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X-ray fluorescence (XRF) is a successful technique often used for the elemental analysis of cultural heritage artefacts. It is non-invasive, the equipment can be miniaturized and made portable and it allows addressing crucial issues such as the fabrication technology, authenticity and provenance of the artefacts. Depending on the components' selection (e.g., the primary source, the detector and the focusing optics, if present), the analytical performance and the consequent suitability to investigate a given class of materials may vary significantly. The present paper discusses the analytical performance—with special regard to the limits of detection and the quantification uncertainty—of two portable XRF spectrometers developed within a collaboration between INFN-LNF-FISMEL and CNR-ISPC. The devices are expressly designed for heritage materials. In particular, one is equipped with focusing optics and it is intended to analyze small details on glasses and pigmented surfaces, whereas the other has a 70 kV X-ray tube, which greatly improves sensitivity for medium-Z elements, which is important in copper-based artefacts. Finally, this paper discusses two case studies to highlight the features of the instruments: one concerns Etruscan vitreous material beads and the other pre- and proto-historic copper-based artefacts from Tyrrhenian Central Italy. Thanks to the small size of the equipment, both investigations could easily be carried out in situ, namely, at the Museo Nazionale Etrusco in Rome and the Museo della Preistoria della Tuscia e della Rocca Farnese at Valentano. [ABSTRACT FROM AUTHOR]

Traditionally, it has been considered that the Ptolemaic or classical maps from the four editions of Ptolemy's Geography published in Rome (1478, 1490, 1507, and 1508) are apparently indistinguishable at first glance because they have been printed from the same plates. This poses a problem for antiquarians, collectors, and curators who wish to accurately date their copies. Recently, two very comprehensive articles have been published on the different paper watermarks associated with each edition, which would allow for the correct identification of each one. However, there are occasions when the maps do not display watermarks. This article aims to provide some keys to distinguish between the incunabula editions (1478, 1490) and those of 1507–1508 in cases of the absence of watermarks. In this process of detecting differences, we have used digitized images of the maps. The results show small modifications in the copper plates made between the editions of 1490 and 1507/08. Our findings reveal that seven previously unknown reworked maps have been identified. [ABSTRACT FROM AUTHOR]

This paper explores the relationship between territory and urban space, discussing the joint development processes of urban and territorial morphologies. The paper argues that territorial structure is a precursor to urban design. It also discusses how landscape architecture can respond to the morphological needs of contemporary urban design as the boundaries between city and territory merge. The introduction and framework review section examines various approaches to studying the relationship between urban morphology and interstitial spaces or unbuilt geographies, which are often still considered empty spaces, physically incorporated but excluded from urban design. It also briefly discusses the role that green spaces and territorial morphologies have played, or not played, in defining urban form from antiquity to modernity. The paper then focuses on the role of hydromorphologies in shaping the urban form of Rome, Boston and Bari. These cities are analyzed as case studies to discuss 20th-century approaches to urban planning in relation to territorial layout. Finally, this study analyzes a marginal area of the metropolitan city of Bari in order to propose possible landscape morphologies of reconnection for the resulting interstitial areas. [ABSTRACT FROM AUTHOR]

The topic of the paper is tax and the tax system of the Byzantine Empire. The tax system analysed in this paper was created and applied from the 3rd to the 9th century. In this research, the author tried to point out the changes that took place in the property relations in the agriculture of the Empire, which in many ways affected the organization and method of tax collection. The paper provides an analysis from which it can be noted that the organization of tax collection followed the changes that took place in Byzantine society. Agricultural production in the first centuries was based on the relationship between the colonists and the landowners. That relationship began to change from the beginning of the 7th century, when an increasing number of free peasants began to appear in agricultural production. The Roman and then the Byzantine system of tax collection was based on the registration of the land in the cadastre. Every land owner had to be registered in the cadastre, and thus was obliged to pay taxes. The financial administration of the Empire gave estimates every year of how much tax should be collected. The tax system in these times is going through changes in the way it is collected. The old relationship in which head tax and land tax are collected is abandoned and a system of special assessments, household tax and land tax is introduced. The changes that occurred in the method of tax collection influenced the further development of relations in Byzantine agriculture. Throughout this period, taxes were collected in money, mostly gold. [ABSTRACT FROM AUTHOR]

The call for papers for this Special Issue Iidentifies contemporary humanity as experiencing a global "biogeochemical ... political, economic, technological, ethical, and therefore, biocultural" crisis and asks scholars to consider how "religion may function as an adaptive or maladaptive presence" in response. Unasked is the adaptive capacity of scholarship as a crisis response. When buildings fall in earthquakes, or cities burn in wildfires, or second stories flood, few people just keep on doing what they were doing, "with a change of focus". This is "studying Rome while it burns". It's time to put out the fire if we can and survive it if we cannot. We scholar/teachers can't go on doing the same things and expecting different results. Unprecedented circumstances call for unprecedented actions in response. What would actual crisis responses on our part look like? What steps do we need to take as human beings in response to this crisis? How will that affect us as professionals? Seeking an ecology, rather than unanimity, of action and thought, and guided by Brian Walker's resilience theory and a number of Indigenous scholars, I suggest a process of reintegration, analogous to regenerative agriculture, which is at once both socio-cultural and ecological. This process, necessarily rooted in place, progressively situates us experientially in a dynamic, creative, and relational world characterized by connection, collaboration, and relation. As scholars, we will find forms of discovery, discussion, and dissemination that share these qualities. As teachers, we will model this world to our students and embody it in our classrooms and curricula. [ABSTRACT FROM AUTHOR]

This paper analyzes and interprets the prose of Ernest Koliqi including his short story collections Hija e maleve (“The Shadow of the Mountains”, 1929), published in Zadar; Pasqyrat e Narçizit (“The Mirrors of Narcissus”, 1934), published in Bari and Rome; Tregtar flamujsh (“Flag Merchant”, 1935), published in Tirana; and the novel Shija e bukës së mbrume (“The Taste of Leavened Bread”, 1960), published in Rome. Pasqyrat e Narçizit/“The Mirrors of Narcissus” (1934) is written in a style between poetry and prose. In Hija e maleve/“The Shadow of the Mountains” (1929), the author remains truthful about Albanian traditions. The theme of this collection portrays the main elements of the Albanian way of living and their mentality. The central aspect of Koliqi’s works deals with the drama of the homeland, the struggles of the Albanian intellectuals in general and those of Shkodër in particular. Most stories present cohabitation with mythological creatures; however, there is also Tregtar flamujsh/“Flag Merchant” (1935) which shows modern symbolism with an element of psychoanalysis. In Shija e bukës së mbrume/“The Taste of Leavened Bread” (1960) Koliqi writes about life, the struggles, and the atmosphere of Albanian life. This novel is filled with patriotic, social, and moral values of the Albanian people, even though the main character of the story lives in Albania and abroad. Ernest Koliqi’s characters are typical Albanian people, and the spirit of his works is also of the typical Albanian spirit. [ABSTRACT FROM AUTHOR]

Recent crises have highlighted the vulnerabilities of global supply chains and, consequently, a profound need for food system transformation. In this scenario, local food policy and agroecology arise as two different but converging paradigms capable of fostering an inclusive and sustainable transition of the food systems, especially in urban contexts. The purpose of this paper is to strengthen the relationship between these two paradigms by proposing agroecological assessment as a tool for formulating evidence-based local food policies. Considering the city-region food system of Rome (Italy) as a reference context, the paper proposes an adaptation of the Tool for Agroecology Performance Evaluation (TAPE) model on a sample of 20 farms to analyse urban agriculture and understand the extent to which it contributes to the transformation of the food system. Data processing shows that, in the city-region context of Rome, agroecological principles are not fully adopted by the majority of farms considered. In addition, farms with the highest agroecological level are those driven mainly by social factors and have a lower propensity for innovation. This could be read as a constraining aspect because it hinders and slows down the transformation process of food systems. However, these data turn out to be essential to the implementation of local food policy and in identifying pathways toward sustainability. [ABSTRACT FROM AUTHOR]

Optical and Synthetic Aperture Radar (SAR) remote sensing has a long history of use and reached a good level of maturity in archaeological and cultural heritage applications, yet further advances are viable through the exploitation of novel sensor data and imaging modes, big data and high-performance computing, advanced and automated analysis methods. This paper showcases the main research avenues in this field, with a focus on archaeological prospection and heritage site protection. Six demonstration use-cases with a wealth of heritage asset types (e.g. excavated and still buried archaeological features, standing monuments, natural reserves, burial mounds, paleo-channels) and respective scientific research objectives are presented: the Ostia-Portus area and the wider Province of Rome (Italy), the city of Wuhan and the Jiuzhaigou National Park (China), and the Siberian "Valley of the Kings" (Russia). Input data encompass both archive and newly tasked medium to very high-resolution imagery acquired over the last decade from satellite (e.g. Copernicus Sentinels and ESA Third Party Missions) and aerial (e.g. Unmanned Aerial Vehicles, UAV) platforms, as well as field-based evidence and ground truth, auxiliary topographic data, Digital Elevation Models (DEM), and monitoring data from geodetic campaigns and networks. The novel results achieved for the use-cases contribute to the discussion on the advantages and limitations of optical and SAR-based archaeological and heritage applications aimed to detect buried and sub-surface archaeological assets across rural and semi-vegetated landscapes, identify threats to cultural heritage assets due to ground instability and urban development in large metropolises, and monitor post-disaster impacts in natural reserves. [ABSTRACT FROM AUTHOR]

This paper sheds light on the manufacturing processes, techniques, and materials used in the splendid illuminations of the oldest surviving copy of De Balneis Puteolanis, preserved at the Angelica Library in Rome (Ms. 1474). The codex is one of the masterpieces of mid-13th-century Italian-Southern illumination, traditionally referred to as the commission of Manfredi, son of Frederick II. The findings reported in the article result from the interdisciplinary study conducted in 2021–2023 in the framework of "Codex 4D: journey in four dimensions into the manuscript", a multidisciplinary project involving many competences and dealing with art-historical studies on manuscripts, diagnostic and conservative analyses, scientific dissemination, storytelling, and public engagement. The considerations we present aims at increasing the knowledge of book artefacts while respecting their extraordinary complexity; data from non-invasive diagnostic investigations (X-ray fluorescence, Vis-NIR reflectance and Raman spectroscopies, hyperspectral imaging, and multi-band imaging techniques as ultraviolet, reflectography, and thermography), carried out in situ with portable instruments on the book, have been integrated with observations resulting from the historical-artistic study, and the reading of some ancient treatises on the production and use of the pigments and dyes employed in illumination. [ABSTRACT FROM AUTHOR]

This paper proposes the assessment of the impacts of using electric vehicles for urban service trips. In particular, the focus is on trips performed for delivering and installing products, as well as for reverse logistics. Such components of commercial traffic in urban areas have not received the level of attention it deserves. In fact, recent research on commercial traffic mainly deals with shop restocking, service visits to establishments and e-commerce deliveries, and limited attention has been paid to the service sector (e.g., installation, maintenance, repairs) which can have a high impact on city sustainability in terms of pollution emissions, congestion as well as land use for parking. Furthermore, pushed by the current trend towards the promotion of electric vehicles, an assessment is developed comparing potential service patterns using real data from the inner area of Rome (Italy) when the electric fleet replaces the traditional one. Results show the opportunity to decouple the delivery operation from the installation one, and to integrate service with reverse logistics. These significant results could address the adoption of suitable integrated urban policies to make the most of the opportunities arising from the use of electric vehicles. [ABSTRACT FROM AUTHOR]

Electric micromobility, both as a private option and as a shared service, can represent an alternative to cars, particularly for given user groups (market segments) and specific classes of travel distance. The paper explores the potential for shifting from cars to electric micromobility (specifically, e-bikes and e-scooters) for commuting trips, investigated through floating car data (FCD). The methodology combines the calibration of random utility models (RUMs) and the subsequent simulation through the adoption of FCD spanning the entire city of Rome (Italy). The data used for the calibration of RUM models have been sourced from an online revealed preferences and stated preferences survey carried out between November 2020 and January 2021. Socioeconomic factors, along with transport features (travel time, access time, monetary costs, and perceived safety levels), enter into the definition of the mode choice probability. The first results showed that in Rome, the potential demand for electric micromobility could range between 14% of the FCD sample in the best case (low cost, high accessibility, and road infrastructures with a high perceived level of safety) and about 2% in the worst case (high cost, low accessibility, and a low perceived level of safety). [ABSTRACT FROM AUTHOR]

Recently, there has been increased interest in adopting novel sensing technologies for continuously monitoring structural systems. In this respect, micro-electrical mechanical system (MEMS) sensors are widely used in several applications, including structural health monitoring (SHM), in which accelerometric samples are acquired to perform modal analysis. Thanks to their significantly lower cost, ease of installation in the structure, and lower power consumption, they enable extensive, pervasive, and battery-less monitoring systems. This paper presents an innovative high-performance device for SHM applications, based on a low-noise triaxial MEMS accelerometer, providing a guideline and insightful results about the opportunities and capabilities of these devices. Sensor nodes have been designed, developed, and calibrated to meet structural vibration monitoring and modal identification requirements. These components include a protocol for reliable command dissemination through network and data collection, and improvements to software components for data pipelining, jitter control, and high-frequency sampling. Devices were tested in the lab using shaker excitation. Results demonstrate that MEMS-based accelerometers are a feasible solution to replace expensive piezo-based accelerometers. Deploying MEMS is promising to minimize sensor node energy consumption. Time and frequency domain analyses show that MEMS can correctly detect modal frequencies, which are useful parameters for damage detection. The acquired data from the test bed were used to examine the functioning of the network, data transmission, and data quality. The proposed architecture has been successfully deployed in a real case study to monitor the structural health of the Marcus Aurelius Exedra Hall within the Capitoline Museum of Rome. The performance robustness was demonstrated, and the results showed that the wired sensor network provides dense and accurate vibration data for structural continuous monitoring. [ABSTRACT FROM AUTHOR]

The continuous improvement of the energy and sustainability performances of buildings is stimulated by mandatory rules, economic incentives and voluntary sustainability pathway of which energy efficiency is one of the most important components. The tools to evaluate the energy, sustainability, automation and energy metering performances of buildings, to check the status and lead the investments, are often complex, slow, expensive and related to the specific Countries, making difficult the job for the facility management departments of national or international organizations in EU. The present paper wants to give a contribute to existing literature by providing a new energy, sustainability, automation and energy metering label system to quickly, simply and economically evaluate the performances of office buildings in Europe. This tool has been tested on a case study, a research center of the European Space Agency (ESA-ESRIN) in Rome, Italy. The results of the test show that the tool has been successfully applied on the buildings of the research center using the data provided by the facility management department of ESA-ESRIN and the energy audit of the center. The labels can correctly represent the state of the buildings in a more cost-effective way if compared to the national energy certification and to international sustainability protocols. This study provides the facility management departments of public and private companies in EU - especially if they manage buildings in different EU nations - a reliable tool to quicky evaluate the energy, sustainability, automation and energy metering performances of their buildings. [Display omitted] • Energy and sustainability performances of buildings are evaluated through protocols. • Facility managers need quick tools: the proposed labeling tool for offices can help. • It labels energy, sustainability, automation and energy metering performances. • This tool considers Trans-national European Union differences (primary energy, CO 2). • The first application has been on the European Space Agency Italian research center. [ABSTRACT FROM AUTHOR]

The aim of this study was to assess the methodical protection of the lingual nerve via the use of a standardized step-by-step procedure in the surgical extraction of the lower third molar. A 5-year retrospective analysis of surgical third molar surgery conducted by third-year oral surgery specialty program students was performed in the oral surgery department of Policlinico Umberto I in Rome, from 2017 to 2022. All surgeries were carried out using a standardized step-by-step procedure to protect the lingual flap during the surgery. Every patient underwent a review on the initial postoperative day, and subsequently, one week after the surgery, coinciding with the removal of the sutures. During each postoperative visit, thorough examinations were conducted to assess any sensory nerve impairment of the inferior alveolar, lingual, or mylohyoid nerves. None of the cases reported postsurgical lingual nerve injury; there was zero incidence of lingual nerve paresthesia or dysesthesia. The systematic application of lingual flap protection proved to be an effective and reproducible approach for the surgical removal of lower third molars without raising the risk of lingual nerve sensory impairment, regardless of the operator's experience. [ABSTRACT FROM AUTHOR]

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Purpose: The aim of the present work is to explore the impact of the COVID-19 pandemic on research activities in a vast multidisciplinary academic community to identify the most critical issues. Method: To this purpose we planned a survey addressed to the entire academic research staff at "Sapienza" University of Rome, which represents the largest Italian academic community. A questionnaire consisting of both open and closed-ended questions was delivered to 4118 individuals in April 2021. Results: A total of 544 responses were collected. All academic roles were sufficiently represented in the study cohort. The median number of critical issues experienced by academic research staff was three. Among these, the three most frequently reported were related to: "Access to libraries / laboratories / research sites" (21.9%), "Limitation to stay abroad / study / research periods" (17.6%), "Progress of experimental work" (14.7%), with variable prevalence according to academic position and gender. Older subjects reported issues with "Projects' financial reporting" and "Expiration of acquired consumable material more frequently". The most common critical aspects reported in relation to the economic burden were: being "Unable to allocate funds" (31.4%), a "Reduction in clinical and scientific activity" (26.3%) and experiencing "Increased expenses (comprising private costs)" (21.2%) with no differences between genders. Researchers in Applied Sciences and Natural Sciences reported a higher frequency of problems in clinical and scientific activities, whereas increased expenses were reported also by researchers operating in the Humanities field. As a possible solution aimed at improving these issues, most subjects, especially those aged >45 years, indicated "Economic aid" (22.6%), "Reduction in bureaucracy" (19.9%) or "Enhancement of the scientific and clinical activities", whereas those aged ≤45 years felt that an increased duration and better access to PhD programs were to be prioritized. Conclusion: Our findings highlight the most critical issues related to research activities during the COVID-19 pandemic in a large academic community. The information achieved may be useful to identify researchers' needs and to design appropriate policies aimed at preparing research institutions for unexpected catastrophic events and limiting the negative impact on academic research activities. [ABSTRACT FROM AUTHOR]

Background: Human papilloma virus (HPV) infection and the management of its persistence is still a great medical challenge. Recently, scientific evidence has supported the potential therapeutic effects of four combined natural molecules—epigallocatechin gallate (EGCG), folic acid, vitamin B12 and hyaluronic acid (HA)—in counteracting HPV DNA positivity and related cytological lesions. Methods: Each patient of these five clinical cases had persistent HPV positivity in the anogenital site and assumed a dietary supplement based on a combination of 200 mg of EGCG, 50 mg of HA, 1 mg of vitamin B12 and 400 mcg of folic acid (Pervistop®, Farmares s.r.l., Rome, Italy) at a dosage of 1 or 2 caps/day for 6 or 3 months, respectively, depending on clinical history. Results: After treatment, all the patients reported a negative HPV DNA test and improved cytological lesions, thus demonstrating the ability of these combined molecules to counteract both anal and cervical HPV infection and related manifestations. Conclusions: Overall, these data corroborate previous evidence about the effectiveness of such natural molecules in the management of HPV infection and its persistence. Naturally, further studies with a larger population and long-term follow-up will contribute to reinforce the positive effects of this dietary supplement in counteracting HPV infection. [ABSTRACT FROM AUTHOR]

Background: The introduction of biological drugs in the management of chronic rhinosinusitis with nasal polyps (CRSwNP) is allowing new and increasingly promising therapeutic options. This manuscript aims to provide a multicenter trial in a real-life setting on Mepolizumab treatment for severe uncontrolled CRSwNP with or without comorbid asthma. Methods: A retrospective data analysis was jointly conducted at the Otolaryngology–Head and Neck Surgery departments of La Sapienza University and San Camillo Forlanini Hospital in Rome. Both institutions participated by sharing clinical information on patients with CRSwNP treated with Mepolizumab. Patients were evaluated before starting Mepolizumab, at six months and at twelve months from the first drug administration. During follow–up visits, patients underwent endoscopic evaluation, quality of life assessment, nasal symptoms assessment, and blood tests to monitor mainly neutrophils, basophils, eosinophils, and IgG, IgA, and IgE assay. Results: Twenty patients affected by CRSwNP and treated with Mepolizumab were enrolled (12 females and 8 males with a mean age of 63.7 years). Sixteen patients (80%) had concomitant asthma. During follow-up, a gradual improvement in nasal polyp score, quality of life and nasal symptoms, assessed by SNOT-22 and VAS and loss of smell measured by olfactory VAS, was found. Regarding blood tests, eosinophils decreased gradually, while other blood parameters showed no statistically significant changes. Conclusions: Mepolizumab has been shown to be effective in the therapeutic management of patients with CRSwNP. Further studies are needed to support our findings and better understand the underlying immune pathways to predict patients' response to biological treatment in CRSwNP. [ABSTRACT FROM AUTHOR]

Background: SARS-CoV-2 is the coronavirus responsible for the COVID-19 pandemic. Even though we are no longer in a pandemic situation, people are still getting infected, some of them need hospitalization and a few of them die. Methods: We conducted a retrospective study including 445 patients who accessed the Emergency Section of Policlinico Umberto I, Rome, Italy, where they had routine blood exams. In this study, we focused on the complete blood count, serum creatinine and azotemia. The data were analyzed using ANOVA, Spearman correlation and ROC analyses. They were divided into four groups based on their clinical outcomes: (1) the emergency group (patients who had mild forms and were quickly discharged); (2) the hospital ward group (patients who were admitted to the emergency section and were then hospitalized in a COVID-19 ward); (3) the intensive care unit (ICU) group (patients who required intensive assistance after the admission in the emergency section); (4) the deceased group (patients who had a fatal outcome after admission to the emergency section). Results: We found significant changes for creatinine, azotemia, hematocrit, mean corpuscular hemoglobin concentration, basophils, monocytes, red blood cell distribution width, hemoglobin, hematocrit and red blood cell numbers using ANOVA according to their clinical outcomes, particularly for the deceased group. Also, we found linear correlations of clinical outcomes with eosinophils, hemoglobin, hematocrit, mean corpuscular hemoglobin concentration, lymphocyte, neutrophil, platelet and red blood cell number and red blood cell distribution width. Conclusions: This study discloses an early association between "classical" routine blood biomarkers and the severity of clinical outcomes in Omicron patients. [ABSTRACT FROM AUTHOR]

Objective: Studies on resilience in advanced cancer caregiving typically focus on the interplay between resilience-promoting resources and coping strategies that may be associated with resilience. However, no studies have investigated the emergence of trajectories of resilience and distress in individuals confronted with a cancer diagnosis of a loved one. Methods: Ideal-type analysis, a method for constructing typologies from qualitative data, was used to identify trajectories involving resilience or the lack thereof based on fifty-four interviews conducted with seventeen partners of patients recently diagnosed with advanced cancer over a period of three years. Findings: Six trajectories could be distinguished, three of which involved resilience (rapidly adapting resilience, gradually adapting resilience, and slowly adapting resilience), while the other three trajectories (continuing distress, delayed distress, and frozen disconnection) reflected a less optimal adjustment. These different trajectories seemed to be rooted in the individual characteristics of partners, the behavior of a support network, and interactions between the two. Conclusion: The differentiation between these trajectories in partners of patients diagnosed with cancer not only furthers research on resilience in the face of adversity, but also promises to assist healthcare professionals in optimizing support for this often-neglected group of partners of patients diagnosed with cancer. [ABSTRACT FROM AUTHOR]

A devastating earthquake took place on 8 April 1893, close to the town of Svilajnac, central Serbia. Over the past decade, significant historical data on the effects of this earthquake has been collected from a variety of sources, including books, scientific publications, reports, newspapers, and coeval chronicles. Additionally, this earthquake was recorded 750 km from the epicenter at the seismological station Rocca di Papa in Rome, Italy. Based on critical review and analysis of the historical data, we demonstrate that the epicentral area of this earthquake was 531 km2, and the macroseismic effects were recorded at epicentral distances up to 600 km towards the west (Vienna, Austria) towards the north, up to 500 km (Košice–Michalovce, Slovakia), towards the east up to 460 km (Brašov–Borsec, Romania); and towards the south up to about 300 km (Radoviš, North Macedonia). Finally, we show that the key parameters of the 1893 Svilajnac earthquake are as follows: (1) epicentral intensity, I0 = IX EMS-98, (2) the estimations of the moment magnitude and focal depth based on the observed intensities, MW = 6.8 and h = 13 km, respectively, and (3) the epicenter coordinates, 44.160° N and 21.354° E. [ABSTRACT FROM AUTHOR]

Highly contagious diseases, such as mumps, are a global concern as new epidemics continue to emerge, even in highly vaccinated populations. The risk of transmission and spread of these viruses is even higher for individuals who are more likely to be exposed, including healthcare workers (HCWs). In healthcare settings, both HCWs and patients are at risk of infection during the care process, potentially leading to nosocomial epidemic outbreaks. Mumps is often underestimated compared with measles and rubella, despite being milder and less likely to spread. In fact, the risk of complications following mumps infection is extremely high, especially if the disease occurs in adulthood. The measles–mumps–rubella (MMR) vaccine has been shown to be an excellent preventive measure. Unfortunately, the mumps component appears to be less effective in inducing immunity than those for measles and rubella (two-dose effectiveness of 85%, 95% and 97%, respectively). The main aim of our study was to investigate the prevalence of detectable mumps antibodies (serum IgG antibodies) in a cohort of Italian and foreign HCWs in relation to personal and occupational factors. We included in the study 468 subjects who underwent health surveillance at the Occupational Medicine Unit of the Tor Vergata Polyclinic in Rome during the period from January 2021 to March 2023. In our study, the proportion of HCWs found to be unprotected against mumps was very high (8.3%), and those found to be immune are below the WHO threshold for herd immunity (95%). From our data, it seems essential that all occupational health services carry out an accurate screening with a dose of anti-mumps antibodies to assess serological protection before starting a job, regardless of an individual's vaccination history. This approach is proving to be beneficial, accurate, as it allows all serologically non-immune individuals to be vaccinated in the workplace, including those who would be protected by their vaccination history but have lost the antibody response. [ABSTRACT FROM AUTHOR]

Rome is vulnerable to chemical, biological, radiological, nuclear, and explosive (CBRNe) attacks. The study evaluates Rome's advanced emergency departments' state of emergency plans for massive influx of injures (PEIMAF) plans for CBRNe attacks. We propose a chemical attack on Saint Peter's Square during the Pope's General Assembly and its effects. The National Stockpile Antidotes' activation and territorial distribution timing work well for chemical attacks. We also estimated activation timing. Our data show that despite a good organization, travel times can be improved. We also believe that all major Roman hospitals must develop the PEIMAF, which should be followed by an organized training plan involving theoretical teaching and indoor and outdoor simulation to train hospital staff and evaluate PEIMAF weaknesses and vulnerabilities. The effectiveness and efficiency of first aid depend on timing, and each PEIMAF analyzed, while coherent and adequate for internal purposes, fails to integrate with the other hospitals. Integration can speed up National Stockpile Antidotes delivery and save lives. For the best CBRNe response, detailed intervention protocols must be created, updated daily, and exercised. [ABSTRACT FROM AUTHOR]

The opportunistic network is a type of ad hoc network that relies on the chance encounters between nodes to transmit messages. It also uses store-and-carry-forward techniques for data transfer between nodes. Developing effective message forwarding strategies based on opportunistic network characteristics and node behavior poses a significant challenge. In this paper, we delve into the mobility and social characteristics of nodes using historical encounter information. Furthermore, we calculate the migration degree and community relations to build the Meta Meeting Mountain, which representing node encounter characteristics. Moreover, we introduce the concept of Forwarding Degree to measure the nodes' ability to deliver messages, enhancing the predictability of message delivery. Furthermore, a new forwarding strategy is proposed, which is equipped with Meta Meeting Mountain and Forwarding degree to improve the delivery rate. Our experimental scenarios include Infocom06, Rome taxi, and Helsinki. Therefore, the impact of buffer size and TTL is discussed in detail regarding the different opportunistic routing algorithms. Finally, extensive experimental results show that the proposed algorithm outperforms UBPR, MaxProp, PRoPHET, Spray And Wait and RAPAR in terms of delivery rate in the above scenarios by 127.905%, 93.7525%, 138.6888%, 175.3663%, and 281.4625%, respectively, while keeping the hopcount value less than 5. [ABSTRACT FROM AUTHOR]

Background: Physical fatigue is one of the most disabling symptoms in people with Multiple Sclerosis (PwMS). Several factors might influence the development of fatigue, such as gender, education, body mass index (BMI), Expanded Disability Status Scale (EDSS), disease duration, working status (Ws), physiotherapy (Ph), and disease-modifying therapies (DMTs). Fatigue Symptoms and Impacts Questionnaire-Relapsing Multiple Sclerosis (FSIQ-RMS) is a patient-reported outcome (PRO) that allows one to define the impact of fatigue in PwMS clearly. This study aimed to assess fatigue impact on PwMS by using FSIQ-RMS. Methods: The participants were enrolled from May to July 2021 in MS Centers of Sant'Andrea Hospital and Policlinico Umberto I Hospital in Rome. Fatigue was evaluated using the FSIQ-RMS, validated, and culturally adapted in Italian. Clinical and demographic data were collected at the same time. Results: We enrolled 178 PwMS [Female 74.16%; RMS 82.58%, SPMS 17.52%]. FSIQ-RMS scores were significantly correlated with EDSS (p-value < 0.01). Analysis of variance between means showed a statistically significant difference between the BMI groups at the 24hours_FSIQ-RMS score and the 7days_FSIQ-RMS score (p < 0.01), with the lower BMI group having the highest scores. Furthermore, perceived fatigue significantly improved both in subjects performing Ph (p < 0.05) and in those who actively work (p < 0.01). Conclusions: The use of FSIQ-RMS in a real-world setting confirmed that underweight and high levels of disability are closely related to fatigue. In addition, Ph and active Ws are strongly correlated with fatigue in PwMS. [ABSTRACT FROM AUTHOR]

This study described 17 cases of children admitted to the Bambino Gesù Children's Hospital with acute hepatitis of unknown origin between mid-April and November 2022. Following the World Health Organization's working case definition of probable cases, 17 children, with a median age of 2.1 years (interquartile range: 1.0–7.1), presenting with acute hepatitis non-AE, with serum transaminase >500 IU/L, were included in the study. A pre-specified set of microbiological tests was performed on different biological specimens for all pediatric patients. All patients resulted negative for the common hepatotropic viruses. The most common pathogen detected in blood specimens was human-herpes-virus-7 (52.9%). Adenovirus was detected more frequently in stool specimens (62.5%) than in respiratory (20.0%) or blood samples (17.6%). Regarding Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, one child tested positive two days after admission, while antibodies against spike and nucleoprotein were present in 82.3% of patients. A co-pathogen detection was observed in 94.1% of children. Overall, 16 children recovered without clinical complications, while one patient required liver transplantation. In these cases of acute hepatitis of unknown origin, adenovirus was mainly detected in stool samples. A co-pathogen detection was also frequently observed, suggesting that the etiology of this acute hepatitis is most probably multifactorial. [ABSTRACT FROM AUTHOR]

The conformation and dynamics of metropolitanisation act as propulsive elements of territorial transformations. The deficiency of infrastructural equipment, the heterogeneity of urban fabric and the lack of services and public spaces contribute to severing the identity ties between settled communities and territories. In light of this, within the more general reflection concerning urban regeneration, we recall the role that cultural heritage plays in the physical and functional organisation of the city, as a reflection of the interaction between community and context. The contribution is contextualized in the research work on the activities related to Thematic Line 4 of the Extended Partnership 5—CHANGES (NRRP). The thematic line activities follow three phases: 1. contextualization; 2. operational phase; 3. experimentation. The research work presented here is part of the 'operational phase', to identify strategies and projects for heritage-led regeneration. The article analyses the pilot case of CSOA Forte Prenestino as a starting point for thinking about expanding the research activity to other similar cases. It is a self-managed community centre in Rome (Italy) located in the nineteenth-century Forte, which has become a symbol of collective identity. The case study was identified following three levels of investigation: 1. identification of the municipality, first-level administrative subdivision of the city of Rome (Italy); 2. identification of the main historical, archaeological and architectural emergencies of the municipality; 3. identification of an asset to be analysed as "Heritage by designation" (involvement of experts) and "Heritage by appropriation" (involvement of communities). The research results show the "Recognition Path" of Forte Prenestina: according to what has been 'designated' by urban planning instruments, project instruments, legislative instruments and authors of scientific publications and conferences; and on the basis of the bottom-up 'appropriation' process of the asset that has allowed its management, assessment of its cultural and social potential and its development. The research results allow us to reflect on heritage-led urban regeneration as a strategy capable of capturing and promoting the links between social integration and cultural–historical identity. [ABSTRACT FROM AUTHOR]

In recent years, the increased use of heavy commercial vehicles with higher axle weights has required the development of innovative technologies to improve the mechanical properties of asphalt concrete conglomerates, such as fatigue resistance and rutting. This study offers a comprehensive comparative analysis of different types of asphalt concrete tested in four trial sections (S1, S2, S3, S4) of the SP3 Ardeatina rural road in Rome, under actual traffic and operational conditions. More precisely, the pavement technologies applied include modified asphalt concrete with graphene and recycled hard plastics for S1, asphalt concrete modified with styrene–butadiene–styrene (SBS) for S2, asphalt concrete with a standard polymeric compound for S3, and traditional asphalt concrete for S4. The evaluation approach involved visual inspections in order to calculate the pavement condition index (PCI) and falling weight deflectometer (FWD) tests. In addition, back-calculation analyses were performed using ELMOD software to assess the mechanical properties. The laboratory tests revealed superior properties of M1 in terms of its resistance to permanent deformations (+13%, +15%, and +19.5% compared to M2, M3, and M4, respectively) and stiffness (10,758 MPa for M1 vs. 9259 MPa, 7643 MPa, and 7289 MPa for M2, M3, and M4, respectively). These findings were further corroborated by the PCI values (PCIS1 = 65; PCIS2 = 17; PCIS3 = 28; PCIS4 = 29) as well as the FWD test results after 5 years of investigation, which suggests greater durability and resistance than the other sections. [ABSTRACT FROM AUTHOR]

Persistently, urban regions grapple with the ongoing challenge of vehicular traffic, a predicament fueled by the incessant expansion of the population and the rise in the number of vehicles on the roads. The recurring challenge of vehicular congestion casts a negative influence on urban mobility, thereby diminishing the overall quality of life of residents. It is hypothesized that a dynamic clustering method of vehicle trajectory data can provide an accurate and up-to-date representation of real-time traffic behavior. To evaluate this hypothesis, data were collected from three different cities: San Francisco, Rome, and Guayaquil. A dynamic clustering algorithm was applied to identify traffic congestion patterns, and an indicator was applied to identify and evaluate the congestion conditions of the areas. The findings indicate a heightened level of precision and recall in congestion classification when contrasted with an approach relying on static cells. [ABSTRACT FROM AUTHOR]

The Middle Pleistocene was characterized by the presence in continental Europe of at least two different species of hippopotamus: Hippopotamus antiquus and H. amphibius. Although suspected, the presence of both hippopotamuses in the same geographical area has not yet been proven. The following manuscript describes findings from Malagrotta (Rome, central Italy), dating back to the time span between 0.45 and 0.38 Ma. These findings offer new insights into the Middle Pleistocene period. The fragmented mandible has a slender and low corpus, the humerus is robust with a deltoid tuberosity placed medially on the diaphysis, the unciform shows a facet for the MCIV wider than the one for the MCV and the calcaneum is clepsydra-shaped. The morphological characteristics of the sample are closer to those of H. antiquus, despite the fact that the morphometric measurements are smaller than those of the samples coming from Valdarno (Italy), Untermaßfeld (Germany) or Colle Curti (Italy). Considering all the information, the material from Malagrotta is here attributed to H. cf. antiquus, indicating the survival of the European hippopotamus until at least 0.38 Ma in central Italy. The coexistence of H. amphibius and H. antiquus in the same geographical area is also discussed. [ABSTRACT FROM AUTHOR]

Although functional dyspepsia (FD) is a common functional gastroduodenal disorder with a high socioeconomic burden, little is known about its global prevalence. Thus, we performed a comprehensive study to estimate long-term trends in the prevalence of FD. We searched PubMed/MEDLINE, Embase, and Google Scholar from 1990 to 2022 for population-based studies that reported the prevalence of FD in adults (≥ 18 years old) according to Rome I, II, III, or IV criteria. The prevalence of FD was extracted from included studies to obtain pooled prevalence with 95% confidence intervals (CI) and 95% prediction intervals. Subgroup analysis was performed according to certain characteristics, including geographic region. A total of 44 studies met the eligibility criteria, including 256,915 participants from 40 countries across six continents. The overall global pooled prevalence of FD was 8.4% (95% CI 7.4–.9.5). The prevalence was the highest in Rome I (11.9%; 95% CI 5.1–25.4) and lowest in Rome IV (6.8%; 95% CI 5.8–7.9). Developing countries showed a higher prevalence than developed countries (9.1% versus 8.0%), and prevalence was higher in women, irrespective of the definition used (9.0% versus 7.0%). The pooled prevalence gradually decreased from 1990 to 2020 (12.4% [8.2–18.3] in 1990–2002 versus 7.3% [6.1–8.7] in 2013–2020). The prevalence of FD differs by country, economic status, geographical region, and sex, and the global prevalence has been gradually declining. Despite the heterogeneity of sample population, our study estimates the current global burden of FD and provides information to heath care policy decisions. [ABSTRACT FROM AUTHOR]

Electric scooter sharing mobility services have recently spread in major cities all around the world. However, the bad parking behavior of users has become a major source of issues, provoking accidents and compromising urban decorum of public areas. Reducing wild parking habits can be pursued by setting reserved parking spaces. In this work, we consider the problem faced by a municipality that hosts e-scooter sharing services and must choose which locations in its territory may be rented as reserved parking lots to sharing companies, with the aim of maximizing a return on renting and while taking into account spatial consideration and parking needs of local residents. Since this problem may result difficult to solve even for a state-of-the-art optimization software, we propose a hybrid metaheuristic solution algorithm combining a quantum-inspired ant colony optimization algorithm with an exact large neighborhood search. Results of computational tests considering realistic instances referring to the Italian capital city of Rome show the superior performance of the proposed hybrid metaheuristic. [ABSTRACT FROM AUTHOR]

Background: The ocular involvement of neuroendocrine neoplasms (NENs) is uncommon and mainly represented by metastases from gastrointestinal and lung neuroendocrine tumors. Primary orbital NENs are even less common and their diagnostic and therapeutic management is a challenge. Methods: A systematic review of the literature was conducted from 1966 to September 2023 on PubMed to identify articles on orbital NENs and to summarize their clinical–pathological features, diagnosis and therapeutic management. Furthermore, we presented a case of a locally advanced retro-orbital primary neuroendocrine tumor that was referred to the certified Center of Excellence of Sant'Andrea Hospital, La Sapienza University of Rome, Italy. Results: The final analysis included 63 records on orbital NENs and 11 records focused on primary orbital NENs. The localization was mostly unilateral and in the right orbit; proptosis or exophthalmos represented the initial symptoms. The diagnostic work-up and therapeutic management was discussed and a diagnostic algorithm for the suspicion of primary orbital NENs was proposed. Conclusions: A multidisciplinary approach is required for the management of primary orbital NENs, emphasizing the importance of early referral to dedicated centers for prompt differential diagnosis, tailored treatment, and an improved quality of life and survival. [ABSTRACT FROM AUTHOR]

Introduction: Delayed discharge represents the difficulty in proceeding with discharge of patients who do not have any further benefit from prolonged stay. A quota of this problem is related to organizational issues. In the Lazio region in Italy, a macro service re-organization in on the way, with a network of hospital and territorial centers engaged in structuring in- and out- of hospital patient pathways, with a special focus on intermediate care structures. Purpose of this study is to quantify the burden of delayed discharge on a single hospital structure, in order to estimate costs and occurrence of potential resource misplacement. Material and methods: Observational Retrospective study conducted at the Santo Spirito Hospital in Rome, Italy. Observation period ranged from 1/09/2022, when the local database was instituted, to 1/03/2023 (6 months). Data from admissions records was anonymously collected. Data linkage with administrative local hospital database was performed in order to identify the date a discharge request was fired for each admission. Surgical discharges and Intensive Care Unit (ICU) discharges were excluded from this study. A Poisson hierarchical regression model was employed to investigate for the role of ward, Severity of Disease (SoD) and Risk of Mortality (RoM) on elongation of discharge time. Results: 1222 medical ward admissions were recorded in the timeframe. 16% of them were considered as subject to potentially elongated stay, and a mean Delay in discharge of 6.3 days (SD 7.9) was observed. Discussion and conclusions: Delayed discharge may cause a "bottleneck" in admissions and result in overcrowded Emergency Department, overall poor performance, and increase in overall costs. A consisted proportion of available beds can get inappropriately occupied, and this inflates both direct and indirect costs. Clinical conditions on admission are not a good predictor of delay in discharge, and the root causes of this phenomenon likely lie in organizational issues (on structure\system level) and social issues (on patient's level). [ABSTRACT FROM AUTHOR]

Copyright of Arenal.Revista de Historia de las Mujeres is the property of Arenal. Revista de Historia de las Mujeres and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Urbanization and urban regeneration can significantly impact cultural heritage, but a greater knowledge of the past natural and historical features is needed to value the past and understand the present. The lost Villa Peretti Montalto in Rome, once located in the area that corresponds to the current front side of Termini station, deserves great attention due to its cultural value. This work aimed to provide a floristic and functional reconstruction of the gardens of the villa during the XVI and XVII Centuries. From several bibliographic and iconographic sources, a critical analysis and interpretation of plant names was conducted. A list of 87 species and their location in the different garden sectors, during different periods with their specific uses, is provided. The arboreal design was made by classical species in the Roman context, like Cupressus sempervirens, Pinus pinea, Quercus ilex, and Ulmus glabra. In addition, ancient lost varieties of fruit trees (mainly Pyrus communis and Ficus carica) and several species of conservation interest were found. The knowledge of the ancient flora in historical gardens could be a key tool in urban greenery planning and touristic and cultural valorization. [ABSTRACT FROM AUTHOR]

Copyright of Archeomatica is the property of MediaGEO and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The article presents a methodology to analyze the Greek amphora epigraphy produced during the Roman Empire in its eastern part. The detailed information that appears as an abbreviated form in thousands of inscriptions distributed throughout the Roman territory is an essential element to under- stand the imperial socio-economic dynamics. Here we present a guide to using the Roman Open Data exploratory interface in its Greek text search section, and how, based on cases, we can determine for the first time the possible existence of a complex system of productions whose contracts would even be monthly. The relational search system makes this interface the only one that allows the user to singularize their searches, granulating them based on their experience. [ABSTRACT FROM AUTHOR]

We report here the results of a multi-analytical approach to characterize twelve Roman coins dating from the third century B.C. to fifth century A.D. that were found in the surroundings of Rome and for which the year of minting is determined by numismatic analysis. The coins were studied using SEM-EDS, EMPA, XRD, and FTIR techniques, enabling semi-quantitative and quantitative determinations of the chemical and mineralogical composition of the alloys and corrosion products. SEM-EDS analyses highlighted the occurrence of corrosion products on the surfaces and wide chemical variations due to selective enrichment or depletions of the alloying metals. The EMP analyses showed that three of the twelve coins are made of copper (1), one is a copper–tin alloy (2), five are copper–tin–lead alloys with elements in different proportions (3), two are copper–lead alloys (4), and another one is a subaerata coin (5). In addition, the physical parameters of the coins, i.e., density, weight, and diameters, were measured to have an overall characterization. [ABSTRACT FROM AUTHOR]

School–museum partnerships have gained considerable attention in the academic literature in recent decades. However, their role in enhancing science education is still an under-researched topic. This work reports on the outcomes of the recovery, study, cataloging, and valorization of the 18th century geo-mineralogical collection belonging to the Collegio Nazareno, now housed at the Istituto San Giuseppe Calasanzio in Rome. The project, which was participated in by the students enrolled in the fourth- and fifth-grade high school classes, revealed rare specimens such as the mineralogical collection donated by the Holy Roman Emperor Joseph II (1741–1740) in 1785. Furthermore, the laboratory activities organized from the stored samples highlighted educational approaches that helped students to cope with the complexities of authentic scientific work and cultural related issues. This work thus offers significant insights into the importance of natural history school museums as useful (and oft-forgotten) learning tools in science education. [ABSTRACT FROM AUTHOR]

Background: Ambient air pollution has been associated with hypertensive disorders of pregnancy (HDP), but few studies rely on assessment of fine-scale variation in air quality, specific subtypes and multi-pollutant exposures., Aim: To study the impact of long-term exposure to individual and mixture of air pollutants on all and specific subtypes of HDP., Methods: We obtained data from 130,470 liveborn singleton pregnacies in Rome during 2014-2019. Spatiotemporal land-use random-forest models at 1 km spatial resolution assigned to the maternal residential addresses were used to estimate the exposure to particulate matter (PM 2.5 and PM 10 ), nitrogen dioxide (NO 2 ), and ozone (O 3 )., Results: For PM 2.5, PM 10 and NO 2 , there was suggestive evidence of increased risk of preeclampsia (PE, n = 442), but no evidence of increased risk for all subtypes of HDP (n = 2297) and gestational hypertension (GH, n = 1901). For instance, an interquartile range of 7.0 μg/m 3 increase in PM 2.5 exposure during the first trimester of pregnancy was associated with an odds ratio (OR) of 1.06 (95% confidence interval: 0.81, 1.39) and 1.04 (0.92, 1.17) after adjustment for NO 2 and the corresponding results for a 15.7 μg/m 3 increase in NO 2 after adjustment for PM 2.5 were 1.11 (0.92, 1.34) for PE and 0.83 (0.76, 0.90) for HDP. Increased risks for HDP and GH were suggested for O 3 in single-pollutant models and for PM after adjustment for NO 2 , but all other associations were stable or attenuated in two-pollutant models., Conclusions: The results of our study suggest that PM 2.5 , PM 10 and NO 2 increases the risk of PE and that these effects are robust to adjustment for O 3 while the increased risks for GH and HDP suggested for O 3 attenuated after adjustment for PM or NO 2 . Additional studies are needed to evaluate the effects of source-specific component of PM on subtypes as well as all types of HDP which would help to target preventive actions., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)

The peopling of Europe during the Middle Pleistocene is a debated topic among paleoanthropologists. Some authors suggest the coexistence of multiple human lineages in this period, while others propose a single evolving lineage from Homo heidelbergensis to Homo neanderthalensis. The recent reassessment of the stratigraphy at the Sedia del Diavolo (SdD) site (Latium, Italy), now dated to the beginning of marine isotope stage (MIS) 8, calls for a revision of the human fossils from the site. In this paper, we present the morphometric, biomechanical and palaeopathological study of the second right metatarsal SdD2, to both re-evaluate its taxonomical affinities and possibly determine the levels of physical activity experienced by the individual during lifetime. Results demonstrate the persistence of archaic features in SdD2 suggesting new insights into the technology and hunting strategies adopted by Homo between MIS 9 and MIS 8., (© 2024. The Author(s).)

Eye diseases impose a significant burden on health services due to high case numbers. However, exposure to outdoor air pollution is seldom mentioned as potential harmful factor. We conducted a time-series analysis in Rome, Italy, to estimate the association between daily mean concentration of NO 2 , PM 10 and PM 2.5 and daily number of emergency room (ER) admissions for a selected cluster of eye diseases from 2006 to 2016. We used Poisson regression adjusted for time trend, population decrease during summer vacations and holidays, day of week, apparent temperature (hot and cold) and daily concentration of nine pollen species. We observed 581,868 ER admissions during the study period. 44.74% of cases were observed in subjects with less than 20 years, 19.50% in 51-65 age category and 13.4% among children (0-14 years). No differences between sexes were recorded. Mean values of pollutant concentrations were 54.75, 31.01 and 18.14 μg/m 3 for NO 2 , PM 10 and PM 2.5 respectively. The air temperature ranged from -1 °C to 32.5 °C, with a mean value of 16 °C (SD = 6.88). The apparent temperature spaced from -3.58 °C to 34.08 °C (mean = 15.61 °C, SD = 8.5). The highest percent risk increases for 10 μg/m 3 increases of the three pollutants were observed at lag0-1 day (1.3%, 0.63-1.98 for PM 2.5 ; 1.03%, 0.56-1.51 for PM 10 and 0.6%, 0.13-1.07 for NO 2 ). Risk increased significantly also at lag0 and lag0-5 day for each pollutant. Secondary analyses showed higher effects in the elderly compared to younger subjects. No differences emerged between sexes. The dose response analysis suggested of possible effects on ER admission risk also at low-level concentrations of PM 2.5 . A strong confounding effect of pollen was not detected. RESULTS: of this study are coherent with previous analyses. Speculation can be done about the biological mechanisms that link air pollution to eye damage., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)