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BackgroundPreeclampsia (PE) is one of the most common hypertensive diseases, affecting 2%-8% of all pregnancies. The high maternal and fetal mortality rates of PE are due to a lack of early identification of affected pregnant women that would have led to closer monitoring and care. Recent data suggest that misfolded proteins might be a promising biomarker for PE prediction, which can be detected in urine samples of pregnant women according to their congophilia (aggregated) characteristic. ObjectiveThe main purpose of this trial is to evaluate the value of the urine congophilia-based detection of misfolded proteins for the imminent prediction of PE in women presenting with suspected PE. The secondary objectives are to demonstrate that the presence of urine misfolded proteins correlates with PE-related maternal or neonatal adverse outcomes, and to establish an accurate PE prediction model by combining misfolded proteins with multiple indicators. MethodsAt least 300 pregnant women with clinical suspicion of PE will be enrolled in this prospective cohort study. Participants should meet the following inclusion criteria in addition to a suspicion of PE: ≥18 years old, gestational week between 20+0 and 33+6, and single pregnancy. Consecutive urine samples will be collected, blinded, and tested for misfolded proteins and other PE-related biomarkers at enrollment and at 4 follow-up visits. Clinical assessments of PE status and related complications for all participants will be performed at regular intervals using strict diagnostic criteria. Investigators and participants will remain blinded to the results. Follow-up will be performed until 42 days postpartum. Data from medical records, including maternal and fetal outcomes, will be collected. The performance of urine misfolded proteins alone and combined with other biomarkers or clinical variables for the prediction of PE will be statistically analyzed. ResultsEnrollment started in July 2023 and was still open upon manuscript submission. As of March 2024, a total of 251 eligible women have been enrolled in the study and enrollment is expected to continue until August 2024. Results analysis is scheduled to start after all participants reach the follow-up endpoint and complete clinical data are collected. ConclusionsUpon completion of the study, we expect to derive an accurate PE prediction model, which will allow for proactive management of pregnant women with clinical suspicion of PE and possibly reduce the associated adverse pregnancy outcomes. The additional prognostic value of misfolded proteins is also expected to be confirmed. Trial RegistrationChinese Clinical Trials Registry ChiCTR2300074878; https://www.chictr.org.cn/showproj.html?proj=202096 International Registered Report Identifier (IRRID)PRR1-10.2196/54026

In this work, the effect of minor Ag addition on shear performance of ball grid array (BGA) structure Cu/SnBi/Cu solder joints under electric current stressing was investigated. The results show that the shear strength of solder joints decreased with increasing current density, and the effect of Ag addition on shear strength changed from an elevating state to a deteriorating state. The elevating effect of Ag addition was due to the dominance of Sn/Bi phase refinement and Ag3Sn dispersion, which was weakened gradually with the increase in current density. The deteriorating effect of Ag addition was attributed to the more inhomogeneous distribution of current density and higher thermal gradient induced by the finer phase of the solder matrix as well as the consequent severer strain mismatch at the Sn/Bi phase interface. The finer Sn/Bi phase was also conductive to easier lattice atom migration under current stressing, resulting in a rapid decrease in shear strength. Moreover, the dominant factor on the shear strength reduction tended to change from Joule heating to athermal effect of current stressing. The fracture of solder joints indicated an insignificant influence by the Ag addition, which all occurred in the solder matrix in a ductile mode.

To realize the low-carbon operation of integrated energy systems (IESs), this paper proposes a low-carbon optimal scheduling method. First of all, considering the integrated demand response of price-based electricity and heating, an economic scheduling model of the IES integrated demand response based on chance-constrained programming is proposed to minimize the integrated operating cost in an uncertain environment. Through the comprehensive demand response model, the impact of the demand response ratio on the operating economy of the IES is explored. Afterward, the carbon emission index is introduced, and gas turbines and energy storage devices are used as the actuators of multi-energy coupling to further explore the potential interactions between the coupling capacities of various heterogeneous energy sources and carbon emissions. Finally, the original uncertainty model is transformed into a mixed-integer linear-programming model and solved using sequence operation theory and the linearization method. The results show that the operating economy of the IES is improved by coordinating the uncertainty of the integrated demand response and renewable energy. In addition, the tradeoff between the working economy and reliability of the EIS can be balanced via the setting of an appropriate confidence level for the opportunity constraints.

Apoptosis in postmortem muscle is a potential factor affecting meat quality. This study aimed to investigate the changes in apoptotic genes and proteins, reactive oxygen species (ROS), caspase-3 activity and their underlying relationship with meat tenderization. As postmortem time extended, there was a significant increase in myofibril fragmentation index (MFI) and destruction of muscle fibers. Oxidative stress deepened alongside the onset of apoptosis. Mitochondrial membrane potential (MMP) decreased, and caspase-3 activity increased during the first 24 h postmortem. Forty apoptotic genes displayed significant differences, involving DNA damage, autophagy, the death receptor pathway, the mitochondrial pathway, the Bcl-2 family, and the caspases family. The expression of most apoptotic genes was abundant in the early postmortem stage, enhancing the potential for early apoptosis. Apoptotic proteins of apoptosis-inducing factor, mitochondrion-associated 1 (AIFM1) and endonuclease G (ENDOG) showed the damage of apoptosis to DNA. Also, the decreasing expression of Bcl2 and increasing expression of Bak1 with time demonstrated the effects of mitochondrial apoptosis on postmortem muscle. These findings suggest that postmortem muscle apoptosis is a physiological process co-regulated by multiple genes, and potentially contributes to meat tenderization and quality.

We theoretically investigate that mechanical quantum squeezing in a dissipative optomechanical system, driven by two driving tones, can be improved through quadratic dispersive coupling (QDC) which appears by adjusting a membrane in an appropriate position of an optical cavity. The analytical expressions are derived for revealing the intrinsic mechanism of the mechanical squeezing improvement. Remarkably, compared with the case without QDC, an optimal condition involved the QDC is found to considerably enhance the mechanical squeezing, without reducing the purity of the mechanical squeezed state which even increases at low temperature. We also show that, in this scheme, the mechanical squeezing is still improved by QDC and beyond 3 dB even though the temperature rises. This improvement effect can be reflected by the broader frequency band of the measurable squeezing output field from the cavity. This provides a new opportunity to explore high-precision measurements and quantum nature of macroscopic objects.

This study evaluated the effects of three polysaccharides, xanthan gum (XG), kappa-carrageenan (CA), and guar gum (GG), on the foaming and emulsifying properties of egg white liquid (EWL) and explored the intermolecular interactions and aggregation states in the initial polysaccharide–EWL complex. The results showed that the addition of XG and GG significantly improved the foaming stability of EWL on the one hand, from 66% to 78% and 69%, respectively (p < 0.05). On the other hand, the addition of XG and GG significantly improved the foam uniformity and density, and the average foam area decreased from 0.127 to 0.052 and 0.022 mm2, respectively (p < 0.05). The addition of XG and CA significantly improved the emulsification activity index (from 13.32 to 14.58 and 14.36 m2/mg, respectively, p < 0.05) and the emulsion stability index (from 50.89 to 53.62 and 52.18 min, respectively, p < 0.05), as well as the interfacial protein adsorption at the oil–water interface; it also reduced the creaming index. However, GG negatively affected these indicators. Furthermore, the electrostatic and hydrophobic interactions among molecules in EWL due to XG and the electrostatic, hydrogen bonding, and hydrophobic interactions among molecules in EWL due to CA ultimately led to the irregular aggregation of egg white proteins. Hydrophobic interactions and disulfide bonds between molecules in EWL–containing GG formed filamentous aggregations of egg white proteins. This work reveals that molecules in the polysaccharide–egg white complexes aggregate by interaction forces, which in turn have different effects on the foaming and emulsifying properties of egg white proteins.

The objective of this study was to reveal the secrets of the unique meat characteristics of Beijing-you chicken (BJY) and to compare the difference of quality and flavor with Luhua chicken (LH) and Arbor Acres broiler (AA) at their typical market ages. The results showed the meat of BJY was richer in essential amino acids, arachidonic acid contents, inosine monophosphate (IMP), and guanosine monophosphate (GMP). The total fatty acid and unsaturated fatty acid contents of BJY chicken and LH chicken were lower than that of AA broilers, whereas the ratios of unsaturated fatty acids/saturated fatty acids (2.31) and polyunsaturated fatty acids/monounsaturated fatty acids (1.52) of BJY chicken were the highest. The electronic nose and SPME-GC/MS analysis confirmed the significant differences among these three chickens, and the variety and relative content of aldehydes might contribute to a richer flavor of BJY chicken. The meat characteristics of BJY were fully investigated and showed that BJY chicken might be favored among these three chicken breeds with the best flavor properties and the highest nutritional value. This study also provides an alternative way to identify BJY chicken from other chickens.

Plasma as the fourth state of matter has attracted great attention for material surface modification, which could induce changes in material microscopic factors, such as defects, phase transitions, crystallinity, and so on. However, the interactions among those microscopic factors and regulation mechanism of macroscopic properties have rarely been investigated. Two-dimensional (2D) transition metal dichalcogenide with tunable structure and phase is one of the most promising electromagnetic wave (EMW) absorbers, which provides a favorable platform for systematically studying the dynamic coupling of its microscopic factors. Herein, we constructed a NaBH4 solution-assisted Ar plasma method to modify the 2H-MoS2 and 1T-WS2 for exploring the regulation mechanism of microscopic factors. For MoS2 and WS2, NaBH4 solution-assisted Ar plasma treatment behaves with different effects on dielectric responses, realizing dynamic coupling of material microscopic factors to collaboratively promote EM losses coupling. Consequently, the MS-D3-0.5 (MoS2, 3 ​kV voltage, 0.5 ​mol ​L−1 NaBH4 solution) displays an optimum effective absorption bandwidth of 8.01 ​GHz, which is 319.4 ​% more than that of MS-raw sample. This study not only reveals the novel mechanism of plasma induced dynamic coupling of microscopic factors for EMW dissipation, but also presents a new method of plasma-dominated surface modification to optimize the EMW absorption performance.

ABSTRACTComposite structures are sensitive to impact damage in practical engineering. Electric resistance change method (ERCM) is an ideal technique for damage monitoring of composite structures. Due to the anisotropy of fiber-resin matrix composites, impact location monitoring is difficult, and research on impact location of fiber composite laminates (FRPs) is limited. A preparation method of MXene/CNT/CuNps thin film sensor is proposed. According to the modeling simulation and theoretical calculation, the resistance change characteristics of the thin film sensor are obtained, the relationship between the impact distance and the resistance change is established, and the sensor array is designed. A three-point localization algorithm and a weight function compensation localization algorithm are proposed, which can improve the imaging accuracy of the impact position. The impact point location was observed and analyzed using ultrasonic C-scan technology. The results show that the weight function compensation positioning algorithm can accurately locate the impact of the composite structure, and the error in the X direction is 7.1%, the error in the Y direction is 0.03%, which verifies the effectiveness of the method.

This paper focuses on a 1000 MW Francis turbine and conducts a numerical analysis of the entire flow passage using computational fluid dynamics (CFD) under steady-state conditions. Building upon prior research, we further investigate the impact of an uneven gap distribution caused by radial co-directional installation deviations of 0.1 mm, 0.3 mm, 0.5 mm, 1.5 mm, and 2.5 mm on the pressures and radial forces at various locations of the turbine, including the upper crown chamber, the vaneless zone, and the bottom ring chamber, all under steady-state rated operating conditions. By examining the maximum and minimum pressure values under different conditions, we determined that different pressure reading methods should be applied to distinct surfaces. Additionally, we derived the patterns illustrating how different components are affected by radial installation deviations. The significance of this study lies in its comprehensive exploration of the influence of radial installation deviations on the performance of a Francis turbine, particularly under steady-state rated conditions. Through numerical analysis, we elucidated the specific effects of various deviation magnitudes on the pressures and radial forces at different turbine locations. These findings provide valuable insights for the optimization of turbine design and operation. The novelty of this work stems from its in-depth investigation of radial co-directional installation deviations and the extensive results obtained through numerical simulations. These results hold significant implications for improving turbine performance and reliability, surpassing previous efforts in the literature.

Seawalls are vital for protecting coastal areas. However, the seabed in front of seawalls may undergo severe scouring. This can result in destabilization of the seawall structure, the underlying mechanisms of which remains unclear. Therefore, an integrated observation system consisting of acoustic and optical instruments was deployed in areas with severe seabed scouring. This observation system was used to observe sediment dynamics elements such as waves, currents, tides, turbulence and suspended sediment concentration (SSC) for 31 days in winter. Using advanced time–frequency analysis techniques including wavelet transform and spectrum analysis, we examined the dynamic factors associated with sediment resuspension and transport. In calm weather conditions, a notable increase in SSC was not observed indicating that the tidal dynamics were not sufficient for sediment suspension. During high winds, the SSC increased sharply to 12,222 mg/L, and the sediment vertical diffusion flux induced by turbulence was coupled to SSC, indicating that the increased SSC was predominantly attributed to local resuspension. Consistent temporal distribution of turbulence-induced sediment vertical diffusion flux and momentum flux in high wavelet power spectra highlights the important role of turbulence in sediment dynamics. Enhanced longshore currents during high wave conditions intensified sediment transportation. Horizontal net sediment fluxes notably increased to 769 t/m2 per day during winter gales, which had a significant effect on seabed erosion. This study reveals the key processes associated with seabed scouring in front of seawalls during gale events.

The problems of energy waste and pollutant gas emissions caused by the high-temperature construction of high viscosity asphalt (HVA) for porous pavements may be effectively solved by the warm-mix asphalt (WMA) additives. In this paper, the rheological properties of HVA with WMA additives were investigated considering the application in porous pavement. First, the influences of different dosages of Sasobit, EC120, Evotherm, foaming water on the conventional properties of HVA were investigated by rotational viscosity, absolute viscosity (60 °C), toughness and tenacity, penetration, softening point, and ductility (5 °C). The four optimum dosages of Sasobit (3%), EC120 (3%), Evotherm (1%), and foaming water (4%) were determined. Second, the rheological properties at the high-temperature, intermediate-temperature, and low-temperature of HVA with the four optimum dosages of WMA additives were studied by dynamic shear rheometer (DSR) test and bending beam rheometer (BBR) test. The result showed that the rotational viscosity (135 °C) of HVA was significantly reduced by the WMA additives, thereby improving the workability of the HVA. Meanwhile, the WMA additives at optimum dosage can improve the high-temperature rheological properties of HVA except for foaming water. However, Sasobit, EC120, and foaming water have adverse effects on the intermediate-temperature fatigue performance and low-temperature crack resistance of HVA. By comprehensive comparison, it is suggested that HVA with 1% Evotherm is more suitable for the construction in porous asphalt pavements.

To reduce the cost of high-viscosity modifier (HVM) and alleviate white pollution problems, we prepared the environment-friendly HVM (E-HVM) by using waste-low density polyethylene/styrene-butadiene-styrene (waste-LDPE/SBS) composite. The physical characteristics of the E-HVM modifier were first investigated. Additionally, the effects of E-HVM modifier dosage (8 wt% to 20 wt%) on the rheological properties and microstructure of asphalt were, respectively, researched by dynamic shear rheometer (DSR), bending beam rheometer (BBR), and fluorescence microscopy (FM). The results show that the E-HVM modifier has lower molecular weight, and its distribution is wider than that of the Tafpack-Super (TPS) modifier; thus, the E-HVM modifier had better compatibility with asphalt, which has also been proven by FM images. Due to these reasons, the E-HVM modifier improves the high-temperature performances of asphalt more effectively than the TPS modifier, which is shown by the higher dynamic viscosity (60 °C) and G* and the lower δ and Jnr(τ) Furthermore, compared to TPS modified asphalt, E-HVM modified asphalt also has a higher fatigue life at different strain levels (2.5% and 5.0%), but worse low-temperature performance. Following a comprehensive consideration of performances, the reasonable dosage range of E-HVM modifier is 12 wt% to 16 wt%.

In this work, multi-walled carbon nanotube composites (MWCNCs) were produced by catalytic pyrolysis of post-consumer plastics with aluminium oxide-supported nickel, cobalt, and their bimetallic (Ni/α–Al2O3, Co/α–Al2O3, and NiCo/α–Al2O3) oxide-based catalysts. The influence of catalyst composition and catalytic reaction temperature on the carbon yield and structure of CNCs were investigated. Different temperatures (800, 900, 950, and 1000 °C) and catalyst compositions (Ni, Co, and Ni/Co) were explored to maximize the yield of carbon deposited on the catalyst. The obtained results showed that at the same catalytic temperature (900 °C), a Ni/Co bimetallic catalyst exhibited higher carbon yield than the individual monometallic catalysts due to a better cracking capability on carbon-hydrogen bonds. With the increase of temperature, the carbon yield of the Ni/Co bimetallic catalyst increased first and then decreased. At a temperature of 950 °C, the Ni/Co bimetallic catalyst achieved its largest carbon yield, which can reach 255 mg g−1plastic. The growth of CNCs followed a “particle-wire-tube” mechanism for all studied catalysts. This work finds the potential application of complex oxide composite material catalysts for the generation of CNCs in catalytic pyrolysis of wasted plastic.