1. How we use angiopoietin-2 in the diagnosis and management of vascular anomalies.
- Author
-
Engel ER, Le Cras TD, and Ricci KW
- Subjects
- Humans, Biomarkers blood, Hemangioendothelioma blood, Hemangioendothelioma diagnosis, Hemangioendothelioma therapy, Kasabach-Merritt Syndrome blood, Kasabach-Merritt Syndrome diagnosis, Kasabach-Merritt Syndrome therapy, Angiopoietin-2 blood, Vascular Malformations blood, Vascular Malformations diagnosis, Vascular Malformations therapy
- Abstract
The diagnosis of vascular anomalies remains challenging due to significant clinical heterogeneity and uncertain etiology. Evaluation using biopsy and/or genetic testing for somatic variants is invasive, expensive, and prone to sampling error. There is great need for noninvasive and easily measured blood laboratory biomarkers that can aid not only in diagnosis, but also management of treatments for vascular anomalies. Angiopoietin-2, a circulating blood angiogenic factor, is highly elevated in patients with kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon and kaposiform lymphangiomatosis. Here, we describe our clinical experience using serum angiopoietin-2 as a biomarker for diagnosis and monitoring response to treatment., (© 2024 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.)
- Published
- 2024
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