164 results on '"Fabio Anastasio"'
Search Results
2. What Strain Analysis Adds to Diagnosis and Prognosis in Heart Failure Patients
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Guido Pastorini, Fabio Anastasio, and Mauro Feola
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heart failure ,echocardiography ,global longitudinal strain ,Medicine - Abstract
Heart failure (HF) is a common disease that requires appropriate tools to correctly predict cardiovascular outcomes. Echocardiography represents the most commonly used method for assessing left ventricular ejection fraction and a cornerstone in the detection of HF, but it fails to procure an optimal level of inter-observer variability, leading to unsatisfactory prediction of cardiovascular outcomes. In this review, we discuss emerging clinical tools (global longitudinal strain of the left ventricle, the right ventricle, and the left atrium) that permitted an improvement in the diagnosis and ameliorated the risk stratification across different HF phenotypes. The review analyzes the speckle-tracking contributions to the field, discussing the limitations and advantages in clinical practice.
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- 2023
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3. The Analysis of Arterial Stiffness in Heart Failure Patients: The Prognostic Role of Pulse Wave Velocity, Augmentation Index and Stiffness Index
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Fabio Anastasio, Marzia Testa, Cinzia Ferreri, Arianna Rossi, Gaetano Ruocco, and Mauro Feola
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arterial stiffness ,heart failure ,prognosis ,pulse wave velocity ,augmentation index and stiffness index ,Medicine - Abstract
Background: The role of arterial stiffness in the pathogenesis and clinical outcome of heart failure (HF) patients has to be clarified. The aim of this study was to evaluate the prognostic role of arterial stiffness in HF patients discharged after acute episode of decompensation by evaluating cut-off values for clinical assessment. Methods: Patients admitted for decompensated heart failure (ADHF) underwent pre-discharge evaluation. Arterial stiffness was measured by aortic pulse wave velocity (aPWV), augmentation index (AIx75) and stiffness index (β0). Patients were also evaluated after discharge for a variable follow-up time. Results: We observed 199 patients (male 61.3%, age 76.2 ± 10.7 years) after discharge for a median of 437 days (IQR 247-903), 69 (34.7%) patients suffered HF with preserved ejection fraction (HFpEF), 45 (22.6%) patients experienced HF with mid-range ejection fraction (HFmEF) and 85 (42.7%) reported an HF with reduced ejection fraction (HFrEF). After the adjustment for principal confounders, aPWV, AIx75 and β0 were inversely correlated with free-event survival (p = 0.006, p < 0.001, p = 0.001): only β0 was inversely correlated with overall survival (p = 0.03). Analysing the threshold, overall survival was inversely correlated with β0 ≥3 (HR 2.1, p = 0.04) and free-event survival was inversely correlated with aPWV ≥10 m/s (HR 1.7, p = 0.03), AIx75 ≥ 25 (HR 2.4, p < 0.001), and β0 ≥ 3 (HR 2.0, p = 0.009). Dividing HF patients for LV ejection fraction, β0 and AIx75 appeared to be accurate prognostic predictors among the three different classes according to free-event survival. Conclusions: The non-invasive measurements of arterial stiffness proved to be strong prognostic parameters in HF patients discharged after an acute HF decompensation.
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- 2022
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4. P54 Age-specific, Pressure-independent Acute Changes in Carotid-femoral Pulse Wave Velocity During Head-up Tilt
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Giacomo Pucci, Alberto Avolio, Bart Spronck, Gaetano Vaudo, Fabio Anastasio, Anton H. Van den Meiracker A.H, and Francesco U.S. Mattace-Raso
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Specialties of internal medicine ,RC581-951 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Introduction: Acute, gravity-induced blood pressure (BP) changes during head-up tilt may generate concomitant variations in carotid-femoral pulse wave velocity (cf-PWV). We aimed to separate the pressure-dependent and -independent components of cf-PWV changes observed during head-up tilt. Methods: 30 healthy individuals (age 48 ± 18 years (mean ± SD), 38% males, BP 130/74 ± 12/8 mmHg) underwent head-up passive tilting at a = 0°, 30°, and 60°. BP was taken at the upper arm, constantly kept at heart level. Aortic BP was reconstructed from radial tonometry (SphygmoCor). Stiffness index b0 was estimated at 0°. 1 Assumptions: [1] from MRI2, the effective cf-PWV travel distance (ETD, 80% of straight carotid-to-femoral distance) begins at heart level; [2] the change in DBP along the aorta is predictable from the hydrostatic pressure gradient (0.73 mmHg/cm) 3; [3] cf-PWV and hydrostatic pressure relate linearly, hence predicted cf-PWV can be calculated as the average of aortic (PWVaorta, using b0 and aortic DBP) and femoral (PWVfem, using b0 and femoral DBP, corresponding to aortic DBP + (ETD × sin(a)*0.73)) PWVs. Results: Both young (24–48 years) and old (48–82 years) individuals showed increasing trends for peripheral SBP, DBP, PP, and central DBP with tilting; central SBP remained unchanged. Heart rate (HR) and cf-PWV increased with body tilt in both groups (Figure, left). b0 linearly correlated with age (R = 0.70, p < 0.01). After adjustment for HR4, observed-vs-predicted cf-PWV exponentially increased as a function of age (R2 = 0.38, p < 0.01 for quadratic equation, p = 0.04, vs. linear; Figure, right). Conclusion: With aging, the acute relationship between BP and cf-PWV becomes progressively nonlinear.
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- 2020
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5. Contributors
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Agabiti-Rosei, Claudia, primary, Agabiti-Rosei, Enrico, additional, Agnoletti, Davide, additional, Alastruey, Jordi, additional, AlGhatrif, Majd, additional, Almada, Horacio, additional, Ángela, Sardella, additional, Argyris, Antonios, additional, Aristizabal, Dagnovar, additional, Armeni, Eleni, additional, Avolio, Alberto, additional, Badariene, Jolita, additional, Badhwar, Smriti, additional, Barbosa, Eduardo Costa Duarte, additional, Barroso, Weimar Kunz Sebba, additional, Bascetin, Rümeyza, additional, Baynard, Tracy, additional, Becerra, Carlos Ramos, additional, Bennett, Nadia, additional, Bianchini, Elisabetta, additional, Bohn, Lucimere, additional, Borghi, Claudio, additional, Bortolotto, Luiz Aparecido, additional, Boutouyrie, Pierre, additional, Bruno, Rosa Maria, additional, Burnier, Michel, additional, Butlin, Mark, additional, Calabria, Fabiana, additional, Camafort, Miguel, additional, Cavero-Redondo, Iván, additional, Challande, Pascal, additional, Chirinos, Julio A., additional, Climie, Rachel Emma, additional, Cockcroft, John, additional, Cotter, Jorge, additional, Cruickshank, J. Kennedy, additional, Cunha, Pedro Guimarães, additional, Damianaki, Aikaterini, additional, De Backer, Tine, additional, De Buyzere, Marc L., additional, De Caterina, Raffaele, additional, De Ciuceis, Carolina, additional, Debette, Stephanie, additional, Edsfeldt, Andreas, additional, Fernhall, Bo, additional, Ferreira, Isabel, additional, Fisher, Simon, additional, Forcada, Pedro, additional, S. Franklin, Stanley, additional, Garcia, Ricardo, additional, Georgiopoulos, Georgios, additional, Ghiadoni, Lorenzo, additional, Goncalves, Isabel, additional, Gottsäter, Mikael, additional, Graham, Delyth, additional, Greene, Katherine, additional, Guala, Andrea, additional, Hametner, Bernhard, additional, Hashimoto, Junichiro, additional, Hering, Dagmara, additional, Hibner, Brooks A., additional, Højlund, Kurt, additional, Hughes, Alun, additional, Ikonomidis, Ignatios, additional, Johansson, Madeleine, additional, Jordan, Jens, additional, Kario, Kazuomi, additional, Kotsis, Vasilios, additional, Kozakova, Michaela, additional, Lacolley, Patrick, additional, Lagrange, Jérémy, additional, Lakatta, Edward G., additional, Lambrinoudaki, Irene, additional, Laucyte-Cibulskiene, Agne, additional, Laurent, Stéphane, additional, Lopes, Wendell Arthur, additional, Lopez-Jaramillo, Patricio, additional, Magalhaes, Lucélia Batista Neves Cunha, additional, Magnussen, Costan G., additional, Mavraganis, Georgios, additional, Mayer, Christopher Clemens, additional, Maynard, Hannah, additional, McBride, Martin W., additional, McDonnell, Barry J., additional, McEniery, Carmel M., additional, Mota, Jorge, additional, Motl, Robert W., additional, Mozos, Ioana, additional, Muiesan, Maria Lorenza, additional, Muñoz, Ernesto Cardona, additional, Narkiewicz, Krzysztof, additional, Nemcsik, János, additional, Neves, Mario Fritsch, additional, Nilsson, Jan, additional, Nilsson, Peter M., additional, Oberhoffer-Fritz, Renate, additional, Ochoa, Juan Eugenio, additional, Okawa, Jaqueline Lyrio Bermudes, additional, Okawa, Rogério Toshiro Passos, additional, Olesen, Thomas Bastholm, additional, Oliveira, José, additional, Oliveras, Anna, additional, Hecht Olsen, Michael, additional, Ortiz, Luis Garcia, additional, Pahkala, Katja, additional, Paini, Anna, additional, Palombo, Carlo, additional, Parati, Gianfranco, additional, Park, Chloe, additional, Pavlidis, George, additional, Piani, Federica, additional, Pierce, Gary L., additional, Pizzala, Pablo G., additional, Protogerou, Athanase D., additional, Pucci, Giacomo, additional, Pupi, Luis María, additional, Pupi, Pablo María, additional, Raitakari, Olli T., additional, Rajkumar, C., additional, Ramirez, Agustín, additional, Raso, Francesco Mattace, additional, Recchia, Fabio Anastasio, additional, Regnault, Veronique, additional, Rietzschel, Ernst, additional, Rizzoni, Damiano, additional, Rodilla, Enrique, additional, Rovio, Suvi P., additional, Ryliskyte, Ligita, additional, Salvi, Paolo, additional, Sanchez, Ramiro, additional, Sáry, Javier Osvaldo, additional, Schillaci, Giuseppe, additional, Schmidt-Trucksäss, Arno, additional, Scuteri, Angelo, additional, Segers, Patrick, additional, Sharman, James, additional, Sierra, Cristina, additional, Stamatelopoulos, Kimon, additional, Steckelings, Ulrike M., additional, Stehouwer, Coen D.A., additional, Stoner, Lee, additional, Taddei, Stefano, additional, Terentes-Printzios, Dimitrios, additional, Tomiyama, Hirofumi, additional, Trivett, Cara, additional, Tsioufis, Costas, additional, Turroni, Silvia, additional, Urbina, Elaine M., additional, Van Bortel, L., additional, van de Laar, Roel J., additional, van der Heide, Frank C.T., additional, Vázquez, Susana, additional, Vishram-Nielsen, Julie, additional, Vlachopoulos, Charalambos, additional, Vlastos, Dimitrios, additional, Walker, Ashley, additional, Wang, Mingyi, additional, Weber, Thomas, additional, Xaplanteris, Panagiotis, additional, Zanoli, Luca, additional, and Zhou, Manshi, additional
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- 2024
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6. P7.19 ARTERIAL STIFFNESS AND DISEASE-RELATED ORGAN DAMAGE IN SYSTEMIC LUPUS ERYTHEMATOSUS
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Giacomo Pucci, Francesca Battista, Elena Bartoloni Bocci, Fabio Anastasio, Mariano Crapa, Leandro Sanesi, Roberto Gerli, and Giuseppe Schillaci
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Specialties of internal medicine ,RC581-951 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Hypothesis: increased arterial stiffness has been reported in subjects with systemic lupus erythematosus (SLE) compared with healthy controls. In SLE, indexes of organ damage are related to a poor clinical status and worse prognosis independently from the activity of the disease. Data are controversial about the association between SLE-related organ damage and arterial stiffness. Methods: 40 subjects with history of SLE (mean age 45±12 years, 90% women) and a median disease duration of 12 years (IQR 5–19), underwent assessment of carotid-femoral pulse wave velocity (cf-PWV) by means of applanation tonometry (SphygmoCor). A comprehensive clinical, metabolic and immunological assessment was performed. Irreversible organ damage, not related to active inflammation, was assessed through the Systemic Lupus International Collaborating Clinics (SLICC) damage index. Results: mean BP was 128/75±16/10 mmHg. 9 subjects (23%) were on anti-hypertensive treatment, 4 (10%) had had previous cardiovascular events, 17 (42%) were treated with steroids, 29 (71%) with hydroxychloroquine, 15 (37%) with other immunosuppressants. Median SLICC index was 2 (IQR 1–3), average cf-PWV was 7.5±1.9 m/s. cf-PWV significantly increased across SLICC damage index categories (F=3.141, p
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- 2015
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7. 1.2 AGE-DEPENDENT ASSOCIATION OF 24-HOUR PERIPHERAL AND CENTRAL PULSE PRESSURES WITH STROKE VOLUME
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Giacomo Pucci, Francesca Battista, Fabio Anastasio, Mariano Edoardo Crapa, Leandro Sanesi, and Giuseppe Schillaci
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Specialties of internal medicine ,RC581-951 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objective: Pulse pressure (PP) is a complex physiologic trait affected by many variables, including LV contractility (reflected by stroke volume), arterial stiffness, and central-to-brachial amplification.The impact of age on the relationship between stroke volume and central or brachial PP has not been investigated. Methods: 3765 untreated hypertensive adults (men 56%, age 50 ± 12 years) underwent 24-hour ambulatory BP monitoring (SpaceLabs) and M-mode echocardiography. In a subset of 982 subjects in whom central PP was measured by applying a transfer function to radial pulse wave (SphygmoCor), we also estimated central office (or 24 h) PP by regression equations based on office (or 24 h) PP and MAP, heart rate, age, height and sex (R2 = 0.92 between estimated and measured central PP).The same equations were then applied to the original population to obtain estimated central PP. Results: Stroke volume had a significant direct association with both brachial and central 24 h PP up to the age of 39 years. The above relationship weakened with age and became mostly non-significant after the age of 40 (all r < 0.10). Similar, although weaker, trends were observed for office PP (both brachial and central). Conclusions: 24-h PP has a strong direct association with LV stroke volume in the young only, and might more exclusively depend on arterial stiffness later in life. Since the above relationship was also observed with estimated central PP, it may not depend on PP amplification. The “young” and “old” pathophysiological patterns of PP may help to explain the increasingly adverse prognostic value of PP observed with advancing age.
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- 2015
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8. P8.1 CENTRAL HEMODYNAMICS IN SYSTEMIC SCLEROSIS: A CASE-CONTROL STUDY
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Francesca Battista, Giacomo Pucci, Elena Bartoloni Bocci, Francesca Cannarile, Alessia Alunno, Fabio Anastasio, Roberto Gerli, and Giuseppe Schillaci
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Specialties of internal medicine ,RC581-951 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background: Although a few studies have suggested an alteration in aortic stiffness in patients with systemic sclerosis (SS), a disease characterized by immunological and microvascular changes and by tissue fibrosis, the functional properties of the large arteries have been understudied in SS. Methods: 34 women with SS [age 60±14 years, BP 123/70±17/10 mmHg] and 34 healthy age- and BP-matched women underwent determination of carotid-femoral pulse wave velocity (PWV, a direct measure of aortic stiffness) and aortic augmentation (SphygmoCor, AtCor). All participants also underwent determination of carotid-radial PWV, as a measure of stiffness of upper-limb arteries. We excluded participants with overt cardiovascular disease and concomitant important disease. Results: Age and brachial BP were nearly identical in the 2 groups. Patients and controls did not differ by carotid-femoral PWV (9.2±3 vs 9.1±2 m/s, p=0.91) or carotid-radial PWV. Aortic augmentation, was higher in women with SS; unadjusted: 16.1±8 vs 11.5±7, p=0.014; adjusted for pulse pressure and heart rate (AIx@75): 30.9±16 vs 22.2±12, p=0.012). SS independently predicted AIx@75 in a multivariate analysis. Among patients with SS, age, brachial mean BP and serum C-reactive protein all predicted carotid-femoral PWV. Age and mean BP were the only predictors of AIx@75. Organ damage scores had no significat correlation with central hemodynamics parameters. Conclusions: SS is associated with an increase in aortic augmentation (as a measure of the contribution of reflected wave to central waveform), but not in aortic or upper-limb arterial stiffness. Microvascular involvement might occur earlier than stiffening of the large arteries in SS.
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- 2015
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9. Detour test performance of cloned minipigs from three different clone populations
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Paganelli, Aurora, Felici, Martina, Turini, Luca, Baragli, Paolo, Carlucci, Lucia, Recchia, Fabio Anastasio, and Sgorbini, Micaela
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- 2023
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10. 72 - Intraneural pudendal nerve recording and stimulation in animal models for the closed-loop control of lower urinary tract dysfunction
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Giannotti, Alice, primary, Lo Vecchio, Sara, additional, Salatino, Laura, additional, Poggi, Valentina, additional, Bernini, Fabio, additional, Gabisonia, Khatia, additional, Carlucci, Lucia, additional, Musco, Stefania, additional, Lacour, Stephanie, additional, Recchia, Fabio Anastasio, additional, Del Popolo, Giulio, additional, and Micera, Silvestro, additional
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- 2023
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11. Pulmonary function and functional capacity at 3, 6 and 12 months in COVID-19 patients and effect of physical activity on recovery
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Fabio ANASTASIO, Giacomo PUCCI, Elisa SCARNECCHIA, Alessandro GONELLA, Sarah BARBUTO, Manuel CACCONE, Giulio ROSSI, and Pierpaolo PARRAVICINI
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Pulmonary and Respiratory Medicine - Published
- 2023
12. Assessment of nocturnal hypertension by ambulatory blood pressure monitoring at the forearm in people with morbid obesity
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Graziana Lupattelli, Vito Gandolfo, Marco D’Abbondanza, Riccardo Alcidi, Matteo Camilli, Valeria Bisogni, Fabio Anastasio, Gaetano Vaudo, Stefano Ministrini, Natasa Mojovic, and Giacomo Pucci
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medicine.medical_specialty ,Ambulatory blood pressure ,Endocrinology, Diabetes and Metabolism ,Concordance ,Diastole ,Blood Pressure ,030204 cardiovascular system & hematology ,Nocturnal ,Morbid obesity ,03 medical and health sciences ,0302 clinical medicine ,Forearm ,Blood Pressure Monitoring ,Internal medicine ,Ambulatory ,Internal Medicine ,medicine ,Humans ,Obesity ,030212 general & internal medicine ,Circadian rhythm ,Morbid ,business.industry ,Blood Pressure Measurement ,Blood Pressure Monitoring, Ambulatory ,morbid obesity ,Circadian Rhythm ,Obesity, Morbid ,ambulatory blood pressure monitoring ,nocturnal hypertension ,Blood pressure ,medicine.anatomical_structure ,Hypertension ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
Blood pressure (BP) measurement at the forearm (FA) has been proposed as alternative site to upper arm (UA) in people with morbid obesity (MO). We compared nocturnal BP readings simultaneously taken at FA and UA by ambulatory blood pressure monitoring (ABPM). Fourteen individuals with MO and seven normal‐weight controls underwent nocturnal ABPM with two devices placed at the UA and contralateral FA, respectively. Agreement between FA‐UA BP, diagnosis of nocturnal hypertension, and potential determinants of BP differences were evaluated. BP at the FA was significantly higher than UA in both people with MO and controls. FA‐UA differences in systolic and diastolic BP were similar in people with MO and controls. Nocturnal hypertension was diagnosed in 10 subjects (48%) according to UA BP and in 13 subjects (62%) according to FA BP (concordance 76%, moderate agreement). ΔFA‐UA systolic BP was associated with ratio between FA/UA circumferences (R = 0.45, P
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- 2020
13. Age-Specific Acute Changes in Carotid-Femoral Pulse Wave Velocity With Head-up Tilt
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Lisanne Tap, G. Pucci, Alberto Avolio, Francesco U.S. Mattace-Raso, Fabio Anastasio, Bart Spronck, Gaetano Vaudo, Anton H. van den Meiracker, Internal Medicine, Biomedische Technologie, and RS: Carim - H07 Cardiovascular System Dynamics
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Adult ,Male ,medicine.medical_specialty ,Aging ,Supine position ,hypertension ,Manometry ,Hydrostatic pressure ,Posture ,pressure dependence ,Hemodynamics ,early vascular aging ,BLOOD-PRESSURE ,030204 cardiovascular system & hematology ,PARAMETERS ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Vascular Stiffness ,Internal medicine ,Heart rate ,Internal Medicine ,Medicine ,Humans ,030212 general & internal medicine ,Pulse wave velocity ,INDEX ,Aged ,Aged, 80 and over ,business.industry ,Age Factors ,blood pressure ,AORTIC STIFFNESS ,Middle Aged ,medicine.disease ,arterial function ,Blood pressure ,arterial stiffness ,Carotid-Femoral Pulse Wave Velocity ,Cardiology ,Arterial stiffness ,Aortic stiffness ,Female ,business - Abstract
BACKGROUND Aortic stiffness as measured by carotid–femoral pulse wave velocity (cfPWV) is known to depend on blood pressure (BP), and this dependency may change with age. Therefore, the hydrostatic BP gradient resulting from a change in body posture may elicit a cfPWV change that is age-dependent. We aimed to analyze the relationship between BP gradient—induced by head-up body tilting—and related changes in cfPWV in individuals of varying age. METHODS cfPWV and other hemodynamic parameters were measured in 30 healthy individuals at a head-up tilt of 0° (supine), 30°, and 60°. At each angle, the PWV gradient and resulting cfPWV were also estimated (predicted) by assuming a global nonlinear, exponential, pressure–diameter relationship characterized by a constant β0, and taking into account that (diastolic) foot-to-foot cfPWV acutely depends on diastolic BP. RESULTS cfPWV significantly increased upon body tilting (8.0 ± 2.0 m/s supine, 9.1 ± 2.6 m/s at 30°, 9.5 ± 3.2 m/s at 60°, P for trend CONCLUSIONS Under a hydrostatic pressure gradient, the pulse wave traveling along the aorta undergoes an age-related, nonlinear PWV increase exceeding the increase predicted from BP dependency.
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- 2020
14. Mid-term impact of mild-moderate COVID-19 on cardiorespiratory fitness in élite athletes
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Tommaso La Macchia, Giacomo Pucci, Marco D’Abbondanza, Rosa Curcio, Fabio Anastasio, Giulio Rossi, and Gaetano Vaudo
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,biology ,Athletes ,business.industry ,Confounding ,COVID-19 ,Physical Therapy, Sports Therapy and Rehabilitation ,Cardiorespiratory fitness ,biology.organism_classification ,Pulmonary function testing ,Oxygen Consumption ,Cardiorespiratory Fitness ,Internal medicine ,medicine ,Cardiology ,Exercise Test ,Aerobic exercise ,Humans ,Orthopedics and Sports Medicine ,Elite athletes ,business ,Bioelectrical impedance analysis - Abstract
Background Mid- and long-term sequelae of COVID-19 on cardiorespiratory fitness are unknown. Aim of the study was to assess the mid-term impact of mild-moderate COVID-19 on cardiorespiratory fitness evaluated by cardiopulmonary exercise testing (CPET) in elite athletes. Methods 13 elite cross-country skiers with previous mild-moderate COVID-19 symptoms underwent CPET before resuming seasonal training (COVID athletes). 13 elite detrained cross-country skiers, matched for principal confounding factors, were taken as controls (control group). Resting peripheral oxygen saturation, pulmonary function test, echocardiography, bioelectrical impedance analysis and CPET (modified XELG2, Woodway, USA) were performed in all participants. Results Median recovery time in COVID athletes was 34 days (IQR 33-38 days). COVID athletes reached earlier the onset of the aerobic threshold (4'48" vs 6'28", R2=0.15, F=4.37, p Conclusions Elite cross-country athletes, previously affected by mild-moderate COVID-19, reached earlier the aerobic threshold than controls, whereas the remaining CPET parameters did not differ between groups. Such changes were not associated with any detectable difference in resting pulmonary and cardiac examination. Subjects affected by mild-moderate COVID-19 may require a longer time course of re-adaptation to aerobic exercise.
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- 2021
15. Association between Ideal Cardiovascular Health and aortic stiffness in Italian adolescents. The MACISTE study
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Francesco Desantis, Leandro Sanesi, Lucas Troiani, Valeria Bisogni, Marco D’Abbondanza, Giacomo Pucci, Fabio Anastasio, Mariano Edoardo Crapa, Gaetano Vaudo, F. Papi, and Francesca Battista
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Male ,medicine.medical_specialty ,Mean arterial pressure ,Multivariate analysis ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Health Status ,Health Behavior ,Medicine (miscellaneous) ,Adolescents ,Risk Assessment ,Ideal Cardiovascular Health ,Young Adult ,Vascular Stiffness ,Internal medicine ,Heart rate ,medicine ,Humans ,cardiovascular diseases ,Healthy Lifestyle ,Pulse wave velocity ,Nutrition and Dietetics ,business.industry ,Confounding ,Age Factors ,Protective Factors ,Cardiovascular risk ,medicine.disease ,Arterial stiffness ,Health Surveys ,nervous system diseases ,Blood pressure ,Cross-Sectional Studies ,Italy ,Adolescent Behavior ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Carotid-Femoral Pulse Wave Velocity ,Aortic stiffness ,Female ,Cardiology and Cardiovascular Medicine ,business ,Risk Reduction Behavior - Abstract
BACKGROUND AND AIMS Ideal Cardiovascular Health (ICH), defined as optimal levels of cardiovascular (CV) health factors and behaviors, has been reported to be very low in adults and children, with consequent several negative health outcomes and higher CV risk. The present study investigated the burden of ICH among Italian adolescents and its association with carotid-femoral pulse wave velocity (cf-PWV). METHODS AND RESULTS 387 healthy adolescents (mean age 17.1 ± 1.4 years) attending the "G. Donatelli" High School in Terni, Italy, were evaluated. ICH was assessed through clinical evaluation, laboratory measures and interviewer-administered questionnaires. Cf-PWV was measured by arterial tonometry (SphygmoCor). For each ICH metric, a score of 2 was assigned for ideal levels, 1 for intermediate, and 0 for poor. All subjects showed at least one ICH metric, whereas none showed all ICH 7 metrics. The average number of ICH metrics was 4.3 ± 1.1. The highest rates were observed for fasting blood glucose (98%), whereas an ideal healthy diet was achieved only by 8% of subjects. The Cf-PWV was inversely and linearly associated with the sum of ICH metrics (p = 0.03) and the ICH score (p
- Published
- 2021
16. Relationship between serum myostatin levels and carotid-femoral pulse wave velocity in healthy young male adolescents. The Maciste Study
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Elisa Nulli Migliola, Marco D’Abbondanza, Graziana Lupattelli, Stefano Ministrini, Francesca Battista, Gaetano Vaudo, Fabio Anastasio, Giacomo Pucci, Leandro Sanesi, Federico Carbone, Mariano Edoardo Crapa, and Luisa Nunziangeli
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0301 basic medicine ,Male ,medicine.medical_specialty ,hypertension ,Adolescent ,Physiology ,Myostatin ,030204 cardiovascular system & hematology ,Pulse Wave Analysis ,03 medical and health sciences ,0302 clinical medicine ,Vascular Stiffness ,Interquartile range ,Physiology (medical) ,Internal medicine ,Heart rate ,medicine ,Humans ,adolescents ,Pulse wave velocity ,Schools ,biology ,Hand Strength ,business.industry ,medicine.disease ,030104 developmental biology ,Endocrinology ,Cross-Sectional Studies ,arterial stiffness ,Carotid-Femoral Pulse Wave Velocity ,atherosclerosis ,myostatin ,Arterial stiffness ,Lean body mass ,biology.protein ,Aortic stiffness ,business ,Body mass index - Abstract
Serum Myostatin (sMSTN) is a proteic compound that regulates skeletal muscle growth, adipogenesis, and production of extracellular matrix. Its relationship with functional and structural properties of the arterial wall is still understudied. We aimed at evaluating the association between sMSTN and carotid-femoral pulse wave velocity (cf-PWV), a measure of aortic stiffness, in a cohort of healthy male adolescents. Fifteen healthy male adolescents were recruited among participants of the MACISTE study, a cross-sectional survey conducted at the "Renato Donatelli" High School in Terni, Italy. sMSTN was measured through Enzyme-Linked Immunosorbent Assay (ELISA). cf-PWV was measured through high-fidelity applanation tonometry. Muscle strength and body composition were measured through handgrip and bioimpedentiometry, respectively. sMSTN levels showed a skewed distribution (median 6.0 ng/mL, interquartile range 2.2 - 69.2 ng/mL). Subjects with sMSTN above median value showed higher values of brachial DBP and increased cf-PWV (6.1±1.1 m/s vs 4.6±0.7 m/s, p
- Published
- 2021
17. Coronary and total thoracic calcium scores predict mortality and provides pathophysiologic insights in COVID-19 patients
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Giovanni Landoni, Andrea Biagi, Nicola Sverzellati, Roberto Ferrari, Fabio Anastasio, Gianluigi Patelli, Claudia Costa, Piergiorgio Turchio, Arif A. Khokhar, Alessandra Scoccia, Pietro Andrea Bonaffini, Cristiano Spreafico, Camillo Talei Franzesi, Gianni Casella, Edda Boccia, Antonio Esposito, Marco Toselli, Aldo P. Maggioni, Elisabetta Mancini, Chiara Gnasso, Luigi Vignali, Alessandro Sticchi, Elisa Scarnecchia, Antonio Colombo, Giacomo Bellani, Gianluca Pontone, Alberto Cereda, Caterina Chiara De Carlini, Marco Manfrini, Francesco Ponticelli, Stefano Maggiolini, Anna Palmisano, Claudio Rapezzi, Marco Loffi, Alberto Pacielli, Francesca Besana, Michele Senni, Lucio Baffoni, Sandro Sironi, Evgeny Fominskiy, Gianmarco Iannopollo, Francesco De Cobelli, Daniele Andreini, Giorgio Benatti, Paolo Giacomo Vaudano, Francesco Giannini, Gian Battista Danzi, Chiara Micossi, Alberto Monello, Tommaso Nannini, Massimiliano Sperandio, Carlo Tacchetti, Mario Iannaccone, Davide Vignale, Attilio Iacovoni, Riccardo Leone, Davide Ippolito, Gianluca Campo, Francesco Paolo Lombardo, Elisabetta Cesini, Valeria Nicoletti, Margherita Muri, Iljia Gardi, Giannini, F., Toselli, M., Palmisano, A., Cereda, A., Vignale, D., Leone, R., Nicoletti, V., Gnasso, C., Monello, A., Manfrini, M., Khokhar, A., Sticchi, A., Biagi, A., Turchio, P., Tacchetti, C., Landoni, G., Boccia, E., Campo, G., Scoccia, A., Ponticelli, F., Danzi, G. B., Loffi, M., Muri, M., Pontone, G., Andreini, D., Mancini, E. M., Casella, G., Iannopollo, G., Nannini, T., Ippolito, D., Bellani, G., Franzesi, C. T., Patelli, G., Besana, F., Costa, C., Vignali, L., Benatti, G., Sverzellati, N., Scarnecchia, E., Lombardo, F. P., Anastasio, F., Iannaccone, M., Vaudano, P. G., Pacielli, A., Baffoni, L., Gardi, I., Cesini, E., Sperandio, M., Micossi, C., De Carlini, C. C., Spreafico, C., Maggiolini, S., Bonaffini, P. A., Iacovoni, A., Sironi, S., Senni, M., Fominskiy, E., De Cobelli, F., Maggioni, A. P., Rapezzi, C., Ferrari, R., Colombo, A., Esposito, A., Giannini, F, Toselli, M, Palmisano, A, Cereda, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Manfrini, M, Khokhar, A, Sticchi, A, Biagi, A, Turchio, P, Tacchetti, C, Landoni, G, Boccia, E, Campo, G, Scoccia, A, Ponticelli, F, Danzi, G, Loffi, M, Muri, M, Pontone, G, Andreini, D, Mancini, E, Casella, G, Iannopollo, G, Nannini, T, Ippolito, D, Bellani, G, Franzesi, C, Patelli, G, Besana, F, Costa, C, Vignali, L, Benatti, G, Sverzellati, N, Scarnecchia, E, Lombardo, F, Anastasio, F, Iannaccone, M, Vaudano, P, Pacielli, A, Baffoni, L, Gardi, I, Cesini, E, Sperandio, M, Micossi, C, De Carlini, C, Spreafico, C, Maggiolini, S, Bonaffini, P, Iacovoni, A, Sironi, S, Senni, M, Fominskiy, E, De Cobelli, F, Maggioni, A, Rapezzi, C, Ferrari, R, Colombo, A, and Esposito, A
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Aortic valve ,Male ,Computed Tomography Angiography ,Aorta, Thoracic ,030204 cardiovascular system & hematology ,Severity of Illness Index ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Thoracic aorta ,Aged, 80 and over ,Middle Aged ,Coronary Vessels ,Pathophysiology ,Calcium score ,In-hospital mortality ,medicine.anatomical_structure ,Italy ,Aortic Valve ,Cardiology ,Aortic valve, Calcification, Calcium score, Coronary artery, COVID-19, Thoracic aorta, In-hospital mortality ,Female ,Cardiology and Cardiovascular Medicine ,Artery ,Research Paper ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Pneumonia, Viral ,Aortic Diseases ,chemistry.chemical_element ,Calcium ,Coronary artery ,NO ,Calcification ,03 medical and health sciences ,Predictive Value of Tests ,medicine.artery ,Internal medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Vascular Calcification ,Aged ,Retrospective Studies ,business.industry ,SARS-CoV-2 ,COVID-19 ,medicine.disease ,Pneumonia ,chemistry ,business - Abstract
BACKGROUND: Coronavirus disease 2019 (COVID-19) has spread worldwide determining dramatic impacts on healthcare systems. Early identification of high-risk parameters is required in order to provide the best therapeutic approach. Coronary, thoracic aorta and aortic valve calcium can be measured from a non-gated chest computer tomography (CT) and are validated predictors of cardiovascular events and all-cause mortality. However, their prognostic role in acute systemic inflammatory diseases, such as COVID-19, has not been investigated. OBJECTIVES: The aim was to evaluate the association of coronary artery calcium and total thoracic calcium on in-hospital mortality in COVID-19 patients. METHODS: 1093 consecutive patients from 16 Italian hospitals with a positive swab for COVID-19 and an admission chest CT for pneumonia severity assessment were included. At CT, coronary, aortic valve and thoracic aorta calcium were qualitatively and quantitatively evaluated separately and combined together (total thoracic calcium) by a central Core-lab blinded to patients' outcomes. RESULTS: Non-survivors compared to survivors had higher coronary artery [Agatston (467.76 â± â570.92 vs 206.80 â± â424.13 âmm2, p â
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- 2021
18. Surgical access and stimulation of pudendal nerve in pigs to restore the micturition control
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Alice, Giannotti, Ivo, Strauss, Stefania, Musco, Fabio, Bernini, Lenzi, Carla, Coli, Alessandra, Giannessi, Elisabetta, Fabio Anastasio Recchia, Giulio Del Popolo, and Silvestro, Micera
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- 2021
19. Impact of clinical and subclinical coronary artery disease as assessed by coronary artery calcium in COVID-19
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Arif A. Khokhar, Alberto Pacielli, Francesco Ponticelli, Marco Toselli, Gianmarco Iannopollo, Alberto Monello, Davide Ippolito, Antonio Colombo, Alessandro Sticchi, Antonio Esposito, Anna Palmisano, Luigi Vignali, Gianluca Campo, Pietro Andrea Bonaffini, Valeria Nicoletti, Caterina Chiara De Carlini, Daniele Andreini, Claudia Costa, Riccardo Leone, Giorgio Benatti, Giacomo Bellani, Marco Loffi, Andrea Biagi, Carlo Tacchetti, Fabio Anastasio, Elisa Scarnecchia, Chiara Gnasso, Alessandra Scoccia, Stefano Maggiolini, Gian Battista Danzi, Roberto Ferrari, Francesca Besana, Gianluigi Patelli, Claudio Rapezzi, Mario Iannaccone, Davide Vignale, Michele Senni, Gianluca Pontone, Guglielmo Gallone, Francesco Giannini, Gianni Casella, Alberto Cereda, Paolo Giacomo Vaudano, Scoccia, A, Gallone, G, Cereda, A, Palmisano, A, Vignale, D, Leone, R, Nicoletti, V, Gnasso, C, Monello, A, Khokhar, A, Sticchi, A, Biagi, A, Tacchetti, C, Campo, G, Rapezzi, C, Ponticelli, F, Danzi, G, Loffi, M, Pontone, G, Andreini, D, Casella, G, Iannopollo, G, Ippolito, D, Bellani, G, Patelli, G, Besana, F, Costa, C, Vignali, L, Benatti, G, Iannaccone, M, Vaudano, P, Pacielli, A, De Carlini, C, Maggiolini, S, Bonaffini, P, Senni, M, Scarnecchia, E, Anastasio, F, Colombo, A, Ferrari, R, Esposito, A, Giannini, F, Toselli, M, Scoccia, A., Gallone, G., Cereda, A., Palmisano, A., Vignale, D., Leone, R., Nicoletti, V., Gnasso, C., Monello, A., Khokhar, A., Sticchi, A., Biagi, A., Tacchetti, C., Campo, G., Rapezzi, C., Ponticelli, F., Danzi, G. B., Loffi, M., Pontone, G., Andreini, D., Casella, G., Iannopollo, G., Ippolito, D., Bellani, G., Patelli, G., Besana, F., Costa, C., Vignali, L., Benatti, G., Iannaccone, M., Vaudano, P. G., Pacielli, A., De Carlini, C. C., Maggiolini, S., Bonaffini, P. A., Senni, M., Scarnecchia, E., Anastasio, F., Colombo, A., Ferrari, R., Esposito, A., Giannini, F., and Toselli, M.
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0301 basic medicine ,Male ,medicine.medical_specialty ,coronary artery calcifications ,Coronary Artery Disease ,Coronary artery calcification ,030204 cardiovascular system & hematology ,Coronary Angiography ,Agatston score ,Coronary artery disease ,Article ,NO ,COVID-19, Coronary artery disease, Atherosclerosis, Agatston score, Coronary artery calcifications, Calcium score, In-hospital mortality ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Risk Factors ,Internal medicine ,Coronary artery calcifications ,Clinical endpoint ,Medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Coronary atherosclerosis ,Subclinical infection ,Aged ,Retrospective Studies ,business.industry ,SARS-CoV-2 ,Hazard ratio ,COVID-19 ,Middle Aged ,medicine.disease ,Atherosclerosis ,Coronary Vessels ,Calcium score ,In-hospital mortality ,030104 developmental biology ,Atherosclerosi ,Cardiology ,Calcium ,atherosclerosis ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background and aims The potential impact of coronary atherosclerosis, as detected by coronary artery calcium, on clinical outcomes in COVID-19 patients remains unsettled. We aimed to evaluate the prognostic impact of clinical and subclinical coronary artery disease (CAD), as assessed by coronary artery calcium score (CAC), in a large, unselected population of hospitalized COVID-19 patients undergoing non-gated chest computed tomography (CT) for clinical practice. Methods SARS-CoV 2 positive patients from the multicenter (16 Italian hospitals), retrospective observational SCORE COVID-19 (calcium score for COVID-19 Risk Evaluation) registry were stratified in three groups: (a) “clinical CAD” (prior revascularization history), (b) “subclinical CAD” (CAC >0), (c) “No CAD” (CAC=0). Primary endpoint was in-hospital mortality and the secondary endpoint was a composite of myocardial infarction and cerebrovascular accident (MI/CVA). Results Amongst 1625 patients (male 67.2%, median age 69 [interquartile range 58-77] years), 31%, 57.8% and 11.1% had no, subclinical and clinical CAD, respectively. Increasing rates of in-hospital mortality (11.3% vs. 27.3% vs. 39.8%, p400, respectively, p, Graphical abstract Image 1
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- 2021
20. Impact of Corticosteroids and Anticoagulant Combined Treatment on Patients Affected by COVID-19 Pneumonia
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Fabio, Anastasio, primary, Elisa, Scarnecchia, additional, Sarah, Barbuto, additional, Fabio, Spitaleri, additional, Valeria, Bisogni, additional, and Giacomo, Pucci, additional
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- 2021
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21. Transthoracic Sensor for Noninvasive Assessment of Left Ventricular Contractility: Validation in A Minipig Model of Chronic Heart Failure
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GEMIGNANI, VINCENZO, BIANCHINI, ELISABETTA, FAITA, FRANCESCO, LIONETTI, VINCENZO, CAMPAN, MANUELA, RECCHIA, FABIO ANASTASIO, PICANO, EUGENIO, and BOMBARDINI, TONINO
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- 2010
- Full Text
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22. AGE-SPECIFIC ACUTE CHANGES IN CAROTID-FEMORAL PULSE WAVE VELOCITY DURING HEAD-UP TILTING
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Bart Spronk, Anton Van De Meiracker, Fabio Anastasio, Lisanne Tap, Gaetano Vaudo, Giacomo Pucci, Alberto Avolio, and Francesco U.S. Mattace-Raso
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medicine.medical_specialty ,Head up tilting ,Physiology ,business.industry ,Internal medicine ,Internal Medicine ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Age specific ,Pulse wave velocity - Published
- 2021
23. Medium-term impact of COVID-19 on pulmonary function, functional capacity and quality of life
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Paolo Cosma, Sarah Barbuto, Pierpaolo Parravicini, Giulio Rossi, Mirco Parravicini, Elisa Scarnecchia, Alessandro Fugagnoli, and Fabio Anastasio
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Pulmonary and Respiratory Medicine ,Spirometry ,ARDS ,medicine.medical_specialty ,Pneumonia severity index ,Pulmonary function testing ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diffusing capacity ,Fraction of inspired oxygen ,medicine ,Humans ,Respiratory function ,030212 general & internal medicine ,Lung ,medicine.diagnostic_test ,SARS-CoV-2 ,business.industry ,COVID-19 ,medicine.disease ,Respiratory Function Tests ,Pneumonia ,030228 respiratory system ,Quality of Life ,Cardiology ,Original Article ,business - Abstract
Background Coronavirus disease 2019 (COVID-19) has spread worldwide determining a dramatic impact on the healthcare system. Aim of this study is to evaluate mid-term clinical impact of COVID-19 on respiratory function. Methods 379 patients were evaluated 4 months after SARS-COV-2 diagnosis. Patients were divided in two groups based on the presence of pneumonia during COVID. Clinical conditions, quality of life, symptomatology, 6-min walking test, pulmonary function test with spirometry and diffusing capacity of carbon monoxide were analysed. Data were compared to clinical evolution during COVID (development of acute respiratory distress syndrome [ARDS], needing of invasive mechanical ventilation [IMV], partial oxygen saturation/ fraction of inspired oxygen [SpO2/FiO2] ratio and pneumonia severity index [PSI]). Results After a median of 135 days, 260 (68.6%) of 379 patients referred almost one symptom. Patients who developed pneumonia during COVID-19 showed lower SpO2 at rest (p, COVID-19 severe lung involvement can reduce respiratory performance at a mid/long-term. Respiratory rehabilitation is recommended in COVID-19 survivors who showed severe clinical and radiological signs of the disease.
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- 2021
24. P54 Age-specific, Pressure-independent Acute Changes in Carotid-femoral Pulse Wave Velocity During Head-up Tilt
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Francesco U.S. Mattace-Raso, Anton H. Van den Meiracker A.H, Fabio Anastasio, Bart Spronck, Giacomo Pucci, Alberto Avolio, and Gaetano Vaudo
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lcsh:Diseases of the circulatory (Cardiovascular) system ,medicine.medical_specialty ,lcsh:Specialties of internal medicine ,business.industry ,Head up tilt ,General Medicine ,Age specific ,lcsh:RC581-951 ,lcsh:RC666-701 ,Internal medicine ,cardiovascular system ,Cardiology ,medicine ,cardiovascular diseases ,business ,Pulse wave velocity ,circulatory and respiratory physiology - Abstract
Introduction: Acute, gravity-induced blood pressure (BP) changes during head-up tilt may generate concomitant variations in carotid-femoral pulse wave velocity (cf-PWV). We aimed to separate the pressure-dependent and -independent components of cf-PWV changes observed during head-up tilt. Methods: 30 healthy individuals (age 48 ± 18 years (mean ± SD), 38% males, BP 130/74 ± 12/8 mmHg) underwent head-up passive tilting at a = 0°, 30°, and 60°. BP was taken at the upper arm, constantly kept at heart level. Aortic BP was reconstructed from radial tonometry (SphygmoCor). Stiffness index b0 was estimated at 0°. 1 Assumptions: [1] from MRI2, the effective cf-PWV travel distance (ETD, 80% of straight carotid-to-femoral distance) begins at heart level; [2] the change in DBP along the aorta is predictable from the hydrostatic pressure gradient (0.73 mmHg/cm) 3; [3] cf-PWV and hydrostatic pressure relate linearly, hence predicted cf-PWV can be calculated as the average of aortic (PWVaorta, using b0 and aortic DBP) and femoral (PWVfem, using b0 and femoral DBP, corresponding to aortic DBP + (ETD × sin(a)*0.73)) PWVs. Results: Both young (24–48 years) and old (48–82 years) individuals showed increasing trends for peripheral SBP, DBP, PP, and central DBP with tilting; central SBP remained unchanged. Heart rate (HR) and cf-PWV increased with body tilt in both groups (Figure, left). b0 linearly correlated with age (R = 0.70, p < 0.01). After adjustment for HR4, observed-vs-predicted cf-PWV exponentially increased as a function of age (R2 = 0.38, p < 0.01 for quadratic equation, p = 0.04, vs. linear; Figure, right). Conclusion: With aging, the acute relationship between BP and cf-PWV becomes progressively nonlinear.
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- 2020
25. Morning pressor surge, blood pressure variability, and arterial stiffness in essential hypertension
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Giuseppe Schillaci, Fabio Anastasio, Francesca Battista, and Giacomo Pucci
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Blood pressure variability ,Adult ,Male ,medicine.medical_specialty ,Mean arterial pressure ,Morning blood pressure surge ,Ambulatory blood pressure ,Physiology ,Blood Pressure ,030204 cardiovascular system & hematology ,Pulse Wave Analysis ,Essential hypertension ,Ambulatory blood pressure monitoring ,Arterial stiffness ,Hypertension ,Pulse wave velocity ,Blood Pressure Monitoring, Ambulatory ,Circadian Rhythm ,Essential Hypertension ,Female ,Heart Rate ,Humans ,Middle Aged ,Sleep ,Vascular Stiffness ,03 medical and health sciences ,0302 clinical medicine ,Blood Pressure Monitoring ,Internal medicine ,Ambulatory ,Heart rate ,Internal Medicine ,medicine ,030212 general & internal medicine ,business.industry ,medicine.disease ,Blood pressure ,Cardiology ,Aortic stiffness ,Cardiology and Cardiovascular Medicine ,business - Abstract
OBJECTIVE An excess morning blood pressure surge (MBPS) may portend an increased cardiovascular risk, but the mechanisms thereof have been little investigated. The link between MBPS, short-term blood pressure (BP) variability, and arterial stiffness has not been entirely defined. METHODS In 602 consecutive untreated hypertensive patients (48 ± 12 years, 61% men, office BP 149/93 ± 17/10 mmHg), we measured carotid-femoral pulse wave velocity (cf-PWV, SphygmoCor) and 24-h ambulatory BP. Using self-reported sleep and wake times, MBPS was defined as sleep-trough (ST-MBPS), prewaking, rising. Short-term BP variability was calculated as weighted 24-h SBP SD and average real variability of 24-h SBP (ARV), that is, average of absolute differences between consecutive SBP readings. RESULTS ST-MBPS (r = 0.16, P
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- 2016
26. Tabagism, Physical activity and cardiovascular risk in youth. An analysis of MACISTE study
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Giuseppe Fiorenzano, Fabio Anastasio, Giuseppe Schillaci, Leandro Sanesi, Lucas Troiani, Mariano Edoardo Crapa, Marco D' Abbondanza, Francesca Battista, and Giacomo Pucci
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High rate ,Cardiovascular investigation ,medicine.medical_specialty ,biology ,business.industry ,Athletes ,Physical activity ,biology.organism_classification ,Lower prevalence ,Physical therapy ,Medicine ,Analysis of variance ,Educational interventions ,business ,Demography ,Sedentary lifestyle - Abstract
Background: the MACISTE study (Metabolic and Cardiovascular Investigation at School, Terni) aimed at evaluating the metabolic and cardiovascular abnormalities and behaviors in healthy adolescents attending a High School. We evaluated the prevalence of smoking habits and the relationship between smoking and physical activity. Methods: 539 students (302 boys, 237 girls) were evaluated through: 1- self-reported questionnaires about lifestyles, smoking and physical habits, 2-measurement of exaled carbon-monoxide. Results: 65 subjects (12%) did not answer about smoking. Among the 474 subjects, 125 subjects (26%) were smokers, and 349 (74%) were non-smokers. Smoking prevalence significantly increased among the female sex and age-groups (R. 14 - 19)(Figure). 97 subjects (21%) reported sedentary lifestyle, 157 (33%) were involved in non-competitive physical activities, and 220 (46%) were involved in competitive sports. Smoking was more prevalent in sedentaries (37%), than in non-agonistic athletes (27%), and in athletes (21%, ANOVA p=0.009). The measurement of exaled carbon-monoxide, available in 250 subjects, was in agreement with self-reported data about smoking habits. Conclusions: smoking prevalence is disproportionately high among young Italian adolescents. Phisical activity is associated with a lower prevalence of smoking. However, the unacceptably high rate of smokers among athletes requires dedicated educational interventions.
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- 2016
27. [The SERVE-HF study]
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Maria Vittoria, Matassini, Fabio, Anastasio, Giacomo, Pucci, and Giuseppe, Schillaci
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Heart Failure ,Continuous Positive Airway Pressure ,Practice Guidelines as Topic ,Humans ,Stroke Volume ,Prognosis ,Sleep Apnea, Central - Published
- 2016
28. Effects of gravity-induced upper-limb blood pressure changes on wave transmission and arterial radial waveform
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Benjamin Gavish, Giuseppe Schillaci, Mark Butlin, Francesca Battista, Leandro Sanesi, Alberto Avolio, Giacomo Pucci, and Fabio Anastasio
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Adult ,Male ,medicine.medical_specialty ,Mean arterial pressure ,Supine position ,Brachial Artery ,Physiology ,Posture ,030204 cardiovascular system & hematology ,Pulse Wave Analysis ,augmentation index ,Upper Extremity ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Heart Rate ,medicine.artery ,Internal medicine ,Heart rate ,Internal Medicine ,medicine ,Humans ,Arterial Pressure ,030212 general & internal medicine ,Radial artery ,aortic augmentation ,blood pressure ,gravity ,pulse wave analysis ,radial artery ,Aged ,Blood Pressure Determination ,Female ,Middle Aged ,Radial Artery ,Gravitation ,aortic augmentation, augmentation index, blood pressure, gravity, pulse wave analysis, radial artery ,business.industry ,Aortic Augmentation Index ,Surgery ,medicine.anatomical_structure ,Blood pressure ,Cuff ,Cardiology ,Upper limb ,Cardiology and Cardiovascular Medicine ,business - Abstract
BACKGROUND Local blood pressure (BP) changes induced by arm tilting may influence pressure wave transmission and reflection. We investigated the effects of upper-limb tilting on radial augmentation index (rAIx) and related central measures [aortic augmentation index (aAIx)]. METHODS In 45 volunteers (age 49 ± 19 years), supine brachial BP and radial artery waveforms were obtained by applanation tonometry with the dominant arm stretched and gently supported in three different positions: at the heart level, with the BP cuff 15 cm above heart level (approximately +30°), and 15 cm below heart level (-30°). RESULTS Brachial SBP/DBP was 120/68 ± 17/8 mmHg. Mean arterial pressure changed predictably with arm tilting (99 ± 12 mmHg at -30°, 88 ± 10 mmHg at 0°, 77 ± 11 mmHg at +30°, all P
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- 2016
29. Assessing Cardiac Metabolism
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Taegtmeyer, Heinrich, Young, Martin E., Lopaschuk, Gary D., Abel, E. Dale, Brunengraber, Henri, Darley Usmar, Victor, Des Rosiers, Christine, Gerszten, Robert, Glatz, Jan F., Griffin, Julian L., Gropler, Robert J., Holzhuetter, Hermann Georg, Kizer, Jorge R., Lewandowski, E. Douglas, Malloy, Craig R., Neubauer, Stefan, Peterson, Linda R., Portman, Michael A., Recchia, FABIO ANASTASIO, Van Eyk, Jennifer E., and Wang, Thomas J.
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cardiac ,Physiology ,AHA Scientific Statements ,metabolic pathways ,metabolism, cardiac ,molecular biology ,radionuclide imaging ,systems biology ,Animals ,Cardiac Imaging Techniques ,Cardiovascular Diseases ,Computational Biology ,Humans ,Myocardium ,United States ,American Heart Association ,Cardiology and Cardiovascular Medicine ,metabolism - Published
- 2016
30. 1.2 AGE-DEPENDENT ASSOCIATION OF 24-HOUR PERIPHERAL AND CENTRAL PULSE PRESSURES WITH STROKE VOLUME
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Mariano Edoardo Crapa, Leandro Sanesi, Giuseppe Schillaci, Fabio Anastasio, Giacomo Pucci, and Francesca Battista
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medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,lcsh:Specialties of internal medicine ,business.industry ,Pulse (signal processing) ,Age dependent ,General Medicine ,Stroke volume ,Peripheral ,lcsh:RC581-951 ,lcsh:RC666-701 ,Internal medicine ,Cardiology ,Medicine ,business - Abstract
Objective: Pulse pressure (PP) is a complex physiologic trait affected by many variables, including LV contractility (reflected by stroke volume), arterial stiffness, and central-to-brachial amplification.The impact of age on the relationship between stroke volume and central or brachial PP has not been investigated. Methods: 3765 untreated hypertensive adults (men 56%, age 50 ± 12 years) underwent 24-hour ambulatory BP monitoring (SpaceLabs) and M-mode echocardiography. In a subset of 982 subjects in whom central PP was measured by applying a transfer function to radial pulse wave (SphygmoCor), we also estimated central office (or 24 h) PP by regression equations based on office (or 24 h) PP and MAP, heart rate, age, height and sex (R2 = 0.92 between estimated and measured central PP).The same equations were then applied to the original population to obtain estimated central PP. Results: Stroke volume had a significant direct association with both brachial and central 24 h PP up to the age of 39 years. The above relationship weakened with age and became mostly non-significant after the age of 40 (all r < 0.10). Similar, although weaker, trends were observed for office PP (both brachial and central). Conclusions: 24-h PP has a strong direct association with LV stroke volume in the young only, and might more exclusively depend on arterial stiffness later in life. Since the above relationship was also observed with estimated central PP, it may not depend on PP amplification. The “young” and “old” pathophysiological patterns of PP may help to explain the increasingly adverse prognostic value of PP observed with advancing age.
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- 2015
31. P7.19 ARTERIAL STIFFNESS AND DISEASE-RELATED ORGAN DAMAGE IN SYSTEMIC LUPUS ERYTHEMATOSUS
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Giuseppe Schillaci, Elena Bartoloni Bocci, Francesca Battista, Leandro Sanesi, Roberto Gerli, Mariano Edoardo Crapa, Giacomo Pucci, and Fabio Anastasio
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Pathology ,medicine.medical_specialty ,business.industry ,Specialties of internal medicine ,General Medicine ,Disease ,medicine.disease ,Organ damage ,RC581-951 ,RC666-701 ,Arterial stiffness ,medicine ,Diseases of the circulatory (Cardiovascular) system ,business - Abstract
Hypothesis: increased arterial stiffness has been reported in subjects with systemic lupus erythematosus (SLE) compared with healthy controls. In SLE, indexes of organ damage are related to a poor clinical status and worse prognosis independently from the activity of the disease. Data are controversial about the association between SLE-related organ damage and arterial stiffness. Methods: 40 subjects with history of SLE (mean age 45±12 years, 90% women) and a median disease duration of 12 years (IQR 5–19), underwent assessment of carotid-femoral pulse wave velocity (cf-PWV) by means of applanation tonometry (SphygmoCor). A comprehensive clinical, metabolic and immunological assessment was performed. Irreversible organ damage, not related to active inflammation, was assessed through the Systemic Lupus International Collaborating Clinics (SLICC) damage index. Results: mean BP was 128/75±16/10 mmHg. 9 subjects (23%) were on anti-hypertensive treatment, 4 (10%) had had previous cardiovascular events, 17 (42%) were treated with steroids, 29 (71%) with hydroxychloroquine, 15 (37%) with other immunosuppressants. Median SLICC index was 2 (IQR 1–3), average cf-PWV was 7.5±1.9 m/s. cf-PWV significantly increased across SLICC damage index categories (F=3.141, p
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- 2015
32. NON-INVASIVE MEASUREMENT OF HEART-FEMORAL PULSE WAVE VELOCITY
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G. Pucci, F.U.S. Mattace Raso, Fabio Anastasio, C. Magistri, and Francesca Battista
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Reproducibility ,Physiology ,business.industry ,Non invasive ,Internal Medicine ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Pulse wave velocity ,Biomedical engineering - Published
- 2018
33. Intracoronary Cytoprotective Gene Therapy: A Study of VEGF-B167 in a Pre-Clinical Animal Model of Dilated Cardiomyopathy
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Woitek, Felix, Zentilin, Lorena, Hoffman, Nicholas E, Powers, Jeffery C, Ottiger, Isabel, Parikh, Suraj, Kulczycki, Anna M, Hurst, Marykathryn, Ring, Nadja, Wang, Tao, Shaikh, Farah, Gross, Polina, Singh, Harinder, Kolpakov, Mikhail A, Linke, Axel, Houser, Steven R, Rizzo, Victor, Sabri, Abdelkarim, Madesh, Muniswamy, Giacca, Mauro, Recchia, FABIO ANASTASIO, Woitek, Felix, Zentilin, Lorena, Hoffman, Nicholas E., Powers, Jeffery C., Ottiger, Isabel, Parikh, Suraj, Kulczycki, Anna M., Hurst, Marykathryn, Ring, Nadja, Wang, Tao, Shaikh, Farah, Gross, Polina, Singh, Harinder, Kolpakov, Mikhail A., Linke, Axel, Houser, Steven R., Rizzo, Victor, Sabri, Abdelkarim, Madesh, Muniswamy, Giacca, Mauro, and Recchia, Fabio A.
- Subjects
Cardiomyopathy, Dilated ,Male ,Infusions ,Vascular Endothelial Growth Factor B ,Cardiomyopathy ,heart failure ,Transgene ,Dogs ,Dilated ,Dog ,Animals ,Infusions, Intra-Arterial ,Transgenes ,Translational Medical Research ,Coronary Vessel ,translational approach ,Intra-Arterial ,Animal ,Medicine (all) ,Genetic Therapy ,Coronary Vessels ,gene therapy ,Disease Models, Animal ,Treatment Outcome ,Cardiology and Cardiovascular Medicine ,Disease Models - Abstract
BACKGROUND: Vascular endothelial growth factor (VEGF)-B activates cytoprotective/antiapoptotic and minimally angiogenic mechanisms via VEGF receptors. Therefore, VEGF-B might be an ideal candidate for the treatment of dilated cardiomyopathy, which displays modest microvascular rarefaction and increased rate of apoptosis. OBJECTIVES: This study evaluated VEGF-B gene therapy in a canine model of tachypacing-induced dilated cardiomyopathy. METHODS: Chronically instrumented dogs underwent cardiac tachypacing for 28 days. Adeno-associated virus serotype 9 viral vectors carrying VEGF-B167 genes were infused intracoronarily at the beginning of the pacing protocol or during compensated heart failure. Moreover, we tested a novel VEGF-B167 transgene controlled by the atrial natriuretic factor promoter. RESULTS: Compared with control subjects, VEGF-B167 markedly preserved diastolic and contractile function and attenuated ventricular chamber remodeling, halting the progression from compensated to decompensated heart failure. Atrial natriuretic factor-VEGF-B167 expression was low in normally functioning hearts and stimulated by cardiac pacing; it thus functioned as an ideal therapeutic transgene, active only under pathological conditions. CONCLUSIONS: Our results, obtained with a standard technique of interventional cardiology in a clinically relevant animal model, support VEGF-B167 gene transfer as an affordable and effective new therapy for nonischemic heart failure.
- Published
- 2015
34. Revascularization of hibernating myocardium: uneven reflorescence after the drought
- Author
-
Recchia, FABIO ANASTASIO
- Subjects
Myocardial Stunning ,Myocytes ,cardiac ,Myocardium ,Coronary Stenosis ,cytoskeletal proteins ,myocardial ischemia ,contractile proteins ,proteomics ,stents ,regeneration ,Myocardial Revascularization ,Animals ,myocytes ,Myocytes, Cardiac - Published
- 2015
35. P9.10 EXCESS PRESSURE IS INDEPENDENTLY RELATED TO LV MASS AND CONCENTRIC GEOMETRY IN ESSENTIAL HYPERTENSION
- Author
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Giuseppe Schillaci, Siegfried Wassertheurer, Francesca Battista, Bernhard Hametner, Fabio Anastasio, and G. Pucci
- Subjects
medicine.medical_specialty ,business.industry ,Specialties of internal medicine ,General Medicine ,Concentric ,Essential hypertension ,medicine.disease ,RC581-951 ,Internal medicine ,RC666-701 ,medicine ,Cardiology ,Diseases of the circulatory (Cardiovascular) system ,business - Published
- 2014
36. 3.5 EFFECTS OF BETA-BLOCKERS WITH OR WITHOUT VASODILATING PROPERTIES ON CENTRAL BLOOD PRESSURE: A META-ANALYSIS OF RANDOMIZED TRIALS IN HYPERTENSION
- Author
-
Maria Giovanna Ranalli, Mariano Edoardo Crapa, Giuseppe Schillaci, Francesca Battista, Fabio Anastasio, and Giacomo Pucci
- Subjects
medicine.medical_specialty ,lcsh:Diseases of the circulatory (Cardiovascular) system ,lcsh:Specialties of internal medicine ,business.industry ,Hemodynamics ,Vasodilation ,General Medicine ,medicine.disease ,vitamin D deficiency ,law.invention ,Randomized controlled trial ,law ,lcsh:RC581-951 ,lcsh:RC666-701 ,Internal medicine ,Meta-analysis ,medicine ,Cardiology ,Observational study ,Aortic stiffness ,business ,Beta (finance) - Abstract
(0.16 1.9 vs -0.12 2.2 m/s; PZ0.4), or any other haemodynamic variable relative to control at six or 12 months (all P > 0.05). Conclusions: Despite many observational studies to suggest that vitamin D supplementation could be a useful therapy for improving aortic stiffness and associated haemodynamic indices, 12-months intervention yielded no improvement in older people with vitamin D deficiency. These results do not support use of vitamin D supplementation to improve cardiovascular health in this patient population.
- Published
- 2014
37. [OP.7C.01] CENTRAL-TO-PERIPHERAL DIASTOLIC BLOOD PRESSURE ATTENUATION IN HEALTHY ADOLESCENT AND THE EFFECTS OF HEART RATE. THE MACISTE STUDY
- Author
-
Mariano Edoardo Crapa, G. Pucci, Francesca Battista, Fabio Anastasio, F. Papi, Giuseppe Schillaci, and Leandro Sanesi
- Subjects
medicine.medical_specialty ,Blood pressure ,Physiology ,business.industry ,Internal medicine ,Attenuation ,Heart rate ,Internal Medicine ,Cardiology ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,Peripheral - Published
- 2017
38. Imatinib Activates Pathological Hypertrophy by Altering Myocyte Calcium Regulation
- Author
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Barr, Larry A, Makarewich, Catherine A, Berretta, Remus M, Gao, Hui, Troupes, Constantine D, Woitek, Felix, Recchia, FABIO ANASTASIO, Kubo, Hajime, Force, Thomas, and Houser, Steven R.
- Subjects
Heart Ventricles ,Apoptosis ,Cardiomegaly ,Piperazines ,Rats, Sprague-Dawley ,Mice ,Original Research Articles ,molecular biology ,Animals ,Myocytes, Cardiac ,Calcium Signaling ,Phosphorylation ,Cell Nucleus ,Myocytes ,NFATC Transcription Factors ,Calcineurin ,calcium ,cancer pharmacology ,hypertrophy ,Benzamides ,Calcium ,Calcium-Calmodulin-Dependent Protein Kinase Type 2 ,Protein Transport ,Pyrimidines ,Rats ,Imatinib Mesylate ,Sprague-Dawley ,Cardiac - Abstract
Imatinib mesylate is a selective tyrosine-kinase inhibitor used in the treatment of multiple cancers, most notably chronic myelogenous leukemia. There is evidence that imatinib can induce cardiotoxicity in cancer patients. Our hypothesis is that imatinib alters calcium regulatory mechanisms and can contribute to development of pathological cardiac hypertrophy.Neonatal rat ventricular myocytes (NRVMs) were treated with clinical doses (low: 2 μM; high: 5 μM) of imatinib and assessed for molecular changes. Imatinib increased peak systolic Ca(2+) and Ca(2+) transient decay rates and Western analysis revealed significant increases in phosphorylation of phospholamban (Thr-17) and the ryanodine receptor (Ser-2814), signifying activation of calcium/calmodulin-dependent kinase II (CaMKII). Imatinib significantly increased NRVM volume as assessed by Coulter counter, myocyte surface area, and atrial natriuretic peptide abundance seen by Western. Imatinib induced cell death, but did not activate the classical apoptotic program as assessed by caspase-3 cleavage, indicating a necrotic mechanism of death in myocytes. We expressed AdNFATc3-green fluorescent protein in NRVMs and showed imatinib treatment significantly increased nuclear factor of activated T cells translocation that was inhibited by the calcineurin inhibitor FK506 or CaMKII inhibitors.These data show that imatinib can activate pathological hypertrophic signaling pathways by altering intracellular Ca(2+) dynamics. This is likely a contributing mechanism for the adverse cardiac effects of imatinib.
- Published
- 2014
39. Cardio-ankle vascular index and subclinical heart disease
- Author
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Giuseppe Schillaci, L. Settimi, Francesca Battista, Fabio Anastasio, and Giacomo Pucci
- Subjects
Adult ,Male ,medicine.medical_specialty ,Heart disease ,Heart Diseases ,Physiology ,midwall fractional shortening ,pulse wave velocity ,Diagnostic Techniques, Cardiovascular ,Pulse Wave Analysis ,Cardiovascular ,Vascular Stiffness ,inappropriate left ventricular mass ,Internal medicine ,medicine.artery ,Internal Medicine ,medicine ,Humans ,cardiovascular diseases ,Pulse wave velocity ,Subclinical infection ,Aged ,Aorta ,business.industry ,arterial stiffness ,cardio-ankle vascular index ,Middle Aged ,medicine.disease ,Diagnostic Techniques ,Blood pressure ,medicine.anatomical_structure ,Ventricle ,Female ,cardiovascular system ,Cardiology ,Arterial stiffness ,Cardiology and Cardiovascular Medicine ,business ,Body mass index - Abstract
The relationship between arterial stiffness, measured as pulse wave velocity (PWV), and the left ventricle is confounded by the effects of blood pressure. We evaluated the relationship between carotid-femoral PWV and cardio-ankle vascular index (CAVI), a less pressure-dependent measurement of the stiffness constant (β) of the aorta and the iliac, femoral and tibial arteries, and obtained prognostically relevant measurements of left ventricular structure and systolic function. CAVI, carotid-femoral PWV and echocardiographic left ventricular mass and systolic function were determined in 133 subjects with either hypertension or high-normal blood pressure (33% treated; 56 ± 16 years, blood pressure 145/89 ± 21/12 mm Hg). Carotid-femoral PWV exhibited a direct relationship with systolic and diastolic blood pressure (r = 0.33/0.26, P0.001/0.014), whereas CAVI demonstrated no such relationship (r = 0.12/-0.05, both P0.1). Both CAVI and PWV correlated significantly with left ventricular mass index (r = 0.31, P0.001; r = 0.21, P = 0.014). Subjects with inappropriately high left ventricular masses for a given cardiac workload (n = 44) had higher CAVI values (9.1 ± 2.0 vs. 7.9 ± 1.6, P0.001), but not higher PWV values (8.5 ± 2.5 vs. 8.7 ± 2.4, P0.1). In a multivariate regression model, CAVI was independently associated with inappropriate left ventricular mass (β = 0.40, P0.001), along with body mass index. CAVI also demonstrated a negative relationship with left ventricular midwall fractional shortening (r = -0.41, P = 0.001) that was independent of age, sex, blood pressure and left ventricular mass in a multivariate analysis. In conclusion, a high CAVI is associated with inappropriately high left ventricular mass and low midwall systolic function. As a marker of arterial diastolic-to-systolic stiffening, CAVI may have a relationship with left ventricular structure and function that is independent of blood pressure levels.
- Published
- 2014
40. Three-dimensional magnetic resonance mapping of cardiac metabolism by hyperpolarized 13C-pyruvate in a pig model of ischemia-reperfusion
- Author
-
Aquaro, Giovanni Donato, Frijia, Francesca, Positano, Vincenzo, Menichetti, Luca, Santarelli, Maria Filomena, Ardenkjaer-Larsen, Jan Henrik, Wiesinger, Florian, Lionetti, Vincenzo, Romano, Simone Lorenzo, Bianchi, Giacomo, Neglia, Danilo, Giovannetti, Giulio, Schulte, Rolf F., Recchia, Fabio Anastasio, Landini, Luigi, and Lombardi, Massimo
- Subjects
Article - Published
- 2013
41. Intracoronary Gene Delivery of VEGF-B167, a Selective VEGFR-1 Agonist, Exerts Potent Therapeutic Effects in Dogs with Pacing-Induced Dilated Cardiomyopathy
- Author
-
Woitek, F, Zentilin, L, Powers, Jc, Hurst, M, Ring, N, Lam, A, Kulczycki, Am, Sabri, A, Vallem, S, Hoffman, Ne, Madesh, M, Giacca, M, and Recchia, FABIO ANASTASIO
- Published
- 2013
42. The Gut Hormone Ghrelin Partially Reverses Energy Substrate Metabolic Alterations in the Failing Heart
- Author
-
Mitacchione, G, Powers, J, Grifoni, G, Hurst, M, Kulczycki, Am, Lam, A, Ly, L, Settanni, F, Granata, R, and Recchia, FABIO ANASTASIO
- Published
- 2013
43. Hemodynamic Challenges and Efficacy of Vasodilator-enhanced Antegrade Intracoronary AAV9 Gene Delivery with and without Coronary Sinus Blockage
- Author
-
Woitek, F, Hurst, M, Powers, Jc, Kulczycki, Am, Lam, A, Sabri, A, and Recchia, FABIO ANASTASIO
- Published
- 2013
44. Effective Antegrade Cardiac Gene Therapy with VEGF-B167 for Pacing-induced Dilated Cardiomyopathy in a Pre-clinical Large Animal Model of Heart Failure
- Author
-
Woitek, F, Hurst, M, Ring, N, Kulczycki, Am, Lam, A, Powers, Jc, Sabri, A, Giacca, M., and Recchia, FABIO ANASTASIO
- Published
- 2013
45. [OP.6A.02] IDEAL CARDIOVASCULAR HEALTH IS INVERSELY ASSOCIATED WITH INCREASED CAROTID-FEMORAL PULSE WAVE VELOCITY IN ITALIAN ADOLESCENTS. THE MACISTE STUDY
- Author
-
Giuseppe Schillaci, Mariano Edoardo Crapa, G. Pucci, F. Papi, Leandro Sanesi, Fabio Anastasio, L. Troiani, Francesca Battista, Marco D’Abbondanza, and F. Desantis
- Subjects
medicine.medical_specialty ,Ideal (set theory) ,Physiology ,business.industry ,Cardiovascular health ,Internal medicine ,Internal Medicine ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Pulse wave velocity - Published
- 2016
46. [PP.04.02] SODIUM CONSUMPTION, CENTRAL AND PERIPHERAL BLOOD PRESSURE, AND FOOD HABITS IN A POPULATION OF HEALTHY ADOLESCENTS. THE MACISTE STUDY
- Author
-
Giuseppe Schillaci, Francesca Battista, F. Desantis, Marco D’Abbondanza, Mariano Edoardo Crapa, G. Pucci, F. Papi, Leandro Sanesi, Fabio Anastasio, and L. Troiani
- Subjects
Consumption (economics) ,education.field_of_study ,Physiology ,business.industry ,Sodium ,Population ,chemistry.chemical_element ,Food habits ,Peripheral blood ,chemistry ,Environmental health ,Internal Medicine ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,education - Published
- 2016
47. Testing the Oxidative Stress Hypothesis of Aging in Primate Fibroblasts: Is There a Correlation Between Species Longevity and Cellular ROS Production?
- Author
-
Csiszar, A, Podlutsky, A, Podlutskaya, N, Sonntag, We, Merlin, Sz, Philipp, Ee, Doyle, K, Davila, A, Recchia, FABIO ANASTASIO, Ballabh, P, Pinto, Jt, and Ungvari, Z.
- Published
- 2012
48. Functional and cellular heterogeneity in a porcine model of pacing induced heart failure
- Author
-
Czuriga, D, Balogh, A, Pasztor, Et, Bodnar, A, Lionetti, Vincenzo, Czuriga, I, Toth, A, Edes, I, Recchia, FABIO ANASTASIO, and Papp, Z.
- Published
- 2012
49. Acute Vagal Stimulation Attenuates Cardiac Metabolic Response to Beta-adrenergic Stress in Chronically Instrumented Dogs
- Author
-
Qanud, K, Vimercati, C, Ilsar, I, Mitacchione, G, Sarnari, R, Mania, D, Faulk, R, Stanley, Wc, Sabbah, Hn, and Recchia, FABIO ANASTASIO
- Published
- 2012
50. Cardiac adeno-associated virus 9-mediated delivery of nestin-640 prevents myocardial remodeling in a rodent model of post-ischemic heart failure
- Author
-
Romano, S. L., Matteucci, Marco, Zentilin, L., Scebba, Francesca, Bianchi, G., Pucci, A., Giacca, M., Recchia, FABIO ANASTASIO, and Lionetti, Vincenzo
- Published
- 2012
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