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2 results on '"cnidium officinale extract"'

1. Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation

Author

Mine Sibel Gurun, Zulfiye Gul, Deniz Bagdas, Julie A. Meade, Betul Cam, Nilufer Cinkilic, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Farmakoloji Anabilim Dalı., Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı., Cam, Betül, Cinkılıç, Nilüfer, Gürün, Mine Sibel, AAH-5296-2021, CGO-3719-2022, and DVX-8040-2022

Subjects
Antioxidant, Inflammatory pain, Cnidium officinale extract, medicine.medical_treatment, Chronic pain, Review, Pharmacology, Antinociception, 0302 clinical medicine, Pharmacology (medical), Inflammatory, Hypericum perforatum extract, General Medicine, Chlorogenic, Psychiatry and Mental health, Nociception, Neurology, Medicinal herbs, Ion channel, Drug mechanism, Analgesic agent, Human, endocrine system, Antiinflammatory activity, Incuded liver-injury, Gated potassium channels, Disease models, Carlina Oxide, Lonicera, 03 medical and health sciences, Chlorogenic acid, Antiinflammatory agent, Sepsis, Humans, Porana sinensis extract, Oxygen species ros, Pharmacology & pharmacy, Animal, Disease model, Arthritis, medicine.disease, Antiallodynic, 030104 developmental biology, Gaba receptor agonists, chemistry, Degenerative disease, Neurology (clinical), Complication, 030217 neurology & neurosurgery, 0301 basic medicine, Unclassified drug, Neuropathic pain, medicine.disease_cause, In-vitro, In vivo study, chemistry.chemical_compound, Anti-inflammatory agents, Analgesics, Plant extract, Antihyperalgesic, Cheilanthes farinose extract, Erycibe obtusifolia extract, Encephalitis, medicine.symptom, Bidens pilosa extract, NF-Kappa B, Consensus, Nitric-oxide synthase, Pain, Inflammation, Chlorogenic acid derivative, Neurosciences & neurology, Neuropharmacology, Acid, medicine, Animals, Rheumatoid arthritis, Caffeic acid, Mansoa alliacea extract, business.industry, Neurosciences, Plant extracts, Ferulic acid, Nonhuman, Urtica circularis extract, Rosae multiflorae extract, Disease Models, Animal, Metabolism, Drug metabolite, Ethnopharmacology, Neuropathic, business, Hypericum-perforatum, Oxidative stress
Abstract

Background: Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks. Objective: This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed. Materials and Methods: An electronic literature search was conducted by authors up to October 2019. Original articles were selected. Results: CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models. Conclusion: The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults.

Published
2020

2. Post-ischemic treatment with toki-shakuyaku-san (tang-gui-shao-yao-san) prevents the impairment of spatial memory induced by repeated cerebral ischemia in rats

Author

Katsunori Iwasaki, Keiichi Irie, Yuki Akiyoshi, Kiyo Iwasaki, Izzettin Hatip-Al-Khatib, Kazunori Sano, Kenichi Mishima, An Xin Liu, Kouji Kurauchi, Michihiro Fujiwara, Fengling Pu, Daisuke Ishibashi, and Nobuaki Egashira

Subjects
Male, genetic structures, Paeonia, Brain Ischemia, Chinese drug, medicinal plant, Muscarinic acetylcholine receptor, rank sum test, Spatial memory impairment, rat, AMPA receptor, rat strain, toki shakuyaku san, Receptor, Angelica, Neurons, TUNEL assay, Cell Death, messenger RNA, Porfia cocos extract, article, Glutamate receptor, Atractylodes lancea, memory disorder, General Medicine, Cerebral ischemia, spatial memory, unclassified drug, multiinfarct dementia, Neuroprotective Agents, cnidium officinale extract, Alisma orientale extract, Anesthesia, plant extract, Alisma, neuroprotection, tang gui shao yao san, medicine.medical_specialty, Neuronal death, animal experiment, nick end labeling, Ischemia, Cnidium, Neuroprotection, animal tissue, Paeonia lactiflora, reverse transcription polymerase chain reaction, Student t test, Internal medicine, cnidium officinale, medicine, Animals, maze test, RNA, Messenger, Receptors, AMPA, Rats, Wistar, Alisma orientale, Maze Learning, nerve cell lesion, Paeonia lactiflora extract, nonhuman, Dose-Response Relationship, Drug, nerve cell necrosis, business.industry, animal model, angelica acutiloba, Antagonist, Atractylodes, Atractylodes extract, Angelica acutiloba extract, bacterial infections and mycoses, medicine.disease, Rats, Disease Models, Animal, Endocrinology, Toki-shakuyaku-san, Complementary and alternative medicine, receptor subunit, business, Porfia cocos, Drugs, Chinese Herbal
Abstract

Previously we have reported that Toki-shakuyaku-san (TSS) ameliorated the impairment of spatial memory induced by single cerebral ischemia (1 × 10 minutes) and scopolamine, a muscarinic receptor antagonist. In this experiment, we studied the effect of TSS on repeated cerebral ischemia (2 × 10 minutes, 1-hour interval) induced impairment of spatial memory and neuronal injury in rats. The 8-day post-ischemic treatment with TSS (30-300 mg/kg) was administered p.o. once per day. TSS dose-dependently prevented the impairment of spatial memory, neuronal death and TUNEL positive cells induced by repeated cerebral ischemia. In order to determine the mechanism of TSS, we also studied the effect of TSS on GluR2 mRNA, one of the glutamate ?-amino-3- hydroxy-5-methyl-4-isoxazole (AMPA) receptor subunits. Repeated cerebral ischemia significantly decreased GluR2 flop mRNA at 1 and 3 days after the occlusion. TSS (300 mg/kg) significantly suppressed the decrease in GluR2 flop at 3 days after repeated cerebral ischemia. These results suggested that the TSS has neuroprotective action which may be indirectly mediated by the AMPA receptor, and TSS may be beneficial for the treatment of cerebrovascular dementia. © 2005 World Scientific Publishing Company. Institute for Advanced Research in Asian Science and Medicine.

Published
2005

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