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This study aimed to evaluate the therapeutic efficacy and effect of blood purification (BP) therapy on severe acute pancreatitis (SAP). Information on 305 patients (BP group 68, control group 237) diagnosed with SAP was retrieved from the Medical Information Mart for Intensive Care IV (MIMIC IV) database. Firstly, the influence of BP treatment was preliminarily evaluated by comparing the outcome indicators of the two groups. Secondly, multiple regression analysis was used to screen the mortality risk factors to verify the impact of BP on the survival outcome of patients. Then, the effect of BP treatment was re-validated with baseline data. Finally, cox regression was used to make the survival curve after matching to confirm whether BP could affect the death outcome. The results indicated that the BP group had a lower incidence of shock (p = 0.012), but a higher incidence of acute kidney injury (AKI) (p < 0.001), with no differences observed in other outcome indicators when compared to the control group. It was also found that the 28-day survival curve of patients between the two groups was significantly overlapped (p = 0.133), indicating that BP treatment had no significant effect on the survival outcome of patients with SAP. Although BP is beneficial in stabilizing hemodynamics, it has no effect on short- and long-term mortality of patients. The application of this technology in the treatment of SAP should be done with caution until appropriate BP treatment methods are developed, particularly for patients who are not able to adapt to renal replacement therapy.

[Objectives] To investigate the protective effect of ethanol extract from sweet potato leaves on liver injury induced by CC14 in mice. [Methods] 25 ICR mice were randomly divided into blank group, model group, high-dose extract group (200 mg/kg), low-dose extract group (100 mg/kg) and positive control group (2 mg/kg colchicine), with 5 mice in each group. All groups except the blank group were given intraperitoneal injection of 20% CC14 olive oil solution (2 mL/kg), and the blank group was given the same dose of olive oil solution three times a week. After 4 weeks, each administration group was given the corresponding dose of drugs (10 mL/kg), and the blank group and model group were given the corresponding amount of normal saline for 2 weeks. After the last intragastric administration, fasting was required, but water was allowed, blood was taken from eyeballs, and upper serum was taken by static centrifugation. Serum AST, ALT, CRP, IL-6 and SOD levels were detected by the kit. [Results] Compared with the blank group, the serum AST and ALT levels in the model group were significantly increased; compared with the model group, the ethanol extract of sweet potato leaves could decrease the levels of ALT, AST, CRP, IL-6 and increase the level of SOD in serum. [Conclusions] The ethanol extract of sweet potato leaves had protective effect on the mice with liver injury induced by CC14, and its mechanism may be to protect the liver by lowering enzymes, inhibiting inflammation and antioxidant stress. [ABSTRACT FROM AUTHOR]