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3. Graft-versus-host-disease prophylaxis with ATG or PTCY in patients with lymphoproliferative disorders undergoing reduced intensity conditioning regimen HCT from one antigen mismatched unrelated donor

Author

Paviglianiti, Annalisa, Ngoya, Maud, Peña, Marta, Boumendil, Ariane, Gülbas, Zafer, Ciceri, Fabio, Bonifazi, Francesca, Russo, Domenico, Fegueux, Nathalie, Stolzel, Friedrich, Bulabois, Claude Eric, Socié, Gerard, Forcade, Edouard, Solano, Carlo, Finel, Hervé, Robinson, Stephen, Glass, Bertram, and Montoto, Silvia

Published
2024
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4. Large B-Cell Lymphoma

Author

Bento, Leyre, Glass, Bertram, Schmitz, Norbert, Sureda, Anna, editor, Corbacioglu, Selim, editor, Greco, Raffaella, editor, Kröger, Nicolaus, editor, and Carreras, Enric, editor

Published
2024
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5. Clinical Practice Recommendations for Hematopoietic Cell Transplantation and Cellular Therapies in Follicular Lymphoma: A Collaborative Effort on Behalf of the American Society for Transplantation and Cellular Therapy and the European Society for Blood and Marrow Transplantation

Author

Iqbal, Madiha, Kumar, Ambuj, Dreger, Peter, Chavez, Julio, Sauter, Craig S., Sureda, Anna M., Bachanova, Veronika, Maziarz, Richard T., Dreyling, Martin, Smith, Sonali M., Jacobson, Caron, Glass, Bertram, Casulo, Carla, Oluwole, Olalekan O., Montoto, Silvia, Advani, Ranjana, Cohen, Jonathon, Salles, Gilles, Hamad, Nada, Kuruvilla, John, Kahl, Brad S., Shadman, Mazyar, Kanate, Abraham S., Budde, Lihua Elizabeth, Kamdar, Manali, Flowers, Christopher, Hamadani, Mehdi, and Kharfan-Dabaja, Mohamed A.

Published
2024
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6. PTCy vs CNI–based GVHD prophylaxis in HLA-matched transplants for Hodgkin lymphoma: a study of the LWP of the EBMT

Author

Montoro, Juan, Ngoya, Maud, Kulagin, Alexander, Giebel, Sebastian, Broers, Annoek E. C., Bramanti, Stefania, Halahleh, Khalid, Pérez-Simón, Jose A., Solano, Carlos, Ozcelik, Tulay, Blaise, Didier, Sanz, Jaime, Henriques, Marta, Peffault de Latour, Régis, Martino, Rodrigo, Scheid, Christof, Fox, Laura, Gromek, Tomasz, Jurado, Manuel, Sakellari, Ioanna, Van Gorkom, Gwendolyn, Matteucci, Paola, Nagler, Arnon, Koc, Yener, and Glass, Bertram

Published
2024
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8. Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis in HLA-Matched and Haploidentical Donor Transplantation for Patients with Hodgkin Lymphoma: A Comparative Study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation

Author

Montoro, Juan, Boumendil, Ariane, Finel, Hervé, Bramanti, Stefania, Castagna, Luca, Blaise, Didier, Dominietto, Alida, Kulagin, Aleksandr, Yakoub-Agha, Ibrahim, Tbakhi, Abdelghani, Solano, Carlos, Giebel, Sebastian, Gulbas, Zafer, López Corral, Lucía, Pérez-Simón, José A., Díez Martín, José Luis, Sanz, Jaime, Farina, Lucia, Koc, Yener, Socié, Gerard, Arat, Mutlu, Jurado, Manuel, Bermudez, Arancha, Labussière-Wallet, Hélène, Villalba, Marta, Ciceri, Fabio, Martinez, Carmen, Nagler, Arnon, Sureda, Anna, and Glass, Bertram

Published
2024
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9. Plain language summary of the TRANSFORM study primary analysis results: liso-cell as a second treatment regimen for large B-cell lymphoma following failure of the first treatment regimen

Author

Abramson, Jeremy S, primary, Solomon, Scott R, additional, Arnason, Jon, additional, Johnston, Patrick B, additional, Glass, Bertram, additional, Bachanova, Veronika, additional, Ibrahimi, Sami, additional, Mielke, Stephan, additional, Mutsaers, Pim, additional, Hernandez-Ilizaliturri, Francisco, additional, Izutsu, Koji, additional, Morschhauser, Franck, additional, Lunning, Matthew, additional, Crotta, Alessandro, additional, Montheard, Sandrine, additional, Previtali, Alessandro, additional, Ogasawara, Ken, additional, and Kamdar, Manali, additional

Published
2024
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10. Clinical Practice Recommendations for Hematopoietic Cell Transplantation and Cellular Therapies in Follicular Lymphoma: A Collaborative Effort on behalf of The American Society of Transplantation and Cellular Therapy and the European Society of Blood and Marrow Transplantation

Author

Iqbal, Madiha, Kumar, Ambuj, Dreger, Peter, Chavez, Julio, Sauter, Craig S., Sureda, Anna M., Bachanova, Veronika, Maziarz, Richard T., Dreyling, Martin, Smith, Sonali M., Jacobson, Caron, Glass, Bertram, Casulo, Carla, Oluwole, Olalekan O., Montoto, Silvia, Advani, Ranjana, Cohen, Jonathon, Salles, Gilles, Hamad, Nada, Kuruvilla, John, Kahl, Brad S., Shadman, Mazyar, Kanate, Abraham S., Budde, L. Elizabeth, Kamdar, Manali, Flowers, Christopher, Hamadani, Mehdi, and Kharfan-Dabaja, Mohamed A.

Abstract

•Autologous-HCT is recommended as an option for consolidation therapy in patients with progression of disease within 24 months of receiving front line chemoimmunotherapy and who do not have evidence of histological transformation and achieve a CR or PR to salvage second line therapy.•CAR-T should be considered a treatment option for patients who do not achieve CR or PR after second or subsequent lines of therapy.•Allogeneic-HCT can be considered as consolidative treatment in select cases of relapsed chemosensitive FL patients who have received 3 or more lines of systemic therapy and are in the following clinical scenarios: post CAR-T failure; lack of access to CAR-T; concomitant therapy related myeloid neoplasm or bone marrow failure syndrome.

Published
2024
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11. Hematopoietic stem cell transplantation for DLBCL: a report from the European Society for Blood and Marrow Transplantation on more than 40,000 patients over 32 years.

Author

Berning P, Fekom M, Ngoya M, Goldstone AH, Dreger P, Montoto S, Finel H, Shumilov E, Chevallier P, Blaise D, Strüssmann T, Carpenter B, Forcade E, Castilla-Llorente C, Trneny M, Ghesquieres H, Capria S, Thieblemont C, Blau IW, Meijer E, Broers AEC, Huynh A, Caillot D, Rösler W, Nguyen Quoc S, Bittenbring J, Nagler A, Galimard JE, Glass B, Sureda A, and Schmitz N

Subjects
Humans, Middle Aged, Male, Female, Adult, Aged, Europe epidemiology, Adolescent, Young Adult, Transplantation Conditioning methods, Transplantation, Homologous, Transplantation, Autologous, Hematopoietic Stem Cell Transplantation methods, Lymphoma, Large B-Cell, Diffuse therapy, Lymphoma, Large B-Cell, Diffuse mortality
Abstract

Autologous(auto-) and allogeneic(allo-) hematopoietic stem cell transplantation (HSCT) are key treatments for relapsed/refractory diffuse large B-cell lymphoma (DLBCL), although their roles are challenged by CAR-T-cells and other immunotherapies. We examined the transplantation trends and outcomes for DLBCL patients undergoing auto-/allo-HSCT between 1990 and 2021 reported to EBMT. Over this period, 41,148 patients underwent auto-HSCT, peaking at 1911 cases in 2016, while allo-HSCT saw a maximum of 294 cases in 2018. The recent decline in transplants corresponds to increased CAR-T treatments (1117 cases in 2021). Median age for auto-HSCT rose from 42 (1990-1994) to 58 years (2015-2021), with peripheral blood becoming the primary stem cell source post-1994. Allo-HSCT median age increased from 36 (1990-1994) to 54 (2015-2021) years, with mobilized blood as the primary source post-1998 and reduced intensity conditioning post-2000. Unrelated and mismatched allo-HSCT accounted for 50% and 19% of allo-HSCT in 2015-2021. Three-year overall survival (OS) after auto-HSCT improved from 56% (1990-1994) to 70% (2015-2021), p < 0.001, with a decrease in relapse incidence (RI) from 49% to 38%, while non-relapse mortality (NRM) remained unchanged (4%). After allo-HSCT, 3-year-OS increased from 33% (1990-1999) to 46% (2015-2021) (p < 0.001); 3-year RI remained at 39% and 1-year-NRM decreased to 19% (p < 0.001). Our data reflect advancements over 32 years and >40,000 transplants, providing insights for evaluating emerging DLBCL therapies., (© 2024. The Author(s).)

Published
2024
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