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1. Design, synthesis and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones as potent p53-MDM2 inhibitors

Author

Zhou, Wei-Huang, Xu, Xi-Guo, Li, Jin, Min, Xiao, Yao, Jian-Zhong, Dong, Guo-Qiang, Zhuang, Chun-Lin, Miao, Zhen-Yuan, and Zhang, Wan-Nian

Abstract

The optimization and structure–activity relationship of 4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones were performed in this manuscript. Most of the compounds showed higher PPI inhibitory activities and antiproliferative activities.

Published
2024
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