer HG, and Woltersdorf G

Abstract

Frequency multiplication is a process in modern electronics in which harmonics of the input frequency are generated in nonlinear electronic circuits. Devices based on the propagation and interaction of spin waves are a promising alternative to conventional electronics. The characteristic frequency of these excitations is in the gigahertz (GHz) range and devices are not readily interfaced with conventional electronics. Here, we locally probe the magnetic excitations in a soft magnetic material by optical methods and show that megahertz-range excitation frequencies cause switching effects on the micrometer scale, leading to phase-locked spin-wave emission in the GHz range. Indeed, the frequency multiplication process inside the magnetic medium covers six octaves and opens exciting perspectives for spintronic applications, such as all-magnetic mixers or on-chip GHz sources.

Published
2022
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