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• Two-stage staggered time integrator with the Jacobi-Anger expansion is introduced. • The method can be twice as faster than the Taylor expansion based time integrator. • Accuracy condition is obtained to bound error of the solution within a preset level. • Optimal strategy for the method is to use allowable maximum time step length. In this study, we introduce a staggered time integrator with the Fourier pseudospectral method to solve the first-order linear wave equation, which is accelerated by using the Jacobi-Anger expansion. The proposed method can reduce the computational cost by approximately half compared to the scheme whose temporal order of accuracy is extended by the Lax-Wendroff method under the equivalent modeling conditions, such as time step length, grid interval and maximum wave propagation speed. This is because the Jacobi-Anger expansion can effectively approximate the sinusoidal function, which in our case is the sine function in the wavenumber domain. Based on the wavenumber domain analysis of the proposed method, a strategy to optimally design the simulation parameters to maintain a preset level of accuracy is also introduced. According to the strategy, as the time step length increases, not only the computational cost of the simulation is reduced, but also the accuracy of the numerical solution is improved. Numerical simulations are also performed by using both homogeneous and heterogeneous models to validate the introduced strategy, which supports the practicality of the proposed method. [ABSTRACT FROM AUTHOR]

To investigate whether dysregulated selection of autoreactive marginal zone (MZ) B cells is involved in autoimmune diseases, we examined MZ B cell profile in multiple strains of mice, and found that type II collagen (CII)-reactive autoreactive CD80 high MZ B cells spontaneously developed in the DBA/1, but not in C57BL/6 mice. CD80 high MZ B cells that were characteristically found in DBA/1 mice expressed higher levels of TACI, SLAM3, and SLAM6 than the usual CD80 low MZ B cells. Notably, the CD80 high MZ B cells were more sensitive to ibrutinib, a Bruton's tyrosine kinase inhibitor, than CD80 low MZ or follicular B cells and their transient depletion via intravenous injection of ibrutinib significantly delayed the induction of collagen-induced arthritis (CIA). In summary, we suggest that the positive selection of CII-reactive CD80 high MZ B cells is a critical homeostatic process predisposing the DBA/1 mice to the CIA induction. [ABSTRACT FROM AUTHOR]