Search

This article discusses the synthesis of a new P-chiral phospholene core-based ligand called LemPhos. The authors propose a method using a chiral diene to create diastereomers that are easier to separate, allowing for the production of P-chiral ligands. The ligands are synthesized and characterized, and their application as catalysts in asymmetric hydrogenation reactions is explored. The document also includes experimental procedures and spectroscopic data for the synthesized compounds. The research is dedicated to the memory of Stanisław Lem, a renowned science-fiction writer. [Extracted from the article]

This article discusses the synthesis and characterization of a thermally stable monoruthenium acetylide radical species. The researchers examined the reactivity and properties of metal acetylide complexes, specifically focusing on mononuclear ruthenium acetylide radicals. They found that the choice of metal center and ligands significantly influenced the reactivity of these complexes. The researchers were able to isolate and characterize a mononuclear ruthenium acetylide radical species, which exhibited high thermal stability. This study provides insights into the design strategy for controlling the reactivity of radicals in metal complexes. [Extracted from the article]

This article, published in the journal Synlett, discusses a study on the development of a rhodium-catalyzed direct vinylene annulation reaction. The researchers focused on using vinyl selenones as vinylene-transfer reagents and successfully demonstrated a three-component reaction to construct isoquinolone scaffolds. The article includes a table showing the optimization of reaction conditions. The study also explored the scope and limitations of the reaction system, proposing a mechanism for the coupling reaction and concluding that further optimization is needed. [Extracted from the article]

This article explores the potential use of molybdenum as a catalyst in organic synthesis, specifically in cross-coupling reactions. The researchers discovered that a molybdenum species, created by reducing a molybdenum precursor with phenylmagnesium bromide, can activate carbon-halogen bonds and produce a cyclized dimerization product. The study highlights the potential of molybdenum catalysts in sustainable catalysis and their applications in cross-coupling reactions of aryl halides. The article also mentions the potential bioactivity of the resulting phthalan derivatives. [Extracted from the article]

This article discusses the synthesis of α-aryl carbonyl compounds using palladium catalysis. The authors focus on the deprotonative α-arylation of Meyers's chiral bicyclic lactams (MCBLs) as a potential method for synthesizing these compounds. They explore various bases and catalytic systems to optimize the reaction conditions and achieve high yields. The authors also investigate the reaction scope by testing different substrates and bridgehead substituents. The results suggest that steric effects play a crucial role in determining the reactivity of the substrates. The authors propose a plausible mechanism for the formation of the arylated lactam products. Overall, this study provides valuable insights into the synthesis of α-aryl carbonyl compounds and highlights the potential of MCBLs as versatile building blocks. [Extracted from the article]

This document provides information on the synthesis and characterization of various thiochromeno[2,3-c]pyrrole derivatives. The compounds were synthesized using specific reactions and their structures were confirmed using spectroscopic techniques. Crystallographic analysis was also performed on one of the compounds. The document includes detailed information on the synthesis, characterization, and analysis of each compound. [Extracted from the article]

This article discusses the metal-free synthesis of trifluoromethyl carbinol-containing imidazo[1,2-a]pyridines through dehydrative coupling. Trifluoromethyl-containing compounds are important in various fields due to their biological activity and stability. Imidazo[1,2-a]pyridines are commonly found in pharmaceuticals, and the construction of CF3-containing imidazo[1,2-a]pyridines is valuable for drug discovery. The use of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a medium for organic synthesis has been explored, and it has been found to promote the hydroxy-trifluoromethylation of imidazo[1,2-a]pyridines with trifluoroacetaldehyde. The optimized reaction conditions using HFIP as a solvent resulted in good yields of the desired products. The substrate scope of this process was also investigated, demonstrating its generality and practicality. This article describes a novel approach for the synthesis of trifluoromethyl carbinol-containing imidazo[1,2-a]pyridines using imidazo[1,2-a]pyridines and trifluoroacetaldehyde via a dehydrative cross-coupling process. The reaction was promoted by HFIP and exhibited wide substrate generality, excellent functional group tolerance, and mild reaction conditions. [Extracted from the article]

This document provides a detailed account of the synthesis of three calyciphylline A-type alkaloids: (+)-daphlongamine E, (+)-calyciphylline R, and (-)-10-deoxydaphnipaxianine A. The authors describe the synthetic efforts and challenges faced in achieving these compounds, as well as the unique protecting group used in the synthesis of (-)-10-deoxydaphnipaxianine A. The synthesized compounds were characterized and compared to their natural counterparts. The document is technical and specific to the field of organic chemistry, making it suitable for researchers in the field. [Extracted from the article]

This document presents the results of a study on the regioselective deprotonation of brominated pyridylthiophene compounds. The researchers found that the position of deprotonation could be switched by adding DMPU as a Lewis base, allowing for the selective deprotonation of each proton on the thiophene moiety. The subsequent halogen dance reaction resulted in the synthesis of four iodinated isomers from a single starting material. This method has potential applications in the synthesis of various substituted pyridylthiophene derivatives. The study was conducted at NAIST and supported by the ARIM Program of MEXT, Japan. [Extracted from the article]

This article discusses the development of a simplified protocol for the large-scale preparation of 4CzIPN and 3DPA2FBN, two photocatalysts used in organic synthesis. The traditional methods for synthesizing these photocatalysts have been expensive and impractical for large-scale production. The authors of this study optimized the original protocol, using a base and a solvent switch to improve efficiency and simplify the process. The resulting protocol allows for the production of 4CzIPN and 3DPA2FBN on a large scale, making them more accessible for use in the pharmaceutical industry. The article also includes information on the crystal structure of 4CzIPN and the synthesis of 3DPA2FBN. Overall, this research provides a valuable contribution to the field of photocatalysis and offers potential applications for these photocatalysts in academia and industry. [Extracted from the article]