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Start Over Author "Liang, Lu" Topic cancer cells Publisher american chemical society

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1. Total Synthesis of Cytotoxic Macrolide Amphidinolide B1 and the Proposed Structure of Amphidinolide B2 .

Author

Liang Lu, Wei Zhang, and Carter, Rich G.

Subjects
*MACROLIDE antibiotics, *CELL-mediated cytotoxicity, *CANCER cells, *CELL lines, *ORGANIC compounds, *ALCOHOLS (Chemical class)
Abstract

The article reports on the total synthesis of cytotoxic macrolide amphidinolide. The compound has gained interest in the synthetic community because of their potent cytotoxic activity against several cancer cell lines. Macrolides represent synthetic challenges because of their highly substituted diene functionality. The cleavage of the ester linkage could lead to the alcohols and the ketophosphonate.

Published
2008
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