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362 results on '"Natori, T."'

2. Impact of the COVID-19 pandemic on the incidence of surgical site infection after orthopaedic surgery: an interrupted time series analysis of the nationwide surveillance database in Japan

Author

Mimura, T., primary, Matsumoto, G., additional, Natori, T., additional, Ikegami, S., additional, Uehara, M., additional, Oba, H., additional, Hatakenaka, T., additional, Kamanaka, T., additional, Miyaoka, Y., additional, Kurogochi, D., additional, Fukuzawa, T., additional, Koseki, M., additional, Kanai, S., additional, and Takahashi, J., additional

Published
2023
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10. Abstract P1-03-02: ASCO/CAP human epidermal growth factor receptor-2 (HER2) in situ hybridization (ISH) categories evaluated by quantitative HER2 protein diagnostic methodologies: A comparative analysis

Author

Buscaglia, B, primary, Turner, B, additional, Goda, H, additional, Huang, W, additional, Leitzel, K, additional, Natori, T, additional, Nakano, Y, additional, Okada, H, additional, Sperinde, J, additional, Ali, S, additional, Vasekar, M, additional, D'Aguiar, M, additional, McMahon, L, additional, Henry, J, additional, Lipton, A, additional, and Hicks, D, additional

Published
2019
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20. RT1.P, rat class Ib genes related to mouse TL: evidence that CD1 molecules but not authentic TL antigens are expressed by rat thymus

Author

Daisuke Kozutsumi, Miyuki Kinebuchi, Y. Hashimoto, Shingo Ichimiya, Shinichi Takayama, Akihiro Matsuura, Kokichi Kikuchi, Ryoichi Honda, Kiyoshi Kasai, and Natori T

Subjects
Sequence analysis, Surface Properties, Pseudogene, Immunology, Molecular Sequence Data, CD1, Thymus Gland, Major histocompatibility complex, Antigens, CD1, Mice, Antigen, Histocompatibility Antigens, Genetics, Animals, Amino Acid Sequence, Gene, Recombination, Genetic, Mice, Inbred BALB C, Membrane Glycoproteins, Polymorphism, Genetic, biology, Base Sequence, Histocompatibility Antigens Class I, Intron, Chromosome Mapping, Sequence Analysis, DNA, Molecular biology, Rats, Mice, Inbred C57BL, CD1D, biology.protein
Abstract

CD1 and TL were once thought to be genetic homologues because of their thymus-specific expression. We investigated their equivalents in the rat to clarify whether their structure and pattern of expression are conserved in rodents. Two rat class Ib genes, containing 3' sequences very similar to mouse TL, were identified and designated RT1.P. Neither of them, however, can encode ordinary class I molecules due to the accumulation of harmful mutations in the 5' regions that are unique to RT1.P, while the 3' TL-like regions still retain protein-coding capacity. Comparison of the structural organization of three types of TL family genes, which include mouse T3/T18-encoding TL antigens, mouse T1/T16, and rat RT1. P1/P2 pseudogenes, revealed the presence of a clear demarcation between the type-specific and TL-specific sequences at intron 3. This finding suggests that recombination plays an important role in creating the TL family genes in rodents. Characteristic features of TL, such as a low level of polymorphism and linkage to the major histocompatibility complex, were also observed in the rat. On the other hand, rat CD1 molecules were expressed at a high level on the surface of thymocytes. Absence of authentic TL antigens and thymic expression of CD1d molecules in the rat suggest the plasticity and conservation of class Ib genes in rodent evolution. Functions of TL may be substituted with CD1 or other class Ib molecules expressed by rat thymus.

Published
1997

27. Regulation of experimental autoimmune uveitis in rats--separation of MHC and non-MHC gene effects

Author

Kazunori Onoé, Natori T, Kazumasa Ogasawara, S Hirose, Yoichi Sasamoto, Hidehiko Matsuda, and Shigeaki Ohno

Subjects
Male, Bordetella pertussis, medicine.medical_treatment, Immunology, Genes, MHC Class II, Molecular Sequence Data, Congenic, Genes, MHC Class I, Enzyme-Linked Immunosorbent Assay, medicine.disease_cause, Major histocompatibility complex, Eye, Autoimmunity, Autoimmune Diseases, Uveitis, Antigen, medicine, Immunology and Allergy, Animals, Hypersensitivity, Delayed, Amino Acid Sequence, Antigens, Eye Proteins, Sensitization, Autoimmune disease, Arrestin, biology, Vaccination, Rats, Inbred Strains, Mycobacterium tuberculosis, medicine.disease, biology.organism_classification, eye diseases, Peptide Fragments, Rats, medicine.anatomical_structure, biology.protein, sense organs, Disease Susceptibility, Adjuvant, Research Article
Abstract

SUMMARYExperimental autoimmune uveitis (EAU) is an organ-specific autoimmune disease and has served as a model of certain ocular inflammatory conditions in man. The present study was aimed at separating the effects of MHC and non-MHC genes on the development of EAU in the rat. EAU-susceptible LEW (RT1l) EAU-resistant WKAH (RTIk), and WKAH.1L (RTF) MHC congenic strain of WKAH background rats were immunized with retinal soluble antigen (S-Ag) in Freund's complete adjuvant (FCA). LEW rats showed typical EAU, while neither WKAH nor WKAH. 1L congenic rats developed EAU. However, when an additional i.v. injection of Bordetella pertussis was given, all rat strains developed EAU. Furthermore, when immunized with peptide M, an 18-mer synthetic peptide, which corresponds to amino acid positions 303–320 of bovine S-Ag, and given an additional i.v. injection of B. pertussis, LEW and WKAH. IL rats developed EAU, whereas WKAH did not. When ACI (RTIavl), BUF (RTIb), LEJ (RTIl), W(RTIk), F344(RTI1v1), BN (RTIq), NIG-III (RTIq), TO (RT1I), and SDJ (RT1u) rats were immunized with peptide M or S-Ag and then given B. pertussis, all strains developed EAU by immunization with S-Ag plus B. pertussis, but only F344 and NIG-III developed EAU by immunization with peptide M. These findings suggest that susceptibility to EAU in rats is controlled by both MHC and non-MHC genes; and that in the absence of B. pertussis adjuvant, the form of disease induced by native S-Ag in FCA is governed by non-MHC gene(s). However, this effect of non-MHC gene(s) could no longer be observed when the rats were also injected with B. pertussis adjuvant at sensitization.

Published
1991

28. Mapping and transcriptional properties of RT1 class II region genes

Author

Natori T, Mitsuaki Kakinuma, Hiroaki Fujii, and Takashi Yoshiki

Subjects
endocrine system, Transcription, Genetic, Genes, MHC Class II, HLA-DP, Major histocompatibility complex, law.invention, Transcription (biology), law, Histocompatibility Antigens, Animals, Northern blot, Gene, Alleles, Genetics, Transplantation, Messenger RNA, biology, Histocompatibility Antigens Class II, Chromosome Mapping, Rats, Inbred Strains, DNA, Blotting, Northern, Rats, Haplotypes, biology.protein, Recombinant DNA, Restriction fragment length polymorphism, DNA Probes, Polymorphism, Restriction Fragment Length
Abstract

The class II region of major histocompatibility complex of the rat. Rattus norvegicus (RT1) consists of RT1.B, RT1.D, and RT1.H subregions. The gene order around the H subregion was determined as RT1.A--H beta-H alpha--B by RFLP analysis of naturally occurring intra-RT1 recombinant rats with HLA DP probes. A unique recombinant strain, LEJ, was found to have its recombinational site between H beta and H alpha (RT1.AuH beta uH alpha bBbDb). Northern analysis of class II mRNAs showed that transcripts of RT1.D alpha, RT1.D beta, and RT1.B alpha shared identical sizes among various strains of rats, but RT1.B beta mRNA showed allele-specific size heterogeneities. Northern hybridization with HLA DP alpha probes detected possible RT1.H alpha transcripts. On the other hand, no clear signal of H beta was observed. BDIX whose RT1.B products had not been identified was found to transcribe B alpha and B beta mRNAs.

Published
1991

29. Polymorphism of the class II gene of rat major histocompatibility complex, RT1: partial sequence comparison of the first domain of the RT1.B beta 1 alleles

Author

Takashi Yoshiki, Natori T, Mitsuaki Kakinuma, and Hiroaki Fujii

Subjects
Genetics, Polymorphism, Genetic, Base Sequence, Immunology, Genes, MHC Class II, Molecular Sequence Data, Nucleic acid sequence, Immunogenetics, Biology, Major histocompatibility complex, Polymerase Chain Reaction, Human genetics, Rats, Class II gene, Exon, Histocompatibility Antigens, biology.protein, Animals, Amino Acid Sequence, Allele, Chromosome Deletion, Gene, Alleles
Published
1991

31. IL-12 Production Induced byAgaricus blazeiFraction H (ABH) Involves Toll-like Receptor (TLR)

Author

Kasai, H., primary, He, L. M., additional, Kawamura, M., additional, Yang, P. T., additional, Deng, X. W., additional, Munkanta, M., additional, Yamashita, A., additional, Terunuma, H., additional, Hirama, M., additional, Horiuchi, I., additional, Natori, T., additional, Koga, T., additional, Amano, Y., additional, Yamaguchi, N., additional, and Ito, M., additional

Published
2004
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