1. Vision- and Health-Related Quality of Life in Patients With Behcet Uveitis
- Author
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Mehmet Akman, Sumru Onal, Haluk Kazokoglu, Fulya Savar, Onal, Sumru, Savar, Fulya, Akman, Mehmet, and Kazokoglu, Haluk
- Subjects
Adult ,Male ,medicine.medical_specialty ,Multivariate analysis ,Visual acuity ,Adolescent ,genetic structures ,SF-36 ,Health Status ,Eye disease ,Visual Acuity ,QUESTIONNAIRE ,Systemic therapy ,THERAPY ,DISEASE ,Uveitis ,Young Adult ,TURKISH VERSION ,Quality of life ,Sickness Impact Profile ,Surveys and Questionnaires ,Humans ,Medicine ,In patient ,Prospective Studies ,VALIDITY ,Vision, Ocular ,business.industry ,INTERFERON ALPHA-2A ,Behcet Syndrome ,Middle Aged ,medicine.disease ,Health Surveys ,CANCER ,eye diseases ,Ophthalmology ,RELIABILITY ,Quality of Life ,Behcet uveitis ,Physical therapy ,Educational Status ,Female ,medicine.symptom ,business - Abstract
Objective: To investigate vision- and health-related quality of life in patients with Behcet disease. Methods: Fifty-one consecutive patients with Behcet uveitis were enrolled in the study from January 1 through June 30, 2008. The National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25) and the 36-Item Short Form Health Survey (SF-36) were administered. Sociodemographic and clinical data were also collected. Main outcome measures were comparison of the NEI-VFQ-25 and SF-36 subscale item scores among subgroups and multivariate analysis of the NEI-VFQ-25 and SF-36 subscale item scores. Results: Patients rated the general health subscale score of the NEI-VFQ-25 and all subscale item scores of the SF-36 lower than the NEI-VFQ-25 subscales related to vision. The NEI-VFQ-25 subscale item scores showed significant differences with respect to age, educational level, Behcet uveitis activity and severity, and visual acuity in the better and worse eyes. The SF-36 subscale item scores revealed significant differences according to sex, educational level, and the systemic treatment used. In the best model of linear regression, independent variables accounted for 57.0% of the variance in the NEI-VFQ-25 subscale item (color vision subscale; adjusted R 2 =0.57, P < .001) and for only 23.0% of the variance in the SF-36 subscale item score (role limitation owing to emotional problems subscale; adjusted R 2 =0.23, P=.004). Conclusions: General health is more affected than visual functioning in patients with Behcet uveitis. Sociodemographic and clinical variables had a significant effect on vision- and health-related quality of life. Multivariate analysis of the NEI-VFQ-25 and SF-36 subscales revealed that each subscale item score is affected by additional factor(s) other than those analyzed here.
- Published
- 2010