Search

Non-steroid anti-inflammatory drug, "Riripen" (Daiichi P h arm. Co.) was administered to patients with various urological diseases. The results are summarized as follows. 1. The drug was given to a total of 28 patients consisting of 16 with a cute cystitis, 3 with acute epididymitis, 4 with urethral stricture, 1 with genital trauma and 4 with other diseases. 2. In patients with acute cystitis, a single treatment with "Riripen" showed no r emarkable effect, but a combination with other chemotherapeutic agents produced a secure effectiveness. 3. In patients with acute epididymitis, a combination therapy of "Riripen" wit h chemotherapeutic agents resulted in an excellent analgetic effect although the necessitate duration of drug administration was unable to be shortened. 4. In patients with urethral s tricture, the drug showed an excellent effect for elimination of urethral damages following bougienage. 5. Although case treated w as limited in only one, a patient with genital trauma showed an excellent response to the single treatment with "Riripen" 6. The drug was given to patients who w e re performed cystoscopic examination with a good effect for releasing pain. 7. In a few cases, t h e therapy with "Riripen" suggested a possibility that an administration of the drug may be used for auxotherapy or abolition of adrenocortical hormone therapy. 8. No noticeable side effect was encountered.

掲載許可調整中の画像は表示されません

掲載許可調整中の画像は表示されません

UROCALUN, a new therapeutic agent for urolithiasis, was used with the following results. 1) Five out of eleven cases with ureteral calculus passed stone after administration of this drug for ten days or more. One of them passed a stone larger than 10mm in diameter. 2) Two cases of kidney stone were treated with long term administration of two to three months. In one case, it seemed effective. 3) This drug was useful for the patients with long term indwelling catheter to prevent calculi.

1.In an attempt to study its usefulness as a contrast medium for retrograde pyelography, a 2-fold dilution (33.4%) of sodium. iothalamate 66.8% (Conray 400) was used in 23 cases and the results were compared with those with 38% Urografin. The test medium was demonstrated to be not inferior to Urografin in its capacity of visualizing the renal pelvis. 2. In 20 (87%) out of the entire 23 cases the contrast medium gave a clear-cut pyelogram with no blurring of the picture which makes the film incompetent for diagnostic purpose as seen in any instances. 3. As compared to Urografin which was administered contra laterally, Conray 400 was found to be more excellent in 13% and equally satisfactory in 78.3% in its visualization. 4. No adverse reactions worthy of mention was noted. 5. An experiment on the rate of injection confirmed that Conray 400, being lower in viscosity, is far easier to inject than Urografin.

Spontaneous pyelo-duodenal fistula is exceedingly rare. Twenty-four cases of it have been reported in Europe and America, and 2 cases in Japan. A 36-year-old female was admitted for right loin pain and recurrent high fever. Retrograde pyelography showed the contrast dye passing through the pelvis into the duodenum, and intravenous pyelography showed a non-visualizing right kidney with a calculus. The left kidney was normal. Laboratory findings showed no abnormality. After the clinical diagnosis of pyelo-duodenal fistula was established, the definitive surgery by nephrectomy, excision of the fistulous tract and closure of the duodenum were carried out sa tisfactorily.

掲載許可調整中の画像は表示されません

掲載許可調整中の画像は表示されません

(1) Many new drugs have been discovered lately and most clinicians have been very busy in conducting clinical studies with them. Therefore, cases of experiments at each institution have decreased. Thus, it seems meaningless to collect many clinical results which have been obtained by different methods of study. For that reason, the methods of study were unified beforehand and cooperative clinical studies with cephaloglycin have been made at four universities. As this was the first trial of cooperative clinical studies, the expected purpose "as not attained because of insufficient contact among researchers. But it seems that this trial will be helpful to further cooperative clinical study. (2) One gram of cephaloglycin per day was given to patients of acute uncomplicated cystitis for three days and it was effective in twenty-three cases out of twenty-five (92 %). This result was gained by judging its efficiency from symptoms, urinalysis and culture study. When its efficiency was judged from symptoms and urine findings, it was effective in forty-five cases out of fifty-three (85 %). (3) A comparative study was made between remedial results of a group of patients who had been given cephaloglycin from beginning to healing, and that of another one of patients who had been given cephaloglycin until their conditions of illness were less serious and then given sulfisomezole (2 grams per day) until healing. But significant difference was not observed.

掲載許可調整中の画像は表示されません

掲載許可調整中の画像は表示されません

掲載許可調整中の画像は表示されません

掲載許可調整中の画像は表示されません

Among the 1103 urine specimens obtained from patients with urinary tract infections for the recent 3 years, Pseudomonas aeruginosa was isolated in 145 (13 %). All patients were suffering from chronic infection with other urogenital diseases and majority of them had received various antibiotics in the past. Kasugamycin was administered in 21 paitent with chronic urinary tract infection due to Pseudomonas aeruginosa. Excellent, good and poor responses were obtained in 4, 11 and 6 cases, respectively, showing effectiveness to be 70.1 % (15 cases). Side effects were minimal.

A case of four-year-old girl having dysuria, recurrent fever and incontinence due to bladder neck obstruction with reflux and hydronephrosis was presented, in which YV-plasty operation was carried out with success. A excretory urogram taken about five months after operation revealed no hydronephrosis and reflux. A long term follow-up study will determine whether the improvement is permanent or not.

掲載許可調整中の画像は表示されません

Two alpha1-globulin bands of fetal serum with relative mobilities against bromophenol blue of 0.55 and 0.58 on 7% polyacrylamide gel electrophoresis reacted with a monospecific rabbit antiserum to alpha-fetoprotein (AFP). The former globulin band was clearly detected in the fetal liver supernatant. AFP was immunochemically purified from both the fetal serum and liver, and their electrophoretic and immunochemical properties were compared. Liver AFP purified by immunoadsorbent column yielded electrophoretic mobilities and relative amounts of the two electrophoretically distinct components identical with the purified serum AFP. The immunological reactivity of the two components of the purified preparations from serum and liver against the monospecific anti-AFP serum was also indistinguishable. After the removal of the sialic acid residues from purified serum and liver AFP by treatment with neuraminidase for 6 to 12 hr, disc electrophoretic patterns on 5% polyacrylamide gel and immunoelectrophoretic patterns of the treated AFP were found to be closely similar in both preparations. It may be possible to conclude that serum and liver AFP are structurally indistinguishable and probably identical.

(1) Many new drugs have been discovered lately and most clinicians have been very busy in conducting clinical studies with them. Therefore, cases of experiments at each institution have decreased. Thus, it seems meaningless to collect many clinical results which have been obtained by different methods of study. For that reason, the methods of study were unified beforehand and cooperative clinical studies with cephaloglycin have been made at four universities. As this was the first trial of cooperative clinical studies, the expected purpose "as not attained because of insufficient contact among researchers. But it seems that this trial will be helpful to further cooperative clinical study. (2) One gram of cephaloglycin per day was given to patients of acute uncomplicated cystitis for three days and it was effective in twenty-three cases out of twenty-five (92 %). This result was gained by judging its efficiency from symptoms, urinalysis and culture study. When its efficiency was judged from symptoms and urine findings, it was effective in forty-five cases out of fifty-three (85 %). (3) A comparative study was made between remedial results of a group of patients who had been given cephaloglycin from beginning to healing, and that of another one of patients who had been given cephaloglycin until their conditions of illness were less serious and then given sulfisomezole (2 grams per day) until healing. But significant difference was not observed.

1.In an attempt to study its usefulness as a contrast medium for retrograde pyelography, a 2-fold dilution (33.4%) of sodium. iothalamate 66.8% (Conray 400) was used in 23 cases and the results were compared with those with 38% Urografin. The test medium was demonstrated to be not inferior to Urografin in its capacity of visualizing the renal pelvis. 2. In 20 (87%) out of the entire 23 cases the contrast medium gave a clear-cut pyelogram with no blurring of the picture which makes the film incompetent for diagnostic purpose as seen in any instances. 3. As compared to Urografin which was administered contra laterally, Conray 400 was found to be more excellent in 13% and equally satisfactory in 78.3% in its visualization. 4. No adverse reactions worthy of mention was noted. 5. An experiment on the rate of injection confirmed that Conray 400, being lower in viscosity, is far easier to inject than Urografin.

UROCALUN, a new therapeutic agent for urolithiasis, was used with the following results. 1) Five out of eleven cases with ureteral calculus passed stone after administration of this drug for ten days or more. One of them passed a stone larger than 10mm in diameter. 2) Two cases of kidney stone were treated with long term administration of two to three months. In one case, it seemed effective. 3) This drug was useful for the patients with long term indwelling catheter to prevent calculi.

Spontaneous pyelo-duodenal fistula is exceedingly rare. Twenty-four cases of it have been reported in Europe and America, and 2 cases in Japan. A 36-year-old female was admitted for right loin pain and recurrent high fever. Retrograde pyelography showed the contrast dye passing through the pelvis into the duodenum, and intravenous pyelography showed a non-visualizing right kidney with a calculus. The left kidney was normal. Laboratory findings showed no abnormality. After the clinical diagnosis of pyelo-duodenal fistula was established, the definitive surgery by nephrectomy, excision of the fistulous tract and closure of the duodenum were carried out sa tisfactorily.

A case of four-year-old girl having dysuria, recurrent fever and incontinence due to bladder neck obstruction with reflux and hydronephrosis was presented, in which YV-plasty operation was carried out with success. A excretory urogram taken about five months after operation revealed no hydronephrosis and reflux. A long term follow-up study will determine whether the improvement is permanent or not.

Among the 1103 urine specimens obtained from patients with urinary tract infections for the recent 3 years, Pseudomonas aeruginosa was isolated in 145 (13 %). All patients were suffering from chronic infection with other urogenital diseases and majority of them had received various antibiotics in the past. Kasugamycin was administered in 21 paitent with chronic urinary tract infection due to Pseudomonas aeruginosa. Excellent, good and poor responses were obtained in 4, 11 and 6 cases, respectively, showing effectiveness to be 70.1 % (15 cases). Side effects were minimal.

Non-steroid anti-inflammatory drug, "Riripen" (Daiichi P h arm. Co.) was administered to patients with various urological diseases. The results are summarized as follows. 1. The drug was given to a total of 28 patients consisting of 16 with a cute cystitis, 3 with acute epididymitis, 4 with urethral stricture, 1 with genital trauma and 4 with other diseases. 2. In patients with acute cystitis, a single treatment with "Riripen" showed no r emarkable effect, but a combination with other chemotherapeutic agents produced a secure effectiveness. 3. In patients with acute epididymitis, a combination therapy of "Riripen" wit h chemotherapeutic agents resulted in an excellent analgetic effect although the necessitate duration of drug administration was unable to be shortened. 4. In patients with urethral s tricture, the drug showed an excellent effect for elimination of urethral damages following bougienage. 5. Although case treated w as limited in only one, a patient with genital trauma showed an excellent response to the single treatment with "Riripen" 6. The drug was given to patients who w e re performed cystoscopic examination with a good effect for releasing pain. 7. In a few cases, t h e therapy with "Riripen" suggested a possibility that an administration of the drug may be used for auxotherapy or abolition of adrenocortical hormone therapy. 8. No noticeable side effect was encountered.