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Uric acid (UA) levels are significant in the monitoring of human health, making their detection very important. In this paper, a simple and innovative electrochemical method for the detecting UA was established, using a sensing platform based on hybrid electrodes of Nickel-Metal Organic Framework (Ni-MOF) and carboxylated multi-walled carbon nanotubes (MWCNTs-COOH). Detailed investigations into the electrocatalytic activity of Ni-MOF/MWCNTs-COOH/GCE for The Ni-MOF/MWCNTs-COOH exhibited remarkable catalytic activity for UA oxidation. The detection limit was 0.005μM, with a sensitivity calculation result of 6.377µAµM-1, and a wide linearity interval (0.03 - 10μM, 10 - 300μM). Utilizing its high sensitivity and selectivity, this sensor was used for the measurement of UA in biological fluids, including human serum and urine samples, recovery amounts being 96.6 - 100.8%, and 98.9 - 101.3%. This work is highly significant; offering new perspectives for the application of Ni-MOF based chemical sensors in the realms of environmental monitoring and healthcare.

A novel and facile electrochemical determination of Sertraline at nanomolar concentration using bimetallic MXene NbTiCTxand MWCNTs hybridized electrodes as sensing platforms is demonstrated. NbTiCTx/MWCNTs composites were produced by etching NbTiAlC to obtain NbTiCTx, and ultrasonically mixing this with MWCNTs. An electrochemical sensor based on NbTiCTx/MWCNTs nanocomposite modified (NbTiCTx/MWCNTs/GCE) was constructed, for use in the sensitive detection of Sertraline (SER). The successful preparation of NbTiCTx/MWCNTs and the electrochemical performance of the electrodes were verified by Scanning electron microscopy, X-ray diffraction, cyclic voltammetry and electrochemical impedance characterization methods. The experimental results show that NbTiCTx/MWCNTs/GCE can increase the SER oxidation peak current, with two good linear relationships (R2 = 0.9910 and 0.9967) between the current and the concentration of SER (5.0–10.0 μM and 10.0–100.0 μM), with a detection limit of 0.16 μM (S/N = 3). The sensor has good selectivity, repeatability, reproducibility and stability, and enables the sensitive determination of SER in human serum and urine samples of clinical biological fluids. It is believed that this work is significant and is of broad interest for work in innovative material development and biomedical applications.