497 results on '"Ping Zhou"'
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2. Depth-Perception-Based Representation in Holistic Rating on ESL Essay Writing
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Lian Li, Jiehui Hu, Yu Dai, Ping Zhou, and Wanhong Zhang
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This paper proposes to use depth perception to represent raters' decision in holistic evaluation of ESL essays, as an alternative medium to conventional form of numerical scores. The researchers verified the new method's accuracy and inter/intra-rater reliability by inviting 24 ESL teachers to perform different representations when rating 60 essays written by Chinese ESL learners. During numerical representation, the raters expressed their evaluation in the form of numbers, while with the DP-based method, the raters expressed their evaluation by marking distances with nail tags on a wood ruler with hidden scale marks. Then the researchers translated the distance results into numbers and compared the accuracy and inter/intra-rater consistency of the two approaches by referring to these essays' criteria scores from eight expert raters. The results showed that DP-based method could improve raters' performance, producing more similar results to experts' scores, with higher consistency both among different raters and within the same individual rater.
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- 2024
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3. Study of Water Resource System Adaptability Based on the Connection Number and Three-Dimensional Risk Matrix
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Zhengwei, Pan, Yunhui, Cui, Yuliang, Zhou, Ping, Zhou, and Jing, Wang
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- 2024
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4. Biomechanical changes of oblique lumbar interbody fusion with different fixation techniques in degenerative spondylolisthesis lumbar spine: a finite element analysis
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Er-Xu Tao, Ren-Jie Zhang, Bo Zhang, Jia-Qi Wang, Lu-Ping Zhou, and Cai-Liang Shen
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Oblique lateral interbody fusion (OLIF) ,Degenerative lumbar spondylolisthesis (DLS) ,Cortical bone trajectory (CBT) ,Traditional trajectory (TT) ,Finite element analysis (FEA) ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Objective There is a dearth of comprehensive research on the stability of the spinal biomechanical structure when combining Oblique Lumbar Interbody Fusion (OLIF) with internal fixation methods. Hence, we have devised this experiment to meticulously examine and analyze the biomechanical changes that arise from combining OLIF surgery with different internal fixation techniques in patients diagnosed with degenerative lumbar spondylolisthesis. Methods Seven validated finite element models were reconstructed based on computed tomography scan images of the L3-L5 segment. These models included the intact model, a stand-alone (S-A) OLIF model, a lateral screw rod (LSR) OLIF model, a bilateral pedicle screw (BPS) OLIF model, an unilateral pedicle screw (UPS) OLIF model, a bilateral CBT (BCBT) OLIF model, and an unilateral CBT(UCBT) OLIF model. The range of motion (ROM), as well as stress levels in the cage, L4 lower endplate, L5 upper endplate, and fixation constructs were assessed across these different model configurations. Results S-A model had the highest average ROM of six motion modes, followed by LSR, UPS, UCBT, BPS and BCBT. The BCBT model had a relatively lower cage stress than the others. The maximum peak von Mises stress of the fixation constructs was found in the LSR model. The maximum peak von Mises stress of L4 lower endplate was found in the S-A model. The peak von Mises stress on the L4 lower endplate of the rest surgical models showed no significant difference. The maximum peak von Mises stress of the L5 upper endplate was found in the S-A model. The minimum peak von Mises stress of the L5 upper endplate was found in the BCBT model. No significant difference was found for the peak von Mises stress of the L5 upper endplate among LSR, BPS, UPS and UCBT models. Conclusion Among the six different fixation techniques, BCBT exhibited superior biomechanical stability and minimal stress on the cage-endplate interface. It was followed by BPS, UCBT, UPS, and LSR in terms of effectiveness. Conversely, S-A OLIF demonstrated the least stability and resulted in increased stress on both the cage and endplates. Combining OLIF with BCBT fixation technique enhanced biomechanical stability compared to BPS and presented as a less invasive alternative treatment for patients with degenerative lumbar spondylolisthesis.
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- 2024
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5. Structure, Nutritional Value, Extraction, Functional Properties of Walnut Proteins and Their Application in Foods: A Review
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WU Ping, ZHOU Jisong, DENG Qianchun, DONG Juan, JIN Weiping, SHANG Wei, LIU Changsheng, PENG Dengfeng
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walnut proteins ,composition ,structure ,nutritional value ,extraction methods ,functional properties ,modification ,Food processing and manufacture ,TP368-456 - Abstract
China is the world’s largest walnut producer, with an annual output of 4.795 9 million tons. Walnut kernels have high nutritional value, containing 65%−69% of oil and 15%−20% of protein. Walnut meal, an abundant byproduct of walnut oil production, is mainly used in animal feed and fertilizers with low processing efficiency, whose potential for high-value utilization is far from being excavated. Studies have found that walnut meal contains a large amount of protein (42%−54%), its amino acid composition is rich, and the proportion of amino acids in walnut meal is suitable for human absorption. Walnut meal is a source of high-quality plant protein with a true protein digestibility score of 86.22%, and a biological valence of 98.77%. Therefore, high-efficiency utilization of walnut meal proteins is an important pathway for the high-value utilization of walnut meal. In this article, the composition, structure, and nutritional value of walnut proteins are reviewed. The extraction methods and functional characteristics of walnut proteins are summarized. The effect of modification on their functionalities and digestibility is also summarized. Finally, the application potential of walnut protein in foods is discussed.
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- 2024
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6. Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma
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Wei Liu, Hongchao Cao, Jing Wang, Areeg Elmusrati, Bing Han, Wei Chen, Ping Zhou, Xiyao Li, Stephen Keysar, Antonio Jimeno, and Cun-Yu Wang
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Science - Abstract
Abstract Histone lysine methyltransferase 2D (KMT2D) is the most frequently mutated epigenetic modifier in head and neck squamous cell carcinoma (HNSCC). However, the role of KMT2D in HNSCC tumorigenesis and whether its mutations confer any therapeutic vulnerabilities remain unknown. Here we show that KMT2D deficiency promotes HNSCC growth through increasing glycolysis. Additionally, KMT2D loss decreases the expression of Fanconi Anemia (FA)/BRCA pathway genes under glycolytic inhibition. Mechanistically, glycolytic inhibition facilitates the occupancy of KMT2D to the promoter/enhancer regions of FA genes. KMT2D loss reprograms the epigenomic landscapes of FA genes by transiting their promoter/enhancer states from active to inactive under glycolytic inhibition. Therefore, combining the glycolysis inhibitor 2-DG with DNA crosslinking agents or poly (ADP-ribose) polymerase (PARP) inhibitors preferentially inhibits tumor growth of KMT2D-deficient mouse HNSCC and patient-derived xenografts (PDXs) harboring KMT2D-inactivating mutations. These findings provide an epigenomic basis for developing targeted therapies for HNSCC patients with KMT2D-inactivating mutations.
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- 2024
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7. Assessment of chemical degradation of epoxy resin binder used in the service of the Qin terracotta warriors
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Siyu Tian, Wenhua Ma, Hua Li, Chunyan Wang, Yin Xia, Desheng Lan, Ping Zhou, and Daodao Hu
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Terracotta warriors ,Chemical degradation ,Epoxy resin ,Binder ,Medicine ,Science - Abstract
Abstract Since the Qin terracotta warriors were unearthed, polyamide 650 cross-linked E-44 epoxy resin binder has been employed to bond and restore them. In this paper, the chemical aging of the binders service in indoor natural environment during the past 30 years in the terracotta warriors was studied by means of infrared spectroscopy, X-ray photoelectron spectroscopy and thermogravimetric analysis. The results indicated that the binders did not emerge the characteristic peak of carbonyl stretching vibration at 1700 cm−1 in the IR spectra of all determined binders, and their thermal decomposition curves did not emerge any abnormal changes, and the thermal decomposition mainly occurred above 300 °C. There are evident ceramic grains attached to the surface of the binders being peeled off for sampling. These results that the binders service in the Qin terracotta warriors did not exhibit an observable chemical aging and still has strong adhesion. Generally, discrepancies were observed between natural aging and accelerated artificial aging due to the ineffectiveness of the latter to reproduce the effects of complex weather conditions. Compared to artificially accelerated aging, the evaluation results in a long-term natural aging of the binder which is used for restoration of the life-size Qin terracotta warriors, providing in the present investigation, are more reliable in terms of predicting the safety of restored terracotta warriors.
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- 2024
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8. AI-based rock strength assessment from tunnel face images using hybrid neural networks
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Lianbaichao Liu, Zhanping Song, Ping Zhou, XinHe He, and Liang Zhao
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Tunnel face ,Rock strength ,Neural network ,Lithology identification ,Weathering degree ,Medicine ,Science - Abstract
Abstract In geological engineering and related fields, accurately and quickly identifying lithology and assessing rock strength are crucial for ensuring structural safety and optimizing design. Traditional rock strength assessment methods mainly rely on field sampling and laboratory tests, such as uniaxial compressive strength (UCS) tests and velocity tests. Although these methods provide relatively accurate rock strength data, they are complex, time-consuming, and unable to reflect real-time changes in field conditions. Therefore, this study proposes a new method based on artificial intelligence and neural networks to improve the efficiency and accuracy of rock strength assessments. This research utilizes a Transformer + UNet hybrid model for lithology identification and an optimized ResNet-18 model for determining rock weathering degrees, thereby correcting the strength of the tunnel face surrounding rock. Experimental results show that the Transformer + UNet hybrid model achieves an accuracy of 95.57% in lithology identification tasks, while the optimized ResNet model achieves an accuracy of 96.13% in rock weathering degree determination. Additionally, the average relative error in tunnel face strength detection results is only 9.33%, validating the feasibility and effectiveness of this method in practical engineering applications. The multi-model neural network system developed in this study significantly enhances prediction accuracy and efficiency, providing robust scientific decision support for tunnel construction, thereby improving construction safety and economy.
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- 2024
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9. Lower energy intake associated with higher risk of cardiovascular mortality in chronic kidney disease patients on a low-protein diets
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Yao Liu, Fei Deng, Ping Zhou, Cong Peng, ChunPeng Xie, Wuyu Gao, Qianyu Yang, Tingyu Wu, and Xiang Xiao
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Chronic kidney disease ,Malnutrition ,Mortality risk ,Epidemiology and outcomes ,Risk factors ,Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Objective An increasing number of studies shown that inadequate energy intake causes an increase in adverse incidents in chronic kidney disease (CKD) patients on low-protein diets (LPD). The study aimed to investigate the relationship between energy intake and cardiovascular mortality in CKD patients on a LPD. Methods This was a cross-sectional study, a total of 4264 CKD patients were enrolled from the NHANES database between 2009 and 2018. Restricted cubic spline plots and Cox regression analysis were used to analyze the association between energy intake and cardiovascular mortality in CKD patients on a LPD. Additionally, a nomogram was constructed to estimate cardiovascular survival in CKD patients on a LPD. Results Among CKD patients on a LPD in the United States, 90.05% had an energy intake of less than 25 kcal/kg/day, compared to 36.94% in CKD patients on a non-LPD. Energy intake and cardiovascular mortality showed a linear relationship in CKD patients on a LPD, while a ‘U-shaped’ relationship was observed in CKD patients on a non-LPD. Multifactorial Cox regression models revealed that for Per-standard deviation (Per-SD) decrement in energy intake, the risk of cardiovascular mortality increased by 41% (HR: 1.41, 95% CI: 1.12, 1.77; P = 0.004) in CKD patients on a LPD. The concordance index of the nomogram was 0.79 (95% CI, 0.75, 0.83). Conclusion CKD patients, especially those on a LPD, have significantly inadequate energy intake. Lower energy intake is associated with higher cardiovascular mortality in CKD patients on a LPD.
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- 2024
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10. Association of early-term birth and breastfeeding practices with nutritional outcomes in singleton term infants: a multicenter cross-sectional study
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Li Zhang, Hui-Juan Liu, Ping Li, Yi Liu, Ting Zhang, Jin-Yi Zhu, Hong-Mei Zhu, Ya-Ping Zhou, Hai-Jun Wang, and Yan Li
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Gestational age ,Early-term ,Breastfeeding ,Malnutrition ,Obesity ,Pediatrics ,RJ1-570 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Limited research has explored the associations of gestational age (GA) and breastfeeding practices with growth and nutrition in term infants. Methods This multicenter cross-sectional study recruited 7299 singleton term infants from well-child visits in Shandong, China, between March 2021 and November 2022. Data on GA, gender, ethnicity, birth weight, parental heights, gestational diabetes and hypertension, age at visit, breastfeeding practices (point-in-time data at visit for infants 4. Linear regression models adjused for covariates explored the impact of GA and breastfeeding practices on LAZ and WLZ, while logistic regression models evaluated their effect on the likelihood of moderate and severe stunting (MSS, LAZ 2). Sensitivity analysis was conducted on normal birth weight infants (2.5–4.0 kg). Results Infants born early-term and exclusively breastfed accounted for 31.1% and 66.4% of the sample, respectively. Early-term birth related to higher WLZ (
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- 2024
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11. Irreversible bilateral lower limb paralysis in a fulminant myocarditis patient treated with peripheral venoarterial extracorporeal membrane oxygenation: A case report
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Han-yang Yue, Wei Peng, Hua Jiang, and Ping Zhou
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Myocarditis ,Lower limb ,Paralysis ,Extracorporeal cardiopulmonary resuscitation ,Extracorporeal membrane oxygenation ,ECPR ,Surgery ,RD1-811 - Published
- 2024
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12. Intelligent prediction of power grid transmission line engineering investment based on XGBoost algorithm.
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Ping Zhou, Ying Du, Yuhong Zhang, Jingyong Chen, Ying Zhou, and Guangxiu Yu
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- 2024
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13. Digital Grid Investment Risk Prediction and Identification under PSO-FAHP Based Intelligent Algorithm.
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Yuhong Zhang, Ying Du, Ying Zhou, Hanjing Liu, Ping Zhou, and Jie Jiao
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- 2024
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14. Exploring Performance and Cost Optimization with ASIC-Based CXL Memory.
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Yupeng Tang, Ping Zhou, Wenhui Zhang, Henry Hu, Qirui Yang, Hao Xiang, Tongping Liu, Jiaxin Shan, Ruoyun Huang, Cheng Zhao, Cheng Chen 0008, Hui Zhang, Fei Liu, Shuai Zhang, Xiaoning Ding, and Jianjun Chen 0001
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- 2024
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15. Variations and future projections of glacial discharge of Urumqi River Headwaters, eastern Tien Shan (1980s–2017)
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Hui Zhang, Fei-Teng Wang, Ping Zhou, and Yi-Da Xie
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Observed glacial discharge ,Temporal variations ,Urumqi River Headwaters ,Eastern Tien Shan ,Simulation and projection ,Meteorology. Climatology ,QC851-999 ,Social sciences (General) ,H1-99 - Abstract
To address data scarcity on long-term glacial discharge and inadequacies in simulating and predicting hydrological processes in the Tien Shan, this study analysed the observed discharge at multiple timescales over 1980s–2017 and projected changes within a representative glacierized high-mountain region: eastern Tien Shan, Central Asia. Hydrological processes were simulated to predict changes under four future scenarios (SSP1, SSP2, SSP3, and SSP5) using a classical hydrological model coupled with a glacier dynamics module. Discharge rates at annual, monthly (June, July, August) and daily timescales were obtained from two hydrological gauges: Urumqi Glacier No.1 hydrological station (UGH) and Zongkong station (ZK). Overall, annual and summer discharge increased significantly (p
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- 2024
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16. Concordance between four PD-L1 immunohistochemical assays and 22C3 pharmDx assay in esophageal squamous cell carcinoma in a multicenter study
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Liyan Xue, Yuan Li, Lili Jiang, Chao Liu, Na Cheng, Changyuan Guo, Yan Jin, Ping Zhou, Xuemin Xue, Yue Wang, Weiya Wang, Yanhui Liu, and Jianming Ying
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Consistency evaluation ,Immunotherapy ,Esophageal squamous cell carcinoma ,PD-L1 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background: The prediction of response to immunotherapy mostly depends on the programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) status, and the 22C3 pharmDx assay has been approved in esophageal squamous cell carcinoma (ESCC). However, the widespread use of the 22C3 pharmDx assay is limited due to its availability. Thus, alternative PD-L1 assays are needed. We aimed to investigate the analytical and clinical diagnostic performances of four PD-L1 assays and to compare their concordances with the 22C3 pharmDx assay. Methods: The PD-L1 22C3 pharmDx assay was performed on the Dako Autostainer Link 48 platform, three testing assays (PD-L1 E1L3N XP antibody [Ab], PD-L1 BP6099 Ab and PD-L1 CST E1L3N Ab) on the Leica BOND-MAX/III platform, and one testing assay (PD-L1 MXR006 Ab) on the Roche VENTANA Benchmark Ultra platform. A total of 218 ESCC cases from four centers were included in this retrospective study. Professionals from each center stained and read the IHC slides independently and determined the combined positive score (CPS) and the tumor proportion score (TPS). Results: Regarding analytical performance, the four testing assays demonstrated good correlations with the 22C3 pharmDx assay when evaluated by the TPS or CPS (ρ > 0.8 for all four assays). Regarding diagnostic performance (CPS ≥ 10 was used as the cutoff), the four testing assays showed moderate concordances with the 22C3 pharmDx assay (kappa > 0.7 for all four assays). The overall percent agreements between each testing assay and the 22C3 pharmDx assay was at least 87.2 %. Conclusion: This study provides insight into the potential interchangeability of the four PD-L1 assays with the 22C3 pharmDx assay.
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- 2024
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17. NMR Studies of the Interactions between Sialyllactoses and the Polysialytransferase Domain for Polysialylation Inhibition
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Bo Lu, Si-Ming Liao, Shi-Jie Liang, Jian-Xiu Li, Xue-Hui Liu, Ri-Bo Huang, and Guo-Ping Zhou
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cancer cell migration ,neuronal cell adhesion molecule (NCAM) ,polysialic acid (polySia) ,polysialyltransferase (polyST) ,polysialyltransferase domain (PSTD) ,sialylactose (SL) ,Biology (General) ,QH301-705.5 - Abstract
It is known that sialyllactose (SL) in mammalians is a major source of sialic acid (Sia), which can further form cytidine monophosphate sialic acid (CMP-Sia), and the final product is polysialic acid (polySia) using polysialyltransferases (polySTs) on the neural cell adhesion molecule (NCAM). This process is called NCAM polysialylation. The overexpression of polysialylation is strongly related to cancer cell migration, invasion, and metastasis. In order to inhibit the overexpression of polysialylation, in this study, SL was selected as an inhibitor to test whether polysialylation could be inhibited. Our results suggest that the interactions between the polysialyltransferase domain (PSTD) in polyST and CMP-Siaand the PSTD and polySia could be inhibited when the 3′-sialyllactose (3′-SL) or 6′-sialyllactose (6′-SL) concentration is about 0.5 mM or 6′-SL and 3 mM, respectively. The results also show that SLs (particularly for 3′-SL) are the ideal inhibitors compared with another two inhibitors, low-molecular-weight heparin (LMWH) and cytidine monophosphate (CMP), because 3’-SL can not only be used to inhibit NCAM polysialylation, but is also one of the best supplements for infant formula and the gut health system.
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- 2024
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18. Multi-gene phylogenetic analyses revealed two novel species and one new record of Trichobotrys (Pleosporales, Dictyosporiaceae) from China
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Wen-Jing Zhang, Gui-Ping Xu, Yu Liu, Yang Gao, Hai-Yan Song, Hai-Jing Hu, Jian-Ping Zhou, Ming-Hui Chen, Deng-Mei Fan, Dian-Ming Hu, and Zhi-Jun Zhai
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Botany ,QK1-989 - Abstract
The rotting wood in freshwater is a unique eco-environment favoring various fungi. During our investigation of freshwater fungi on decaying wood, three hyphomycetes were collected from Jiangxi and Guangxi Provinces, China. Based on the morphological observations and phylogenetic analysis of a combined DNA data containing ITS, LSU, SSU and tef1-α sequences, two new Trichobotrys species, T. meilingensis and T. yunjushanensis, as well as a new record of T. effusa, were introduced. Additionally, a comprehensive description of the genus with both morphological and molecular data was first provided.
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- 2024
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19. Exploring potential neuroimaging biomarkers for the response to non-steroidal anti-inflammatory drugs in episodic migraine
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Heng-Le Wei, Yu-Sheng Yu, Meng-Yao Wang, Gang-Ping Zhou, Junrong Li, Hong Zhang, and Zhengyang Zhou
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Migraine ,Non-steroidal anti-inflammatory drugs ,Multimodal magnetic resonance imaging ,Machine learning ,Percentage of amplitude oscillations ,Medicine - Abstract
Abstract Background Non-steroidal anti-inflammatory drugs (NSAIDs) are considered first-line medications for acute migraine attacks. However, the response exhibits considerable variability among individuals. Thus, this study aimed to explore a machine learning model based on the percentage of amplitude oscillations (PerAF) and gray matter volume (GMV) to predict the response to NSAIDs in migraine treatment. Methods Propensity score matching was adopted to match patients having migraine with response and nonresponse to NSAIDs, ensuring consistency in clinical characteristics and migraine-related features. Multimodal magnetic resonance imaging was employed to extract PerAF and GMV, followed by feature selection using the least absolute shrinkage and selection operator regression and recursive feature elimination algorithms. Multiple predictive models were constructed and the final model with the smallest predictive residuals was chosen. The model performance was evaluated using the area under the receiver operating characteristic (ROCAUC) curve, area under the precision-recall curve (PRAUC), balance accuracy (BACC), sensitivity, F1 score, positive predictive value (PPV), and negative predictive value (NPV). External validation was performed using a public database. Then, correlation analysis was performed between the neuroimaging predictors and clinical features in migraine. Results One hundred eighteen patients with migraine (59 responders and 59 non-responders) were enrolled. Six features (PerAF of left insula and left transverse temporal gyrus; and GMV of right superior frontal gyrus, left postcentral gyrus, right postcentral gyrus, and left precuneus) were observed. The random forest model with the lowest predictive residuals was selected and model metrics (ROCAUC, PRAUC, BACC, sensitivity, F1 score, PPV, and NPV) in the training and testing groups were 0.982, 0.983, 0.927, 0.976, 0.930, 0.889, and 0.973; and 0.711, 0.648, 0.639, 0.667,0.649, 0.632, and 0.647, respectively. The model metrics of external validation were 0.631, 0.651, 0.611, 0.808, 0.656, 0.553, and 0.706. Additionally, a significant positive correlation was found between the GMV of the left precuneus and attack time in non-responders. Conclusions Our findings suggest the potential of multimodal neuroimaging features in predicting the efficacy of NSAIDs in migraine treatment and provide novel insights into the neural mechanisms underlying migraine and its optimized treatment strategy.
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- 2024
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20. Gastric SMARCA4-deficient undifferentiated tumor (SMARCA4-UT): a clinicopathological analysis of four rare cases
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Ping Zhou, Yiyun Fu, Weiya Wang, Yuan Tang, and Lili Jiang
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SWI/SNF ,SMARCA4 ,BRG1 ,Gastric cancer ,Undifferentiated tumor ,Medicine - Abstract
Abstract Background SMARCA4, as one of the subunits of the SWI/SNF chromatin remodeling complex, drives SMARCA4-deficient tumors. Gastric SMARCA4-deficient tumors may include gastric SMARCA4-deficient carcinoma and gastric SMARCA4-deficient undifferentiated tumor (SMARCA4-UT). Gastric SMARCA4-UT is rare and challenging to diagnose in clinical practice. The present report aims to provide insight into the clinicopathological characteristics and genetic alterations of gastric SMARCA4-UTs. Results We retrospectively reported four rare cases of gastric SMARCA4-UTs. All four cases were male, aged between 61 and 82 years. These tumors presented as ulcerated and transmural masses with infiltration, staged as TNM IV in cases 1, 2 and 4, and TNM IIIA in case 3. Pathologically, four cases presented solid architecture with undifferentiated morphology. Cases 2 and 3 showed focal necrosis and focal rhabdoid morphology. Immunohistochemical staining showed negative expression of epithelial markers and deficient expression of SMARCA4. Furthermore, positivity for Syn (cases 1, 2 and 3) and SALL4 (cases 1 and 2) were observed. Mutant p53 expression occurred in four cases, resulting in strong and diffuse staining of p53 expression in cases 1, 2 and 4, and complete loss in case 3. The Ki67 proliferative index exceeded 80%. 25% (1/4, case 4) of cases had mismatch repair deficiency (dMMR). Two available cases (cases 1 and 3) were detected with SMRACA4 gene alterations. The response to neoadjuvant therapy was ineffective in case 1. Conclusions Gastric SMARCA4-UT is a rare entity of gastric cancer with a poor prognosis, predominantly occurs in male patients. The tumors are typically diagnosed at advanced stages and shows a solid architecture with undifferentiated morphology. Negative expression of epithelial markers and complete loss of SMARCA4 immunoexpression are emerging as a useful diagnostic tool for rare gastric SMARCA4-UTs.
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- 2024
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21. IL-17a promotes hepatocellular carcinoma by increasing FAP expression in hepatic stellate cells via activation of the STAT3 signaling pathway
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Dapeng Sun, Wen Li, Dongyang Ding, Kunjiang Tan, Wenbin Ding, Zongyan Wang, Siyuan Fu, Guojun Hou, Wei-ping Zhou, and Fangming Gu
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 ,Cytology ,QH573-671 - Abstract
Abstract Studies have shown that hepatic stellate cells (HSCs) and interleukin-17a (IL-17a) play important roles in liver tumorigenesis. In addition, fibroblast activation protein-α (FAP) has been shown to be a key regulator of hepatic stellate cell activation. In this study, in vivo and in vitro experiments were performed to verify the promoting effects of IL-17a administration, IL-17a overexpression, and FAP upregulation in HSCs on liver fibrosis and liver tumorigenesis. The cleavage under targets & release using nuclease (CUT&RUN) technique was used to verify the binding status of STAT3 to the FAP promoter. The in vitro studies showed that IL-17a activated HSCs and promoted HCC development and progression. FAP and IL-17a overexpression also activated HSCs, promoted HCC cell proliferation and migration, and inhibited HCC cell apoptosis. The in vivo studies suggested that IL-17a and FAP overexpression in HSCs facilitated liver tumor development and progression. The CUT&RUN results indicated that FAP expression was regulated by STAT3, which could bind to the FAP promoter region and regulate its transcription status. We concluded that IL-17a promoted HCC by increasing FAP expression in HSCs via activation of the STAT3 signaling pathway.
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- 2024
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22. De novo transcriptome assembly database for 100 tissues from each of seven species of domestic herbivore
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Yifan Wang, Yiming Huang, Yongkang Zhen, Jiasheng Wang, Limin Wang, Ning Chen, Feifan Wu, Linna Zhang, Yizhao Shen, Congliang Bi, Song Li, Kelsey Pool, Dominique Blache, Shane K. Maloney, Dongxu Liu, Zhiquan Yang, Chuang Li, Xiang Yu, Zhenbin Zhang, Yifei Chen, Chun Xue, Yalan Gu, Weidong Huang, Lu Yan, Wenjun Wei, Yusu Wang, Jinying Zhang, Yifan Zhang, Yiquan Sun, Shengbo Wang, Xinle Zhao, Chengfang Luo, Haodong Wang, Luoyang Ding, Qing-Yong Yang, Ping Zhou, and Mengzhi Wang
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Science - Abstract
Abstract Domesticated herbivores are an important agricultural resource that play a critical role in global food security, particularly as they can adapt to varied environments, including marginal lands. An understanding of the molecular basis of their biology would contribute to better management and sustainable production. Thus, we conducted transcriptome sequencing of 100 to 105 tissues from two females of each of seven species of herbivore (cattle, sheep, goats, sika deer, horses, donkeys, and rabbits) including two breeds of sheep. The quality of raw and trimmed reads was assessed in terms of base quality, GC content, duplication sequence rate, overrepresented k-mers, and quality score distribution with FastQC. The high-quality filtered RNA-seq raw reads were deposited in a public database which provides approximately 54 billion high-quality paired-end sequencing reads in total, with an average mapping rate of ~93.92%. Transcriptome databases represent valuable resources that can be used to study patterns of gene expression, and pathways that are related to key biological processes, including important economic traits in herbivores.
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- 2024
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23. 'Qi Nan' agarwood restores podocyte autophagy in diabetic kidney disease by targeting EGFR signaling pathway
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Ning Li, Xuenan Liu, Hao Wang, Yingling Duan, Yu Zhang, Ping Zhou, Haofu Dai, and Tian Lan
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DKD ,“QN” agarwood ,Podocytes ,Autophagy ,EGFR ,Other systems of medicine ,RZ201-999 - Abstract
Abstract Background Diabetic kidney disease (DKD) is a microvascular complication of diabetes mellitus, contributing to end-stage renal disease with limited treatment options. The development of DKD is attributed to podocyte injury resulting from abnormal podocyte autophagy. Consequently, the restoration of podocyte autophagy is deemed a practicable approach in the treatment of DKD. Methods Diabetic mice were induced by streptozotocin and high-fat diet feeding. Following 8 weeks of “QN” agarwood treatment, metrics such as albuminuria, serum creatinine (Scr), and blood urea nitrogen (BUN) were evaluated. Renal histological lesions were evaluated by H&E, PAS, Masson, and Sirius red staining. Evaluation of the effects of “QN” agarwood on renal inflammation and fibrosis in DKD mice through WB, q-PCR, and IHC staining analysis. Cytoscape 3.7.1 was used to construct a PPI network. With the DAVID server, the gene ontology (GO) functional annotation and the Kyoto encyclopedia of genes and genomes (KEGG) signaling pathways of the target enrichment were performed. Molecular docking and binding affinity calculations were conducted using AutoDock, while PyMOL software was employed for visualizing the docking results of active compounds and protein targets. Results The results of this study show that “QN” agarwood reduced albuminuria, Scr, and BUN in DKD mice, and improved the renal pathological process. Additionally, “QN” agarwood was observed to downregulate the mRNA and protein expression levels of pro-inflammatory and pro-fibrotic factors in the kidneys of DKD mice. Network pharmacology predicts that “QN” agarwood modulates the epidermal growth factor receptor (EGFR) signaling pathway. “QN” agarwood can increase the expression of LC3B and Nphs1 in DKD mice while reducing the expression of EGFR. Conclusion The present study demonstrated that “QN” agarwood ameliorated renal injury in DKD by targeting EGFR and restoring podocyte autophagy. Graphical Abstract
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- 2024
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24. Substrate Conformational Switch Enables the Stereoselective Dimerization in P450 NascB: Insights from Molecular Dynamics Simulations and Quantum Mechanical/Molecular Mechanical Calculations
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Tai-Ping Zhou, Jianqiang Feng, Yongchao Wang, Shengying Li, and Binju Wang
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Chemistry ,QD1-999 - Published
- 2024
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25. Online prediction of sustained muscle force from individual motor unit activities using adaptive surface EMG decomposition
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Haowen Zhao, Yong Sun, Chengzhuang Wei, Yuanfei Xia, Ping Zhou, and Xu Zhang
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Muscle force prediction ,Motor unit ,Real-time EMG decomposition ,Double-thread-parallel ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Decoding movement intentions from motor unit (MU) activities to represent neural drive information plays a central role in establishing neural interfaces, but there remains a great challenge for obtaining precise MU activities during sustained muscle contractions. In this paper, we presented an online muscle force prediction method driven by individual MU activities that were decomposed from prolonged surface electromyogram (SEMG) signals in real time. In the training stage of the proposed method, a set of separation vectors was initialized for decomposing MU activities. After transferring each decomposed MU activity into a twitch force train according to its action potential waveform, a neural network was designed and trained for predicting muscle force. In the subsequent online stage, a practical double-thread-parallel algorithm was developed. One frontend thread predicted the muscle force in real time utilizing the trained network and the other backend thread simultaneously updated the separation vectors. To assess the performance of the proposed method, SEMG signals were recorded from the abductor pollicis brevis muscles of eight subjects and the contraction force was simultaneously collected. With the update procedure in the backend thread, the force prediction performance of the proposed method was significantly improved in terms of lower root mean square deviation (RMSD) of around 10% and higher fitness (R2) of around 0.90, outperforming two conventional methods. This study provides a promising technique for real-time myoelectric applications in movement control and health.
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- 2024
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26. Association between red blood cell distribution width‐to‐albumin ratio and prognosis in non‐ischaemic heart failure
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Ping Zhou, Peng‐Chao Tian, Mei Zhai, Yan Huang, Qiong Zhou, Xiao‐Feng Zhuang, Hui‐Hui Liu, Jin‐Xi Wang, Yu‐Hui Zhang, and Jian Zhang
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Non‐ischaemic heart failure ,Red blood cell distribution width‐to‐albumin ratio ,Inflammation ,Prognosis ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Aims Red blood cell distribution width‐to‐albumin ratio (RAR), an innovate biomarker of inflammation, can independently predict adverse cardiovascular outcomes. However, the association between RAR and prognosis in patients with non‐ischaemic heart failure (NIHF) remains unclear. Methods and results A total of 2077 NIHF patients admitted to the Heart Failure Care Unit, Fuwai Hospital, were consecutively enrolled from December 2006 to October 2017 in this retrospective study. The primary endpoint was a composite outcome of all‐cause mortality and heart transplantation. The correlation between RAR and the composite outcome was assessed by the Kaplan–Meier survival analysis and the Cox regression analysis. Incremental predictive values and the clinical performance of RAR for all‐cause mortality or heart transplantation were also assessed based on a 12‐variable traditional risk model. The median follow‐up time in this study was 1433 (1341, 1525) days. As the gender no longer satisfied the Cox proportional risk assumption after 1150 days, we set 1095 days as the follow‐up time for analysis. A total of 500 patients reached the composite outcome. Multivariable Cox regression showed that per log2 increase of RAR was significantly associated with a 132.9% [hazard ratio 2.329, 95% confidence interval (CI) 1.677–3.237, P
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- 2024
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27. Identification of biomarkers related to tryptophan metabolism in osteoarthritis
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Junjun Yang, Ping Zhou, Tangbing Xu, Kaida Bo, Chenxin Zhu, Xu Wang, and Jun Chang
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Osteoarthritis ,Tryptophan metabolic related genes ,Diagnostic biomarkers ,Machine learning ,Biology (General) ,QH301-705.5 ,Biochemistry ,QD415-436 - Abstract
Background: OA (osteoarthritis) is a common joint disease characterized by damage to the articular cartilage and affects the entire joint tissue, with its main manifestations being joint pain, stiffness, and limited movement.Currently,we know that OA is a complex process composed of inflammatory and metabolic factors.It is reported that the occurrence and development of OA is related to the change of tryptophan metabolism.Therefore, the study of tryptophan metabolism and OA related genes is hopeful to find a new therapeutic target for OA. Methods: Differentially expressed genes (DEGs) in GSE55235 were gained via differential expression analysis (OA samples vs normal samples). The tryptophan metabolic related DEGs (TMR-DEGs) were obtained by overlapping tryptophan metabolism related genes (TMRGs) and DEGs. Further, biomarkers were screening via Least absolute shrinkage and selection operator (LASSO), naive bayes (NB) and supportvector machine-recursive feature elimination (SVM-RFE) algorithm to establish a diagnostic model. Afterward, Gene Set Enrichment Analysis (GSEA) and drug prediction were performed based on diagnostic biomarkers by multiple software and databases. Eventually, expression level of biomarker public databases was verified using real-time quantitative polymerase chain reaction (RT-qPCR). Results: Three tryptophan metabolism related biomarkers (TDO2, AOX1 and SLC3A2) were identified in OA. GSEA analysis demonstrated that biomarkers were associated with the function of ‘FoxO signaling pathway’, ‘spliceosome’ and ‘ribosome’. There were seven drugs with therapeutic potential on TDO2 and AOX1. Ultimately, compared with normal group, expression of AOX1 and SLC3A2 in OA group remarkable lower. Conclusion: Overall, three tryptophan metabolic related diagnostic biomarkers that associated with OA were obtained, which provided a original direction for the diagnosis and treatment of OA.
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- 2024
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28. Four novel species of Pleurotheciaceae collected from freshwater habitats in Jiangxi Province, China
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Wen-Ming He, Jun-Bo Zhang, Zhi-Jun Zhai, Danushka Sandaruwan Tennakoon, Chao-Yu Cui, Jian-Ping Zhou, Ming-Hui Chen, Hai-Jing Hu, Hua Yin, Yang Gao, Dian-Ming Hu, and Hai-Yan Song
- Subjects
diversity ,four novel species ,morphology ,phylogeny ,Pleurotheciella ,Pleurothecium ,Microbiology ,QR1-502 - Abstract
During an investigation of fungal diversity from freshwater environments in different regions in Jiangxi Province, China, four interesting species were collected. Morphology coupled with combined gene analysis of an ITS, LSU, SSU, and rpb2 DNA sequence data showed that they belong to the family Pleurotheciaceae. Four new species, Pleurotheciella ganzhouensis, Pla. irregularis, Pla. verrucosa, and Pleurothecium jiangxiense are herein described. Pleurotheciella ganzhouensis is characterized by its capsule-shaped conidia and short conidiophores, while Pla. irregularis has amorphous conidiophores and 3-septate conidia. Pleurotheciella verrucosa has cylindrical or verrucolose conidiogenous cells, 1-septate, narrowly fusiform, meniscus or subclavate conidia. Pleurothecium jiangxiense characterized in having conidiogenous cells with dense cylindrical denticles and short conidiophores. Pleurothecium obovoideum was transferred to Neomonodictys based on phylogenetic evidence. All species are compared with other similar species and comprehensive descriptions, micrographs, and phylogenetic data are provided.
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- 2024
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29. Management of Meige syndrome with bilateral trigeminal and facial nerves combing
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Tingting Ying, Haopeng Wang, Yinda Tang, Hua Zhao, Xiaomin Cai, Yiman Shen, Baimiao Wang, Wanchun Zhu, Ping Zhou, Xin Zhang, Jun Zhong, Xinjun Wang, Xudong Fu, Jin Zhu, Weituo Zhang, and Shiting Li
- Subjects
Meige syndrome ,combing ,trigeminal nerves ,facial nerve ,BFMDRS-M ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
ObjectiveMeige syndrome (MS) is an adult-onset segmental dystonia for which no satisfactory remedy currently exists. Our team developed a novel surgical approach called bilateral trigeminal/facial nerve combing (BTFC). This study aimed to evaluate the outcomes of patients who underwent BFTC (Clinical Trial Registry Number: ChiCTR2000033481).MethodWe assigned 22 patients with MS to undergo BTFC. The primary outcome was assessed using the movement subscale of the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS-M) at 12 months postoperatively. The second outcome was evaluated using the Medical Outcome Study (MOS) 36-item Short Form Health Survey (SF-36), the dysfunction subscale of the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS-D), and the sub-item scores of the BFMDRS-M. Safety outcomes included the House-Brackmann (HB) functional grading score and the visual analog scale (VAS) for facial numbness.ResultsAt the final follow-up at 12 months, the BFMDRS-M showed a mean improvement of 70.7% from baseline. Mean scores of the BFMDRS-M sub-motor (including the eyes, mouth, and speech/swallowing) improved by 65.6, 81.00, and 60%, respectively. The median score of the total BFMDRS-D score was 0.70 ± 1.17 compared with 1.86 ± 2.21 at baseline. There were no serious operative complications in this population. The quality of life of the patients significantly improved (P < 0.05).ConclusionBFTC has proven to be effective in relieving the symptoms of Meige syndrome. This novel surgical approach offers a new alternative treatment for patients who have failed to respond to medications, botulinum toxin injections, and deep brain stimulation (DBS).Clinical Trial Registrationhttps://www.chictr.org.cn/bin/project/edit?pid=54567, ChiCTR2000033481.
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- 2024
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30. Requirements for and Barriers to Rehabilitation Services for Children With Disabilities in Middle- and High-Income Countries: Scoping Review
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Yijun Xie, Jing Wu, Yao Li, Hui Liu, Yanyan Peng, Ping Zhou, Yizhou Sun, Luyan Kang, Chenghua Jiang, and Hengjing Wu
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Medical technology ,R855-855.5 - Abstract
BackgroundThe rehabilitation of children with disabilities has received considerable attention from the United Nations. However, the state of rehabilitation services for children with disabilities worldwide remains far from optimistic, even in economically affluent middle- and high-income countries. ObjectiveThis scoping review aimed to identify the rehabilitation needs of children with disabilities and their barriers to rehabilitation services in middle- and high-income countries. MethodsA systematic search was conducted using MEDLINE and Web of Science for papers published from January 2013 to December 2023. Studies were included if they were peer-reviewed, full-text articles related to children with disabilities, reporting on their access to rehabilitation services, and conducted in countries classified by the World Bank 2023 as middle- and high-income economies. Exclusion criteria included duplicates, unavailable full texts, and studies without distinct outcomes. A total of 27 studies were selected following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, focusing on children, their families, or service providers. ResultsThe suitability, availability, and affordability of rehabilitation services were identified as the major needs and barriers for children with disabilities in middle- and high-income countries. This included communication barriers, a need for more personnel and facilities, and the stagnation and inadequacy of economic subsidies. ConclusionsMiddle- and high-income countries have relatively well-established rehabilitation infrastructure and support systems. They are nevertheless insufficient for meeting the needs of children with disabilities. More attention should be paid to these issues to improve the well-being of children with disabilities. The data provided by this review can help raise awareness of rehabilitation needs and barriers at the policy level.
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- 2024
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31. Role of tendon-derived stem cells in tendon and ligament repair: focus on tissue engineer
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Wei He, Chao Jiang, Ping Zhou, Xujun Hu, XiaoPeng Gu, and SongOu Zhang
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tendon-derived stem cell ,tendon injury ,tissue engineer ,nanotechnology ,seed cell ,Biotechnology ,TP248.13-248.65 - Abstract
This review offered a comprehensive analysis of tendon and ligament injuries, emphasizing the crucial role of tendon-derived stem cells (TDSCs) in tissue engineering as a potential solution for these challenging medical conditions. Tendon and ligament injuries, prevalent among athletes, the elderly, and laborers, often result in long-term disability and reduced quality of life due to the poor intrinsic healing capacity of these avascular structures. The formation of biomechanically inferior scar tissue and a high rate of reinjury underscore the need for innovative approaches to enhance and guide the regenerative process. This review delved into the complexities of tendon and ligament structure and function, types of injuries and their impacts, and the limitations of the natural repair process. It particularly focused on the role of TDSCs within the context of tissue engineering. TDSCs, with their ability to differentiate into tenocytes, are explored in various applications, including biocompatible scaffolds for cell tracking, co-culture systems to optimize tendon-bone healing, and graft healing techniques. The review also addressed the challenges of immunoreactivity post-transplantation, the importance of pre-treating TDSCs, and the potential of hydrogels and decellularized matrices in supporting tendon regeneration. It concluded by highlighting the essential roles of mechanical and molecular stimuli in TDSC differentiation and the current challenges in the field, paving the way for future research directions.
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- 2024
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32. A real-world, cross-sectional, and longitudinal study on high-risk human papillomavirus genotype distribution in 31,942 women in Dongguan, China
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Huanxia Zhong, Wenwei Pan, Binbin Chen, Jiamin Gu, Yu Liang, Guoli Sun, Xinghua Huang, Huitao Yuan, Haina Guo, Ling Zhong, Zhuanfen Li, Ping Zhou, Siliang Zeng, and Li Tang
- Subjects
screening ,high-risk human papillomavirus ,cervical cytology ,genotype distribution ,infection rate ,China ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundPersistent human papillomavirus (HPV) infection remains a key risk factor for cervical cancer. HPV-based primary screening is widely recommended in clinical guidelines, and further longitudinal studies are needed to optimize strategies for detecting high-grade cervical lesions compared to cytology.MethodsFrom November 2015 to December 2023, 31,942 participants were included in the real-world observational study. Among those, 4,219 participants underwent at least two rounds of HPV tests, and 397 completed three rounds of HPV tests. All participants were tested for high-risk types of HPV 16/18/31/33/35/39/45/51/52/56/58/59/66/68 (hrHPV) and low-risk types of HPV6/11 genotyping. Some participants also received cytology or colposcopy with pathology.ResultsIn the cross-sectional cohort, the prevalence of hrHPV and all HPV subtypes was 6.6% (2,108/31,942) and 6.8% (2,177/31,942), respectively. The three top hrHPV genotypes were HPV52 (1.9%), HPV58 (0.9%), and HPV16 (0.9%). Age distributions showed two peaks at 45–49 and 60–65 years. For the primary screening cohort, the hrHPV prevalence rate increased from 4.8% in 2015–2017 to 7.0% in 2020–2020 and finally reached 7.2% in 2023. For the longitudinal cohort study, the hrHPV prevalence rates in the repeated population (3.9, 5.3, and 6.0%) were lower than the primary hrHPV screening rates (6.6%), which indicated that repeated screening might decrease the prevalence rate. Methodologically, the hrHPV (89.5%) and the screening group of 16 subtypes (92.3%) demonstrated superior sensitivity than the cytology group (54.4%). Moreover, the longitudinal study indicated that the persistent hrHPV subgroup had a significantly higher (p = 0.04) incidence of high-grade squamous intraepithelial lesions and more histology progression events (7/17 vs. 0/5) than the reinfection group.ConclusionThe study indicates a rising high-risk HPV prevalence in Dongguan, with repeated screening reducing this trend. The findings support HPV-based primary screening and might guide HPV vaccination and cervical cancer prevention in South China.
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- 2024
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33. Advances in the interaction of glycolytic reprogramming with lactylation
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Yue Li, Qian Cao, Yibao Hu, Bisha He, Ting Cao, Yun Tang, Xiang ping Zhou, Xiao peng Lan, and Shuang quan Liu
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Glycolytic reprogramming ,Lactylation ,Post-translational modifications ,Lactate ,Warburg effect ,Epigenetics ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Lactylation is a novel post-translational modification (PTM) involving proteins that is induced by lactate accumulation. Histone lysine lactylation alters chromatin spatial configuration, influencing gene transcription and regulating the expression of associated genes. This modification plays a crucial role as an epigenetic regulatory factor in the progression of various diseases. Glycolytic reprogramming is one of the most extensively studied forms of metabolic reprogramming, recognized as a key hallmark of cancer cells. It is characterized by an increase in glycolysis and the inhibition of the tricarboxylic acid (TCA) cycle, accompanied by significant lactate production and accumulation. The two processes are closely linked by lactate, which interacts in various physiological and pathological processes. On the one hand, lactylation levels generally correlate positively with the extent of glycolytic reprogramming, being directly influenced by the lactate concentration produced during glycolytic reprogramming. On the other hand, lactylation can also regulate glycolytic pathways by affecting the transcription and structural functions of essential glycolytic enzymes. This review comprehensively outlines the mechanisms of lactylation and glycolytic reprogramming and their interactions in tumor progression, immunity, and inflammation, with the aim of elucidating the relationship between glycolytic reprogramming and lactylation.
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- 2024
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34. Corrigendum: Ginsenoside Re attenuates high glucose-induced RF/6A injury via regulating PI3K/AKT inhibited HIF-1a/VEGF signaling pathway
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Weijie Xie, Ping Zhou, Muwen Qu, Ziru Dai, Xuelian Zhang, Chenyang Zhang, Xi Dong, Guibo Sun, and Xiaobo Sun
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ginsenoside Re ,diabetic retinopathy ,oxidative stress ,apoptosis ,phosphoinositide 3-kinase/AKTT ,hypoxia-inducible factor-1-alpha ,Therapeutics. Pharmacology ,RM1-950 - Published
- 2024
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35. Artificial intelligence in ischemic stroke images: current applications and future directions
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Ying Liu, Zhongjian Wen, Yiren Wang, Yuxin Zhong, Jianxiong Wang, Yiheng Hu, Ping Zhou, and Shengmin Guo
- Subjects
ischemic stroke ,medical imaging ,deep learning ,machine learning ,artificial intelligence ,prediction model ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
This paper reviews the current research progress in the application of Artificial Intelligence (AI) based on ischemic stroke imaging, analyzes the main challenges, and explores future research directions. This study emphasizes the application of AI in areas such as automatic segmentation of infarct areas, detection of large vessel occlusion, prediction of stroke outcomes, assessment of hemorrhagic transformation risk, forecasting of recurrent ischemic stroke risk, and automatic grading of collateral circulation. The research indicates that Machine Learning (ML) and Deep Learning (DL) technologies have tremendous potential for improving diagnostic accuracy, accelerating disease identification, and predicting disease progression and treatment responses. However, the clinical application of these technologies still faces challenges such as limitations in data volume, model interpretability, and the need for real-time monitoring and updating. Additionally, this paper discusses the prospects of applying large language models, such as the transformer architecture, in ischemic stroke imaging analysis, emphasizing the importance of establishing large public databases and the need for future research to focus on the interpretability of algorithms and the comprehensiveness of clinical decision support. Overall, AI has significant application value in the management of ischemic stroke; however, existing technological and practical challenges must be overcome to achieve its widespread application in clinical practice.
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- 2024
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36. Further evidence from DNAH12 supports favorable fertility outcomes of infertile males with dynein axonemal heavy chain gene family variants
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Hao Geng, Kai Wang, Dan Liang, Xiaoqing Ni, Hui Yu, Dongdong Tang, Mingrong Lv, Huan Wu, Kuokuo Li, Qunshan Shen, Yang Gao, Chuan Xu, Ping Zhou, Zhaolian Wei, Yunxia Cao, Yanwei Sha, Xiaoyu Yang, and Xiaojin He
- Subjects
Reproductive medicine ,Genetics ,Genomics ,Human Genetics ,Molecular biology ,Science - Abstract
Summary: Male infertility is a major concern affecting reproductive health. Biallelic deleterious variants of most DNAH gene family members have been linked to male infertility, with intracytoplasmic sperm injection (ICSI) being an efficacious way to achieve offspring. However, the association between DNAH12 and male infertility is still limited. Here, we identified one homozygous variant and two compound heterozygous variants in DNAH12 from three infertile Chinese men. Semen analysis revealed severe asthenozoospermia, abnormal morphology, and structure of sperm flagella. Furthermore, the Dnah12 knock-out mouse revealed severe spermatogenesis failure and validated the same male infertility phenotype. Favorable fertility outcomes were achieved through ICSI in three human individuals and Dnah12 knock-out mice. Collectively, our study indicated that biallelic variants of DNAH12 can induce male infertility in both human beings and mice. Notably, evidence from DNAH12 enhanced that ICSI was an optimal intervention to achieve favorable fertility outcomes for infertile males with DNAH gene family variants.
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- 2024
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37. Two parallel-machine scheduling with maximum waiting time for an emergency job.
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Yiwei Jiang, Haodong Yuan, Ping Zhou, T. C. E. Cheng, and Min Ji 0001
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- 2024
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38. Adaptive Constraint Penalty-Based Multiobjective Operation Optimization of an Industrial Dynamic System With Complex Multiconstraint.
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Ping Zhou 0003, Shuai Zhang, and Tianyou Chai
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- 2024
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39. Study on the evolution of hot topics in the urban development.
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Ping Zhou and Difei Jiang
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- 2024
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40. Objective PDF-Shaping Based Stochastic Optimization With Probabilistic Constraints and Its Application.
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Mingjie Li 0001, Ping Zhou 0003, and Hong Wang 0001
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- 2024
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41. Optimal Tracking Control of Blast Furnace Molten Iron Quality Based on Krotov's Method and Nonlinear Subspace Identification.
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Yue Liu, Ping Zhou 0003, Xiaoyang Sun, and Tianyou Chai
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- 2024
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42. Online Decomposition of Surface Electromyogram Into Individual Motor Unit Activities Using Progressive FastICA Peel-Off.
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Haowen Zhao, Xu Zhang 0002, Maoqi Chen, and Ping Zhou 0002
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- 2024
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43. Adaptive Online Decomposition of Surface EMG Using Progressive FastICA Peel-Off.
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Haowen Zhao, Xu Zhang 0002, Maoqi Chen, and Ping Zhou 0002
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- 2024
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44. Enhanced Dynamic Surface EMG Decomposition Using the Non-Negative Matrix Factorization and Three-Dimensional Motor Unit Localization.
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Jinbao He, Yang Liu 0072, Sheng Li 0015, Ping Zhou 0002, and Yingchun Zhang
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- 2024
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45. Anomaly Detection of Industrial Smelting Furnace Incorporated With Accelerated Sampling Denoising Diffusion Probability Model and Conv-Transformer.
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Yu Zhang, Ping Zhou 0003, and Enjie Ma
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- 2024
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46. Online Sequential Sparse Robust Neural Networks With Random Weights for Imperfect Industrial Streaming Data Modeling.
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Chaoyao Wen, Ping Zhou 0003, Wei Dai 0004, Liang Dong, and Tianyou Chai
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- 2024
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47. Guest Editorial Special Issue on Learning From Imperfect Data for Industrial Automation.
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Ping Zhou 0003, Xuewu Dai, Kyriakos G. Vamvoudakis, Jan Faigl, and Hong Wang 0001
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- 2024
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48. Construction of community health care integration using artificial intelligence models
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Chen Zhou, Ping Zhou, and Xuan Xiaolan
- Subjects
data mining and intelligent coordination ,elderly mobile population ,pollution ,public health ,strategy optimization ,Environmental technology. Sanitary engineering ,TD1-1066 ,Environmental sciences ,GE1-350 - Abstract
In the information age, there's a growing need to improve eldercare services for the mobile elderly population. Current Chinese eldercare often separates medical and nursing care, leading to low resource use. This study aims to integrate community healthcare with data analysis and intelligent coordination to meet the floating elderly's needs. Using a Stacking model, it identifies key indicators and develops a mobile terminal based community healthcare model. Results show that primary indicators are crucial, scoring between 4.48−5.00, with secondary and tertiary indicators also significant. The KMO value is 0.93, confirming the model's validity. Compared to traditional methods, this new approach enhances accuracy by 7%, offering a valuable framework for community-based eldercare integration in China. HIGHLIGHTS This research mainly focuses on the integration model of the elderly floating population and community health care.; The experimental results showed that the model proposed the importance of community health care indicators for the elderly floating population, with a distribution of 4.48–5.00 and a full score of 52.17–100%.;
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- 2024
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49. The impact of depressive and anxious symptoms on non-suicidal self-injury behavior in adolescents: a network analysis
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Muzhen Guan, Junchang Liu, Xinhong Li, Min Cai, Jing Bi, Ping Zhou, Zhongheng Wang, Songwen Wu, Li Guo, and Huaning Wang
- Subjects
Non-suicidal self-injury ,Adolescent ,network analysis ,Depressive symptoms ,Anxious symptoms ,Psychiatry ,RC435-571 - Abstract
Abstract Purpose Conceptualizing adolescent NSSI and emotional symptoms as a system of causal elements could provide valuable insights into the development of non-suicidal self-injury (NSSI) in adolescent. This study aimed to explore the intricate relationship between NSSI, depressive symptoms, and anxious symptoms in adolescents, identifying key symptoms to establish a theoretical foundation for targeted and effective interventions addressing NSSI behaviors in this population. Methods A total of 412 adolescents with NSSI behaviors were selected from outpatients. Generalized anxious disorder scale (GAD-7) and patient health questionnaire (PHQ-9) were employed to measure anxious symptoms and depressive symptoms, respectively. The adolescent non-suicidal self-injury assessment questionnaire (ANSSIAQ) was used to evaluate NSSI of adolescent. Using network analysis, the NSSI、depressive symptoms and anxious symptoms network were constructed to identify the most central symptoms and the bridge symptoms within the networks. Results The findings revealed that the NSSI functional nodes “coping with sadness and disappointment” and “relieving stress or anxious” exhibited the strongest correlation, with a regularized partial correlation coefficient was 0.401. The symptoms “having a desire to harm oneself and unable to stop” and the node “depressive symptoms” had the highest strength centrality in the network, and their strength centrality indices were 1.267 and 1.263, respectively. The bridge nodes were “having a desire to harm oneself and unable to stop” and “expressing one’s despair and hopelessness”, with expected impact indices of 0.389 and 0.396, respectively. Conclusion In adolescents, the network revealed a closer connection between NSSI and depressive symptoms. “The desire to not stop hurting oneself” is not only broadly connected to other nodes but also could activate other nodes to maintain NSSI behavior. In light of these findings, precise targets for pharmacological treatment, psychotherapy, physical therapy, etc., are identified for adolescents with NSSI. Targeting this specific aspect in interventions may contribute to preventing and reducing NSSI behavior in adolescents.
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- 2024
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50. Role of polyphenols in remodeling the host gut microbiota in polycystic ovary syndrome
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Ping Zhou, Penghui Feng, Baoying Liao, Lin Fu, Hongying Shan, Canhui Cao, Renxin Luo, Tianliu Peng, Fenting Liu, and Rong Li
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Polycystic ovary syndrome ,Gut microbiota ,Polyphenols ,Anthocyanins ,Green tea catechins ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Polycystic ovary syndrome (PCOS) is a common reproductive and metabolic condition in women of childbearing age and a major cause of anovulatory infertility. The pathophysiology of PCOS is complex. Recent studies have reported that apart from hyperandrogenism, insulin resistance, systemic chronic inflammation, and ovarian dysfunction, gut microbiota dysbiosis is also involved in PCOS development and may aggravate inflammation and metabolic dysfunction, forming a vicious cycle. As naturally occurring plant secondary metabolites, polyphenols have been demonstrated to have anticancer, antibacterial, vasodilator, and analgesic properties, mechanistically creating putative bioactive, low-molecular-weight metabolites in the human gut. Here, we summarize the role of gut microbiota dysbiosis in the development of PCOS and demonstrate the ability of different polyphenols - including anthocyanin, catechins, and resveratrol - to regulate gut microbes and alleviate chronic inflammation, thus providing new insights that may assist in the development of novel therapeutic strategies to treat women with PCOS.
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- 2024
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