1. Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression.
- Author
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Jiaming Liu, Jia-Wen Mo, Xunda Wang, Ziqi An, Shuangyang Zhang, Can-Yuan Zhang, Peiwei Yi, Leong, Alex T. L., Jing Ren, Liang-Yu Chen, Ran Mo, Yuanyao Xie, Qianjin Feng, Wufan Chen, Tian-Ming Gao, Wu, Ed X., Yanqiu Feng, and Xiong Cao
- Subjects
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AMYGDALOID body , *NEURAL transmission , *FUNCTIONAL connectivity , *RESPIRATION , *MEDICAL sciences , *LIFE sciences - Abstract
The article presents a study which showed that the astrocytic calcium-deficient mice, inositol 1,4,5-trisphosphate-type-2 receptor knockout mice (Itpr2-/- mice), display abnormal resting-state functional magnetic resonance imaging (rsfMRI) functional connectivity (rsFC) in depression-related networks. Topics include characteristically consistent rsFC changes in major depressive disorder (MDD) patients and Itpr2-/- mice and data acquisition of resting-state fMRI and optogenetic fMRI experiments.
- Published
- 2022
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