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Your search keyword '"Salvati, L."' showing total 17 results
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17 results on '"Salvati, L."'

1. LiteBIRD Science Goals and Forecasts. Mapping the Hot Gas in the Universe

Author

Remazeilles, M., Douspis, M., Rubiño-Martín, J. A., Banday, A. J., Chluba, J., de Bernardis, P., De Petris, M., Hernández-Monteagudo, C., Luzzi, G., Macias-Perez, J., Masi, S., Namikawa, T., Salvati, L., Tanimura, H., Aizawa, K., Anand, A., Aumont, J., Baccigalupi, C., Ballardini, M., Barreiro, R. B., Bartolo, N., Basak, S., Bersanelli, M., Blinov, D., Bortolami, M., Brinckmann, T., Calabrese, E., Campeti, P., Carinos, E., Carones, A., Casas, F. J., Cheung, K., Clermont, L., Columbro, F., Coppolecchia, A., Cuttaia, F., de Haan, T., de la Hoz, E., Della Torre, S., Diego-Palazuelos, P., D'Alessandro, G., Eriksen, H. K., Fuskeland, U., Galloni, G., Galloway, M., Gervasi, M., Génova-Santos, R. T., Ghigna, T., Giardiello, S., Gimeno-Amo, C., Gjerløw, E., González, R. González, Gruppuso, A., Hazumi, M., Henrot-Versillé, S., Hergt, L. T., Herranz, D., Kohri, K., Komatsu, E., Lamagna, L., Lattanzi, M., Leloup, C., Levrier, F., Lonappan, A. I., López-Caniego, M., Maffei, B., Martínez-González, E., Matarrese, S., Matsumura, T., Micheli, S., Migliaccio, M., Monelli, M., Montier, L., Morgante, G., Nagano, Y., Nagata, R., Novelli, A., Omae, R., Pagano, L., Paoletti, D., Pavlidou, V., Piacentini, F., Pinchera, M., Polenta, G., Porcelli, L., Ritacco, A., Ruiz-Granda, M., Sakurai, Y., Scott, D., Shiraishi, M., Stever, S. L., Sullivan, R. M., Takase, Y., Tassis, K., Terenzi, L., Tomasi, M., Tristram, M., Vacher, L., van Tent, B., Vielva, P., Wehus, I. K., Westbrook, B., Weymann-Despres, G., Wollack, E. J., Zannoni, M., and Zhou, Y.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We assess the capabilities of the LiteBIRD mission to map the hot gas distribution in the Universe through the thermal Sunyaev-Zeldovich (SZ) effect. Our analysis relies on comprehensive simulations incorporating various sources of Galactic and extragalactic foreground emission, while accounting for specific instrumental characteristics of LiteBIRD, such as detector sensitivities, frequency-dependent beam convolution, inhomogeneous sky scanning, and $1/f$ noise. We implement a tailored component-separation pipeline to map the thermal SZ Compton $y$-parameter over 98% of the sky. Despite lower angular resolution for galaxy cluster science, LiteBIRD provides full-sky coverage and, compared to the Planck satellite, enhanced sensitivity, as well as more frequency bands to enable the construction of an all-sky $y$-map, with reduced foreground contamination at large and intermediate angular scales. By combining LiteBIRD and Planck channels in the component-separation pipeline, we obtain an optimal $y$-map that leverages the advantages of both experiments, with the higher angular resolution of the Planck channels enabling the recovery of compact clusters beyond the LiteBIRD beam limitations, and the numerous sensitive LiteBIRD channels further mitigating foregrounds. The added value of LiteBIRD is highlighted through the examination of maps, power spectra, and one-point statistics of the various sky components. After component separation, the $1/f$ noise from LiteBIRD is effectively mitigated below the thermal SZ signal at all multipoles. Cosmological constraints on $S_8=\sigma_8\left(\Omega_{\rm m}/0.3\right)^{0.5}$ obtained from the LiteBIRD-Planck combined $y$-map power spectrum exhibits a 15% reduction in uncertainty compared to constraints from Planck alone. This improvement can be attributed to the increased portion of uncontaminated sky available in the LiteBIRD-Planck combined $y$-map., Comment: 38 pages, 13 figures, abstract shortened, submitted to JCAP

Published
2024

2. Euclid. I. Overview of the Euclid mission

Author

Euclid Collaboration, Mellier, Y., Abdurro'uf, Barroso, J. A. Acevedo, Achúcarro, A., Adamek, J., Adam, R., Addison, G. E., Aghanim, N., Aguena, M., Ajani, V., Akrami, Y., Al-Bahlawan, A., Alavi, A., Albuquerque, I. S., Alestas, G., Alguero, G., Allaoui, A., Allen, S. W., Allevato, V., Alonso-Tetilla, A. V., Altieri, B., Alvarez-Candal, A., Alvi, S., Amara, A., Amendola, L., Amiaux, J., Andika, I. T., Andreon, S., Andrews, A., Angora, G., Angulo, R. E., Annibali, F., Anselmi, A., Anselmi, S., Arcari, S., Archidiacono, M., Aricò, G., Arnaud, M., Arnouts, S., Asgari, M., Asorey, J., Atayde, L., Atek, H., Atrio-Barandela, F., Aubert, M., Aubourg, E., Auphan, T., Auricchio, N., Aussel, B., Aussel, H., Avelino, P. P., Avgoustidis, A., Avila, S., Awan, S., Azzollini, R., Baccigalupi, C., Bachelet, E., Bacon, D., Baes, M., Bagley, M. B., Bahr-Kalus, B., Balaguera-Antolinez, A., Balbinot, E., Balcells, M., Baldi, M., Baldry, I., Balestra, A., Ballardini, M., Ballester, O., Balogh, M., Bañados, E., Barbier, R., Bardelli, S., Baron, M., Barreiro, T., Barrena, R., Barriere, J. -C., Barros, B. J., Barthelemy, A., Bartolo, N., Basset, A., Battaglia, P., Battisti, A. J., Baugh, C. M., Baumont, L., Bazzanini, L., Beaulieu, J. -P., Beckmann, V., Belikov, A. N., Bel, J., Bellagamba, F., Bella, M., Bellini, E., Benabed, K., Bender, R., Benevento, G., Bennett, C. L., Benson, K., Bergamini, P., Bermejo-Climent, J. R., Bernardeau, F., Bertacca, D., Berthe, M., Berthier, J., Bethermin, M., Beutler, F., Bevillon, C., Bhargava, S., Bhatawdekar, R., Bianchi, D., Bisigello, L., Biviano, A., Blake, R. P., Blanchard, A., Blazek, J., Blot, L., Bosco, A., Bodendorf, C., Boenke, T., Böhringer, H., Boldrini, P., Bolzonella, M., Bonchi, A., Bonici, M., Bonino, D., Bonino, L., Bonvin, C., Bon, W., Booth, J. T., Borgani, S., Borlaff, A. S., Borsato, E., Bose, B., Botticella, M. T., Boucaud, A., Bouche, F., Boucher, J. S., Boutigny, D., Bouvard, T., Bouwens, R., Bouy, H., Bowler, R. A. A., Bozza, V., Bozzo, E., Branchini, E., Brando, G., Brau-Nogue, S., Brekke, P., Bremer, M. N., Brescia, M., Breton, M. -A., Brinchmann, J., Brinckmann, T., Brockley-Blatt, C., Brodwin, M., Brouard, L., Brown, M. L., Bruton, S., Bucko, J., Buddelmeijer, H., Buenadicha, G., Buitrago, F., Burger, P., Burigana, C., Busillo, V., Busonero, D., Cabanac, R., Cabayol-Garcia, L., Cagliari, M. S., Caillat, A., Caillat, L., Calabrese, M., Calabro, A., Calderone, G., Calura, F., Quevedo, B. Camacho, Camera, S., Campos, L., Canas-Herrera, G., Candini, G. P., Cantiello, M., Capobianco, V., Cappellaro, E., Cappelluti, N., Cappi, A., Caputi, K. I., Cara, C., Carbone, C., Cardone, V. F., Carella, E., Carlberg, R. G., Carle, M., Carminati, L., Caro, F., Carrasco, J. M., Carretero, J., Carrilho, P., Duque, J. Carron, Carry, B., Carvalho, A., Carvalho, C. S., Casas, R., Casas, S., Casenove, P., Casey, C. M., Cassata, P., Castander, F. J., Castelao, D., Castellano, M., Castiblanco, L., Castignani, G., Castro, T., Cavet, C., Cavuoti, S., Chabaud, P. -Y., Chambers, K. C., Charles, Y., Charlot, S., Chartab, N., Chary, R., Chaumeil, F., Cho, H., Chon, G., Ciancetta, E., Ciliegi, P., Cimatti, A., Cimino, M., Cioni, M. -R. L., Claydon, R., Cleland, C., Clément, B., Clements, D. L., Clerc, N., Clesse, S., Codis, S., Cogato, F., Colbert, J., Cole, R. E., Coles, P., Collett, T. E., Collins, R. S., Colodro-Conde, C., Colombo, C., Combes, F., Conforti, V., Congedo, G., Conseil, S., Conselice, C. J., Contarini, S., Contini, T., Conversi, L., Cooray, A. R., Copin, Y., Corasaniti, P. -S., Corcho-Caballero, P., Corcione, L., Cordes, O., Corpace, O., Correnti, M., Costanzi, M., Costille, A., Courbin, F., Mifsud, L. Courcoult, Courtois, H. M., Cousinou, M. -C., Covone, G., Cowell, T., Cragg, C., Cresci, G., Cristiani, S., Crocce, M., Cropper, M., Crouzet, P. E, Csizi, B., Cuby, J. -G., Cucchetti, E., Cucciati, O., Cuillandre, J. -C., Cunha, P. A. C., Cuozzo, V., Daddi, E., D'Addona, M., Dafonte, C., Dagoneau, N., Dalessandro, E., Dalton, G. B., D'Amico, G., Dannerbauer, H., Danto, P., Das, I., Da Silva, A., da Silva, R., Doumerg, W. d'Assignies, Daste, G., Davies, J. E., Davini, S., Dayal, P., de Boer, T., Decarli, R., De Caro, B., Degaudenzi, H., Degni, G., de Jong, J. T. A., de la Bella, L. F., de la Torre, S., Delhaise, F., Delley, D., Delucchi, G., De Lucia, G., Denniston, J., De Paolis, F., De Petris, M., Derosa, A., Desai, S., Desjacques, V., Despali, G., Desprez, G., De Vicente-Albendea, J., Deville, Y., Dias, J. D. F., Díaz-Sánchez, A., Diaz, J. J., Di Domizio, S., Diego, J. M., Di Ferdinando, D., Di Giorgio, A. M., Dimauro, P., Dinis, J., Dolag, K., Dolding, C., Dole, H., Sánchez, H. Domínguez, Doré, O., Dournac, F., Douspis, M., Dreihahn, H., Droge, B., Dryer, B., Dubath, F., Duc, P. -A., Ducret, F., Duffy, C., Dufresne, F., Duncan, C. A. J., Dupac, X., Duret, V., Durrer, R., Durret, F., Dusini, S., Ealet, A., Eggemeier, A., Eisenhardt, P. R. M., Elbaz, D., Elkhashab, M. Y., Ellien, A., Endicott, J., Enia, A., Erben, T., Vigo, J. A. Escartin, Escoffier, S., Sanz, I. Escudero, Essert, J., Ettori, S., Ezziati, M., Fabbian, G., Fabricius, M., Fang, Y., Farina, A., Farina, M., Farinelli, R., Farrens, S., Faustini, F., Feltre, A., Ferguson, A. M. N., Ferrando, P., Ferrari, A. G., Ferré-Mateu, A., Ferreira, P. G., Ferreras, I., Ferrero, I., Ferriol, S., Ferruit, P., Filleul, D., Finelli, F., Finkelstein, S. L., Finoguenov, A., Fiorini, B., Flentge, F., Focardi, P., Fonseca, J., Fontana, A., Fontanot, F., Fornari, F., Fosalba, P., Fossati, M., Fotopoulou, S., Fouchez, D., Fourmanoit, N., Frailis, M., Fraix-Burnet, D., Franceschi, E., Franco, A., Franzetti, P., Freihoefer, J., Frenk, C. . S., Frittoli, G., Frugier, P. -A., Frusciante, N., Fumagalli, A., Fumagalli, M., Fumana, M., Fu, Y., Gabarra, L., Galeotta, S., Galluccio, L., Ganga, K., Gao, H., García-Bellido, J., Garcia, K., Gardner, J. P., Garilli, B., Gaspar-Venancio, L. -M., Gasparetto, T., Gautard, V., Gavazzi, R., Gaztanaga, E., Genolet, L., Santos, R. Genova, Gentile, F., George, K., Gerbino, M., Ghaffari, Z., Giacomini, F., Gianotti, F., Gibb, G. P. S., Gillard, W., Gillis, B., Ginolfi, M., Giocoli, C., Girardi, M., Giri, S. K., Goh, L. W. K., Gómez-Alvarez, P., Gonzalez-Perez, V., Gonzalez, A. H., Gonzalez, E. J., Gonzalez, J. C., Beauchamps, S. Gouyou, Gozaliasl, G., Gracia-Carpio, J., Grandis, S., Granett, B. R., Granvik, M., Grazian, A., Gregorio, A., Grenet, C., Grillo, C., Grupp, F., Gruppioni, C., Gruppuso, A., Guerbuez, C., Guerrini, S., Guidi, M., Guillard, P., Gutierrez, C. M., Guttridge, P., Guzzo, L., Gwyn, S., Haapala, J., Haase, J., Haddow, C. R., Hailey, M., Hall, A., Hall, D., Hamaus, N., Haridasu, B. S., Harnois-Déraps, J., Harper, C., Hartley, W. G., Hasinger, G., Hassani, F., Hatch, N. A., Haugan, S. V. H., Häußler, B., Heavens, A., Heisenberg, L., Helmi, A., Helou, G., Hemmati, S., Henares, K., Herent, O., Hernández-Monteagudo, C., Heuberger, T., Hewett, P. C., Heydenreich, S., Hildebrandt, H., Hirschmann, M., Hjorth, J., Hoar, J., Hoekstra, H., Holland, A. D., Holliman, M. S., Holmes, W., Hook, I., Horeau, B., Hormuth, F., Hornstrup, A., Hosseini, S., Hu, D., Hudelot, P., Hudson, M. J., Huertas-Company, M., Huff, E. M., Hughes, A. C. N., Humphrey, A., Hunt, L. K., Huynh, D. D., Ibata, R., Ichikawa, K., Iglesias-Groth, S., Ilbert, O., Ilić, S., Ingoglia, L., Iodice, E., Israel, H., Israelsson, U. E., Izzo, L., Jablonka, P., Jackson, N., Jacobson, J., Jafariyazani, M., Jahnke, K., Jain, B., Jansen, H., Jarvis, M. J., Jasche, J., Jauzac, M., Jeffrey, N., Jhabvala, M., Jimenez-Teja, Y., Muñoz, A. Jimenez, Joachimi, B., Johansson, P. H., Joudaki, S., Jullo, E., Kajava, J. J. E., Kang, Y., Kannawadi, A., Kansal, V., Karagiannis, D., Kärcher, M., Kashlinsky, A., Kazandjian, M. V., Keck, F., Keihänen, E., Kerins, E., Kermiche, S., Khalil, A., Kiessling, A., Kiiveri, K., Kilbinger, M., Kim, J., King, R., Kirkpatrick, C. C., Kitching, T., Kluge, M., Knabenhans, M., Knapen, J. H., Knebe, A., Kneib, J. -P., Kohley, R., Koopmans, L. V. E., Koskinen, H., Koulouridis, E., Kou, R., Kovács, A., Kovačić, I., Kowalczyk, A., Koyama, K., Kraljic, K., Krause, O., Kruk, S., Kubik, B., Kuchner, U., Kuijken, K., Kümmel, M., Kunz, M., Kurki-Suonio, H., Lacasa, F., Lacey, C. G., La Franca, F., Lagarde, N., Lahav, O., Laigle, C., La Marca, A., La Marle, O., Lamine, B., Lam, M. C., Lançon, A., Landt, H., Langer, M., Lapi, A., Larcheveque, C., Larsen, S. S., Lattanzi, M., Laudisio, F., Laugier, D., Laureijs, R., Laurent, V., Lavaux, G., Lawrenson, A., Lazanu, A., Lazeyras, T., Boulc'h, Q. Le, Brun, A. M. C. Le, Brun, V. Le, Leclercq, F., Lee, S., Graet, J. Le, Legrand, L., Leirvik, K. N., Jeune, M. Le, Lembo, M., Mignant, D. Le, Lepinzan, M. D., Lepori, F., Reun, A. Le, Leroy, G., Lesci, G. F., Lesgourgues, J., Leuzzi, L., Levi, M. E., Liaudat, T. I., Libet, G., Liebing, P., Ligori, S., Lilje, P. B., Lin, C. -C., Linde, D., Linder, E., Lindholm, V., Linke, L., Li, S. -S., Liu, S. J., Lloro, I., Lobo, F. S. N., Lodieu, N., Lombardi, M., Lombriser, L., Lonare, P., Longo, G., López-Caniego, M., Lopez, X. Lopez, Alvarez, J. Lorenzo, Loureiro, A., Loveday, J., Lusso, E., Macias-Perez, J., Maciaszek, T., Maggio, G., Magliocchetti, M., Magnard, F., Magnier, E. A., Magro, A., Mahler, G., Mainetti, G., Maino, D., Maiorano, E., Malavasi, N., Mamon, G. A., Mancini, C., Mandelbaum, R., Manera, M., Manjón-García, A., Mannucci, F., Mansutti, O., Outeiro, M. Manteiga, Maoli, R., Maraston, C., Marcin, S., Marcos-Arenal, P., Margalef-Bentabol, B., Marggraf, O., Marinucci, D., Marinucci, M., Markovic, K., Marleau, F. R., Marpaud, J., Martignac, J., Martín-Fleitas, J., Martin-Moruno, P., Martin, E. L., Martinelli, M., Martinet, N., Martin, H., Martins, C. J. A. P., Marulli, F., Massari, D., Massey, R., Masters, D. C., Matarrese, S., Matsuoka, Y., Matthew, S., Maughan, B. J., Mauri, N., Maurin, L., Maurogordato, S., McCarthy, K., McConnachie, A. W., McCracken, H. J., McDonald, I., McEwen, J. D., McPartland, C. J. R., Medinaceli, E., Mehta, V., Mei, S., Melchior, M., Melin, J. -B., Ménard, B., Mendes, J., Mendez-Abreu, J., Meneghetti, M., Mercurio, A., Merlin, E., Metcalf, R. B., Meylan, G., Migliaccio, M., Mignoli, M., Miller, L., Miluzio, M., Milvang-Jensen, B., Mimoso, J. P., Miquel, R., Miyatake, H., Mobasher, B., Mohr, J. J., Monaco, P., Monguió, M., Montoro, A., Mora, A., Dizgah, A. Moradinezhad, Moresco, M., Moretti, C., Morgante, G., Morisset, N., Moriya, T. J., Morris, P. W., Mortlock, D. J., Moscardini, L., Mota, D. F., Mottet, S., Moustakas, L. A., Moutard, T., Müller, T., Munari, E., Murphree, G., Murray, C., Murray, N., Musi, P., Nadathur, S., Nagam, B. C., Nagao, T., Naidoo, K., Nakajima, R., Nally, C., Natoli, P., Navarro-Alsina, A., Girones, D. Navarro, Neissner, C., Nersesian, A., Nesseris, S., Nguyen-Kim, H. N., Nicastro, L., Nichol, R. C., Nielbock, M., Niemi, S. -M., Nieto, S., Nilsson, K., Noller, J., Norberg, P., Nouri-Zonoz, A., Ntelis, P., Nucita, A. A., Nugent, P., Nunes, N. J., Nutma, T., Ocampo, I., Odier, J., Oesch, P. A., Oguri, M., Oliveira, D. Magalhaes, Onoue, M., Oosterbroek, T., Oppizzi, F., Ordenovic, C., Osato, K., Pacaud, F., Pace, F., Padilla, C., Paech, K., Pagano, L., Page, M. J., Palazzi, E., Paltani, S., Pamuk, S., Pandolfi, S., Paoletti, D., Paolillo, M., Papaderos, P., Pardede, K., Parimbelli, G., Parmar, A., Partmann, C., Pasian, F., Passalacqua, F., Paterson, K., Patrizii, L., Pattison, C., Paulino-Afonso, A., Paviot, R., Peacock, J. A., Pearce, F. R., Pedersen, K., Peel, A., Peletier, R. F., Ibanez, M. Pellejero, Pello, R., Penny, M. T., Percival, W. J., Perez-Garrido, A., Perotto, L., Pettorino, V., Pezzotta, A., Pezzuto, S., Philippon, A., Pierre, M., Piersanti, O., Pietroni, M., Piga, L., Pilo, L., Pires, S., Pisani, A., Pizzella, A., Pizzuti, L., Plana, C., Polenta, G., Pollack, J. E., Poncet, M., Pöntinen, M., Pool, P., Popa, L. A., Popa, V., Popp, J., Porciani, C., Porth, L., Potter, D., Poulain, M., Pourtsidou, A., Pozzetti, L., Prandoni, I., Pratt, G. W., Prezelus, S., Prieto, E., Pugno, A., Quai, S., Quilley, L., Racca, G. D., Raccanelli, A., Rácz, G., Radinović, S., Radovich, M., Ragagnin, A., Ragnit, U., Raison, F., Ramos-Chernenko, N., Ranc, C., Rasera, Y., Raylet, N., Rebolo, R., Refregier, A., Reimberg, P., Reiprich, T. H., Renk, F., Renzi, A., Retre, J., Revaz, Y., Reylé, C., Reynolds, L., Rhodes, J., Ricci, F., Ricci, M., Riccio, G., Ricken, S. O., Rissanen, S., Risso, I., Rix, H. -W., Robin, A. C., Rocca-Volmerange, B., Rocci, P. -F., Rodenhuis, M., Rodighiero, G., Monroy, M. Rodriguez, Rollins, R. P., Romanello, M., Roman, J., Romelli, E., Romero-Gomez, M., Roncarelli, M., Rosati, P., Rosset, C., Rossetti, E., Roster, W., Rottgering, H. J. A., Rozas-Fernández, A., Ruane, K., Rubino-Martin, J. A., Rudolph, A., Ruppin, F., Rusholme, B., Sacquegna, S., Sáez-Casares, I., Saga, S., Saglia, R., Sahlén, M., Saifollahi, T., Sakr, Z., Salvalaggio, J., Salvaterra, R., Salvati, L., Salvato, M., Salvignol, J. -C., Sánchez, A. G., Sanchez, E., Sanders, D. B., Sapone, D., Saponara, M., Sarpa, E., Sarron, F., Sartori, S., Sartoris, B., Sassolas, B., Sauniere, L., Sauvage, M., Sawicki, M., Scaramella, R., Scarlata, C., Scharré, L., Schaye, J., Schewtschenko, J. A., Schindler, J. -T., Schinnerer, E., Schirmer, M., Schmidt, F., Schmidt, M., Schneider, A., Schneider, M., Schneider, P., Schöneberg, N., Schrabback, T., Schultheis, M., Schulz, S., Schuster, N., Schwartz, J., Sciotti, D., Scodeggio, M., Scognamiglio, D., Scott, D., Scottez, V., Secroun, A., Sefusatti, E., Seidel, G., Seiffert, M., Sellentin, E., Selwood, M., Semboloni, E., Sereno, M., Serjeant, S., Serrano, S., Setnikar, G., Shankar, F., Sharples, R. M., Short, A., Shulevski, A., Shuntov, M., Sias, M., Sikkema, G., Silvestri, A., Simon, P., Sirignano, C., Sirri, G., Skottfelt, J., Slezak, E., Sluse, D., Smith, G. P., Smith, L. C., Smith, R. E., Smit, S. J. A., Soldano, F., Solheim, B. G. B., Sorce, J. G., Sorrenti, F., Soubrie, E., Spinoglio, L., Mancini, A. Spurio, Stadel, J., Stagnaro, L., Stanco, L., Stanford, S. A., Starck, J. -L., Stassi, P., Steinwagner, J., Stern, D., Stone, C., Strada, P., Strafella, F., Stramaccioni, D., Surace, C., Sureau, F., Suyu, S. H., Swindells, I., Szafraniec, M., Szapudi, I., Taamoli, S., Talia, M., Tallada-Crespí, P., Tanidis, K., Tao, C., Tarrío, P., Tavagnacco, D., Taylor, A. N., Taylor, J. E., Taylor, P. L., Teixeira, E. M., Tenti, M., Idiago, P. Teodoro, Teplitz, H. I., Tereno, I., Tessore, N., Testa, V., Testera, G., Tewes, M., Teyssier, R., Theret, N., Thizy, C., Thomas, P. D., Toba, Y., Toft, S., Toledo-Moreo, R., Tolstoy, E., Tommasi, E., Torbaniuk, O., Torradeflot, F., Tortora, C., Tosi, S., Tosti, S., Trifoglio, M., Troja, A., Trombetti, T., Tronconi, A., Tsedrik, M., Tsyganov, A., Tucci, M., Tutusaus, I., Uhlemann, C., Ulivi, L., Urbano, M., Vacher, L., Vaillon, L., Valageas, P., Valdes, I., Valentijn, E. A., Valenziano, L., Valieri, C., Valiviita, J., Broeck, M. Van den, Vassallo, T., Vavrek, R., Vega-Ferrero, J., Venemans, B., Venhola, A., Ventura, S., Kleijn, G. Verdoes, Vergani, D., Verma, A., Vernizzi, F., Veropalumbo, A., Verza, G., Vescovi, C., Vibert, D., Viel, M., Vielzeuf, P., Viglione, C., Viitanen, A., Villaescusa-Navarro, F., Vinciguerra, S., Visticot, F., Voggel, K., von Wietersheim-Kramsta, M., Vriend, W. J., Wachter, S., Walmsley, M., Walth, G., Walton, D. M., Walton, N. A., Wander, M., Wang, L., Wang, Y., Weaver, J. R., Weller, J., Wetzstein, M., Whalen, D. J., Whittam, I. H., Widmer, A., Wiesmann, M., Wilde, J., Williams, O. R., Winther, H. -A., Wittje, A., Wong, J. H. W., Wright, A. H., Yankelevich, V., Yeung, H. W., Yoon, M., Youles, S., Yung, L. Y. A., Zacchei, A., Zalesky, L., Zamorani, G., Vitorelli, A. Zamorano, Marc, M. Zanoni, Zennaro, M., Zerbi, F. M., Zinchenko, I. A., Zoubian, J., Zucca, E., and Zumalacarregui, M.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Astrophysics of Galaxies, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The current standard model of cosmology successfully describes a variety of measurements, but the nature of its main ingredients, dark matter and dark energy, remains unknown. Euclid is a medium-class mission in the Cosmic Vision 2015-2025 programme of the European Space Agency (ESA) that will provide high-resolution optical imaging, as well as near-infrared imaging and spectroscopy, over about 14,000 deg^2 of extragalactic sky. In addition to accurate weak lensing and clustering measurements that probe structure formation over half of the age of the Universe, its primary probes for cosmology, these exquisite data will enable a wide range of science. This paper provides a high-level overview of the mission, summarising the survey characteristics, the various data-processing steps, and data products. We also highlight the main science objectives and expected performance., Comment: Accepted for publication in the A&A special issue`Euclid on Sky'

Published
2024

3. Cosmological constraints from the Chandra-Planck galaxy cluster sample

Author

Aymerich, G., Douspis, M., Pratt, G. W., Salvati, L., Soubrié, E., Andrade-Santos, F., Forman, W., Jones, C., Aghanim, N., Kraft, R., and van Weeren, R. J.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We provide a new $Y_{SZ} - M_{500}^{Y_X}$ scaling relation using a sample of clusters from the Planck Early Sunyaev-Zeldovich (ESZ) catalogue observed in X-rays by Chandra, and compare it to the results of the Planck collaboration from XMM-Newton observations of a subsample of the ESZ. We calibrate a mass bias for a subset of the Planck cosmological cluster sample using published weak-lensing data from the Canadian Cluster Cosmology Project and Multi Epoch Nearby Cluster Survey, for the new scaling relation as well as that from the Planck collaboration. We propose a novel method to account for selection effects and find a mass bias of $(1-b)=0.89\pm0.04$ for the new scaling relation, and $(1-b)=0.76\pm0.04$ for the Planck scaling relation. With these mass biases, we obtain $Y_{SZ} - M_{500}$ scaling relations that we apply to the full Planck cosmological cluster sample, to obtain new constraints on the cosmological parameters. We find fully consistent constraints regardless of the X-ray sample used, with $\sigma_8 = 0.77\pm0.02$, $\Omega_m = 0.31\pm0.02$ and $S_8 \equiv \sigma_8 \sqrt{\Omega_m / 0.3}=0.78\pm0.02$. We also provide constraints with a redshift evolution of the scaling relation fitted from the data instead of fixing it to the self-similar value. We find a redshift evolution significantly deviating from the self-similar value, leading to a higher value of $S_8=0.81\pm0.02$. We compare our results to those from recent analyses based on various cosmological probes, and find that our $S_8$ constraints are competitive with the tightest constraints from the literature. When assuming a self-similar redshift evolution, our constraints are in agreement with most late time probes and in tension with constraints from the CMB primary anisotropies. When fitting the redshift evolution from the data, we find no significant tension with results from either late time probes or the CMB., Comment: 16 pages, 17 figures, submitted to A&A

Published
2024

4. SPT Clusters with DES and HST Weak Lensing. II. Cosmological Constraints from the Abundance of Massive Halos

Author

Bocquet, S., Grandis, S., Bleem, L. E., Klein, M., Mohr, J. J., Schrabback, T., Abbott, T. M. C., Ade, P. A. R., Aguena, M., Alarcon, A., Allam, S., Allen, S. W., Alves, O., Amon, A., Anderson, A. J., Annis, J., Ansarinejad, B., Austermann, J. E., Avila, S., Bacon, D., Bayliss, M., Beall, J. A., Bechtol, K., Becker, M. R., Bender, A. N., Benson, B. A., Bernstein, G. M., Bhargava, S., Bianchini, F., Brodwin, M., Brooks, D., Bryant, L., Campos, A., Canning, R. E. A., Carlstrom, J. E., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., Castander, F. J., Cawthon, R., Chang, C. L., Chang, C., Chaubal, P., Chen, R., Chiang, H. C., Choi, A., Chou, T-L., Citron, R., Moran, C. Corbett, Cordero, J., Costanzi, M., Crawford, T. M., Crites, A. T., da Costa, L. N., Pereira, M. E. S., Davis, C., Davis, T. M., DeRose, J., Desai, S., de Haan, T., Diehl, H. T., Dobbs, M. A., Dodelson, S., Doux, C., Drlica-Wagner, A., Eckert, K., Elvin-Poole, J., Everett, S., Everett, W., Ferrero, I., Ferté, A., Flores, A. M., Frieman, J., Gallicchio, J., García-Bellido, J., Gatti, M., George, E. M., Giannini, G., Gladders, M. D., Gruen, D., Gruendl, R. A., Gupta, N., Gutierrez, G., Halverson, N. W., Harrison, I., Hartley, W. G., Herner, K., Hinton, S. R., Holder, G. P., Hollowood, D. L., Holzapfel, W. L., Honscheid, K., Hrubes, J. D., Huang, N., Hubmayr, J., Huff, E. M., Huterer, D., Irwin, K. D., James, D. J., Jarvis, M., Khullar, G., Kim, K., Knox, L., Kraft, R., Krause, E., Kuehn, K., Kuropatkin, N., Kéruzoré, F., Lahav, O., Lee, A. T., Leget, P. -F., Li, D., Lin, H., Lowitz, A., MacCrann, N., Mahler, G., Mantz, A., Marshall, J. L., McCullough, J., McDonald, M., McMahon, J. J., Mena-Fernández, J., Menanteau, F., Meyer, S. S., Miquel, R., Montgomery, J., Myles, J., Natoli, T., Navarro-Alsina, A., Nibarger, J. P., Noble, G. I., Novosad, V., Ogando, R. L. C., Omori, Y., Padin, S., Pandey, S., Paschos, P., Patil, S., Pieres, A., Malagón, A. A. Plazas, Porredon, A., Prat, J., Pryke, C., Raveri, M., Reichardt, C. L., Roberson, J., Rollins, R. P., Romero, C., Roodman, A., Ruhl, J. E., Rykoff, E. S., Saliwanchik, B. R., Salvati, L., Sánchez, C., Sanchez, E., Cid, D. Sanchez, Saro, A., Schaffer, K. K., Secco, L. F., Sevilla-Noarbe, I., Sharon, K., Sheldon, E., Shin, T., Sievers, C., Smecher, G., Smith, M., Somboonpanyakul, T., Sommer, M., Stalder, B., Stark, A. A., Stephen, J., Strazzullo, V., Suchyta, E., Tarle, G., To, C., Troxel, M. A., Tucker, C., Tutusaus, I., Varga, T. N., Veach, T., Vieira, J. D., Vikhlinin, A., von der Linden, A., Wang, G., Weaverdyck, N., Weller, J., Whitehorn, N., Wu, W. L. K., Yanny, B., Yefremenko, V., Yin, B., Young, M., Zebrowski, J. A., Zhang, Y., Zohren, H., and Zuntz, J.

Subjects
Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

We present cosmological constraints from the abundance of galaxy clusters selected via the thermal Sunyaev-Zel'dovich (SZ) effect in South Pole Telescope (SPT) data with a simultaneous mass calibration using weak gravitational lensing data from the Dark Energy Survey (DES) and the Hubble Space Telescope (HST). The cluster sample is constructed from the combined SPT-SZ, SPTpol ECS, and SPTpol 500d surveys, and comprises 1,005 confirmed clusters in the redshift range $0.25-1.78$ over a total sky area of 5,200 deg$^2$. We use DES Year 3 weak-lensing data for 688 clusters with redshifts $z<0.95$ and HST weak-lensing data for 39 clusters with $0.6

Published
2024

5. Characterising galaxy clusters’ completeness function in Planck

Author

Gallo S., Douspis M., Soubrié E., and Salvati L.

Subjects
Physics, QC1-999
Abstract

Galaxy cluster number counts are an important probe to constrain cosmological parameters. One of the main ingredients of the analysis is the selection function, and in particular the completeness, associated to the cluster sample one is considering. Incorrectly characterising this function can lead to biases in the cosmological constraints. In this work we study the selection function of the Planck cosmological cluster catalogue. In particular, we detail the case in which the cluster model assumed in the detection method differs from the true galaxy clusters, both in terms of profile and shape. We find that varying the cluster pressure profile has a significant effect on the completeness, with clusters with steeper profiles producing a higher completeness than ones with flatter profiles. On the other hand, cluster shapes seem to have a smaller impact on the completeness.

Published
2024
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6. Cosmology with galaxy clusters: An improved multiwavelength analysis

Author

Aymerich G., Douspis M., Pratt G.W., Salvati L., Soubrié E., Andrade-Santos F., Forman W., and Jones C.

Subjects
Physics, QC1-999
Abstract

We provide a new scaling relation using a sample of clusters from a full re-observation by the X-ray Chandra telescope of the Planck ESZ catalogue, and compare it to the results of the Planck collaboration obtained from a smaller sample of XMM-Newton observations. We discuss the expected effects of the change of the scaling relation parameters on the cosmological constraints obtained from the Planck cluster sample, and the remaining steps to obtain final constraints from this new scaling relation.

Published
2024
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7. Constraining the mass and redshift evolution of the hydrostatic mass bias using the gas mass fraction in galaxy clusters

Author

Wicker R., Douspis M., Salvati L., and Aghanim N.

Subjects
Physics, QC1-999
Abstract

The gas mass fraction in galaxy clusters is a quantity which can be used as a robust cosmological probe. It is however subject to various effects from the baryonic physics inside galaxy clusters, which may bias the obtained cosmological constraints. Among different aspects of the baryonic physics, in these proceedings we focus on the impact of the hydrostatic equilibrium assumption. From X-ray measurements of cluster gas fraction in the Planck-ESZ sample, we analyse the hydrostatic mass bias B, constraining a possible mass and redshift evolution of this quantity and its impact on the cosmological constraints. We show a degeneracy between the redshift dependence of the bias and cosmological parameters. In particular we find a 3.8σ evidence for a redshift dependence of the bias when assuming a Planck prior on Ωm. On the other hand, assuming a constant mass bias would lead to the extreme large value of Ωm > 0.860. We however show these results to be depending on the mass and redshift selections inside the main sample. Nevertheless, in all the analyses we find a value for the amplitude of the bias that is consistent with B ∼ 0.8, as expected from hydrodynamical simulations and local measurements, but still in tension with the low value of B ∼ 0.6 derived from the combination of cosmic microwave background primary anisotropies with cluster number counts. We also discuss cosmological constraints obtained from gas fraction data, combined with other probes like cluster number counts.

Published
2024
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8. Planck and SPT cluster catalogs: A combined analysis

Author

Salvati L.

Subjects
Physics, QC1-999
Abstract

We show the results for the first combined analysis of clusters detected by the Planck satellite and the South Pole Telescope. The combination of these two experiments, with different resolution, mass and redshift range, allows to track the full cosmological evolution of galaxy clusters and the interplay between astrophysics and cosmology. In particular, we exploit the cosmological constraining power of SPT-SZ clusters to provide an independent calibration of Planck scaling relations, and therefore a new estimation of Planck cluster masses. Combining the two cluster catalogs we are thus able to test the hypotheses of self-similarity and hydrostatic equilibrium. We show therefore the huge potentiality of combining catalogs from different experiments, in improving the cosmological analysis and the treatment of different astrophysical and systematic uncertainties.

Published
2024
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10. Effect of antimetabolite regimen on cellular and humoral immune response to SARS-COV-2 vaccination in solid organ transplant recipients.

Author

Capone M, Vanni A, Salvati L, Lamacchia G, Mazzoni A, Maggi L, Cosmi L, Liotta F, Romagnani P, Cirillo L, Buti E, Terlizzi V, Azzari C, Citera F, Barbati F, Rossolini GM, Bresci S, Borchi B, Cavallo A, Mencarini J, Francalanci E, Kiros ST, Bartoloni A, and Annunziato F

Subjects
Humans, Male, Female, Adult, Vaccination, Middle Aged, Cystic Fibrosis immunology, Immunologic Memory, Organ Transplantation adverse effects, Kidney Transplantation adverse effects, Lung Transplantation adverse effects, Immunization, Secondary, Immunity, Humoral, COVID-19 immunology, COVID-19 prevention & control, SARS-CoV-2 immunology, Transplant Recipients, Immunosuppressive Agents therapeutic use, COVID-19 Vaccines immunology, COVID-19 Vaccines administration & dosage, Immunocompromised Host, Immunity, Cellular, Antibodies, Viral immunology, Antibodies, Viral blood
Abstract

Objective: Novel mRNA-based vaccines have been proven to be powerful tools in combating the global pandemic caused by SARS-CoV-2 protecting individuals, especially the immunocompromised, from COVID-19. Still, it remains largely unknown how solid organ transplant and different immunosuppressive medications affect development of vaccine-induced immunity., Methods: In this work, we monitored humoral and cellular memory responses after mRNA SARS-CoV-2 two-doses and booster doses vaccination in cystic fibrosis lung transplanted patients (CFT) and compared them with both cystic fibrosis patients without lung transplant (CF) and with kidney transplant recipients (KT). In particular, we investigated the effects of immunosuppressive regimens on immune memory to SARS-CoV-2 after mRNA SARS-CoV-2 vaccine in transplanted patients., Results: Our results showed that immunocompromised transplanted patients displayed a weak cellular and humoral memory to SARS-CoV-2 mRNA vaccination. In addition, obtained data clearly demonstrate that immunosuppressive therapy regimen including antimetabolites, further reduces patients' ability to respond to vaccination at both humoral and cell-mediated level. Notably, patient treated with antimetabolites showed a lower humoral and cellular response also after a booster dose vaccination., Conclusion: These results, even if obtained on a small patient's cohort, question whether immunocompromised patients need interventions to improve vaccine SARS-CoV-2 mRNA vaccine response such as additional jab or modulation of immunosuppressive therapy., Competing Interests: Declaration of competing interest Regarding the submission of our manuscript entitled “Effect of antimetabolite regimen on cellular and humoral immune response to SARS-COV-2 vaccination in solid organ transplant recipients”, I'm writing to confirm that the authors declare that they have no conflict of interest., (Copyright © 2024. Published by Elsevier B.V.)

Published
2024
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12. Disseminated nocardiosis and anti-GM-CSF antibodies.

Author

Brugnoli B, Salvati L, Di Lauria N, Botta A, Tozzetti C, Biscarini A, Capone M, Ferrentino F, Naldi C, Ascione G, Mazzoni A, Maggi L, Campo I, Carey B, Trapnell B, Liotta F, Cosmi L, Bartoloni A, Annunziato F, Parronchi P, and Palterer B

Subjects
Humans, Female, Middle Aged, Nocardia Infections diagnosis, Nocardia Infections immunology, Nocardia Infections microbiology, Nocardia Infections drug therapy, Autoantibodies blood, Autoantibodies immunology, Granulocyte-Macrophage Colony-Stimulating Factor immunology, Nocardia immunology
Abstract

Infections that are unusually severe or caused by opportunistic pathogens are a hallmark of primary immunodeficiency (PID). Anti-cytokine autoantibodies (ACA) are an emerging cause of acquired immunodeficiency mimicking PID. Nocardia spp. are Gram-positive bacteria generally inducing disseminated infections in immunocompromised patients, but seldom also occurring in apparently immunocompetent hosts. Anti-GM-CSF autoantibodies are associated with autoimmune pulmonary alveolar proteinosis (PAP). In those patients, an increased incidence of disseminated nocardiosis and cryptococcosis has been observed. It is unclear whether the PAP or the autoantibodies predispose to the infection. We report an apparently immunocompetent woman presenting with disseminated nocardiosis without any evidence of PAP. Clinical data and radiological images were retrospectively collected. Lymphocyte populations were analyzed by flow cytometry. Anti-GM-CSF autoantibodies were measured by ELISA. A 55-year-old otherwise healthy woman presented with cerebral and pulmonary abscesses. Personal and familial history of infections or autoimmunity were negative. After extensive examinations, a final diagnosis of disseminated nocardiosis was made. Immunologic investigations including neutrophilic function and IFN-γ/IL-12 circuitry failed to identify a PID. Whole-exome sequencing did not find pathogenic variants associated with immunodeficiency. Serum anti-GM-CSF autoantibodies were positive. There were no clinical or instrumental signs of PAP. Trimethoprim-sulfamethoxazole and imipenem were administered, with progressive improvement and recovery of the infectious complication. We identified anti-GM-CSF autoantibodies as the cause of disseminated nocardiosis in a previously healthy and apparently immunocompetent adult. This case emphasizes the importance of including ACA in the differential diagnosis of PID, especially in previously healthy adults. Importantly, anti-GM-CSF autoantibodies can present with disseminated nocardiosis without PAP., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Published
2024
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13. Pembrolizumab-associated anti-MDA5 dermatomyositis in a patient with lung cancer: a first case report.

Author

Pilia AM, Salvati L, Guidolin A, Mazzoni F, Antonuzzo L, Parronchi P, and Liotta F

Subjects
Humans, Male, Middle Aged, Autoantibodies, Interferon-Induced Helicase, IFIH1 immunology, Antibodies, Monoclonal, Humanized adverse effects, Antibodies, Monoclonal, Humanized therapeutic use, Dermatomyositis chemically induced, Dermatomyositis immunology, Lung Diseases, Interstitial chemically induced, Lung Diseases, Interstitial diagnosis, Lung Neoplasms drug therapy, Lung Neoplasms complications
Abstract

We report the first case of anti-melanoma differentiation-associated gene 5 (MDA5)-positive dermatomyositis as a systemic immune-related adverse event in a 64-year-old man receiving pembrolizumab to treat advanced lung cancer. The patient experienced hypothyroidism, myalgia, skin involvement, dyspnoea and diarrhoea. Laboratory tests revealed raised inflammatory markers, hypercreatinekinasemia and anti-MDA5 autoantibodies. Electroneuromyography and pathognomonic signs on physical examination confirmed the diagnosis of pauci-myopathic dermatomyositis. Pembrolizumab was discontinued and immunosuppressive therapy led to rapid and progressive improvement, with complete remission of dermatomyositis. This case report widens the spectrum of systemic immune-related adverse events associated with pembrolizumab.

Published
2024
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14. Farm forests, seasonal hunger, and biomass poverty: Evidence of induced intensification from panel data in the Ethiopian Highlands.

Author

Morrow N, Mock NB, Gatto A, Colantoni A, and Salvati L

Subjects
Humans, Female, Farms, Ethiopia, Seasons, Biomass, Food Supply, Poverty, Hunger
Abstract

Seasonal hunger is the most common food insecurity experience for millions of small dryland farmers. This study tests the relationships between food insecurity, farm forests, and biomass poverty using a longitudinal dataset from the Amhara region of Ethiopia. These data form part of the Ethiopia Socioeconomic Survey, which collected panel data over three survey rounds from 530 households between 2011 and 2016. This dataset represents a collection of unique socioeconomic, wellbeing, and micro-land use measures, including farm forests. Hierarchical mixed effect regression models assessed the relationship between food insecurity and farm forests as well as the conditional effects of biomass poverty among the poorest farmers and women-headed households. Over a six-year study period, farmers reported increased stress from smaller land holdings, higher prices, and climate-related shocks. A clear trend towards spontaneous dispersed afforestation is observed by both researchers and satellite remote sensing. Model results indicate, dedicating approximately 10% of farm area to forest reduces months of food insecurity by half. The greatest reductions in food insecurity from farm forests are reported by ultra-poor and crop residue-burning households, suggesting that biomass poverty may be a major constraint to resilient food security on these farms. This research provides novel quantitative evidence of induced intensification and food security impacts of farm management preserving and building stores of biomass value as green assets. The results reported here have important implications for nature-based solutions as a major strategy to achieve sustainable development in some contexts., (© 2023. The Author(s).)

Published
2024
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15. Presentation and progression of MPO-ANCA interstitial lung disease.

Author

Salvati L, Palterer B, Lazzeri E, Vivarelli E, Amendola M, Allinovi M, Caroti L, Mazzoni A, Lasagni L, Emmi G, Cavigli E, Del Carria M, Di Pietro L, Scavone M, Cammelli D, Lavorini F, Tomassetti S, Rosi E, and Parronchi P

Abstract

The association between MPO-ANCA-associated vasculitis (AAV) and interstitial lung disease (ILD) has been well established. Pulmonary fibrosis may coexist with, follow, or even precede the diagnosis of AAV, and its presence adversely affects the prognosis. The optimal approach to investigating ANCA in patients with ILD remains a subject of ongoing debate. Here we aim to describe presentation and progression of MPO-ANCA ILD. We conducted a retrospective evaluation of a cohort of individuals diagnosed with MPO-ANCA ILD, with or without accompanying renal impairment, at the Immunology and Cell Therapy Unit, Careggi University Hospital, Florence, Italy, between June 2016 and June 2022. Clinical records, imaging studies, pathologic examinations, and laboratory test results were collected. Among the 14 patients identified with MPO-ANCA ILD, we observed a significant association between MPO-ANCA titers assessed at the time of ILD diagnosis and renal involvement. Renal impairment in these cases often manifested as subclinical or slowly progressive kidney damage. Interestingly, complement C3 deposits were consistently found in all renal biopsy specimens, thereby suggesting the potential for novel therapeutic targets in managing renal complications associated with MPO-ANCA ILD. The presentation of MPO-ANCA vasculitis as ILD can be the first and only clinical manifestation. MPO-ANCA levels at ILD diagnosis could warn on the progression to renal involvement in patients with MPO-ANCA ILD, hence caution is needed because renal disease can be subclinical or smoldering., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)

Published
2024
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16. The importance of caregivers for patients with advanced basal cell carcinoma treated with hedgehog-pathway inhibitors: an observational prospective study.

Author

Trane L, Salvati L, Silvestri F, Venturi F, Zuccaro B, Perillo G, and De Giorgi V

Subjects
Male, Female, Humans, Aged, Prospective Studies, Caregivers, Hedgehog Proteins metabolism, Pyridines adverse effects, Anilides therapeutic use, Skin Neoplasms pathology, Carcinoma, Basal Cell pathology, Antineoplastic Agents therapeutic use
Abstract

Oral targeted therapy with hedgehog pathway inhibitors has revolutionized the standard of care for patients with advanced basal cell carcinoma (BCC). These patients are frail and elderly, have various comorbidities, and receive pharmacological polytherapy. Moreover, adverse events may have a significant impact on therapeutic adherence, which must be managed by the clinician. We evaluated the impact of caregivers on the treatment of patients with advanced BCC in terms of continuation of therapy over time. All patients included in this observational prospective study had histologically confirmed metastatic or locally advanced BCC (LaBCC) and were treated with hedgehog pathway inhibitors from January 2016 to December 2021 at the Department of Dermatology at the University of Florence, Italy. The collected patient data included: age, sex, BCC site and area of spread; number of cycles, dose, duration and tolerability of therapy; marital status (single, divorced, married/living with a partner, widow/widower); and information such as living with someone, and the presence of any caregivers. Of the 34 patients included, 33 had LaBCC and one metastatic BCC. There were 11 females (32.4%) and 23 males (67.6%). Patients who were married or living with a caregiver -tolerated therapy better than single patients who lived alone. Indeed, patients with married/live-in caregivers and/or those with an adequate caregiver experienced greater therapeutic adherence and tolerance of adverse events. Given the greater therapeutic adherence of patients with live-in caregivers as partners, it is essential to consider patients' marital status. It is advisable to involve the caregiver early on, and there should be a training discussion on the various possible adverse events and the best way to mitigate them. Therapeutic success is linked not only to patients being informed but also to training of caregivers.

Published
2024
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17. Optimization of the diagnosis and characterization of gibberellin-regulated protein sensitization: An Italian cohort study.

Author

Cecchi L, Poncet P, Maltagliati L, Carli G, Macchia D, Maggi L, Meucci E, Parronchi P, Mazzoni A, Salvati L, Scala E, Sénéchal H, Aizawa T, Villalta D, Annunziato F, Cosmi L, and Farsi A

Subjects
Humans, Plant Proteins, Antigens, Plant, Gibberellins, Cohort Studies, Allergens, Immunoglobulin E, Italy, Food Hypersensitivity diagnosis, Prunus persica adverse effects
Abstract

Background: Pru p 7 was the first gibberellin-regulated protein (GRP) to be identified as a food allergen as the basis of a pollen food allergy syndrome., Objective: To clinically and biologically characterize a group of patients with suspected allergy to Pru p 7 to optimize the diagnostic workup of GRP sensitization., Methods: Allergy to Pru p 7 was suspected in the presence of a systemic allergic reaction to plant food, positive skin prick test results for cypress pollen and lipid-transfer protein-enriched peach extract, and absence of Pru p 3-specific immunoglobulin E. Controls were patients with food allergies, patients sensitized to Pru p 3, and patients with cypress allergy without food allergy. Diagnostic workup included skin tests, basophil activation test, Western blot, and single and multiplex assays., Results: In total, 23 patients and 14 controls were enrolled. The most implicated food was peach (91.3%). Approximately 70% of patients reacted to multiple foods. Mueller 4 reactions were 8.7%. In 26.1% of cases, a cofactor triggered the reaction. The basophil activation test results were positive for rPru p 7 in 87% of the patients. Specific immunoglobulin E to Pru p 7 was detected in 95.7% by singleplex and in 73.9% by multiplex assays in patients with suspected allergies; 73.9% of them also reacted to cypress pollen GRP (Cup s 7) in Western blot analysis., Conclusion: Patients with Pru p 7-Cup s 7 allergy in our cohort confirm a mild-to-severe clinical syndrome characterized by pollen and food allergy. The diagnosis may benefit from the proposed selection criteria that can be used as preliminary steps to further characterize the cross-reactive GRP sensitization., (Copyright © 2023 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)

Published
2024
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