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4 results on '"Yang, Baoli"'

1. Metformin is a potential therapeutic for COVID-19/LUAD by regulating glucose metabolism.

Author

Hou, Yongwang, Yang, Zhicong, Xiang, Baoli, Liu, Jiangmin, Geng, Lina, Xu, Dandan, Zhan, Minghua, Xu, Yuhuan, and Zhang, Bin

Subjects
METFORMIN, GLUCOSE metabolism, PI3K/AKT/MTOR pathway, COVID-19, CELLULAR signal transduction, INHIBITION of cellular proliferation, ENERGY metabolism
Abstract

Lung adenocarcinoma (LUAD) is the most common and aggressive subtype of lung cancer, and coronavirus disease 2019 (COVID-19) has become a serious public health threat worldwide. Patients with LUAD and COVID-19 have a poor prognosis. Therefore, finding medications that can be used to treat COVID-19/LUAD patients is essential. Bioinformatics analysis was used to identify 20 possible metformin target genes for the treatment of COVID-19/LUAD. PTEN and mTOR may serve as hub target genes of metformin. Metformin may be able to cure COVID-19/LUAD comorbidity through energy metabolism, oxidoreductase NADH activity, FoxO signalling pathway, AMPK signalling system, and mTOR signalling pathway, among other pathways, according to the results of bioinformatic research. Metformin has ability to inhibit the proliferation of A549 cells, according to the results of colony formation and proliferation assays. In A549 cells, metformin increased glucose uptake and lactate generation, while decreasing ATP synthesis and the NAD+/NADH ratio. In summary, PTEN and mTOR may be potential targets of metformin for the treatment of COVID-19/LUAD. The mechanism by which metformin inhibits lung adenocarcinoma cell proliferation may be related to glucose metabolism regulated by PI3K/AKT signalling and mTOR signalling pathways. Our study provides a new theoretical basis for the treatment of COVID-19/LUAD. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Findings from Nanjing Medical University Provide New Insights into Hepatitis C Virus (Diagnosis, Treatment, and Associated Factors Among Patients With Hcv Infection - Jiangsu Province, China, 2004-2020).

Subjects
HEPATITIS C virus, DIAGNOSIS, DIGESTIVE system diseases, INFECTION, RNA virus infections, HEPATITIS C
Abstract

A recent study conducted by Nanjing Medical University in Jiangsu Province, China, examined the diagnosis, treatment, and associated factors among individuals infected with the hepatitis C virus (HCV). The study found that there are still significant gaps in the diagnosis and treatment of HCV, leading to an increasing number of deaths related to the virus. The researchers emphasized the importance of timely diagnosis and increased uptake of HCV treatment in order to reduce the burden of HCV-related health problems and achieve the global target of eliminating hepatitis C. This research has been peer-reviewed and provides valuable insights into the current state of HCV in Jiangsu Province, China. [Extracted from the article]

Published
2024

3. Dreaming and Self-Cultivation in China, 300 BCE–800 CE

Author

Robert Ford Campany and Robert Ford Campany

Subjects
Dreams--History.--China, Dream interpretation--History--To 1500.--Chi, Buddhism--Discipline--History--To 1500.--C, Taoism--Discipline--History--To 1500.--Chi, Confucianism--Discipline--History--To 1500
Abstract

Practitioners of any of the paths of self-cultivation available in ancient and medieval China engaged daily in practices meant to bring their bodies and minds under firm control. They took on regimens to discipline their comportment, speech, breathing, diet, senses, desires, sexuality, even their dreams. Yet, compared with waking life, dreams are incongruous, unpredictable—in a word, strange. How, then, did these regimes of self-fashioning grapple with dreaming, a lawless yet ubiquitous domain of individual experience? In Dreaming and Self-Cultivation in China, 300 BCE–800 CE, Robert Ford Campany examines how dreaming was addressed in texts produced and circulated by practitioners of Daoist, Buddhist, Confucian, and other self-cultivational disciplines. Working through a wide range of scriptures, essays, treatises, biographies, commentaries, fictive dialogues, diary records, interpretive keys, and ritual instructions, Campany uncovers a set of discrete paradigms by which dreams were viewed and responded to by practitioners. He shows how these paradigms underlay texts of diverse religious and ideological persuasions that are usually treated in mutual isolation. The result is a provocative meditation on the relationship between individuals'nocturnal experiences and one culture's persistent attempts to discipline, interpret, and incorporate them into waking practice.

Published
2024

4. Findings from Nanjing Medical University Provide New Insights into Hepatitis C Virus (Diagnosis, Treatment, and Associated Factors Among Patients With Hcv Infection - Jiangsu Province, China, 2004-2020)

Subjects
Medical research -- Health aspects, Medicine, Experimental -- Health aspects, Hepatitis C virus -- Health aspects -- Research, Health
Abstract

2024 APR 22 (NewsRx) -- By a News Reporter-Staff News Editor at Hepatitis Weekly -- Current study results on Liver Diseases and Conditions - Hepatitis C Virus have been published. [...]

Published
2024

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