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Your search keyword '"Zhao, Wenyi"' showing total 1 results
Start Over Author "Zhao, Wenyi" Topic suzuki reaction Publisher american chemical society
1 results on '"Zhao, Wenyi"'

1. A Highly Concise and Convergent Synthesis of HCV PolymeraseInhibitor Deleobuvir (BI 207127): Application of a One-Pot Borylation–SuzukiCoupling Reaction.

Author

Zhang, Yongda, Lu, Bruce Z., Li, Guisheng, Rodriguez, Sonia, Tan, Jonathan, Wei, Han-Xun, Liu, Jianxiu, Roschangar, Frank, Ding, Fei, Zhao, Wenyi, Qu, Bo, Reeves, Diana, Grinberg, Nelu, Lee, Heewon, Heckmann, Golo, Niemeier, Oliver, Brenner, Michael, Tsantrizos, Youla, Beaulieu, Pierre L., and Hossain, Azad

Subjects
*PALLADIUM catalysts, *HEPATITIS C virus, *POLYMERASES, *ENZYME inhibitors, *SUZUKI reaction, *ORGANIC reaction mechanisms, *CHEMICAL synthesis
Abstract

A highlyconcise and convergent synthesis of HCV polymerase inhibitorDeleobuvir (BI 207127, 1) was achieved, featuring efficientPd-catalyzed one-pot borylation–Suzuki coupling where TFP wasidentified as the unique ligand effective for these transformations. [ABSTRACT FROM AUTHOR]

Published
2014
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