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189 results on '"Zhu, Ruixin"'

8. Differences between HbA1c and glucose-related variables in predicting weight loss and glycaemic changes in individuals with overweight and hyperglycaemia – The PREVIEW trial

Author

P Silvestre, Marta, Fogelholm, Mikael, Alves, Marta, Papoila, Ana, Adam, Tanja, Liu, Amy, Brand-Miller, Jennie, Martinez, J. Alfredo, Westerterp-Plantenga, Margriet, Handjieva-Darlenska, Teodora, Macdonald, Ian A., Zhu, Ruixin, Jalo, Elli, Muirhead, Roslyn, Carretero, Santiago Navas, Handjiev, Svetoslav, Taylor, Moira A., Raben, Anne, and Poppitt, Sally D.

Published
2023
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9. Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW

Author

Zhu, Ruixin, Craciun, Ionut, Bernhards-Werge, Jan, Jalo, Elli, Poppitt, Sally D., Silvestre, Marta P., Huttunen-Lenz, Maija, McNarry, Melitta A., Stratton, Gareth, Handjiev, Svetoslav, Handjieva-Darlenska, Teodora, Navas-Carretero, Santiago, Sundvall, Jouko, Adam, Tanja C., Drummen, Mathijs, Simpson, Elizabeth J., Macdonald, Ian A., Brand-Miller, Jennie, Muirhead, Roslyn, Lam, Tony, Vestentoft, Pia S., Færch, Kristine, Martinez, J. Alfredo, Fogelholm, Mikael, and Raben, Anne

Published
2022
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16. Multi-kingdom microbial signatures in excess body weight colorectal cancer based on global metagenomic analysis.

Author

Zhu, Xinyue, Xu, Pingping, Zhu, Ruixin, Gao, Wenxing, Yin, Wenjing, Lan, Ping, Zhu, Lixin, and Jiao, Na

Subjects
BODY weight, COLORECTAL cancer, METAGENOMICS, CLOSTRIDIOIDES difficile, GUT microbiome, IRINOTECAN, BACTEROIDES fragilis
Abstract

Excess body weight (EBW) increases the risk of colorectal cancer (CRC) and is linked to lower colonoscopy compliance. Here, we extensively analyzed 981 metagenome samples from multiple cohorts to pinpoint the specific microbial signatures and their potential capability distinguishing EBW patients with CRC. The gut microbiome displayed considerable variations between EBW and lean CRC. We identify 44 and 37 distinct multi-kingdom microbial species differentiating CRC and controls in EBW and lean populations, respectively. Unique bacterial-fungal associations are also observed between EBW-CRC and lean-CRC. Our analysis revealed specific microbial functions in EBW-CRC, including D-Arginine and D-ornithine metabolism, and lipopolysaccharide biosynthesis. The best-performing classifier for EBW-CRC, comprising 12 bacterial and three fungal species, achieved an AUROC of 0.90, which was robustly validated across three independent cohorts (AUROC = 0.96, 0.94, and 0.80). Pathogenic microbial species, Anaerobutyricum hallii, Clostridioides difficile and Fusobacterium nucleatum, are EBW-CRC specific signatures. This work unearths the specific multi-kingdom microbial signatures for EBW-CRC and lean CRC, which may contribute to precision diagnosis and treatment of CRC. Metagenomic analysis reveals distinctive multi-kingdom species, functional signatures and bacteria-fungi interactions pattern between excess body weight CRC and lean CRC in gut microbiome, which contribute to precision medicine of CRC. [ABSTRACT FROM AUTHOR]

Published
2024
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17. CyclicPepedia: a knowledge base of natural and synthetic cyclic peptides.

Author

Liu, Lei, Yang, Liu, Cao, Suqi, Gao, Zhigang, Yang, Bin, Zhang, Guoqing, Zhu, Ruixin, and Wu, Dingfeng

Subjects
CYCLIC peptides, PEPTIDOMIMETICS, KNOWLEDGE base, DRUG patents, PATENT applications
Abstract

Cyclic peptides offer a range of notable advantages, including potent antibacterial properties, high binding affinity and specificity to target molecules, and minimal toxicity, making them highly promising candidates for drug development. However, a comprehensive database that consolidates both synthetically derived and naturally occurring cyclic peptides is conspicuously absent. To address this void, we introduce CyclicPepedia (https://www.biosino.org/iMAC/cyclicpepedia/), a pioneering database that encompasses 8744 known cyclic peptides. This repository, structured as a composite knowledge network, offers a wealth of information encompassing various aspects of cyclic peptides, such as cyclic peptides' sources, categorizations, structural characteristics, pharmacokinetic profiles, physicochemical properties, patented drug applications, and a collection of crucial publications. Supported by a user-friendly knowledge retrieval system and calculation tools specifically designed for cyclic peptides, CyclicPepedia will be able to facilitate advancements in cyclic peptide drug development. [ABSTRACT FROM AUTHOR]

Published
2024
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23. NAFLDkb: A Knowledge Base and Platform for Drug Development against Nonalcoholic Fatty Liver Disease

Author

Xu, Tingjun, Gao, Wenxing, Zhu, Lixin, Chen, Wanning, Niu, Chaoqun, Yin, Wenjing, Ma, Liangxiao, Zhu, Xinyue, Ling, Yunchao, Gao, Sheng, Liu, Lei, Jiao, Na, Chen, Weiming, Zhang, Guoqing, Zhu, Ruixin, and Wu, Dingfeng

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease with a broad spectrum of histologic manifestations. The rapidly growing prevalence and the complex pathologic mechanisms of NAFLD pose great challenges for treatment development. Despite tremendous efforts devoted to drug development, there are no FDA-approved medicines yet. Here, we present NAFLDkb, a specialized knowledge base and platform for computer-aided drug design against NAFLD. With multiperspective information curated from diverse source materials and public databases, NAFLDkb presents the associations of drug-related entities as individual knowledge graphs. Practical drug discovery tools that facilitate the utilization and expansion of NAFLDkb have also been implemented in the web interface, including chemical structure search, drug-likeness screening, knowledge-based repositioning, and research article annotation. Moreover, case studies of a knowledge graph repositioning model and a generative neural network model are presented herein, where three repositioning drug candidates and 137 novel lead-like compounds were newly established as NAFLD pharmacotherapy options reusing data records and machine learning tools in NAFLDkb, suggesting its clinical reliability and great potential in identifying novel drug-disease associations of NAFLD and generating new insights to accelerate NAFLD drug development. NAFLDkb is freely accessible at https://www.biosino.org/nafldkband will be updated periodically with the latest findings.

Published
2024
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25. Associations of obesity phenotypes with weight change, cardiometabolic benefits, and type 2 diabetes incidence during a lifestyle intervention: results from the PREVIEW study

Author

Zhu, Ruixin, primary, Huttunen-Lenz, Maija, additional, Stratton, Gareth, additional, Handjieva-Darlenska, Teodora, additional, Handjiev, Svetoslav, additional, Sundvall, Jouko, additional, Silvestre, Marta P., additional, Jalo, Elli, additional, Pietiläinen, Kirsi H., additional, Adam, Tanja C., additional, Drummen, Mathijs, additional, Simpson, Elizabeth J., additional, Taylor, Moira A., additional, Poppitt, Sally D., additional, Navas-Carretero, Santiago, additional, Martinez, J. Alfredo, additional, Schlicht, Wolfgang, additional, Fogelholm, Mikael, additional, Brand-Miller, Jennie, additional, and Raben, Anne, additional

Published
2023
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28. NAFLDkb: A Knowledge Base and Platform for Drug Development against Nonalcoholic Fatty Liver Disease

Author

Xu, Tingjun, primary, Gao, Wenxing, additional, Zhu, Lixin, additional, Chen, Wanning, additional, Niu, Chaoqun, additional, Yin, Wenjing, additional, Ma, Liangxiao, additional, Zhu, Xinyue, additional, Ling, Yunchao, additional, Gao, Sheng, additional, Liu, Lei, additional, Jiao, Na, additional, Chen, Weiming, additional, Zhang, Guoqing, additional, Zhu, Ruixin, additional, and Wu, Dingfeng, additional

Published
2023
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31. Differences between HbA1c and glucose-related variables in predicting weight loss and glycaemic changes in individuals with overweight and hyperglycaemia – the PREVIEW Trial

Author

Silvestre, Marta P, primary, Fogelholm, Mikael, additional, Alves, Marta, additional, Papoila, Ana, additional, Adam, Tanja, additional, Liu, Amy, additional, Brand-Miller, Jennie, additional, Martinez, J. Alfredo, additional, Westerterp-Plantenga, Margriet, additional, Handjieva-Darlenska, Teodora, additional, Macdonald, Ian A, additional, Zhu, Ruixin, additional, Jalo, Elli, additional, Muirhead, Roslyn, additional, Carretero, Santiago Navas, additional, Handjiev, Svetoslav, additional, Taylor, Moira A, additional, Raben, Anne, additional, and Poppitt, Sally D, additional

Published
2023
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39. Effect of non- and low-caloric sweeteners on substrate oxidation, energy expenditure, and catecholamines in humans — A systematic review

Author

Andersen, Sabina Stoffer Hjorth, Zhu, Ruixin, Kjølbæk, Louise, and Raben, Anne

Subjects
Low-caloric sweeteners, Catecholamines, Respiration chamber, Carbohydrate oxidation, Ventilated hood, Faculty of Science, Energy expenditure, Energy homeostasis, Non-caloric sweeteners, Fat oxidation
Abstract

The use of non- and low-caloric sweetener(s) (NCS and LCS) as a means to prevent overweight and obesity is highly debated, as both NCS and LCS have been proposed to have a negative impact on energy homeostasis. This systematic review aimed to assess the impact of NCS and LCS on fasting and postprandial substrate oxidation, energy expenditure, and catecholamines, compared to caloric sweeteners or water, across different doses and types of NCS and LCS, acutely and in the longer-term. A total of 20 studies were eligible: 16 studies for substrate oxidation and energy expenditure and four studies for catecholamines. Most studies compared the acute effects of NCS or LCS with caloric sweeteners under non-isoenergetic conditions. These studies generally found higher fat oxidation and lower carbohydrate oxidation with NCS or LCS than with caloric sweeteners. Findings for energy expenditure were inconsistent. With the limited number of studies, no convincing pattern for the remaining outcomes and comparisons could be seen. In conclusion, drinks or meals with NCS or LCS resulted in higher fat and lower carbohydrate oxidation compared to caloric sweeteners. No other conclusions could be drawn due to insufficient or inconsistent results. Further studies in this research field are warranted.

Published
2023

41. Effect of Non- and Low-Caloric Sweeteners on Substrate Oxidation, Energy Expenditure, and Catecholamines in Humans—A Systematic Review.

Author

Andersen, Sabina S. H., Zhu, Ruixin, Kjølbæk, Louise, and Raben, Anne

Abstract

The use of non- and low-caloric sweetener(s) (NCS and LCS) as a means to prevent overweight and obesity is highly debated, as both NCS and LCS have been proposed to have a negative impact on energy homeostasis. This systematic review aimed to assess the impact of NCS and LCS on fasting and postprandial substrate oxidation, energy expenditure, and catecholamines, compared to caloric sweeteners or water, across different doses and types of NCS and LCS, acutely and in the longer-term. A total of 20 studies were eligible: 16 studies for substrate oxidation and energy expenditure and four studies for catecholamines. Most studies compared the acute effects of NCS or LCS with caloric sweeteners under non-isoenergetic conditions. These studies generally found higher fat oxidation and lower carbohydrate oxidation with NCS or LCS than with caloric sweeteners. Findings for energy expenditure were inconsistent. With the limited number of studies, no convincing pattern for the remaining outcomes and comparisons could be seen. In conclusion, drinks or meals with NCS or LCS resulted in higher fat and lower carbohydrate oxidation compared to caloric sweeteners. No other conclusions could be drawn due to insufficient or inconsistent results. Further studies in this research field are warranted. [ABSTRACT FROM AUTHOR]

Published
2023
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43. MCPIP1 restrains mucosal inflammation by orchestrating the intestinal monocyte to macrophage maturation via an ATF3-AP1S2 axis

Author

Lu, Huiying, primary, Zhang, Cui, additional, Wu, Wei, additional, Chen, Huimin, additional, Lin, Ritian, additional, Sun, Ruicong, additional, Gao, Xiang, additional, Li, Gengfeng, additional, He, Qiong, additional, Gao, Han, additional, Wu, Xiaohan, additional, Lin, Jian, additional, Zhu, Ruixin, additional, Niu, Jianli, additional, Kolattukudy, Pappachan E, additional, and Liu, Zhanju, additional

Published
2022
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45. results from the diabetes prevention study PREVIEW

Author

Zhu, Ruixin, Craciun, Ionut, Bernhards-Werge, Jan, Jalo, Elli, Poppitt, Sally D, Silvestre, Marta P, Huttunen-Lenz, Maija, McNarry, Melitta A, Stratton, Gareth, Handjiev, Svetoslav, Handjieva-Darlenska, Teodora, Navas-Carretero, Santiago, Sundvall, Jouko, Adam, Tanja C, Drummen, Mathijs, Simpson, Elizabeth J, Macdonald, Ian A, Brand-Miller, Jennie, Muirhead, Roslyn, Lam, Tony, Vestentoft, Pia S, Færch, Kristine, Martinez, J Alfredo, Fogelholm, Mikael, Raben, Anne, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Weight loss, SDG 3 - Good Health and Well-being, Men, Women, Young people, Obesity, Older people, Cardiovascular disease, Middle-aged people, Weight loss maintenance
Abstract

Funding: Open Access funding provided by University of Helsinki including Helsinki University Central Hospital. This research was supported by the EU Seventh Framework Programme (FP7; 2007– 2013) (grant no. 312057); National Health and Medical Research Council (EU Collaborative Grant AUS 8, ID 1067711); Glycemic Diabetologia Index Foundation Australia through royalties to the University of Sydney; Health Research Council of New Zealand (grant no. 14/191) and University of Auckland Faculty Research Development Fund; Cambridge Weight Plan, which donated all products for the 8 week weight loss period; Danish Agriculture & Food Council; Danish Meat Research Institute; National Institute for Health Research Biomedical Research Centre (NIHR BRC) (UK); Biotechnology and Biological Sciences Research Council (BBSRC) (UK); Engineering and Physical Sciences Research Council (EPSRC) (UK); Nutritics (Dublin), which donated all dietary analysis software used by the University of Nottingham; Juho Vainio Foundation (Finland); Academy of Finland (grant nos 272376, 314383, 266286 and 314135); Finnish Medical Foundation; Gyllenberg Foundation (Finland); Novo Nordisk Foundation; Finnish Diabetes Research Foundation; University of Helsinki; Government Research Funds for Helsinki University Hospital; Jenny and Antti Wihuri Foundation (Finland); Emil Aaltonen Foundation (Finland); and China Scholarship Council. The funders were not involved in the design of the study, the collection, analysis and interpretation of the data or writing of the report and did not impose any restrictions regarding the publication of the report. AIMS/HYPOTHESIS: Lifestyle interventions are the first-line treatment option for body weight and cardiometabolic health management. However, whether age groups or women and men respond differently to lifestyle interventions is under debate. We aimed to examine age- and sex-specific effects of a low-energy diet (LED) followed by a long-term lifestyle intervention on body weight, body composition and cardiometabolic health markers in adults with prediabetes (i.e. impaired fasting glucose and/or impaired glucose tolerance). METHODS: This observational study used longitudinal data from 2223 overweight participants with prediabetes in the multicentre diabetes prevention study PREVIEW. The participants underwent a LED-induced rapid weight loss (WL) period followed by a 3 year lifestyle-based weight maintenance (WM) intervention. Changes in outcomes of interest in prespecified age (younger: 25-45 years; middle-aged: 46-54 years; older: 55-70 years) or sex (women and men) groups were compared. RESULTS: In total, 783 younger, 319 middle-aged and 1121 older adults and 1503 women and 720 men were included in the analysis. In the available case and complete case analyses, multivariable-adjusted linear mixed models showed that younger and older adults had similar weight loss after the LED, whereas older adults had greater sustained weight loss after the WM intervention (adjusted difference for older vs younger adults -1.25% [95% CI -1.92, -0.58], p

Published
2022

47. Does the effect of a 3-year lifestyle intervention on body weight and cardiometabolic health differ by prediabetes metabolic phenotype? A post-hoc analysis of the PREVIEW study

Author

Zhu, Ruixin, primary, Jalo, Elli, primary, Silvestre, Marta P., primary, Poppitt, Sally D., primary, Handjieva-Darlenska, Teodora, primary, Handjiev, Svetoslav, primary, Huttunen-Lenz, Maija, primary, Mackintosh, Kelly, primary, Stratton, Gareth, primary, Navas-Carretero, Santiago, primary, Pietiläinen, Kirsi H., primary, Simpson, Elizabeth, primary, Macdonald, Ian A., primary, Muirhead, Roslyn, primary, Brand-Miller, Jennie, primary, Fogelholm, Mikael, primary, Færch, Kristine, primary, Martinez, J. Alfredo, primary, Westerterp-Plantenga, Margriet S., primary, Adam, Tanja C., primary, and Raben, Anne, primary

Published
2022
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50. Microbial multidimensional signature assessment reveals microbial SNVs as the superior non‐invasive biomarkers for early detection of colorectal cancer

Author

Gao, Wenxing, primary, Sun, Ruicong, additional, Zhu, Lixin, additional, Gao, Sheng, additional, Feng, Zhongsheng, additional, Wu, Dingfeng, additional, Gao, Xiang, additional, Zhao, Rui, additional, Yao, Ye, additional, Liu, Zhanjiu, additional, Zhu, Ruixin, additional, and Jiao, Na, additional

Published
2022
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