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基于可恢复功能的概念，提出了一种摩擦耗能型摇摆柱节点。阐述了该节点的构造形式并研究了其抗震性能。通过试验和数值模拟，分析了轴压比、弹簧刚度等参数对节点抗震性能的影响及节点在余震和修复情况下的韧性。研究结果表明，在±3%层间位移角内，节点呈现出低损伤特性，摇摆柱始终保持弹性。在轴向力作用下，滞回曲线呈明显的“旗帜形”，节点具有良好的自复位性能，最大残余转角仅为0.23%。通过重新拧紧螺栓，节点性能即可恢复至震损前水平，实现抗震韧性。弹簧刚度的增大可以显著提高节点的抗弯承载力；增大轴压比可以提高节点的“屈服”弯矩和极限弯矩。在轴向力作用下节点属于典型的半刚性连接，并确定了节点初始转动刚度的取值范围。针对该节点提出了一个简化的恢复力模型，理论结果与试验结果吻合度较好，为进一步对整体结构进行分析和设计奠定了基础。

Objective To observe the effect of Krüppel-like factor 4 (KLF4) on cholesterol deposition in macrophages treated with high glucose, and to explore the mechanism related to macrophage autophagy. Methods Ten Balb/c mice were randomly divided into the normal control (NC, n=5) group and the DM group (n=5). A diabetic mouse model was established, and the expression level of KLF4 protein in aorta was detected after high fat diet. After induction of THP-1 monocytes into macrophages, they were divided into the LV-NC group, the LV-KLF4 group, the si-NC group and the si-KLF4 group. Changes of cholesterol content, cell apoptosis and the expression level of autophagy related proteins and AKT/mTOR signaling pathway related proteins in THP-1 macrophages were observed after overexpression or knockout of KLF4. Results The expression level of KLF4 protein in aorta of diabetic mice was lower in the DM group than that of the NC group (P＜0.05). Meanwhile, under high glucose concentration, overexpression of KLF4 in THP-1 macrophages significantly decreased cholesterol deposition, cell apoptosis and P62 expression, increased Beclin1 expression, LC3 fluorescence intensity and also inhibited AKT/mTOR signaling pathway related protein expression (P＜0.05). After knocking down KLF4 expression, the results were reversed. Conclusion KLF4 alleviates cholesterol deposition in THP-1 macrophages by promoting autophagy under high glucose concentration. [ABSTRACT FROM AUTHOR]

Copyright of Transportation Science & Technolgy is the property of Transportation Science & Technology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Application Research of Computers / Jisuanji Yingyong Yanjiu is the property of Application Research of Computers Edition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Cultivated land fragmentation is often considered to reduce agricultural productivity, leading to threatening food security. The pattern and drivers of cultivated land fragmentation can be expected to serve as an important prerequisite for scientific management. Taking Jiangsu Province as the study area, this study aims to assess the cultivated land fragmentation at the county level from four dimensions, including PD (patch density), AWMSI (area-weighted mean shape index), SHDI-S (Shannon's diversity index of area), and COHESION (patch cohesion index). A systematic analysis was made on the clustering features of cultivated land fragmentation in different dimensions using the K-means. MGWR (multiscale geography weighted regression) model was applied to explore the driving factors of cultivated land fragmentation in each county from five dimensions: topographic site, soil properties, urbanization, utilization intensity, and protection strength. The results showed that there were north-south differences in the cultivated land, where the PD and AWMSI were higher in the south than those in the north, the SHDI-S was higher in the north than in the south, and the COHESION was higher in the west. The four dimensions of the county-level cropland fineness index showed three types of clustering: Type A and Type B counties were located in the southern part of the province, both of which shared high patch density, irregular shape, and high area diversity. Among them, the Type A counties were higher connectivity of cultivated land than Type B; Type C counties shared lower patch density, regular shape, low area diversity, and high cropland connectivity, which were distributed mainly in the central and northern parts of the province. In addition, spatial heterogeneity was observed in the driving factors of cultivated land fragmentation in different types of regions. Differentiated fragmentation management should be adopted for the different regions. Among them, cultivated land fragmentation in the southern counties and districts (Type A and Type B) was mainly driven by natural factors (elevation, slope, and soil capacity). There were the more complex factors in the central and northern counties (Type C), including cropland allocation and urbanization. Cultivated land in the Type A counties exhibited a high density and irregular shape of patches, but a high degree of connectivity, which was a greater potential for management. Some considerations were given to promote the merging of adjacent cultivated land for large-scale production when the soil properties were similar in the topographic conditions. A low degree of contiguous cultivated land was observed in Type B counties, indicating the more complex driving factors are more difficult to manage. More attention should be paid to protecting the existing cultivated land for future urbanization. Cultivated land in Type C counties shared a low density and regular shape of patches, with the large cultivated land and continuous distribution. Cultivated land in Type C counties was the most affected by the topographic slope and protection. The central and northern regions were mainly plains with flat terrain and arable land, indicating the low potential for management. However, some attention should still be paid to regulating the use of cultivated land. The finding can provide a strong reference to managing the cultivated land fragmentation in Jiangsu Province. The cropland fine fragmentation model can also be optimized to develop the sustainable use of cropland. [ABSTRACT FROM AUTHOR]

This study addresses issues such as low efficiency in maintaining a constant temperature, uneven temperature distribution, uneven mixture, uneven reaction, and large deviations in experimental data observed in the ethyl acetate saponification reaction and iodine clock reaction. To address these problems, improvements are made in two aspects: the reaction vessel and the mixing method of reactants. The use of a jacketed beaker paired with a reaction flask as the reaction vessel and a multi-site magnetic stirrer for rapid mixing of the reactants is proposed. This improvement ensures a uniform and stable temperature in the solution, enhances the uniform dispersion and rapid reaction of the reactants, and enables accurate measurements of solution conductivity and the time for color change. The obtained data provides accurate values for reaction order, rate constant, and activation energy. [ABSTRACT FROM AUTHOR]

In order to solve the problem that the daily rehabilitation training of cardiovascular patients depends on directing by health care professions in rehabilitation centre, during assessing and correcting the movements system about cardiovascular patients independent rehabilitation training at home, this paper proposed an action assessment method for cardiovascular patients' rehabilitation training based on key points of the human skeleton (ASRT-PHS). Firstly, this paper constructed a dataset for rehabilitation training actions using a camera and data augmentation in accordance with the specified rehabilitation training specification for cardiovascular patients. Secondly, this paper employed a deep learning-based detector and pose estimator to capture human body positions and extract key points of the human skeleton, respectively, and then input the results into a convolutional neural network for action recognition. Thirdly, by calculating joint angle thresholds, joint distance ratio and assessing standard motions, this paper constructed a motion segmentation model based on joint distance ratios and an action assessment model based on action joint angle thresholds. This paper investigated the optimal combination of ASRT-PHS by assessing its performance with various joint angle thresholds and action recognition approaches. The results show that ASRT-PHS achieves an average action recognition, segmentation and assessment accuracy of 92.78%, 77.6% and 87%, respectively. Furthermore, case tests about the true cardiovascular patients show that the average accuracy of the prototype system is 71.3%, which provides a feasible intelligent auxiliary system for patients autonomous rehabilitation training at home. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Computational Mechanics / Jisuan Lixue Xuebao is the property of Chinese Journal of Computational Mechanics Editorial Office, Dalian University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Capital Normal University (Natural Science Edition) is the property of Journal of Capital Normal University (Natural Science Edition) Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Computer Engineering & Applications is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To identify the pathogenic mutations in a family with piebaldism. Methods Clinical information and peripheral blood were collected from the patient with piebaldism and their parents. Whole exome sequencing was performed to identify the potential pathogenic mutations. QPCR was used to determine the deletion of the target gene, while gap-PCR and Sanger sequencing was used to determine the size and the specific deletion site. Results The proband had a heterozygous deletion mutation of approximately 1.74 Mb located at chromosome 4, including a full length of the pathogenic gene KIT for mottled disease and it was the smallest micro deletion causing isolated piebaldism due to the loss of the KIT. Conclusions The heterozygous deletion including the KIT is a potential cause of the piebaldism phenotype found in this family. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Shenyang Agricultural University is the property of Journal of Shenyang Agricultural University Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Test & Measurement Technology is the property of Publishing Center of North University of China and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Tobacco Science & Technology is the property of Tobacco Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of High Pressure Physics is the property of Chinese Journal of High Pressure Physics Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Environmental Science & Technology (10036504) is the property of Editorial Board of Environmental Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Granular grain can be stored into the warehouse in food industry. The high loading efficiency is often required to optimize the land use for the effective grain preservation. The crucial warehouse mode has emerged in the regions with limited land resources. The diverse grain varieties can be stored to promote the sustainable development. Currently, the granular grain warehouse normally employs a load-bearing system that constituted by a reinforced concrete frame structure. The vertical gravity load of the grain is supported by the well-beam floors and large-section frame columns, while the lateral pressure exerted by the grain is directly absorbed by reinforced concrete horizontal tie-up beams integrated within the warehouse walls. The structural integrity of granular grain warehouses can also depend on the dynamic lateral pressure exerted by the storage material on the warehouse wall during seismic events. In this study, a scaled-down 1:25 three-story warehouse was designed and then produced to explore the effect of granular grains on the dynamic lateral pressure. Shaking table tests were carried out to simulate the varying ground vibration levels under three seismic waves. The data was collected on the acceleration and the lateral pressure that exerted on its walls. Analysed the seismic response characteristics of the storage material. Furthermore, the overpressure coefficient was obtained from the patterns of dynamic lateral pressure on the walls. The dynamic lateral pressure on the warehouse walls was also calculated. Acorrelation analysis was conducted between the height of warehouse and the timing of the peak moment, when the dynamic lateral pressure was exerted on the warehouse walls. Specifically, there was a noticeable lag in the occurrence of this peak moment, as the height of the building increased. Moreover, the peak moment of dynamic lateral pressure on the warehouse wall was consistently lagged behind that of acceleration on the same wall, particularly with the elevation of the height. The dynamic lateral pressure on the warehouse walls escalated progressively with each ascending floor. In the given floor, this dynamic lateral pressure incrementally intensified along the vertical extent of the warehouse walls. Each floor was found with an average increase of approximately 29% per floor. The dynamic lateral pressure exerted on the upper and middle sections of the warehouse walls was 2.5 and 1.4 times greater than that on the lower sections within the same floor. Consequently, the structural design of granular grain warehouses should consider these variations across different floor levels. The overpressure coefficient of the warehouse wall increased with the elevation of the floor, indicating a higher overall overpressure at upper levels. Within a single floor, the overpressure coefficient peaks at the upper section of the warehouse wall, with the middle and lower sections exhibiting lower and closer. Specifically, the maximum overpressure coefficients were 2.9, 3.4, and 4.1, respectively, for the first, second, and third floors of the warehouse walls. The overpressure on the warehouse walls was of significant concern, when subjected to seismic activity. It is very necessary to consider the influence of the dynamic lateral pressure on the warehouse wall across various floors. The seismic response of the storage materials can be used to elucidate the distribution pattern of dynamic lateral pressure. The overpressure on the warehouse walls can be assessed to calculate the lateral pressure on these walls. The findings can offer a strong reference for the warehouses of granular grains under seismic conditions. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Railway Science & Engineering is the property of Journal of Railway Science & Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Frontiers of Computer Science & Technology is the property of Beijing Journal of Computer Engineering & Applications Journal Co Ltd. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Arteriosclerosis is the property of Chinese Journal of Arteriosclerosis Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Patients with atopic dermatitis (AD) have skin barrier dysfunction, which is closely related to keratinocyte (KC) abnormalities・ Upon stimulation by external factors, KCs release a large number of inflammatory mediators, thereby activating type 2 inflammation, which, in turn, exacerbates skin barrier dysfunction・ Thus, the interaction between KCs and type 2 inflammation is a key factor in the pathogenesis of AD, and exacerbation of inflammation and pruritus・ At present, the innovative medications, such as biologies and small molecule drugs, have been shown anti-inflammatory effects in AD・ Studies also demonstrate their role in skin barrier repair. Therefore, research on the interaction between KCs and type 2 inflammation will help understand the pathogenesis of AD and provide evidence to optimize treatment strategies for AD. [ABSTRACT FROM AUTHOR]

Copyright of Information & Control is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Southwest China Journal of Agricultural Sciences is the property of Editorial Department of Southwest China Journal of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Acta Prataculturae Sinica is the property of Acta Prataculturae Sinica Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Petroleum Geology & Recovery Efficiency is the property of Petroleum Geology & Recovery Efficiency and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)