1. Zinc enhancement through supplementation and dietary implementation – Does it affect oxidative stress and antioxidant status in chronic kidney disease patients?
- Author
-
Sahni, Nancy and Rathi, Manish
- Subjects
- *
ZINC , *CHRONIC kidney failure , *OXIDATIVE stress , *ANTIOXIDANTS , *DIETARY supplements - Abstract
Background: Chronic kidney disease (CKD) patients might be zinc deficient due to compromised nutritional intake and dietary protein restrictions; protein foods being rich in zinc. Zinc deficiency might cause increased oxidative stress and consequently reduced antioxidant parameters. Tailored dietary counseling along with zinc supplementation may play a major role in affecting the zinc and antioxidant status of patients. Aim: The aim of this study was to investigate the effect of zinc supplementation and dietary counseling on oxidative stress and antioxidant parameters in CKD patients. Materials and Methods: 185 subjects were enrolled for the study (145 were predialysis patients [Group-1 (Stage-3 CKD) and Group-2 [Stage-4 CKD]) on the basis of Kidney Disease Outcomes Quality Initiative CKD stages from 1 to 5; and 40 apparently healthy controls. Zinc supplementation alone (Intervention 1) was given to 50 CKD patients (30 Group-1 and 20 Group-2). Diet counseling (Intervention 2) consisted of 45 patients (25 Group-1; 20 Group-2). 50 patients (30 Group-1 and 20 Group-2) received both zinc supplementations along with diet counseling (Intervention 3). Dietary zinc status, oxidative stress and antioxidants were accessed for all subjects. Results: Intervention-1 and 3 groups exhibited highly significant improvement in antioxidant status and lowering of oxidative stress. Conclusion: Improving zinc status through dietary counseling and supplementation may help in combating enhanced oxidative stress by improving antioxidant parameters in renal failure patients. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF