Search

A new shelf-stable and easily scalable difluoromethylthiolating reagent S-(difluoromethyl) benzenesulfonothioate (PhSO2SCF2H) was developed. PhSO2SCF2H is a powerful reagent for radical difluoromethylthiolation of aryl and alkyl boronic acids, decarboxylative difluoromethylthiolation of aliphatic acids, and a phenylsulfonyl-difluoromethylthio difunctionalization of alkenes under mild reaction conditions. [ABSTRACT FROM AUTHOR]

A silver-catalyzed decarboxylative trifluoromethylthiolation of secondary and tertiary carboxylic acids under mild conditions tolerates a wide range of functional groups. The reaction was dramatically accelerated by its performance in an aqueous emulsion, which was formed by the addition of sodium dodecyl sulfate to water. It was proposed that the radical, which was generated from the silver-catalyzed decarboxylation in the 'oil-in-water' droplets, could easily react with the trifluoromethylthiolating reagent to form the product. [ABSTRACT FROM AUTHOR]

Sulfur and friends: A new electrophilic hypervalent iodine reagent 1 has been developed for direct trifluoromethylthiolation. A variety of nucleophiles, including β‐ketoesters, aldehydes, amides, aryl or vinyl boronic acids, and alkynes, reacted with 1 under mild conditions to give the corresponding trifluoromethylthiolated compounds in good to excellent yields. [ABSTRACT FROM AUTHOR]

Healing ligaments have inferior mechanical properties compared to normal ligaments during early healing intervals. The purpose of this study was to investigate if in vivo ligament repair with an interpositional allograft and treatment with hyaluronic acid (HA) would improve the mechanical properties of a medial collateral ligament (MCL) healing from a gap injury. Twenty rabbits were assigned equally to either a donor or recipient group. A gap injury of the MCL was created in both hindlimbs of 10 recipient animals. The right hindlimb was treated with allograft plus HA while the left hindlimb was treated with allograft only. Low-load and high-load mechanical properties, including laxity, relaxation and failure, and histology were evaluated after 6 weeks of healing. Mechanical results were compared to previously published normal MCL and MCL gap scar data. MCL allografts had greater initial force during cyclic relaxation testing and maximum force during failure testing than MCL scars, but were weaker than normal MCLs. Failure stress was the only parameter to demonstrate a statistically significant effect of treatment with HA on the allografts. However, the failure stress of the HA-treated MCL allografts was not different than MCL scars and was less than normal MCLs. In conclusion, interpositional allografts could enhance some mechanical properties of ligament healing but HA, in the way we applied it, did not produce an obvious improvement. © 2008 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 27:400-407, 2009 [ABSTRACT FROM AUTHOR]

The title ylides are found to be useful reagents for the trifluoromethylation of various β-ketoesters and aryl iodides. [ABSTRACT FROM AUTHOR]

Review: 71 refs. [ABSTRACT FROM AUTHOR]

A series of eight trifluoromethanesulfenates is prepared as trifluoromethylthiolating agents. [ABSTRACT FROM AUTHOR]

The article presents chemical equations related to the article "Copper-Catalyzed Trifluoromethylthiolation of Primary and Secondary Alkylboronic Acids" by X. Saho and others, published in the periodical "Journal of Organic Chemistry" in 2014.

The decarboxylative trifluoromethylthiolation of secondary and tertiary carboxylic acids tolerates a wide range of functional groups and is accelerated by performance in an aqueous emulsion. [ABSTRACT FROM AUTHOR]

The air- and moisture-stable reagent (I) allows the direct transfer of the -S-CF3 group to different classes of substrates such as β-ketoesters, boronic acids, alkynes, and aldehydes under mild conditions. [ABSTRACT FROM AUTHOR]

A powerful and valuable reagent for direct trifluoromethylthiolation is reported by L. Lu, Q. Shen, and co‐workers in their Communication on page 3457 ff. This new electrophilic hypervalent iodine reagent reacts with a wide range of substrates under mild conditions. The image shows the reagent and its products within the context of the ancient Chinese symbolism of the round sky and square earth. [ABSTRACT FROM AUTHOR]

Ein leistungsfähiges Reagens für die direkte Trifluormethylthiolierung stellen L. Lu, Q. Shen und Mitarbeiter in ihrer Zuschrift auf S. 3541 ff. vor. Die neue elektrophile hypervalente Iodverbindung reagiert mit einem großen Substratspektrum unter milden Bedingungen. Das Bild zeigt das Reagens und seine Produkte im Kontext des Altchinesischen Symbolismus mit kreisförmigem Himmel und quadratischer Erde. [ABSTRACT FROM AUTHOR]