46 results on '"Jessop, H"'
Search Results
2. Haematopoietic stem cell transplantation for severe autoimmune diseases in children : a review of current literature, registry activity and future directions on behalf of the autoimmune diseases and paediatric diseases working parties of the European Society for Blood and Marrow Transplantation
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Achini‐Gutzwiller, FR, Snowden, JA, Corbacioglu, S, Greco, R, Alexander, T, Snowden, J, Badoglio, M, Labopin, M, Abinun, M, Apte, S, Arnold, R, Domenech, A, Brierley, C, Burman, J, Castilla‐Llorente, C, Cooper, N, Daghia, G, Daikeler, T, del Papa, N, de Vries‐Bouwstra, J, Farge, D, Finke, J, Hagglund, H, Hawkey, C, Henes, J, Hiepe, F, Jessop, H, Kiely, D, Kazmi, M, Kirgizov, K, Kramer, E, Mancardi, G, Marjanovic, Z, Martin, R, Martin, T, Ma, D, Moore, J, Miller, P, Muraro, P, Oliveira, M, Polushin, A, Onida, F, Simoes, B, Puyade, M, Resnick, I, Ricart, E, Rovira, M, Saccardi, R, Saif, M, Sakellari, I, Sharrack, B, Snarski, E, Scherer, HU, Sossa, C, Withers, B, Wulffraat, N, Zaccara, E, Amrolia, P, Ansari, M, Balduzzi, A, Dalassier, A, Dalle, J, Diaz, CH, Feuchtinger, T, Locatelli, F, Lucchini, G, Galimard, J, Vincent, MG, Handgretinger, R, Kleinschmidt, K, Lawitschka, A, Martinez, AP, Peters, C, Rocha, V, Ruggeri, A, Sedlacek, P, Svec, P, Toporski, J, Yesilipek, A, Achini-Gutzwiller, F, Snowden, J, Corbacioglu, S, Greco, R, Alexander, T, Badoglio, M, Labopin, M, Abinun, M, Apte, S, Arnold, R, Domenech, A, Brierley, C, Burman, J, Castilla-Llorente, C, Cooper, N, Daghia, G, Daikeler, T, del Papa, N, de Vries-Bouwstra, J, Farge, D, Finke, J, Hagglund, H, Hawkey, C, Henes, J, Hiepe, F, Jessop, H, Kiely, D, Kazmi, M, Kirgizov, K, Kramer, E, Mancardi, G, Marjanovic, Z, Martin, R, Martin, T, Ma, D, Moore, J, Miller, P, Muraro, P, Oliveira, M, Polushin, A, Onida, F, Simoes, B, Puyade, M, Resnick, I, Ricart, E, Rovira, M, Saccardi, R, Saif, M, Sakellari, I, Sharrack, B, Snarski, E, Scherer, H, Sossa, C, Withers, B, Wulffraat, N, Zaccara, E, Amrolia, P, Ansari, M, Balduzzi, A, Dalassier, A, Dalle, J, Diaz, C, Feuchtinger, T, Locatelli, F, Lucchini, G, Galimard, J, Vincent, M, Handgretinger, R, Kleinschmidt, K, Lawitschka, A, Martinez, A, Peters, C, Rocha, V, Ruggeri, A, Sedlacek, P, Svec, P, Toporski, J, and Yesilipek, A
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autoimmune diseases, haematopoietic stem cell transplantation, paediatric ,ddc:610 ,paediatric ,surgical procedures, operative ,Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,haematopoietic stem cell transplantation ,610 Medizin ,autoimmune diseases ,autoimmune disease ,Hematology - Abstract
Although modern clinical management strategies have improved the outcome of paediatric patients with severe autoimmune and inflammatory diseases over recent decades, a proportion will experience ongoing or recurrent/relapsing disease activity despite multiple therapies often leading to irreversible organ damage, and compromised quality of life, growth/development and long-term survival. Autologous and allogeneic haematopoietic stem cell transplantation (HSCT) have been used successfully to induce disease control and often apparent cure of severe treatment-refractory autoimmune diseases (ADs) in children. However, transplant-related outcomes are disease-dependent and long-term outcome data are limited in respect to efficacy and safety. Moreover, balancing risks of HSCT against AD prognosis with continually evolving non-transplant options is challenging. This review appraises published literature on HSCT strategies and outcomes in individual paediatric ADs. We also provide a summary of the European Society for Blood and Marrow Transplantation (EBMT) Registry, where 343 HSCT procedures (176 autologous and 167 allogeneic) have been reported in 326 children (
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- 2022
3. Report from the Annual Conference of the British Society of Echocardiography, October 2018, ACC Liverpool, Liverpool
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Sharma, V., Al Saikhan, L., Park, C., Hughes, A., Gu, H., Saeed, S., Boguslavskyi, A., Carr-White, G., Chambers, J., Chowienczyk, P., Jain, M., Jessop, H., Turner, C., Bassindale-Maguire, G., Baig, W., Kidambi, A., Abdel-Rahman, S. T., Schlosshan, D., Sengupta, A., Fitzpatrick, A., Sandoval, J., Hickman, S., Procter, H., Taylor, J., Kaur, H., Knowles, C., Wheatcroft, S., Witte, K., Gatenby, K., Willis, J. A., Kendler-Rhodes, A., Slegg, O., Carson, K., Easaw, J., Kandan, S. R., Rodrigues, J. C. L., MacKenzie-Ross, R., Hall, T., Robinson, G., Little, D., Hudson, B., Pauling, J., Redman, S., Graham, R., Coghlan, G., Suntharalingam, J., Augustine, D. X., Nowak, J. W. M., and Masters, A. T.
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- 2020
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4. Universal use of surgical masks is tolerated and prevents respiratory viral infection in stem cell transplant recipients
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Partridge, D.G., primary, Sori, A., additional, Green, D.J., additional, Simpson, R., additional, Poller, B., additional, Raza, M., additional, Kaur, H., additional, Jessop, H., additional, Colton, B., additional, Nield, A., additional, Evans, C.M., additional, and Lee, A., additional
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- 2022
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5. Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidelines and recommendations
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Greco, R., Alexander, T., Burman, J., Papa, N. del, Vries-Bouwstra, J. de, Farge, D., Henes, J., Kazmi, M., Kirgizov, K., Muraro, P.A., Ricart, E., Rovira, M., Saccardi, R., Sharrack, B., Snarski, E., Withers, B., Jessop, H., Boglione, C., Kramer, E., Badoglio, M., Labopin, M., Orchard, K., Corbacioglu, S., Ljungman, P., Mikulska, M., Camara, R. de la, Snowden, J.A., European Soc Blood Marrow Transp, Autoimmune Dis Working Party ADWP, Infect Dis Working Party IDWP, Pediat Working Party PWP, Joint Accreditation Comm Int Soc C, EBMT Nurses Grp, and Patient Advocacy Comm
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Feature ,Adult ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,medicine.medical_treatment ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Best practice ,MEDLINE ,Hematopoietic stem cell transplantation ,Inflammatory bowel disease ,Autoimmune Diseases ,03 medical and health sciences ,Rheumatic diseases ,0302 clinical medicine ,Pandemic ,medicine ,Humans ,Hematologi ,Child ,Intensive care medicine ,Pandemics ,030203 arthritis & rheumatology ,Transplantation ,SARS-CoV-2 ,business.industry ,Public health ,Hematopoietic Stem Cell Transplantation ,COVID-19 ,Hematology ,Infectious diseases ,Immunotherapy ,business ,Neurological disorders ,030217 neurology & neurosurgery - Abstract
Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), represents one of the biggest challenges of 21st century, threatening public health around the globe. Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune diseases (ADs) and immunosuppressive treatments such as haematopoietic stem cell transplantation (HSCT), which are also associated with adverse outcomes. We review the impact of the pandemic on specific groups of patients with neurological, rheumatological, and gastroenterological indications, along with the challenges delivering HSCT in adult and pediatric populations. Moving forward, we developed consensus-based guidelines and recommendations for best practice and quality of patient care in order to support clinicians, scientists, and their multidisciplinary teams, as well as patients and their carers. These guidelines aim to support national and international organizations related to autoimmune diseases and local clinical teams delivering HSCT. Areas of unmet need and future research questions are also highlighted. The waves of the COVID-19 pandemic are predicted to be followed by an “endemic” phase and therefore an ongoing risk within a “new normality”. These recommendations reflect currently available evidence, coupled with expert opinion, and will be revised according to necessary modifications in practice.
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- 2021
6. Autologous haematopoietic stem cell transplantation as a first-line disease-modifying therapy in patients with ‘aggressive’ multiple sclerosis
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Das, J, primary, Snowden, JA, additional, Burman, J, additional, Freedman, MS, additional, Atkins, H, additional, Bowman, M, additional, Burt, RK, additional, Saccardi, R, additional, Innocenti, C, additional, Mistry, S, additional, Laud, PJ, additional, Jessop, H, additional, and Sharrack, B, additional
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- 2021
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7. Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases : updated guidelines and recommendations from the EBMT autoimmune diseases working party (ADWP) and the joint accreditation committee of EBMT and ISCT (JACIE)
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Sharrack, B., Saccardi, R., Alexander, T., Badoglio, M., Burman, J., Farge, D., Greco, R., Jessop, H., Kazmi, M., Kirgizov, K., Labopin, M., Mancardi, G., Martin, R., Moore, J., Muraro, P.A., Rovira, M., Sormani, M.P., and Snowden, J.A.
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surgical procedures, operative - Abstract
These updated EBMT guidelines review the clinical evidence, registry activity and mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple sclerosis (MS) and other immune-mediated neurological diseases and provide recommendations for patient selection, transplant technique, follow-up and future development. The major focus is on autologous HSCT (aHSCT), used in MS for over two decades and currently the fastest growing indication for this treatment in Europe, with increasing evidence to support its use in highly active relapsing remitting MS failing to respond to disease modifying therapies. aHSCT may have a potential role in the treatment of the progressive forms of MS with a significant inflammatory component and other immune-mediated neurological diseases, including chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, myasthenia gravis and stiff person syndrome. Allogeneic HSCT should only be considered where potential risks are justified. Compared with other immunomodulatory treatments, HSCT is associated with greater short-term risks and requires close interspeciality collaboration between transplant physicians and neurologists with a special interest in these neurological conditions before, during and after treatment in accredited HSCT centres. Other experimental cell therapies are developmental for these diseases and patients should only be treated on clinical trials.
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- 2020
8. OA14.02 IMpower131: Final OS Results of Carboplatin + Nab-Paclitaxel ± Atezolizumab in Advanced Squamous NSCLC
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Jotte, R., primary, Cappuzzo, F., additional, Vynnychenko, I., additional, Stroyakovskiy, D., additional, Abreu, D. Rodriguez, additional, Hussein, M., additional, Soo, R., additional, Conter, H., additional, Kozuki, T., additional, Huang, K., additional, Graupner, V., additional, Sun, S., additional, Hoang, T., additional, Jessop, H., additional, Mccleland, M., additional, Ballinger, M., additional, Sandler, A., additional, and Socinski, M., additional
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- 2019
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9. General information for patients and carers considering haematopoietic stem cell transplantation (HSCT) for severe autoimmune diseases (ADs) : A position statement from the EBMT Autoimmune Diseases Working Party (ADWP), the EBMT Nurses Group, the EBMT Patient, Family and Donor Committee and the Joint Accreditation Committee of ISCT and EBMT (JACIE)
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Jessop, H., Farge, D., Saccardi, R., Alexander, T., Rovira Tarrats, Montserrat, Sharrack, B., Greco, R., Wulffraat, N., Moore, J., Kazmi, M., Badoglio, M., Adams, G., Verhoeven, B., Murray, J., Snowden, J.A., Universitat Autònoma de Barcelona, Service de Médecine Interne [Saint-Louis], Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Recherche clinique appliquée à l'hématologie ((EA_3518)), Université Paris Diderot - Paris 7 (UPD7), McGill University = Université McGill [Montréal, Canada], Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), University of Sheffield [Sheffield], San Raffaele Scientific Institute, Vita-Salute San Raffaele University and Center for Translational Genomics and Bioinformatics, St. Vincent's Hospital, Sydney, Guy's Hospital [London], Laboratoire d'Hématologie et d'Immunologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), CEREST-TC [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre International des greffes [CHU Saint-Antoine] (EBMT), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), McGill University, Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Sorbonne Université (SU)-CHU Saint-Antoine [APHP]
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medicine.medical_specialty ,Autoimmune diseases ,MEDLINE ,Disease ,Stem cells ,Hospitals, Special ,Transplantation, Autologous ,Accreditation ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Medicine ,Humans ,Intensive care medicine ,030203 arthritis & rheumatology ,Autoimmune disease ,Transplantation ,business.industry ,Standard treatment ,Hematopoietic Stem Cell Transplantation ,Hematology ,medicine.disease ,Tissue Donors ,3. Good health ,Haematopoiesis ,surgical procedures, operative ,Caregivers ,030220 oncology & carcinogenesis ,Perspective ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Stem cell ,business - Abstract
International audience; Over the last 20 years, haematopoietic stem cell transplantation (HSCT) has been used to treat patients with severe autoimmune and inflammatory diseases whose response to standard treatment options has been limited, resulting in a poor long-term prognosis in terms of survival or disability. The vast majority of patients have received autologous HSCT where an increasing evidence-base supports its use in a wide range of autoimmune diseases, particularly relapsing remitting MS, systemic sclerosis and Crohn’s disease. Compared with standard treatments for autoimmune diseases, HSCT is associated with greater short-term risks, including a risk of treatment-related mortality and long-term complications. There is a need for a careful appraisal of potential benefits and risks by disease and transplant specialists working closely together with patients and carers to determine individual suitability for HSCT. HSCT should be conducted in accredited transplant centres with robust arrangements for long-term follow-up with both disease and transplant specialists. The aim of this open-access position statement is to provide plainly worded guidance for patients and non-specialist clinicians considering HSCT for an autoimmune disease, especially when treatment abroad is being considered. Recent technical publications in the field have been referenced to support the statement and provide more detail for clinicians advising patients.
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- 2019
10. The gonococcal C Antigen partitions into phenol and is immunogenic in mice
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Senior, K. E., Jessop, H. L., Demarco De Hormaeche, R., and Poolman, J. T., editor
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- 1988
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11. Asthma prevalence disparities and differences in sociodemographic associations with asthma, between Native Hawaiian/Other Pacific Islander, Asian, and White adults in Hawaii – Behavioral Risk Factor Surveillance System (BRFSS), 2001–2010
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Jessop, H., primary, Li, D., additional, Katz, A. R., additional, and Hurwitz, E. L., additional
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- 2017
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12. Asthma prevalence disparities and differences in sociodemographic associations with asthma, between Native Hawaiian/Other Pacific Islander, Asian, and White adults in Hawaii - Behavioral Risk Factor Surveillance System (BRFSS), 2001-2010.
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Jessop, H., Li, D., Katz, A. R., and Hurwitz, E. L.
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ASIANS , *ASTHMA , *CHI-squared test , *CONFIDENCE intervals , *ETHNIC groups , *RACE , *SEX distribution , *SURVEYS , *WHITE people , *LOGISTIC regression analysis , *SOCIOECONOMIC factors , *HEALTH equity , *CROSS-sectional method , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
Objectives: Despite high asthma prevalence, relatively little is known about the epidemiology of asthma in Hawaii or among Native Hawaiian/Other Pacific Islanders (NHOPI). We sought to better characterize racial/ethnic differences in asthma prevalence and in sociodemographic factors associated with asthma among Hawaii adults. Design: We conducted multivariable logistic regression using 2001-2010 Behavioral Risk Factor Surveillance System data from Hawaii, and computed adjusted prevalence and ratios. Results: Asthma prevalence markedly varied between self-identified census categories of race in Hawaii, with NHOPI having the highest estimates of both lifetime (20.9%, 95% confidence interval [CI]: 19.5%-22.4%) and current (12.2%, CI: 11.2%-13.3%) asthma. Highest asthma prevalence among NHOPI persisted after controlling for potential confounders and within most sociodemographic categories. Among females Asians reported the lowest asthma prevalence, whereas among males point estimates of asthma prevalence were often lowest for Whites. Females often had greater asthma prevalence than males of the same race, but the degree to which gender modified asthma prevalence differed by both race and sociodemographic strata. Gender disparities in asthma prevalence were greatest and most frequent among Whites, and for current asthma among all races. Sociodemographic factors potentially predictive of adult asthma prevalence in Hawaii varied by race and gender. Conclusion: Asthma disproportionately affects or is recognized more often among women and NHOPI adults in Hawaii, and occurs less or is under-reported among Asian women. The sociodemographic characteristics included in this study’s model did not explain asthma disparities between races and/or gender. This investigation provides a baseline with which to plan additionally needed prevention programs, epidemiological investigations, and surveillance for asthma in Hawaii. [ABSTRACT FROM AUTHOR]
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- 2019
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13. AUTOLOGOUS HAEMOPOIETIC STEM CELL TRANSPLANT IN MS: SHEFFIELD COHORT
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Kelsey, P, primary, Bell, SM, additional, Jessop, H, additional, Snowden, JA, additional, and Sharrack, B, additional
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- 2015
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14. The Extreme Ultraviolet Explorer stellar spectral atlas
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Craig, N. Abbott, M. Finley, D. Jessop, H. Howell, S.B. Mathioudakis, M. Sommers, J. Vallerga, J.V. Malina, R.F.
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Astrophysics::Solar and Stellar Astrophysics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics::Earth and Planetary Astrophysics ,Astrophysics::Galaxy Astrophysics - Abstract
We present an atlas of extreme ultraviolet (EUV) spectra of 95 bright stellar sources observed between 1992 July and 1996 June with the Extreme Ultraviolet Explorer (EUVE) spectrometers. These data are taken in the short-(SW; 70-190 Å), medium-(MW; 140-380 Å), and long-wavelength bandpasses (LW; 280-760 Å) at roughly 0.5, 1, and 2 Å resolution, respectively. We describe the spectrometers and detail the procedure used to reduce the observational data to spectra. The atlas is grouped by the type of source: O-A stars, F-M stars, white dwarfs, and cataclysmic variables. We present a brief overview of the general nature and EUV spectral distribution of each group and present accompanying notes and individual spectra for each source. We show selected F-M sources in more detail with identifications of the brightest spectral lines illustrating the characteristics of the EUV spectra of stars of various temperatures. The current study is the most complete compilation to date of aggregate spectra of bright EUV stellar sources.
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- 1997
15. The adaptive response of bone to mechanical loading in female transgenic mice is deficient in the absence of oestrogen receptor-alpha and -beta
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Lee, KC, primary, Jessop, H, additional, Suswillo, R, additional, Zaman, G, additional, and Lanyon, LE, additional
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- 2004
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16. The Effect of In Vivo Mechanical Loading on Estrogen Receptor α Expression in Rat Ulnar Osteocytes
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Ehrlich, P. J., primary, Noble, B. S., additional, Jessop, H. L., additional, Stevens, H. Y., additional, Mosley, J. R., additional, and Lanyon, L. E., additional
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- 2002
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17. Mechanical Strain and Estrogen Activate Estrogen Receptor α in Bone Cells
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Jessop, H. L., primary, Sjöberg, M., additional, Cheng, M. Z., additional, Zaman, G., additional, Wheeler‐Jones, C. P. D., additional, and Lanyon, L. E., additional
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- 2001
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18. The Extreme Ultraviolet Explorer Stellar Spectral Atlas
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Craig, N., primary, Abbott, M., additional, Finley, D., additional, Jessop, H., additional, Howell, S. B., additional, Mathioudakis, M., additional, Sommers, J., additional, Vallerga, J. V., additional, and Malina, R. F., additional
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- 1997
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19. Better reporting systems for clinicians can improve care of adult inpatients with diabetes.
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Hutchinson L and Jessop H
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- 2008
20. Mechanical strain activates estrogen response elements in bone cells
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Zaman, G., Cheng, M. Z., Jessop, H. L., White, R., and Lanyon, L. E.
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- 2000
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21. Antibodies to the C Epitope of Neisseria gonorrhoeae Are Present in Patients with Gonorrhoea and Absent in Normal Sera
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DE HORMAECHE, R. D., primary, JESSOP, H., additional, and BUNDELL, C., additional
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- 1988
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22. Immunochemical Characterization of the Outer Membrane Complex of Serratia marcescens and Identification of the Antigens Accessible to Antibodies on the Cell Surface
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JESSOP, H. L., primary and LAMBERT, P. A., additional
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- 1985
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23. The Role of Surface Polysaccharide in Determining the Resistance of Serratia marcescens to Serum Killing
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JESSOP, H. L., primary and LAMBERT, P. A., additional
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- 1986
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24. Patient-reported outcomes in HSCT for autoimmune diseases: Considerations on behalf of the EBMT ADWP, PAC, and Nurses Group.
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Alexander T, Tassy N, Domenech A, Kramer E, Jessop H, Kenyon M, Sharrack B, Saccardi R, Bolanos N, Snowden JA, and Greco R
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Background: Over the last 3 decades, hematopoietic stem cell transplantation (HSCT) has been successfully used to treat severe and refractory autoimmune diseases (AIDs). A multidisciplinary appraisal of potential benefits and risks by disease and transplant specialists is essential to determine individual suitability for HSCT., Objective: Our aim was to observe that patient-reported outcomes (PROs) and health-related quality of life instruments can capture the unique patient perspective on disease burden and impact of treatment., Methods: Herein, we describe the basis and complexity of end points measuring patient-reported perceptions of efficacy and tolerability used in clinical practice and trials for patients with AIDs undergoing autologous HSCT., Results: PRO measures and patient-reported experience measures are key tools to evaluate the impact and extent of disease burden for patients affected by AIDs. For formal scientific assessment, it is essential that validated general instruments are used, whereas adaptations have resulted in disease-specific instruments that may help guide tailored interventions. An additional approach relates to qualitative evaluations, from carefully structured qualitative research to informal narratives, as patient stories. The patients' subjectively reported responses to HSCT may be influenced by their preprocedure expectations and investment in the HSCT journey., Conclusions: The complexity of AIDs advocates for individualized and multidisciplinary approach to positively affect the patient journey. PROs and health-related quality of life need to be collected using validated instruments in clinical practice and trials to enable robustness of data and to ensure the impact of the intervention is comprehensively assessed, addressing the main questions and needs of the involved stakeholders., Competing Interests: This work was led and supported by the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the EBMT. The EBMT provided resources via the working party, data office, and registry. Other than EBMT support, there is no funding body supporting this work, commercial or otherwise. Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest., (© 2024 The Author(s).)
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- 2024
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25. Nutritional aspects in autoimmune diseases undergoing hematopoietic stem cell transplantation: overview and recommendations on behalf of the EBMT ADWP and Nurses Group.
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Gandossi C, Jessop H, Hahn A, Heininger L, Henes J, Radaelli AM, Carmagnola A, Morello E, Renica C, Bertulli A, Lazzari L, Kenyon M, Alexander T, Domenech A, and Greco R
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Autoimmune diseases (ADs) represent a heterogeneous group of conditions affecting 5-10% of the global population. In recent decades, hematopoietic stem cell transplant (HSCT), mainly autologous, has been successfully adopted to treat patients affected by severe/refractory ADs. In this context malnutrition has a detrimental impact on relapse, mortality, infection rate, engraftment, long-term survival, and prolongation of hospitalization. However, in this population, the management of nutrition should be improved since nutritional assessment is partially performed in routine clinical practice. A panel of nurses and physicians from the European Society for Blood and Marrow Transplantation (EBMT) reviewed all available evidence based on current literature and expert practices from centers with extensive experience in HSCT for ADs, on the nutritional management of ADs patients during HSCT procedure. In this context, adequate nutritional status predicts a better response to treatment and improves quality of life. Herein, a systematic and comprehensive monitoring of nutritional status before, during and after HSCT, with adequate nutritional support in the case of ADs patients, in addition to assessing the dietary requirements associated with HSCT has been covered. Moreover, given the singularity of each AD, the underlying disease should be considered for an appropriate approach. The management and evaluation of nutritional status must be carried out by a multidisciplinary team to assess the needs, monitor the effectiveness of each intervention, and prevent complications, especially in complex situations as patients affected by ADs., Competing Interests: RG discloses speaking honoraria from Biotest, Pfizer, Medac, Neovii and Magenta. TA received study support from Amgen, Janssen and honoraria from Neovii, GSK, Astra-Zeneca, Abbvie. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Gandossi, Jessop, Hahn, Heininger, Henes, Radaelli, Carmagnola, Morello, Renica, Bertulli, Lazzari, Kenyon, Alexander, Domenech and Greco.)
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- 2024
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26. Methodological reflections on the recruitment and engagement of people for cancer screening research in Wales.
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Yu J, Kenkre J, Wallace S, Thomas S, and Jessop H
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- Female, Humans, Wales, Qualitative Research, Communication Barriers, Early Detection of Cancer, Uterine Cervical Neoplasms diagnosis, Uterine Cervical Neoplasms prevention & control
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Cancer is a major threat to public health and the second leading cause of death globally. Population-based cancer screening is an effective way to improve the early detection of a cancer and reduce mortality. Factors associated with participation in cancer screening have been increasingly explored in research. The challenges to undertaking such research are evident, but there is little discussion about how to address such challenges. This article discusses methodological issues associated with the recruitment and engagement of participants in research, drawing upon our experience of undertaking research exploring the support needs of people residing in Newport West, Wales, to participate in breast, bowel, and cervical screening programs. Four key areas were addressed: sampling issues, language barriers, IT issues, and time demand for participation. The paper highlights the importance of ongoing community engagement, the provision of appropriate study materials, and the adaption to different data collection modes to meet participants' needs to participate in research, thus enabling people who are usually excluded from research to have a voice and make a significant contribution to research.
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- 2023
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27. Phylogeography, colouration, and cryptic speciation across the Indo-Pacific in the sea urchin genus Echinothrix.
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Coppard SE, Jessop H, and Lessios HA
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- Adenosine Triphosphatases genetics, Animal Distribution, Animals, Biological Evolution, Calpain genetics, Cell Nucleus chemistry, DNA, Mitochondrial genetics, DNA, Ribosomal genetics, Evolution, Molecular, Gene Frequency, Indian Ocean, Introns genetics, Pacific Ocean, Phylogeny, RNA, Ribosomal, 16S genetics, RNA, Ribosomal, 28S genetics, Sea Urchins anatomy & histology, Sea Urchins genetics, Species Specificity, Gene Flow, Pigmentation, Sea Urchins classification
- Abstract
The sea urchins Echinothrix calamaris and Echinothrix diadema have sympatric distributions throughout the Indo-Pacific. Diverse colour variation is reported in both species. To reconstruct the phylogeny of the genus and assess gene flow across the Indo-Pacific we sequenced mitochondrial 16S rDNA, ATPase-6, and ATPase-8, and nuclear 28S rDNA and the Calpain-7 intron. Our analyses revealed that E. diadema formed a single trans-Indo-Pacific clade, but E. calamaris contained three discrete clades. One clade was endemic to the Red Sea and the Gulf of Oman. A second clade occurred from Malaysia in the West to Moorea in the East. A third clade of E. calamaris was distributed across the entire Indo-Pacific biogeographic region. A fossil calibrated phylogeny revealed that the ancestor of E. diadema diverged from the ancestor of E. calamaris ~ 16.8 million years ago (Ma), and that the ancestor of the trans-Indo-Pacific clade and Red Sea and Gulf of Oman clade split from the western and central Pacific clade ~ 9.8 Ma. Time since divergence and genetic distances suggested species level differentiation among clades of E. calamaris. Colour variation was extensive in E. calamaris, but not clade or locality specific. There was little colour polymorphism in E. diadema., (© 2021. The Author(s).)
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- 2021
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28. Autologous haematopoietic stem cell transplantation as a first-line disease-modifying therapy in patients with 'aggressive' multiple sclerosis.
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Das J, Snowden JA, Burman J, Freedman MS, Atkins H, Bowman M, Burt RK, Saccardi R, Innocenti C, Mistry S, Laud PJ, Jessop H, and Sharrack B
- Subjects
- Humans, Retrospective Studies, Transplantation, Autologous, Treatment Outcome, Hematopoietic Stem Cell Transplantation, Multiple Sclerosis therapy
- Abstract
Background: Autologous haematopoietic stem cell transplantation (AHSCT) is an effective treatment for patients with multiple sclerosis (MS) who have highly active disease, despite the use of standard disease-modifying therapies (DMTs). However, the optimal time for offering AHSCT to patients with 'aggressive' MS is yet to be established., Objectives: The objective was to explore the safety and efficacy of AHSCT as a first-line DMT in patients with 'aggressive' MS., Methods: All patients with 'aggressive' MS who received AHSCT as a first-line DMT in five European and North American centres were retrospectively evaluated., Results: Twenty patients were identified. The median interval between diagnosis and AHSCT was 5 (1-20) months. All had multiple poor prognostic markers with a median pre-transplant Expanded Disability Status Scale (EDSS) score of 5.0 (1.5-9.5). After a median follow-up of 30 (12-118) months, the median EDSS score improved to 2.0 (0-6.5, p < 0.0001). No patient had further relapses. Three had residual magnetic resonance imaging (MRI) disease activities in the first 6 months post-transplant, but no further new or enhancing lesions were observed in subsequent scans., Conclusion: AHSCT is safe and effective as a first-line DMT in inducing rapid and sustained remission in patients with 'aggressive' MS.
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- 2021
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29. Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidelines and recommendations.
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Greco R, Alexander T, Burman J, Del Papa N, de Vries-Bouwstra J, Farge D, Henes J, Kazmi M, Kirgizov K, Muraro PA, Ricart E, Rovira M, Saccardi R, Sharrack B, Snarski E, Withers B, Jessop H, Boglione C, Kramer E, Badoglio M, Labopin M, Orchard K, Corbacioglu S, Ljungman P, Mikulska M, De la Camara R, and Snowden JA
- Subjects
- Adult, Child, Humans, Pandemics, SARS-CoV-2, Autoimmune Diseases therapy, COVID-19, Hematopoietic Stem Cell Transplantation
- Abstract
Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), represents one of the biggest challenges of 21st century, threatening public health around the globe. Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune diseases (ADs) and immunosuppressive treatments such as haematopoietic stem cell transplantation (HSCT), which are also associated with adverse outcomes. We review the impact of the pandemic on specific groups of patients with neurological, rheumatological, and gastroenterological indications, along with the challenges delivering HSCT in adult and pediatric populations. Moving forward, we developed consensus-based guidelines and recommendations for best practice and quality of patient care in order to support clinicians, scientists, and their multidisciplinary teams, as well as patients and their carers. These guidelines aim to support national and international organizations related to autoimmune diseases and local clinical teams delivering HSCT. Areas of unmet need and future research questions are also highlighted. The waves of the COVID-19 pandemic are predicted to be followed by an "endemic" phase and therefore an ongoing risk within a "new normality". These recommendations reflect currently available evidence, coupled with expert opinion, and will be revised according to necessary modifications in practice.
- Published
- 2021
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30. Autologous haematopoietic stem cell transplantation for refractory stiff-person syndrome: the UK experience.
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Kass-Iliyya L, Snowden JA, Thorpe A, Jessop H, Chantry AD, Sarrigiannis PG, Hadjivassiliou M, and Sharrack B
- Subjects
- Humans, Transplantation, Autologous, Treatment Outcome, United Kingdom, Hematopoietic Stem Cell Transplantation, Stiff-Person Syndrome therapy
- Abstract
Stiff Person Syndrome (SPS) is a rare immune-mediated disabling neurological disorder characterised by muscle spasms and high GAD antibodies. There are only a few case reports of autologous haematopoietic stem cell transplantation (auto-HSCT) as a treatment for SPS., Objective: To describe the UK experience of treating refractory SPS with auto-HSCT., Methods: Between 2015 and 2019, 10 patients with SPS were referred to our institution for consideration of auto-HSCT. Eight patients were deemed suitable for autograft and four were treated. Of the treated patients, three had classical SPS and one had the progressive encephalomyelitis with rigidity and myoclonus variant. All patients were significantly disabled and had failed conventional immunosuppressive therapy. Patients were mobilised with Cyclophosphamide (Cy) 2 g/m
2 + G-CSF and conditioned with Cy 200 mg/kg + ATG followed by auto-HSCT., Results: Despite their significantly reduced performance status, all patients tolerated the procedure with no unexpected toxicities. Following autograft, all patients improved symptomatically and stopped all forms of immunosuppressive therapies. Two patients were able to ambulate independently from being wheelchair dependent. One patient's walking distance improved from 300 meters to 5 miles and one patient's ambulation improved from being confined to a wheelchair to be able to walk with a frame. Two patients became seronegative for anti-GAD antibodies and normalised their neurophysiological abnormalities., Conclusions: Auto-HSCT is an intensive but well tolerated and effective treatment option for patients with SPS refractory to conventional immunotherapy. Further work is warranted to optimise patient selection and establish the efficacy, long-term safety, and cost-effectiveness of this treatment.- Published
- 2021
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31. Rehabilitation Before and After Autologous Haematopoietic Stem Cell Transplantation (AHSCT) for Patients With Multiple Sclerosis (MS): Consensus Guidelines and Recommendations for Best Clinical Practice on Behalf of the Autoimmune Diseases Working Party, Nurses Group, and Patient Advocacy Committee of the European Society for Blood and Marrow Transplantation (EBMT).
- Author
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Roberts F, Hobbs H, Jessop H, Bozzolini C, Burman J, Greco R, Ismail A, Kazmi M, Kirgizov K, Mancardi G, Mawson S, Muraro PA, Puyade M, Saccardi R, Withers B, Verhoeven B, Sharrack B, and Snowden JA
- Abstract
Autologous haematopoietic stem cell transplantation (AHSCT) is increasingly used to treat people with multiple sclerosis (MS). Supported by an evolving evidence base, AHSCT can suppress active inflammation in the central nervous system and induce long-term changes in immune cell populations, thereby stabilizing, and, in some cases, reversing disability in carefully selected MS patients. However, AHSCT is an intensive chemotherapy-based procedure associated with intrinsic risks, including profound cytopenia, infection, and organ toxicity, accompanied by an on-going degree of immuno-compromise and general deconditioning, which can be associated with a transient increase in functional impairment in the early stages after transplantation. Although international guidelines and recommendations have been published for clinical and technical aspects of AHSCT in MS, there has been no detailed appraisal of the rehabilitation needed following treatment nor any specific guidelines as to how this is best delivered by hospital and community-based therapists and wider multidisciplinary teams in order to maximize functional recovery and quality of life. These expert consensus guidelines aim to address this unmet need by summarizing the evidence-base for AHSCT in MS and providing recommendations for current rehabilitation practice along with identifying areas for future research and development., Competing Interests: FR and HH work for Hobbs Rehabilitation, JS declares honoraria for speaking at educational meetings from Sanofi, Jazz, Janssen, Gilead, and Mallinckrodt, BV declares honoraria for speaking at educational meetings and consultancy from Janssen, Takeda, and Amgen. PM reports travel support and speaker honoraria from unrestricted educational activities organized by Novartis, Bayer HealthCare, Bayer Pharma, Biogen Idec, Merck-Serono, and Sanofi Aventis. He also discloses consulting to Magenta Therapeutics and Jasper Therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer EP declared a shared affiliation, with no collaboration, with two of the authors RS and CB to the handling Editor. The Handling Editor declared a past co-authorship with one of the authors GM., (Copyright © 2020 Roberts, Hobbs, Jessop, Bozzolini, Burman, Greco, Ismail, Kazmi, Kirgizov, Mancardi, Mawson, Muraro, Puyade, Saccardi, Withers, Verhoeven, Sharrack and Snowden.)
- Published
- 2020
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32. Atezolizumab in Combination With Carboplatin and Nab-Paclitaxel in Advanced Squamous NSCLC (IMpower131): Results From a Randomized Phase III Trial.
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Jotte R, Cappuzzo F, Vynnychenko I, Stroyakovskiy D, Rodríguez-Abreu D, Hussein M, Soo R, Conter HJ, Kozuki T, Huang KC, Graupner V, Sun SW, Hoang T, Jessop H, McCleland M, Ballinger M, Sandler A, and Socinski MA
- Subjects
- Albumins, Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carboplatin, Humans, Paclitaxel therapeutic use, Carcinoma, Squamous Cell drug therapy, Lung Neoplasms drug therapy
- Abstract
Introduction: Cytotoxic agents have immunomodulatory effects, providing a rationale for combining atezolizumab (anti-programmed death-ligand 1 [anti-PD-L1]) with chemotherapy. The randomized phase III IMpower131 study (NCT02367794) evaluated atezolizumab with platinum-based chemotherapy in stage IV squamous NSCLC., Methods: A total of 1021 patients were randomized 1:1:1 to receive atezolizumab+carboplatin+paclitaxel (A+CP) (n = 338), atezolizumab+carboplatin+nab-paclitaxel (A+CnP) (n = 343), or carboplatin+nab-paclitaxel (CnP) (n = 340) for four or six 21-day cycles; patients randomized to the A+CP or A+CnP arms received atezolizumab maintenance therapy until progressive disease or loss of clinical benefit. The coprimary end points were investigator-assessed progression-free survival (PFS) and overall survival (OS) in the intention-to-treat (ITT) population. The secondary end points included PFS and OS in PD-L1 subgroups and safety. The primary PFS (January 22, 2018) and final OS (October 3, 2018) for A+CnP versus CnP are reported., Results: PFS improvement with A+CnP versus CnP was seen in the ITT population (median, 6.3 versus 5.6 mo; hazard ratio [HR] = 0.71, 95% confidence interval [CI]: 0.60-0.85; p = 0.0001). Median OS in the ITT population was 14.2 and 13.5 months in the A+CnP and CnP arms (HR = 0.88, 95% CI: 0.73-1.05; p = 0.16), not reaching statistical significance. OS improvement with A+CnP versus CnP was observed in the PD-L1-high subgroup (HR = 0.48, 95% CI: 0.29-0.81), despite not being formally tested. Treatment-related grade 3 and 4 adverse events and serious adverse events occurred in 68.0% and 47.9% (A+CnP) and 57.5% and 28.7% (CnP) of patients, respectively., Conclusions: Adding atezolizumab to platinum-based chemotherapy significantly improved PFS in patients with first-line squamous NSCLC; OS was similar between the arms., (Copyright © 2020 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.)
- Published
- 2020
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33. A Case of Multiple Sclerosis-Like Relapsing Remitting Encephalomyelitis Following Allogeneic Hematopoietic Stem Cell Transplantation and a Review of the Published Literature.
- Author
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Das J, Gill A, Lo C, Chan-Lam N, Price S, Wharton SB, Jessop H, Sharrack B, and Snowden JA
- Subjects
- Adrenal Cortex Hormones therapeutic use, Disease Progression, Encephalomyelitis drug therapy, Fatal Outcome, Graft vs Host Disease drug therapy, Humans, Immunologic Factors therapeutic use, Leukemia, Myelogenous, Chronic, BCR-ABL Positive immunology, Lymphocyte Activation, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting drug therapy, Recurrence, Transplantation, Autologous adverse effects, Transplantation, Homologous adverse effects, Encephalomyelitis etiology, Graft vs Host Disease etiology, Hematopoietic Stem Cell Transplantation adverse effects, Leukemia, Myelogenous, Chronic, BCR-ABL Positive surgery, Multiple Sclerosis, Relapsing-Remitting etiology
- Abstract
Complications involving the central nervous system (CNS) occur in 9-14% of patients following allogeneic hematopoietic stem cell transplantation (HSCT), including stroke-like episodes, demyelination, encephalitis, and nonspecific neurological symptoms. Here we report a case of multiple sclerosis (MS) like relapsing remitting encephalomyelitis following allogeneic HSCT, which did not respond to disease modifying therapies (DMTs) and "domino" autologous HSCT. A 53-year-old male was treated with allogeneic HSCT for lymphoid blast transformation of chronic myeloid leukemia. Ten months later he presented with confusion, slurred speech, left sided facial weakness and ataxia. A magnetic resonance imaging brain scan showed multiple enhancing tumefactive lesions. Neuromyelitis optica (NMO) and myelin oligodendrocyte glycoprotein (MOG) antibodies were negative. After extensive investigations for infections, autoimmune disorders and recurrence of malignancy, he underwent brain biopsy, which showed a macrophage rich lesion with severe myelin loss but axonal preservation indicating a demyelinating pathology. Although his symptoms improved with corticosteroids, he relapsed five months later. In the absence of any systemic features suggesting graft versus host disease (GvHD), his presentation was thought to be compatible with MS. The illness followed an aggressive course that did not respond to glatiramer acetate and natalizumab. He was therefore treated with "domino" autologous HSCT, which also failed to induce long-term remission. Despite further treatment with ocrelizumab, he died of progressive disease. An autopsy limited to the examination of brain revealed multifocal destructive leukoencephalopathy with severe myelin and axonal loss. Immunohistochemistry showed macrophage located in the perivascular area, with no T or B lymphocytes. The appearance was unusual and not typical for chronic MS plaques. Reported cases of CNS demyelination following allogeneic HSCT are very limited in the literature, especially in relation to histopathological examination. Although the clinical disease course of our patient following allogeneic HSCT resembled an "MS-like" relapsing remitting encephalomyelitis, the autopsy examination did not show any evidence of active inflammation. The impact of DMTs and HSCT on the histological appearance of "MS-like" CNS pathologies is unknown. Therefore, reporting this and similar cases will improve our awareness and understanding of underlying disease mechanisms., (Copyright © 2020 Das, Gill, Lo, Chan-Lam, Price, Wharton, Jessop, Sharrack and Snowden.)
- Published
- 2020
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34. Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE).
- Author
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Sharrack B, Saccardi R, Alexander T, Badoglio M, Burman J, Farge D, Greco R, Jessop H, Kazmi M, Kirgizov K, Labopin M, Mancardi G, Martin R, Moore J, Muraro PA, Rovira M, Sormani MP, and Snowden JA
- Subjects
- Accreditation, Europe, Humans, Transplantation, Autologous, Autoimmune Diseases, Hematopoietic Stem Cell Transplantation, Multiple Sclerosis therapy
- Abstract
These updated EBMT guidelines review the clinical evidence, registry activity and mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple sclerosis (MS) and other immune-mediated neurological diseases and provide recommendations for patient selection, transplant technique, follow-up and future development. The major focus is on autologous HSCT (aHSCT), used in MS for over two decades and currently the fastest growing indication for this treatment in Europe, with increasing evidence to support its use in highly active relapsing remitting MS failing to respond to disease modifying therapies. aHSCT may have a potential role in the treatment of the progressive forms of MS with a significant inflammatory component and other immune-mediated neurological diseases, including chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, myasthenia gravis and stiff person syndrome. Allogeneic HSCT should only be considered where potential risks are justified. Compared with other immunomodulatory treatments, HSCT is associated with greater short-term risks and requires close interspeciality collaboration between transplant physicians and neurologists with a special interest in these neurological conditions before, during and after treatment in accredited HSCT centres. Other experimental cell therapies are developmental for these diseases and patients should only be treated on clinical trials.
- Published
- 2020
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35. General information for patients and carers considering haematopoietic stem cell transplantation (HSCT) for severe autoimmune diseases (ADs): A position statement from the EBMT Autoimmune Diseases Working Party (ADWP), the EBMT Nurses Group, the EBMT Patient, Family and Donor Committee and the Joint Accreditation Committee of ISCT and EBMT (JACIE).
- Author
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Jessop H, Farge D, Saccardi R, Alexander T, Rovira M, Sharrack B, Greco R, Wulffraat N, Moore J, Kazmi M, Badoglio M, Adams G, Verhoeven B, Murray J, and Snowden JA
- Subjects
- Accreditation, Autoimmune Diseases mortality, Caregivers, Hospitals, Special, Humans, Risk Factors, Tissue Donors, Transplantation, Autologous, Autoimmune Diseases therapy, Hematopoietic Stem Cell Transplantation
- Abstract
Over the last 20 years, haematopoietic stem cell transplantation (HSCT) has been used to treat patients with severe autoimmune and inflammatory diseases whose response to standard treatment options has been limited, resulting in a poor long-term prognosis in terms of survival or disability. The vast majority of patients have received autologous HSCT where an increasing evidence-base supports its use in a wide range of autoimmune diseases, particularly relapsing remitting MS, systemic sclerosis and Crohn's disease. Compared with standard treatments for autoimmune diseases, HSCT is associated with greater short-term risks, including a risk of treatment-related mortality and long-term complications. There is a need for a careful appraisal of potential benefits and risks by disease and transplant specialists working closely together with patients and carers to determine individual suitability for HSCT. HSCT should be conducted in accredited transplant centres with robust arrangements for long-term follow-up with both disease and transplant specialists. The aim of this open-access position statement is to provide plainly worded guidance for patients and non-specialist clinicians considering HSCT for an autoimmune disease, especially when treatment abroad is being considered. Recent technical publications in the field have been referenced to support the statement and provide more detail for clinicians advising patients.
- Published
- 2019
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36. Endocrinology: bone adaptation requires oestrogen receptor-alpha.
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Lee K, Jessop H, Suswillo R, Zaman G, and Lanyon L
- Subjects
- Adaptation, Physiological, Animals, Estrogen Receptor alpha, Estrogen Receptor beta, Female, Gene Deletion, Male, Mice, Mice, Knockout, Osteoblasts metabolism, Receptors, Estrogen genetics, Weight-Bearing, Bone Remodeling, Bone and Bones metabolism, Receptors, Estrogen metabolism
- Published
- 2003
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37. The effect of in vivo mechanical loading on estrogen receptor alpha expression in rat ulnar osteocytes.
- Author
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Ehrlich PJ, Noble BS, Jessop HL, Stevens HY, Mosley JR, and Lanyon LE
- Subjects
- Animals, Animals, Newborn, Biomechanical Phenomena, Estrogen Receptor alpha, Female, Humans, Immunohistochemistry, Male, Osteoporosis, Postmenopausal etiology, Osteoporosis, Postmenopausal metabolism, Osteoporosis, Postmenopausal physiopathology, Rats, Rats, Sprague-Dawley, Stress, Mechanical, Ulna cytology, Ulna metabolism, Ulna physiology, Osteocytes metabolism, Receptors, Estrogen metabolism
- Abstract
The presence of estrogen receptor alpha (ER alpha) in osteocytes was identified immunocytochemically in transverse sections from 560 to 860 microm distal to the midshaft of normal neonatal and adult male and female rat ulnas (n = 3 of each) and from adult male rat ulnas that had been exposed to 10 days of in vivo daily 10-minute periods of cyclic loading producing peak strains of either -3000 (n = 3) or -4000 microstrain (n = 5). Each animal ambulated normally between loading periods, and its contralateral ulna was used as a control. In animals in which limbs were subject to normal locomotor loading alone, 14 +/- 1.2% SEM of all osteocytes in each bone section were ER alpha positive. There was no influence of either gender (p = 0.725) or age (p = 0.577) and no interaction between them (p = 0.658). In bones in which normal locomotion was supplemented by short periods of artificial loading, fewer osteocytes expressed ER alpha (7.5 +/- 0.91% SEM) than in contralateral control limbs, which received locomotor loading alone (14 +/- 1.68% SEM; p = 0.01; median difference, 6.43; 95% CI, 2.60, 10.25). The distribution of osteocytes expressing ER alpha was uniform across all sections and thus did not reflect local peak strain magnitude. This suggests that osteocytes respond to strain as a population, rather than as individual strain-responsive cells. These data are consistent with the hypothesis that ER alpha is involved in bone cells' responses to mechanical strain. High strains appear to decrease ER alpha expression. In osteoporotic bone, the high strains assumed to accompany postmenopausal bone loss may reduce ER alpha levels and therefore impair the capacity for appropriate adaptive remodeling.
- Published
- 2002
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38. Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways.
- Author
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Jessop HL, Rawlinson SC, Pitsillides AA, and Lanyon LE
- Subjects
- Animals, Cell Line drug effects, Cell Line metabolism, MAP Kinase Signaling System drug effects, Osteoblasts cytology, Osteoblasts drug effects, Rats, Stress, Mechanical, MAP Kinase Signaling System physiology, Mitogen-Activated Protein Kinases metabolism, Osteoblasts metabolism
- Abstract
Extracellular regulated kinases (ERKs)-1 and -2 are members of the MAPK family of protein kinases involved in the proliferation, differentiation, and apoptosis of bone cells. We have shown previously that ROS 17/2.8 cells show increased activation of ERK-1 or -2, which is sustained for 24 h, when the strips onto which they are seeded are subjected to a 10 min period of cyclic four point bending that produces physiological levels of mechanical strain along with associated fluid movement of the medium. Movement of the strips through the medium without bending causes fluid movement without strain. This also increases ERK-1/2 activation, but in a biphasic manner over the same time period. Our present study investigates the role of components of signaling pathways in the activation of ERK-1/2 in ROS 17/2.8 cells in response to these stimuli. Using a range of inhibitors we show specific differences by which ERK-1 and ERK-2 are activated in response to fluid movement alone, compared with those induced in response to strain plus its associated fluid movement. ERK-1 activation induced by fluid movement was markedly reduced by nifedipine, and therefore appears to involve L-type calcium channels, but was unaffected by either L-NAME or indomethacin. This suggests independence from prostacyclin (PGI(2)) and nitric oxide (NO) production. In contrast, ERK-1 activation induced by application of strain (and its associated fluid disturbance) was abrogated by TMB-8 hydrochloride, L-NAME, and indomethacin. This suggests that strain-induced ERK-1 activation is dependent upon calcium mobilization from intracellular stores and production of NO and PGI(2). ERK-2 activation appears to be mediated by a separate mechanism in these cells. Its activation by fluid movement alone involved both PGI(2) and NO production, but its activation by strain was not affected by any of the inhibitors used. The G protein inhibitor, pertussis toxin, did not cause a reduction in the activation of ERK-1 or -2 in response to either stimulus. These results are consistent with earlier observations of ERK activation in bone cells in response to both strain (with fluid movement) and fluid movement alone, and further demonstrate that these phenomena stimulate distinct signaling pathways.
- Published
- 2002
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39. Mechanical strain and estrogen activate estrogen receptor alpha in bone cells.
- Author
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Jessop HL, Sjöberg M, Cheng MZ, Zaman G, Wheeler-Jones CP, and Lanyon LE
- Subjects
- Bone and Bones cytology, Butadienes pharmacology, Carrier Proteins pharmacology, Cell Line, Cyclic AMP-Dependent Protein Kinases antagonists & inhibitors, Cyclic AMP-Dependent Protein Kinases drug effects, Cyclic AMP-Dependent Protein Kinases metabolism, Enzyme Activation drug effects, Enzyme Inhibitors pharmacology, Estradiol metabolism, Estradiol pharmacology, Estrogen Receptor alpha, Estrogens pharmacology, Humans, Immunoblotting, Mitogen-Activated Protein Kinase 1 drug effects, Mitogen-Activated Protein Kinase 1 metabolism, Mitogen-Activated Protein Kinase 3, Mitogen-Activated Protein Kinases drug effects, Mitogen-Activated Protein Kinases metabolism, Nitriles pharmacology, Phosphorylation, Receptors, Estrogen drug effects, Serine metabolism, Bone and Bones physiology, Estrogens metabolism, Intracellular Signaling Peptides and Proteins, Receptors, Estrogen metabolism, Stress, Mechanical
- Abstract
Bone cells' early responses to estrogen and mechanical strain were investigated in the ROS 17/2.8 cell line. Immunoblotting with antiphosphorylated estrogen receptor a (ER-alpha) antibody showed that when these cells were exposed for 10 minutes to estrogen (10(-8) M) or a single period of cyclic dynamic strain (peak 3400 microepsilon, 1 Hz, 600 cycles), there was an increase in the intensity of a 66-kDa band, indicating phosphorylation of ser122 in the amino terminus of ER-alpha. Increased phosphorylation was detected within 5 minutes of exposure to estrogen and 5 minutes after the end of the period of strain. Estrogen and strain also activated the mitogen-activated protein kinase (MAPK) family member extracellular regulated kinase-1 (ERK-1). Increases in ERK activation coincided with increased ER-alpha phosphorylation. Activation of ERK-1 and the phosphorylation of ER-alpha, by both estrogen and strain, were prevented by the MAP kinase kinase (MEK) inhibitor U0126 and the protein kinase A (PKA) inhibitor (PKI). These data support previous suggestions that resident bone cells' early responses to strain and estrogen share a common pathway, which involves ER-alpha. This pathway also appears to involve PKA and ERK-mediated phosphorylation of ser122 within the amino terminus of ER-alpha. Reduced availability of this pathway when estrogen levels are reduced could explain diminished effectiveness of mechanically related control of bone architecture after the menopause.
- Published
- 2001
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40. The differentiation of a potential mesenchymal stem cell population within ovine bone marrow.
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Jessop HL, Noble BS, and Cryer A
- Subjects
- Adipose Tissue cytology, Adipose Tissue metabolism, Alkaline Phosphatase metabolism, Animals, Bone Marrow metabolism, Calcium metabolism, Cell Differentiation, Cell Separation, Cells, Cultured, Collagen metabolism, Culture Media, Hematopoietic Stem Cells metabolism, Mesoderm cytology, Osteoblasts cytology, Osteoblasts metabolism, Sheep, Bone Marrow Cells, Hematopoietic Stem Cells cytology
- Published
- 1994
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41. Using differential display in the study of adipocyte differentiation.
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Edwards WD, Jessop HL, and Cryer A
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- 3T3 Cells, Animals, Base Sequence, Cell Differentiation genetics, DNA Primers genetics, Mice, Molecular Sequence Data, RNA, Messenger genetics, RNA, Messenger metabolism, Adipose Tissue cytology, Adipose Tissue metabolism, DNA, Complementary genetics, Polymerase Chain Reaction methods
- Published
- 1994
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42. Antibodies to the C epitope of Neisseria gonorrhoeae are present in patients with gonorrhoea and absent in normal sera.
- Author
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Demarco de Hormaeche R, Jessop H, and Bundell C
- Subjects
- Enzyme-Linked Immunosorbent Assay, Humans, Immunosorbent Techniques, Antibodies, Bacterial immunology, Epitopes immunology, Gonorrhea immunology, Neisseria gonorrhoeae immunology
- Abstract
We have previously described a surface oligosaccharide antigen (epitope C) present in fresh isolates of Neisseria gonorrhoeae and in variants grown in subcutaneous chambers, but poorly formed by variants repeatedly subcultured in vitro. We have now investigated the presence of antibodies to epitope C in sera from normal individuals and from patients with gonorrhoea. Sera were analysed by Western blotting and ELISA, and compared with a pool of sera from normal individuals with no known history of gonorrhoea. Antigenic extracts and monoclonal antibody to the C epitope were used for competition and inhibition studies. Only the sera from patients contained antibodies to epitope C. Antibodies to several other gonococcal antigens were found in sera from patients, and also in normal sera. Collectively, the results indicate that epitope C is expressed in humans, that patients with gonorrhoea develop antibodies to it, and that such antibodies are absent in sera of normal individuals.
- Published
- 1988
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43. Immunochemical characterization of the outer membrane complex of Serratia marcescens and identification of the antigens accessible to antibodies on the cell surface.
- Author
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Jessop HL and Lambert PA
- Subjects
- Electrophoresis, Polyacrylamide Gel, Flagella immunology, Lipopolysaccharides immunology, Porins, Antigens, Bacterial immunology, Bacterial Outer Membrane Proteins immunology, Serratia marcescens immunology
- Abstract
Serratia marcescens New CDC O14:H12 contains major outer membrane proteins of 43.5 kDal, 42 kDal (the porins) and 38 kDal (the OmpA protein) which can be separated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis. Immunoblotting of whole cell or outer membrane preparations using antiserum raised against the whole cells revealed similar complex patterns of antigens. The OmpA protein was the major immunogen, although six other outer membrane proteins were also detected; the porins reacted only weakly with antibodies in this system. Immunoabsorption of antisera with whole cells showed that only the O antigenic chains of lipopolysaccharide and the H (flagella) antigens were accessible to antibody on the cell surface. Failure to detect the OmpA protein and other envelope antigens in this way suggests that their antigenic sites are not able to react with antibodies and are possibly masked by the O antigen.
- Published
- 1985
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44. The role of surface polysaccharide in determining the resistance of Serratia marcescens to serum killing.
- Author
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Jessop HL and Lambert PA
- Subjects
- Bacterial Outer Membrane Proteins analysis, Counterimmunoelectrophoresis, Electrophoresis, Polyacrylamide Gel, Humans, Immunoelectrophoresis, Antigens, Bacterial immunology, Antigens, Surface immunology, Blood Bactericidal Activity, Polysaccharides, Bacterial immunology, Serratia marcescens immunology
- Abstract
Two O14:H12 strains of Serratia marcescens with different sensitivities to killing by normal pooled human serum were investigated. Complement binding, studied by measuring hydrophobicity and using rocket immunoelectrophoresis with anti-human C3, showed the sensitive cells (S1220) rapidly bound and fixed complement whereas the resistant cells (4444-60) bound less C3b. The strains had identical membrane protein composition. Crossed immunoelectrophoresis suggested that in S1220 cells the polysaccharide material including LPS was less antigenic and present in smaller amounts than in 4444-60 cells. This was confirmed by examining extracted polysaccharide material chemically and by SDS-PAGE. The resistant strain had 33% more phenol-extractable polysaccharide material than the sensitive strain, possibly comprising LPS with longer O antigen chain lengths, or a microcapsule of O antigen polysaccharide. Extra polysaccharide material on the surface of the resistant strain prevents complement components binding and reaching the hydrophobic membrane where lytic lesions occur.
- Published
- 1986
- Full Text
- View/download PDF
45. Gonococcal variants selected by growth in vivo or in vitro have antigenically different LPS.
- Author
-
Demarco de Hormaeche R, Jessop H, and Senior K
- Subjects
- Animals, Antibodies, Monoclonal immunology, Blotting, Western, Cross Reactions, Densitometry, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Guinea Pigs, Hydrolysis, Lipopolysaccharides analysis, Lipopolysaccharides immunology, Neisseria gonorrhoeae immunology
- Abstract
Lipopolysaccharide (LPS) was extracted from two variants of strain gc40 of Neisseria gonorrhoeae obtained by repeated subculture in vitro or by growth in vivo in a subcutaneous chamber. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis followed by silver stain analysis revealed that both variants had three main LPS components, but the large size components were predominant in gonococci selected in vivo and the smallest size in those selected in vitro. Western blotting, ELISA and ELISA inhibition using monoclonal and polyclonal antibodies showed that the two variants had antigenically different LPS and that serum sensitivity may be due to the antigenic specificity of the large components. These results indicate that during infection clones of gonococci are selected with LPS of antigenic and physicochemical composition different from those seen after repeated subcultures.
- Published
- 1988
- Full Text
- View/download PDF
46. Immunization of guinea pigs with epitope C-rich lipopolysaccharide from Neisseria gonorrhoea; in vivo selection of gonococcal variants.
- Author
-
Senior KE, Demarco de Hormaeche R, and Jessop HL
- Subjects
- Animals, Antibodies, Bacterial biosynthesis, Antibodies, Bacterial immunology, Bacterial Vaccines administration & dosage, Blotting, Western, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Guinea Pigs, Meningococcal Infections prevention & control, Antigenic Variation, Antigens, Bacterial immunology, Bacterial Vaccines immunology, Epitopes immunology, Neisseria gonorrhoeae immunology, Polysaccharides, Bacterial immunology
- Abstract
The immunogenic potential of lipopolysaccharide (LPS) of a variant of Neisseria gonorrhoeae strain Gc 40 selected by growth in vivo (vivo variant) was investigated in guinea pigs. LPS extracts obtained from the water (WLPS) and the phenol (PLPS) phases of a hot phenol-water extraction were compared for their antigenic capacity and protective effect against infection in subcutaneous chambers. Immunization with PLPS induced significant levels of anti-LPS and anti-epitope C antibodies but WLPS was not antigenic. Two days after challenge, all guinea pigs immunized with WLPS had infections similar to those seen in unimmunized control animals while most animals immunized with PLPS and challenged with either 10(3) or 10(5) gonococci per ml showed low numbers of or no viable gonococci in their chambers. Five days after challenge, however, the same animals had chamber infections with high viable counts similar to controls. Gonococci reisolated from three such animals had physically and antigenically altered lipopolysaccharide and showed patterns of serum sensitivity to pre-challenge chamber fluid from immunized animals which were different from those of the parent vivo variant used for immunization and challenge. The results demonstrate that selection of LPS variants occurs in vivo. This could constitute an immune evasion mechanism.
- Published
- 1989
- Full Text
- View/download PDF
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