1. Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art.
- Author
-
Zinellu A, Fois AG, Mangoni AA, Paliogiannis P, Sotgiu E, Zinellu E, Marras V, Pirina P, and Carru C
- Subjects
- Animals, Arginine metabolism, Humans, Nitric Oxide Synthase genetics, Nitric Oxide Synthase metabolism, Pulmonary Disease, Chronic Obstructive enzymology, Pulmonary Disease, Chronic Obstructive genetics, Arginine analogs & derivatives, Oxidative Stress, Pulmonary Disease, Chronic Obstructive metabolism
- Abstract
Experimental evidence suggests that oxidative stress (OS) may increase the activity of arginine methylating enzymes that produce the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). In addition, it is well documented that OS can significantly decrease the synthesis and/or activity of ADMA degrading enzymes, thus causing ADMA accumulation in biological fluids. Recent reports have focused on circulating methylated arginine concentrations in chronic obstructive pulmonary disease, a disease characterized by a significant increase in OS. This review discusses the results of these studies and the opportunities for further research in this area.
- Published
- 2018
- Full Text
- View/download PDF