1. The immunological synapse balances T cell receptor signaling and degradation
- Author
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Lee, Kyeong-Hee, Dinner, Aaron R., Tu, Chun, Campi, Gabriele, Raychaudhuri, Subhadip, Varma, Rajat, Sims, Tasha N., Burack, W. Richard, Wu, Hui, Wang, Julia, Kanagawa, Osami, Markiewicz, Mary, Allen, Paul M., Dustin, Michael L., Chakraborty, Arup K., and Shaw, Andrey S.
- Subjects
Immunology -- Research ,T cells -- Receptors ,Antigen receptors, T cell -- Research ,Cell research ,Science and technology ,Research - Abstract
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over hours. The role of this specific organization in signaling for T cell activation has been controversial. We use in vitro and in silico experiments to determine that the immunological synapse acts as a type of adaptive controller that both boosts T cell receptor triggering and attenuates strong signals., The mature immunological synapse is characterized by a reorganization of membrane proteins, resulting in a stable central cluster of T cell receptors (TCRs) (the C-SMAC) surrounded by a ring of [...]
- Published
- 2003