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Multicomponent reactions are operationally simple and display a significant role in diverse chemical modification by reducing reaction times as well as additional steps involved. In this review, we highlighted the impact of multi‐component reactions in assistance with modular Click chemistry to develop a library of triazole‐appended scaffolds including 1,2,3‐triazole‐fused heterocycles, glycoconjugates, macrocycles as well as in the combinatorial synthesis of differently functionalized triazoles along with mechanistic insights with a diverse range of applications in the field of medicinal chemistry. [ABSTRACT FROM AUTHOR]

This article discusses the synthesis of isoquinolinone derivatives, specifically 3-amino-substituted isoquinolinones and dihydrophenanthridinediones. The authors explore different synthetic approaches and advancements in the synthesis of these derivatives. They also introduce glycosyl triazole-appended pyridinamide ligands and investigate their catalytic efficacy in the synthesis of these derivatives. The document provides detailed information about the synthesis process, purification methods, physical properties, and spectroscopic data of the compounds. It can be a valuable resource for researchers studying the synthesis and characterization of isoquinolinone derivatives. [Extracted from the article]

A novel organocatalyzed [3+2] cycloaddition reaction of nitroolefins with glycosyl azides as well as organic azides has been developed for successful construction of 1,5-disubstituted triazolyl glycoconjugates. This metal-free and acid-free, regioselective synthetic protocol proceeds in the presence of only Schreiner thiourea organocatalysts, which enable the required activation of nitroolefins through double hydrogen bonding. The straightforward, operationally simple, and regioselectivity of this methodology, complementing to the classical RuAAC catalyzed synthesis of 1,5-disubstituted 1,2,3-triazoles. In the presence of catalytic amount of Schreiner thiourea organocatalyst, organic azides react with a broad array of nitroolefins producing a series of diverse 1,5-disubstituted 1,2,3- triazoles in good yields with excellent regioselectivity., (© 2023 Wiley-VCH GmbH.)