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Metal–organic frameworks (MOFs) have been widely studied as new materials, and many structural regulation strategies have been reported. We report a new defective-MOF design strategy that involves a continuous process of pore space partition, metal center exchange, and ligand removal. In the whole process, the single crystal of MOF is well maintained, which not only points out a rare and clear route for the structure transformation process but also provides an indirect synthesis method for defective materials, which cannot accurately control the vacancy position. It was interesting to find that the removal of the selected ligand endows the MOF with larger pores, higher stability and excellent performance in the selective adsorption and separation of C2H4/C3H6 mixtures and natural gas mixtures. [ABSTRACT FROM AUTHOR]

The pathogenesis of glioma has remained unclear. In this study, it was found that high expression of the outer dense fibers of sperm tail 3B (ODF3B) in gliomas was positively correlated with the grade of glioma. The higher the grade, the worse the prognosis. ODF3B is closely related to the growth and apoptosis of glioma. In terms of mechanism, ODF3B was found to affect the proliferation and apoptosis of glioma through the JAK1 and JAK2/STAT3 pathways. ODF3B was also found to affect the growth and apoptosis of glioma in vivo . We conclude that ODF3B affects glioma proliferation and apoptosis via the JAK/STAT pathway and is a potential therapeutic target., Competing Interests: None., (AJCR Copyright © 2024.)