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The COVID-19 pandemic has led to extraordinary changes in family literacy instruction, forcing face-to-face programmes to shift rapidly (or "on the fly") to online, remote instruction. This study is one of the few on online teaching and learning in family literacy and, to the knowledge of the authors, the first on emergency remote instruction in a family literacy programme during the COVID-19 pandemic. This article examines how the Goodling Institute for Research in Family Literacy at The Pennsylvania State University in the United States has responded to the pandemic by converting its face-to-face family literacy classes into emergency remote instruction using online platforms. Serving eight immigrant families in 2019-2020 who live in the State College area in central Pennsylvania, the "Family Pathways" programme includes adult education, parent education and interactive parent-child literacy activities. The article discusses how teachers created online learning opportunities for parents and children to learn together, the strategies and resources instructors used to teach remotely, how challenges such as discomfort with technology were addressed, and what has been learned from the experience. Although COVID-19 presents unprecedented challenges for educators and learners in family literacy programmes more broadly, it has also compelled instructors in this particular programme to use remote instruction creatively and has revealed the critical importance of family literacy programmes as an educational support system for low-income and immigrant families.

The disruption, trauma, and stressors brought by COVID-19 have increased recognition and normalization of workforce mental health needs. Objective: Given the importance of mental health and well-being assessments to employers' efforts to optimize employee health and well-being, this paper reviews mental health assessments that have utility in the workplace. Data Source: A review of publicly available mental health and well-being assessments was conducted with a primary focus on burnout, general mental health and well-being, loneliness, psychological safety, resilience, and stress. Inclusion Criteria: Assessments had to be validated for adult populations; available in English as a stand-alone tool; have utility in an employer setting; and not have a primary purpose of diagnosing a mental health condition. Data Extraction: All assessments were reviewed by a minimum of two expert reviewers to document number of questions, subscales, fee structure, international use, translations available, scoring/reporting, respondent (ie, employee or organization), and the target of the assessment (ie, mental health domain and organizational or individual level assessments. Data Synthesis & Results: Sixty-six assessments across the six focus areas met inclusion criteria, enabling employers to select assessments that meet their self-identified measurement needs. Conclusion: This review provides employers with resources that can help them understand their workforce's mental health and well-being status across multiple domains, which can serve as a needs assessment, facilitate strategic planning of mental health and well-being initiatives, and optimize evaluation efforts. [ABSTRACT FROM AUTHOR]

In the Pacific Northwest, Alnus rubra Bong. (red alder) is a common deciduous tree species especially prevalent in riparian corridors and disturbed sites, including metropolitan areas undergoing land use changes and development. Importantly, red alder is also considered a bioindicator for ozone pollution and, like all plants, harbors a diverse endophyte community that may interact with aerial pollutants. In this study, we surveyed foliar fungal endophyte communities (microfungi) in red alder leaves from the metropolitan area of Portland, Oregon, USA, using culture-based techniques, and found that communities differed significantly by site. Our results suggest that the fungal endophyte community composition in red alder leaves may be influenced in part by local air pollution sources, likely in conjunction with other site characteristics. As urban areas expand, more studies should focus on how the urban environment affects plant--microbe community ecology and endophyte--host interactions, as well as on the long-term consequences for other ecosystem processes such as leaf litter decomposition.Key words: microbial community, diversity, air pollution, microfungi, urban ecosystems.Dans le Nord-Ouest Pacifique, Alnus rubra Bong. (aulne rouge) est une espece frequente d'arbre decidu, specialement repandue dans les corridors riverains et les sites perturbes, y compris les agglomerations soumises a des changements ou a des developpements en matiere d'utilisation des sols. Fait important, l'aulne rouge est aussi considere comme bio-indicateur de la pollution par l'ozone et, comme tous les vegetaux, heberge une communaute d'endophytes divers qui peut interagir avec les polluants de l'air. Dans cette etude, les auteurs ont examine les communautes d'endophytes fongiques foliaires (microchampignon) d'aulnes rouges de l'agglomeration de Portland, Oregon, Etats-Unis, a l'aide de methodes basees sur la culture, et trouve que les communautes differaient significativement d'un site a l'autre. Leurs resultats suggerent que la composition de la communaute d'endophytes fongiques de l'aulne rouge peut etre influencee en partie par les sources de pollution atmospherique locales, probablement conjuguees a d'autres caracteristiques du site. Au fur et a mesure de l'expansion des zones urbaines, un plus grand nombre d'etudes devraient se concentrer sur la maniere par laquelle l'environnement urbain affecte l'ecologie de la communaute plante--microbe et les interactions endophyte--hote, de meme que sur les consequences a long terme d'autres processus ecosystemiques comme la decomposition de la litiere de feuille. [Traduit par la Redaction]Mots-cles : communaute microbienne, diversite, pollution de l'air, microchampignon, ecosystemes urbains., IntroductionPlant and microbial communities are sensitive to local environmental conditions, especially those resulting from anthropogenic sources. An increase in the levels of atmospheric C[O.sub.2] has been shown to interact with [...]

Background and Purpose: β-Adrenoceptor agonists relieve airflow obstruction by activating β2 -adrenoceptors, which are G protein-coupled receptors (GPCRs) expressed on human airway smooth muscle (HASM) cells. The currently available β-adrenoceptor agonists are balanced agonists, however, and signal through both the stimulatory G protein (Gs )- and β-arrestin-mediated pathways. While Gs signalling is beneficial and promotes HASM relaxation, β-arrestin activation is associated with reduced Gs efficacy. In this context, biased ligands that selectively promote β2 -adrenoceptor coupling to Gs signalling represent a promising strategy to treat asthma. Here, we examined several β-adrenoceptor agonists to identify Gs -biased ligands devoid of β-arrestin-mediated effects.Experimental Approach: Gs -biased ligands for the β2 -adrenoceptor were identified by high-throughput screening and then evaluated for Gs interaction, Gi interaction, cAMP production, β-arrestin interaction, GPCR kinase (GRK) phosphorylation of the receptor, receptor trafficking, ERK activation, and functional desensitization of the β2 -adrenoceptor.Key Results: We identified ractopamine, dobutamine, and higenamine as Gs -biased agonists that activate the Gs /cAMP pathway upon β2 -adrenoceptor stimulation while showing minimal Gi or β-arrestin interaction. Furthermore, these compounds did not induce any receptor trafficking and had reduced GRK5-mediated phosphorylation of the β2 -adrenoceptor. Finally, we observed minimal physiological desensitization of the β2 -adrenoceptor in primary HASM cells upon treatment with biased agonists.Conclusion and Implications: Our work demonstrates that Gs -biased signalling through the β2 -adrenoceptor may prove to be an effective strategy to promote HASM relaxation in the treatment of asthma. Such biased compounds may also be useful in identifying the molecular mechanisms that determine biased signalling and in design of safer drugs. [ABSTRACT FROM AUTHOR]

Endophytes are ubiquitous plant‐associated microbes and although they have the potential to alter the decomposition of infected leaf litter, this has not been well‐studied. The endophyte Rhytisma punctatum infects the leaves of Acer macrophyllum (bigleaf maple), causing the appearance of black 'tar spots' that persist in senesced leaves. Other foliar fungi also cause visible damage in healthy tissues of this host plant system including an unidentified bullseye‐shaped lesion, common in western Washington. Using three treatments of endophyte infection status in leaf tissue (R. punctatum‐infected, bullseye‐infected, lesion‐free), leaf litter discs were submerged in a third‐order temperate stream using mesh litter bags and harvested periodically over two months to determine the effects of litter treatment and incubation time on litter mass loss, fungal sporulation, and microbial community colonization. Litter containing symptomatic endophyte infections (Rhytisma or bullseye) had reduced sporulation of aquatic hyphomycetes, but decomposed significantly faster than lesion‐free or bullseye‐infected litter. Using amplicon‐based sequencing, we found a significant difference in bacterial communities colonizing Rhytisma‐infected and bullseye‐infected leaf litter, a significant difference in fungal communities colonizing Rhytisma‐infected leaf litter compared to the two other treatments, and a change in both community structure and relative abundances of bacterial and fungal taxa throughout the study period. Indicator Species Analysis clarified the drivers of these community shifts at the genus level. Our results show that endophyte‐associated, in‐stream sporulation and microbial community effects are observable within one species of leaf litter. [ABSTRACT FROM AUTHOR]

The article focuses on the value and importance of creating a Culture of Health (CoH) in an organization. It highlights several case studies presented by the Health Enhancement Research Organization (HERO) to emphasize employer wellness programs and the elements that contribute to their success. It also outlines the advantage of the CoH and its related elements as it provides clear guidance and direction for employers interested in developing a culture that fosters health and well-being.