28 results on '"Ying, Li"'
Search Results
2. Machine learning enables interpretable discovery of innovative polymers for gas separation membranes
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Jason Yang, Lei Tao, Jinlong He, Jeffrey R. McCutcheon, and Ying Li
- Subjects
Multidisciplinary - Abstract
Polymer membranes perform innumerable separations with far-reaching environmental implications. Despite decades of research, design of new membrane materials remains a largely Edisonian process. To address this shortcoming, we demonstrate a generalizable, accurate machine learning (ML) implementation for the discovery of innovative polymers with ideal performance. Specifically, multitask ML models are trained on experimental data to link polymer chemistry to gas permeabilities of He, H 2 , O 2 , N 2 , CO 2 , and CH 4 . We interpret the ML models and extract valuable insights into the contributions of different chemical moieties to permeability and selectivity. We then screen over 9 million hypothetical polymers and identify thousands that lie well above current performance upper bounds, including hundreds of never-before-seen ultrapermeable polymer membranes with O 2 and CO 2 permeability greater than 10 4 and 10 5 Barrers, respectively. High-fidelity molecular dynamics simulations confirm the ML-predicted gas permeabilities of the promising candidates, which suggests that many can be translated to reality.
- Published
- 2022
3. Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction.
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Yang Liu, Jing-jing Jiang, Shao-yue Du, Liang-shan Mu, Jian-jun Fan, Jun-chi Hu, Yao Ye, Meng Ding, Wei-yu Zhou, Qiu-han Yu, Yi-fan Xia, Hong-yu Xu, Yi-jie Shi, Shu-wen Qian, Yan Tang, Wei Li, Yong-jun Dang, Xi Dong, Xiao-ying Li, and Cong-jian Xu
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- 2024
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4. Low ABA concentration promotes root growth and hydrotropism through relief of ABA INSENSITIVE 1-mediated inhibition of plasma membrane H+-ATPase 2
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Yue Wang, Yiyong Zhu, Xiaolin Dang, Ying Li, Weifeng Xu, Jianhua Zhang, Wei Yuan, Rui Miao, Irene Garcia-Maquilon, and Pedro L. Rodriguez
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0106 biological sciences ,ATPase ,Mutant ,Arabidopsis ,Hydrotropism ,01 natural sciences ,Dephosphorylation ,03 medical and health sciences ,Phosphoprotein Phosphatases ,BIOQUIMICA Y BIOLOGIA MOLECULAR ,Research Articles ,030304 developmental biology ,0303 health sciences ,Multidisciplinary ,biology ,Arabidopsis Proteins ,Chemistry ,Plant Sciences ,Cell Membrane ,fungi ,Wild type ,SciAdv r-articles ,food and beverages ,Agriculture ,biology.organism_classification ,Apoplast ,Cell biology ,Proton-Translocating ATPases ,Seedlings ,biology.protein ,Efflux ,Research Article ,Abscisic Acid ,010606 plant biology & botany - Abstract
[EN] The hab1-1abi1-2abi2-2pp2ca-1 quadruple mutant (Qabi2-2) seedlings lacking key negative regulators of ABA signaling, namely, clade A protein phosphatases type 2C (PP2Cs), show more apoplastic H+ efflux in roots and display an enhanced root growth under normal medium or water stress medium compared to the wild type. The presence of low ABA concentration (0.1 micromolar), inhibiting PP2C activity via monomeric ABA receptors, enhances root apoplastic H+ efflux and growth of the wild type, resembling the Qabi2-2 phenotype in normal medium. Qabi2-2 seedlings also demonstrate increased hydrotropism compared to the wild type in obliquely-oriented hydrotropic experimental system, and asymmetric H+ efflux in root elongation zone is crucial for root hydrotropism. Moreover, we reveal that Arabidopsis ABA-insensitive 1, a key PP2C in ABA signaling, interacts directly with the C terminus of Arabidopsis plasma membrane H+-dependent adenosine triphosphatase 2 (AHA2) and dephosphorylates its penultimate threonine residue (Thr(947)), whose dephosphorylation negatively regulates AHA2., We are grateful for grant support from the National Key R&D Program of China (2017YFE0118100 and 2018YFD02003025), National Natural Science Foundation of China (nos. 31600209, 31761130073, and 31872169), a Newton Advanced Fellowship (NSFC-RS: NA160430), Fujian Province Education Department Funding (JK2017015), and Research Grant of FAFU (KXGH17005). Work in the laboratory of P.L.R. was supported by the Ministerio de Ciencia, Innovacion y Universidades (MICIU), grant BIO2017-82503-R.
- Published
- 2021
5. Ultrasensitive point-of-care biochemical sensor based on metal-AIEgen frameworks.
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Jiangjiang Zhang, Ying Li, Fengli Chai, Qizhen Li, Dou Wang, Liping Liu, Ben Zhong Tang, and Xingyu Jiang
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GOLD nanoparticles , *MATERIALS science , *HYDROGELS , *CLINICAL chemistry , *COORDINATION polymers , *POINT-of-care testing - Abstract
The article discusses point-of-care (POC) biochemical sensors have found broad applications in areas ranging from clinical diagnosis to environmental monitoring. However, POC sensors often suffer from poor sensitivity. Here, we synthesized a metal-organic framework, where the ligand is the aggregation-induced emission luminogen (AIEgen ), which we call metal-AIEgen frameworks (MAFs), for use in the ultrasensitive POC biochemical sensors.
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- 2022
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6. Synchronization of stochastic expressions drives the clustering of functionally related genes
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Yong Su Jin, Jianzhi Zhang, Zhen Liu, Ying Li, Haiqing Xu, and Jingjing Liu
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Saccharomyces cerevisiae Proteins ,Gene Expression ,Computational biology ,Saccharomyces cerevisiae ,Biology ,Genome ,Gas Chromatography-Mass Spectrometry ,03 medical and health sciences ,Galactokinase ,0302 clinical medicine ,Genetics ,Cluster Analysis ,Cluster analysis ,skin and connective tissue diseases ,Gene ,Research Articles ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,Multidisciplinary ,Models, Genetic ,food and beverages ,SciAdv r-articles ,Yeast ,Expression (mathematics) ,humanities ,Chromatin ,body regions ,Order (biology) ,Enzyme ,chemistry ,Multigene Family ,Galactitol ,sense organs ,030217 neurology & neurosurgery ,Research Article - Abstract
Merely changing the linkage of yeast GAL genes without altering the expression level of any gene toxifies the cell., Functionally related genes tend to be chromosomally clustered in eukaryotic genomes even after the exclusion of tandem duplicates, but the biological significance of this widespread phenomenon is unclear. We propose that stochastic expression fluctuations of neighboring genes resulting from chromatin dynamics are more or less synchronized such that their expression ratio is more stable than that for unlinked genes. Consequently, chromosomal clustering could be advantageous when the expression ratio of the clustered genes needs to stay constant, for example, because of the accumulation of toxic compounds when this ratio is altered. Evidence from manipulative experiments on the yeast GAL cluster, comprising three chromosomally adjacent genes encoding enzymes catalyzing consecutive reactions in galactose catabolism, unequivocally supports this hypothesis and elucidates how disorder in one biological phenomenon—gene expression noise—could prompt the emergence of order in another—genome organization.
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- 2019
7. Fear extinction requires ASIC1a-dependent regulation of hippocampal-prefrontal correlates
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Xing Lei Song, Tian Le Xu, Michael X. Zhu, Ying Li, Qin Wang, Siyu Zhang, Qi Wang, Ti-Fei Yuan, Yan Jiao Wu, Wei Guang Li, Nan-Jie Xu, and Qin Jiang
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0301 basic medicine ,Male ,Regulator ,Hippocampus ,Prefrontal Cortex ,Biology ,Hippocampal formation ,Extinction, Psychological ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Neurotrophic factors ,Memory ,Conditioning, Psychological ,medicine ,Basic Helix-Loop-Helix Transcription Factors ,Animals ,Prefrontal cortex ,Research Articles ,Regulation of gene expression ,Mice, Knockout ,Neurons ,Multidisciplinary ,Brain-Derived Neurotrophic Factor ,SciAdv r-articles ,Life Sciences ,social sciences ,Extinction (psychology) ,Fear ,humanities ,Acid Sensing Ion Channels ,Mice, Inbred C57BL ,030104 developmental biology ,medicine.anatomical_structure ,nervous system ,Gene Expression Regulation ,Neuroscience ,030217 neurology & neurosurgery ,Basolateral amygdala ,Research Article - Abstract
Learning to extinguish traumatic memory depends on fine-tuning of hippocampal-prefrontal connections via the ASIC1a channel., Extinction of conditioned fear necessitates the dynamic involvement of hippocampus, medial prefrontal cortex (mPFC), and basolateral amygdala (BLA), but key molecular players that regulate these circuits to achieve fear extinction remain largely unknown. Here, we report that acid-sensing ion channel 1a (ASIC1a) is a crucial molecular regulator of fear extinction, and that this function requires ASIC1a in ventral hippocampus (vHPC), but not dorsal hippocampus, mPFC, or BLA. While genetic disruption or pharmacological inhibition of ASIC1a in vHPC attenuated the extinction of conditioned fear, overexpression of the channel in this area promoted fear extinction. Channelrhodopsin-2–assisted circuit mapping revealed that fear extinction involved an ASIC1a-dependent modification of the long-range hippocampal-prefrontal correlates in a projection-specific manner. Gene expression profiling analysis and validating experiments identified several neuronal activity–regulated and memory-related genes, including Fos, Npas4, and Bdnf, as the potential mediators of ASIC1a regulation of fear extinction. Mechanistically, genetic overexpression of brain-derived neurotrophic factor (BDNF) in vHPC or supplement of BDNF protein in mPFC both rescued the deficiency in fear extinction and the deficits on extinction-driven adaptations of hippocampal-prefrontal correlates caused by the Asic1a gene inactivation in vHPC. Together, these results establish ASIC1a as a critical constituent in fear extinction circuits and thus a promising target for managing adaptive behaviors.
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- 2018
8. Impacts of species richness on productivity in a large-scale subtropical forest experiment
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Martin Baruffol, Tesfaye Wubet, Jingyun Fang, Liang-Dong Guo, Andreas Schuldt, Goddert von Oheimb, Thomas Scholten, Zhengwen Wang, Walter Durka, Jessica L. M. Gutknecht, Bing Yang Ding, Ying Li, Werner Härdtle, Jürgen Bauhus, Zhiyao Tang, David Eichenberg, Karsten Schmidt, Erik Welk, Helge Bruelheide, Wenhua Xiang, Kequan Pei, Jintang He, Hong-Zhang Zhou, Xiao-Yong Chen, Chao-Dong Zhu, Pascal A. Niklaus, Thorsten Behrens, Stefan Trogisch, Dali Guo, Alexandra-Maria Klein, Yuanyuan Huang, Nadia Castro-Izaguirre, Keping Ma, Shan Li, Caiyun He, Shouren Zhang, Ren Yong Hu, Yuxin Chen, Bo Yang, Stefan G. Michalski, Douglas Chesters, Markus Fischer, Anne C. Lang, Christian Wirth, Xin Yu, Xiaojuan Liu, Yu Liang, Sabine Both, Li Zhu, François Buscot, Xuefei Yang, Xuezheng Shi, Naili Zhang, Thorsten Assmann, Bernhard Schmid, Lydia Hönig, Peter Kühn, Alexandra Erfmeier, Andy Hector, Jiayong Zhang, Minjia Tan, Matteo Brezzi, Michael Scherer-Lorenzen, and Mingjian Yu
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0106 biological sciences ,Multidisciplinary ,Extinction ,010504 meteorology & atmospheric sciences ,ved/biology ,Ecology ,ved/biology.organism_classification_rank.species ,Biodiversity ,food and beverages ,580 Plants (Botany) ,Sustainability Science ,010603 evolutionary biology ,01 natural sciences ,Shrub ,Productivity (ecology) ,Afforestation ,Environmental science ,Ecosystem ,Species richness ,Tropical and subtropical moist broadleaf forests ,0105 earth and related environmental sciences - Abstract
Tree diversity improves forest productivity Experimental studies in grasslands have shown that the loss of species has negative consequences for ecosystem functioning. Is the same true for forests? Huang et al. report the first results from a large biodiversity experiment in a subtropical forest in China. The study combines many replicates, realistic tree densities, and large plot sizes with a wide range of species richness levels. After 8 years of the experiment, the findings suggest strong positive effects of tree diversity on forest productivity and carbon accumulation. Thus, changing from monocultures to more mixed forests could benefit both restoration of biodiversity and mitigation of climate change. Science , this issue p. 80
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- 2018
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9. CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation
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Xin Han, Zongbin Liu, Myeong chan Jo, Kai Zhang, Ying Li, Zihua Zeng, Nan Li, Youli Zu, and Lidong Qin
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Cell type ,animal structures ,viruses ,Cell ,02 engineering and technology ,Computational biology ,Biology ,Hard-to-transfect cells ,03 medical and health sciences ,Genome editing ,medicine ,CRISPR ,Research Articles ,030304 developmental biology ,Genetics ,0303 health sciences ,Multidisciplinary ,Cas9 ,fungi ,Gene targeting ,SciAdv r-articles ,Transfection ,021001 nanoscience & nanotechnology ,Embryonic stem cell ,medicine.anatomical_structure ,embryonic structures ,Microtechnology ,CRISPR-Cas9 ,0210 nano-technology ,Delivery ,Mechanical deformation ,Research Article - Abstract
Virus-free gene editing possible at chromosomes through stretching cells in a micropost array, even for hard-to-transfect cells., The CRISPR (clustered regularly interspaced short palindromic repeats)–Cas (CRISPR-associated) nuclease system represents an efficient tool for genome editing and gene function analysis. It consists of two components: single-guide RNA (sgRNA) and the enzyme Cas9. Typical sgRNA and Cas9 intracellular delivery techniques are limited by their reliance on cell type and exogenous materials as well as their toxic effects on cells (for example, electroporation). We introduce and optimize a microfluidic membrane deformation method to deliver sgRNA and Cas9 into different cell types and achieve successful genome editing. This approach uses rapid cell mechanical deformation to generate transient membrane holes to enable delivery of biomaterials in the medium. We achieved high delivery efficiency of different macromolecules into different cell types, including hard-to-transfect lymphoma cells and embryonic stem cells, while maintaining high cell viability. With the advantages of broad applicability across different cell types, particularly hard-to-transfect cells, and flexibility of application, this method could potentially enable new avenues of biomedical research and gene targeting therapy such as mutation correction of disease genes through combination of the CRISPR-Cas9–mediated knockin system.
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- 2015
10. Transgelin-2 as a therapeutic target for asthmatic pulmonary resistance.
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Yin, Lei-Miao, Xu, Yu-Dong, Peng, Ling-Ling, Duan, Ting-Ting, Liu, Jia-Yuan, Xu, Zhijian, Wang, Wen-Qian, Guan, Nan, Han, Xiao-Jie, Li, Hai-Yan, Pang, Yu, Wang, Yu, Chen, Zhaoqiang, Zhu, Weiliang, Deng, Linhong, Wu, Ying-Li, Ge, Guang-Bo, Huang, Shuang, Ulloa, Luis, and Yang, Yong-Qing
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ASTHMA treatment ,ASTHMATICS ,BRONCHODILATOR agents ,METALLOTHIONEIN ,DEPHOSPHORYLATION ,MYOSIN - Abstract
A transgelin-2 agonist relaxes airway smooth muscle cells and provides therapeutic advantages for asthma. Tickling transgelin-2 for asthma relief: Asthmatics can be refractive to β
2 -agonists, creating a need for new pathways to be targeted in this disease. Yin et al. discovered that the protein metallothionein-2 was able to reduce airway resistance in rodent asthma models. This improvement was mediated through transgelin-2, and they further studied a transgelin-2 agonist as a new asthma therapeutic. The agonist improved airway function in multiple preclinical asthma models and relaxed human airway smooth muscle cells. These data indicate that activating transgelin-2 for asthma treatment may be more effective than targeting β2 -adrenoceptors. There is a clinical need for new bronchodilator drugs in asthma, because more than half of asthmatic patients do not receive adequate control with current available treatments. We report that inhibition of metallothionein-2 protein expression in lung tissues causes the increase of pulmonary resistance. Conversely, metallothionein-2 protein is more effective than β2 -agonists in reducing pulmonary resistance in rodent asthma models, alleviating tension in tracheal spirals, and relaxing airway smooth muscle cells (ASMCs). Metallothionein-2 relaxes ASMCs via transgelin-2 (TG2) and induces dephosphorylation of myosin phosphatase target subunit 1 (MYPT1). We identify TSG12 as a nontoxic, specific TG2-agonist that relaxes ASMCs and reduces asthmatic pulmonary resistance. In vivo, TSG12 reduces pulmonary resistance in both ovalbumin- and house dust mite–induced asthma in mice. TSG12 induces RhoA phosphorylation, thereby inactivating the RhoA-ROCK-MYPT1-MLC pathway and causing ASMCs relaxation. TSG12 is more effective than β2 -agonists in relaxing human ASMCs and pulmonary resistance with potential clinical advantages. These results suggest that TSG12 could be a promising therapeutic approach for treating asthma. [ABSTRACT FROM AUTHOR]- Published
- 2018
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11. FtsZ Protofilaments Use a Hinge-Opening Mechanism for Constrictive Force Generation.
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Ying Li, Jen Hsin, Lingyun Zhao, Yiwen Cheng, Weina Shang, Kerwyn Casey Huang, Hong-Wei Wang, and Sheng Ye
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GUANOSINE triphosphatase , *BACTERIAL protein crystallography , *BACTERIAL fibrils , *MYCOBACTERIUM tuberculosis , *CYTOKINESIS , *HYDROLYSIS kinetics , *PROTEIN conformation , *FORCE & energy - Abstract
The essential bacterial protein FtsZ is a guanosine triphosphatase that self-assembles into a structure at the division site termed the "Z ring". During cytokinesis, the Z ring exerts a constrictive force on the membrane by using the chemical energy of guanosine triphosphate hydrolysis. However, the structural basis of this constriction remains unresolved. Here, we present the crystal structure of a guanosine diphosphate-bound Mycobacterium tuberculosis FtsZ protofilament, which exhibits a curved conformational state. The structure reveals a longitudinal interface that is important for function. The protofilament curvature highlights a hydrolysis-dependent conformational switch at the T3 loop that leads to longitudinal bending between subunits, which could generate sufficient force to drive cytokinesis. [ABSTRACT FROM AUTHOR]
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- 2013
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12. Prevention of Brca1-Mediated Mammary Tumorigenesis in Mice by a Progesterone Antagonist.
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Poole, Ateksandra Jovanovic, Ying Li, Yoon Kim, Lin, Suh-Chin J., Wen-Hwa Lee, and Lee, Eva Y.-H. P.
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BREAST cancer , *BRCA genes , *PROGESTERONE antagonists , *CORPUS luteum , *PROGESTERONE receptors , *CARCINOGENESIS , *MAMMARY glands , *CELLS , *MICE - Abstract
Women with mutations in the breast cancer susceptibility gene BRCA1 are predisposed to breast and ovarian cancers. Why the BRCA1 protein suppresses tumor development specifically in ovarian hormone-sensitive tissues remains unclear. We demonstrate that mammary glands of nulliparous Brca1/p53-deficient mice accumulate lateral branches and undergo extensive alveologenesis, a phenotype that occurs only during pregnancy in wild-type mice. Progesterone receptors, but not estrogen receptors, are overexpressed in the mutant mammary epithelial cells because of a defect in their degradation by the proteasome pathway. Treatment of Brca1/p53-deficient mice with the progesterone antagonist mifepristone (RU 486) prevented mammary tumorigenesis. These findings reveal a tissue-specific function for the BRCA1 protein and raise the possibility that antiprogesterone treatment may be useful for breast cancer prevention in individuals with BRCA1 mutations. [ABSTRACT FROM AUTHOR]
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- 2006
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13. Observation of parity-time symmetry in diffusive systems.
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Pei-Chao Cao, Ran Ju, Dong Wang, Minghong Qi, Yun-Kai Liu, Yu-Gui Peng, Hongsheng Chen, Xue-Feng Zhu, and Ying Li
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PHASE oscillations , *PHASE transitions , *PHASE modulation , *SYMMETRY , *SYMMETRY breaking - Abstract
Phase modulation has scarcely been mentioned in diffusive physical systems because the diffusion process does not carry the momentum like waves. Recently, non-Hermitian physics provides a unique perspective for understanding diffusion and shows prospects in thermal phase regulation, exemplified by the discovery of anti-parity-time (APT) symmetry in diffusive systems. However, precise control of thermal phase remains elusive hitherto and can hardly be realized, due to the phase oscillations. Here we construct the PT-symmetric diffusive systems to achieve the complete suppression of thermal phase oscillation. The real coupling of diffusive fields is readily established through a strong convective background, and the decay-rate detuning is enabled by thermal metamaterial design. We observe the phase transition of PT symmetry breaking with the symmetry-determined amplitude and phase regulation of coupled temperature fields. Our work shows the existence of PT symmetry in dissipative energy exchanges and provides unique approaches for harnessing the mass transfer of particles, wave dynamics in strongly scattering systems, and thermal conduction. [ABSTRACT FROM AUTHOR]
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- 2024
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14. A splenic-targeted versatile antigen courier: iPSC wrapped in coalescent erythrocyte-liposome as tumor nanovaccine.
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Yuewen Zhai, Xiaorong He, Ying Li, Ran Han, Yuying Ma, Peng Gao, Zhiyu Qian, Yueqing Gu, and Siwen Li
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LIPOSOMES , *MONONUCLEAR leukocytes , *T cells , *BILAYER lipid membranes , *ANTIGENS , *ERYTHROCYTE membranes - Published
- 2021
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15. Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa.
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Guangpeng Ren, Xu Zhang, Ying Li, Ridout, Kate, Serrano-Serrano, Martha L., Yongzhi Yang, Ai Liu, Ravikanth, Gudasalamani, Nawaz, Muhammad Ali, Mumtaz, Abdul Samad, Salamin, Nicolas, and Fumagalli, Luca
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MEDICAL marijuana , *DOMESTICATION of animals , *HOPS , *SEX determination , *GENETIC variation , *BOTANY , *PLANT fibers - Abstract
The article focuses on large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa. Topics include the Cannabis sativa has long been an important source of fiber extracted from hemp and both medicinal and recreational drugs based on cannabinoid compounds, and the domestication history using whole-genome resequencing of 110 accessions from worldwide origins.
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- 2021
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16. Therapeutic targeting of CPSF3-dependent transcriptional termination in ovarian cancer.
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Peiye Shen, Kaiyan Ye, Huaijiang Xiang, Zhenfeng Zhang, Qinyang He, Xiao Zhang, Mei-Chun Cai, Junfei Chen, Yunheng Sun, Lifeng Lin, Chunting Qi, Meiying Zhang, Cheung, Lydia W. T., Tingyan Shi, Xia Yin, Ying Li, Wen Di, Rongyu Zang, Li Tan, and Guanglei Zhuang
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OVARIAN cancer , *DNA repair , *DNA damage , *CELL survival , *ANTINEOPLASTIC agents , *POLY ADP ribose - Abstract
Transcriptional dysregulation is a recurring pathogenic hallmark and an emerging therapeutic vulnerability in ovarian cancer. Here, we demonstrated that ovarian cancer exhibited a unique dependency on the regulatory machinery of transcriptional termination, particularly, cleavage and polyadenylation specificity factor (CPSF) complex. Genetic abrogation of multiple CPSF subunits substantially hampered neoplastic cell viability, and we presented evidence that their indispensable roles converged on the endonuclease CPSF3. Mechanistically, CPSF perturbation resulted in lengthened 30-untranslated regions, diminished intronic polyadenylation and widespread transcriptional readthrough, and consequently suppressed oncogenic pathways. Furthermore, we reported the development of specific CPSF3 inhibitors building upon the benzoxaborole scaffold, which exerted potent antitumor activity. Notably, CPSF3 blockade effectively exacerbated genomic instability by down-regulating DNA damage repair genes and thus acted in synergy with poly(adenosine 5'-diphosphate-ribose) polymerase inhibition. These findings establish CPSF3-dependent transcriptional termination as an exploitable driving mechanism of ovarian cancer and provide a promising class of boron-containing compounds for targeting transcription-addicted human malignancies. [ABSTRACT FROM AUTHOR]
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- 2023
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17. Salvage therapy expands highly cytotoxic and metabolically fit resilient CD8+ T cells via ME1 upregulation.
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Gicobi, Joanina K., Zhiming Mao, DeFranco, Grace, Hirdler, Jacob B., Ying Li, Vianzon, Vianca V., Dellacecca, Emilia R., Hsu, Michelle A., Barham, Whitney, Yiyi Yan, Mansfield, Aaron S., Yi Lin, Xiaosheng Wu, Taro Hitosugi, Owen, Dawn, Grams, Michael P., Orme, Jacob J., Lucien, Fabrice, Hu Zeng, and Park, Sean S.
- Abstract
Patients with advanced cancers who either do not experience initial response to or progress while on immune checkpoint inhibitors (ICIs) receive salvage radiotherapy to reduce tumor burden and tumor-related symptoms. Occasionally, some patients experience substantial global tumor regression with a rebound of cytotoxic CD8+ T cells. We have termed the rebound of cytotoxic CD8+ T cells in response to salvage therapy as T cell resilience and examined the underlying mechanisms of resilience. Resilient T cells are enriched for CX3CR1+ CD8+ T cells with low mitochondrial membrane potential, accumulate less reactive oxygen species (ROS), and express more malic enzyme 1 (ME1). ME1 overexpression enhanced the cytotoxicity and expansion of effector CD8+ T cells partially via the type I interferon pathway. ME1 also increased mitochondrial respiration while maintaining the redox state balance. ME1 increased the cytotoxicity of peripheral lymphocytes from patients with advanced cancers. Thus, preserved resilient T cells in patients rebound after salvage therapy and ME1 enhances their resiliency. [ABSTRACT FROM AUTHOR]
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- 2023
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18. Wafer-patterned, permeable, and stretchable liquid metal microelectrodes for implantable bioelectronics with chronic biocompatibility.
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Qiuna Zhuang, Kuanming Yao, Mengge Wu, Zhuogui Lei, Fan Chen, Jiyu Li, Quanjing Mei, Yingying Zhou, Qiyao Huang, Xin Zhao, Ying Li, Xinge Yu, and Zijian Zheng
- Abstract
The article focuses on the development of wafer-patterned, permeable, and stretchable liquid metal microelectrodes for implantable bioelectronics. The topics include the challenges of low permeability and high modulus in thin-film substrates, the development of wafer-scale patterning of supersoft and permeable microelectrodes, and the demonstration of chronic biocompatibility and high-resolution mapping in neural interfaces.
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- 2023
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19. Conformability of flexible sheets on spherical surfaces.
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Siyi Liu, Jinlong He, Yifan Rao, Zhaohe Dai, Huilin Ye, Tanir, John C., Ying Li, and Nanshu Lu
- Abstract
The article presents a science and engineering research study on the conformability of flexible sheets on spherical surfaces, which is important for the development of three-dimensional surface-conformable electronics. Topics include the challenges of achieving conformability on nondevelopable surfaces, various empirical designs that have been explored to improve conformability; and conformability of cut circular sheets on spherical surfaces for using radial slits to improve conformability.
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- 2023
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20. Machine learning enables interpretable discovery of innovative polymers for gas separation membranes.
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Yang, Jason, Lei Tao, Jinlong He, McCutcheon, Jeffrey R., and Ying Li
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GAS separation membranes , *POLYMER fractionation , *POLYMERIC membranes , *POLYIMIDES , *MACHINE learning , *SEPARATION of gases , *FICK'S laws of diffusion - Abstract
The article presents a study on the machine learning (ML) implementation for the discovery of innovative polymers for gas separation membranes. It discusses the mechanism and performance of ML models for gas permeability prediction along with chemical insights from the interpretation of ML models. It also analyzes the discovery of high-performance polymers and validates it using Molecular dynamics (MD) simulations.
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- 2022
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21. INTS11 regulates hematopoiesis by promoting PRC2 function.
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Peng Zhang, Pinpin Sui, Shi Chen, Ying Guo, Ying Li, Guo Ge, Ganqian Zhu, Hui Yang, Rogers, Cody M., Sung, Patrick, Nimer, Stephen D., Mingjiang Xu, and Feng-Chun Yang
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HEMATOPOIESIS , *GENE expression , *DNA-binding proteins , *CELL anatomy , *SMALL nuclear RNA , *MYELOID cells - Published
- 2021
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22. Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52.
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Tao Fu, Mingfang Zhang, Zixuan Zhou, Ping Wu, Chao Peng, Yingli Wang, Xinyu Gong, Ying Li, Yaru Wang, Xiaolong Xu, Miao Li, Liqiang Shen, and Lifeng Pan
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ZINC-finger proteins , *AUTOPHAGY , *AMINO acid sequence - Published
- 2021
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23. Low ABA concentration promotes root growth and hydrotropism through relief of ABA INSENSITIVE 1-mediated inhibition of plasma membrane H+-ATPase 2.
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Rui Miao, Wei Yuan, Yue Wang, Garcia-Maquilon, Irene, Xiaolin Dang, Ying Li, Jianhua Zhang, Yiyong Zhu, Rodriguez, Pedro L., and Weifeng Xu
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ROOT growth , *SORBITOL , *STOMATA , *BOTANY , *ARABIDOPSIS proteins , *PLANT plasma membranes , *TROPISMS - Abstract
The article presents a study on the effects of abscisic acid (ABA) on root growth and hydrotropism of Arabidopsis WT Col-0 in normal medium and water stress medium. It discusses the characterization of ABA, the effect of apoplastic acidication on Arabidopsis, the difference betwen Col-0 WT and a series of mutants impaired in protein phosphatases type 2C in terms of root growth and hydrotropism.
- Published
- 2021
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24. Millikelvin-resolved ambient thermography.
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Kechao Tang, Kaichen Dong, Nicolai, Christopher J., Ying Li, Jiachen Li, Shuai Lou, Cheng-Wei Qiu, Raulet, David H., Jie Yao, and Junqiao Wu
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THERMOGRAPHY , *INFRARED imaging , *THERMAL lensing , *MEDICAL sciences , *MATERIALS science , *IMAGE processing - Abstract
The article presents a study which aimed to improve the noise-equivalent differential temperature (NEDT) or finer thermal sensitivity of thermography, which is used to detect surface temperature and subsurface thermal activity of an object based on Stefan-Boltzmann law. In the study, it was found that the emissivity of thermal imaging sensitizer (TIS) abruptly increases at a preprogrammed temperature.
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- 2020
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25. Synchronization of stochastic expressions drives the clustering of functionally related genes.
- Author
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Haiqing Xu, Jing-Jing Liu, Zhen Liu, Ying Li, Yong-Su Jin, and Jianzhi Zhang
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- 2019
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26. Quantum computation with universal error mitigation on a superconducting quantum processor.
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Chao Song, Jing Cui, Wang, H., Hao, J., Feng, H., and Ying Li
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- 2019
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27. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS.
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Yasushi Ito, Ofengeim, Dimitry, Najafov, Ayaz, Das, Sudeshna, Saberi, Shahram, Ying Li, Junichi Hitomi, Hong Zhu, Hongbo Chen, Mayo, Lior, Jiefei Geng, Amin, Palak, DeWitt, Judy Park, Mookhtiar, Adnan Kasim, Florez, Marcus, Ouchida, Amanda Tomie, Jian-bing Fan, Pasparakis, Manolis, Kelliher, Michelle A., and Ravits, John
- Subjects
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GENETIC mutation , *AMYOTROPHIC lateral sclerosis , *CENTRAL nervous system , *PROTEINS , *DEGENERATION (Pathology) - Abstract
Mutations in the optineurin (OPTN) gene have been implicated in both familial and sporadic amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous system (CNS) and how it may contribute to ALS pathology are unclear. Here, we found that optineurin actively suppressed receptor-interacting kinase 1 (RIPK1)–dependent signaling by regulating its turnover. Loss of OPTN led to progressive dysmyelination and axonal degeneration through engagement of necroptotic machinery in the CNS, including RIPK1, RIPK3, and mixed lineage kinase domain–like protein (MLKL). Furthermore, RIPK1- and RIPK3-mediated axonal pathology was commonly observed in SOD1G93A transgenic mice and pathological samples from human ALS patients. Thus, RIPK1 and RIPK3 play a critical role in mediating progressive axonal degeneration. Furthermore, inhibiting RIPK1 kinase may provide an axonal protective strategy for the treatment of ALS and other human degenerative diseases characterized by axonal degeneration. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
28. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging.
- Author
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Weiqi Zhang, Jingyi Li, Keiichiro Suzuki, Jing Qu, Ping Wang, Junzhi Zhou, Xiaomeng Liu, Ruotong Ren, Xiuling Xu, Ocampo, Alejandro, Tingting Yuan, Jiping Yang, Ying Li, Liang Shi, Dee Guan, Huize Pan, Shunlei Duan, Zhichao Ding, Mo Li, and Fei Yi
- Subjects
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WERNER'S syndrome , *HUMAN embryonic stem cells , *HETEROCHROMATIN , *CELLULAR aging , *MESENCHYMAL stem cells , *CELL differentiation , *OLDER people , *GENETICS of aging , *GENETICS - Abstract
Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency. Here, we report on the generation of a human WS model in human embryonic stem cells (ESCs). Differentiation of WRN-null ESCs to mesenchymal stem cells (MSCs) recapitulates features of premature cellular aging, a global loss of H3K9me3, and changes in heterochromatin architecture. We show that WRN associates with heterochromatin proteins SUV39H1 and HP1a and nuclear lamina--heterochromatin anchoring protein LAP2b. Targeted knock-in of catalytically inactive SUV39H1 in wild-type MSCs recapitulates accelerated cellular senescence, resembling WRN-deficient MSCs. Moreover, decrease in WRN and heterochromatin marks are detected in MSCs from older individuals. Our observations uncover a role for WRN in maintaining heterochromatin stability and highlight heterochromatin disorganization as a potential determinant of human aging. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
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