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Your search keyword '"Cong, Mian-er"' showing total 8 results
Start Over Author "Cong, Mian-er" Publisher american society for microbiology
8 results on '"Cong, Mian-er"'

2. Protection against Rectal Transmission of an Emtricitabine-Resistant Simian/Human Immunodeficiency Virus SHIV162p3 M184V Mutant by Intermittent Prophylaxis with Truvada

Author

Cong, Mian-er, primary, Youngpairoj, Ae S., additional, Zheng, Qi, additional, Aung, Wutyi, additional, Mitchell, James, additional, Sweeney, Elizabeth, additional, Hanson, Debra L., additional, Hendry, R. Michael, additional, Dobard, Charles, additional, Heneine, Walid, additional, and García-Lerma, J. Gerardo, additional

Published
2011
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3. Natural Substrate Concentrations Can Modulate the Prophylactic Efficacy of Nucleotide HIV Reverse Transcriptase Inhibitors

Author

García-Lerma, J. Gerardo, primary, Aung, Wutyi, additional, Cong, Mian-er, additional, Zheng, Qi, additional, Youngpairoj, Ae S., additional, Mitchell, James, additional, Holder, Angela, additional, Martin, Amy, additional, Kuklenyik, Susan, additional, Luo, Wei, additional, Lin, Carol Yen-Chin, additional, Hanson, Debra L., additional, Kersh, Ellen, additional, Pau, Chou-Pong, additional, Ray, Adrian S., additional, Rooney, James F., additional, Lee, William A., additional, and Heneine, Walid, additional

Published
2011
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4. Complete Protection from Repeated Vaginal Simian-Human Immunodeficiency Virus Exposures in Macaques by a Topical Gel Containing Tenofovir Alone or with Emtricitabine

Author

Parikh, Urvi M., primary, Dobard, Charles, additional, Sharma, Sunita, additional, Cong, Mian-er, additional, Jia, Hongwei, additional, Martin, Amy, additional, Pau, Chou-Pong, additional, Hanson, Debra L., additional, Guenthner, Patricia, additional, Smith, James, additional, Kersh, Ellen, additional, Garcia-Lerma, J. Gerardo, additional, Novembre, Francis J., additional, Otten, Ron, additional, Folks, Thomas, additional, and Heneine, Walid, additional

Published
2009
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6. Frequent Simian Foamy Virus Infection in Persons Occupationally Exposed to Nonhuman Primates

Author

Switzer, William M., primary, Bhullar, Vinod, additional, Shanmugam, Vedapuri, additional, Cong, Mian-er, additional, Parekh, Bharat, additional, Lerche, Nicholas W., additional, Yee, JoAnn L., additional, Ely, John J., additional, Boneva, Roumiana, additional, Chapman, Louisa E., additional, Folks, Thomas M., additional, and Heneine, Walid, additional

Published
2004
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7. Sequence Heterogeneity of TT Virus and Closely Related Viruses

Author

Khudyakov, Yury E., primary, Cong, Mian-er, additional, Nichols, Barbara, additional, Reed, Deoine, additional, Dou, Xiao-Guang, additional, Viazov, Sergei O., additional, Chang, Joy, additional, Fried, Michael W., additional, Williams, Ian, additional, Bower, William, additional, Lambert, Stephen, additional, Purdy, Michael, additional, Roggendorf, Michael, additional, and Fields, Howard A., additional

Published
2000
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8. Protection against rectal transmission of an emtricitabine-resistant simian/human immunodeficiency virus SHIV162p3M184V mutant by intermittent prophylaxis with Truvada.

Author

Cong ME, Youngpairoj AS, Zheng Q, Aung W, Mitchell J, Sweeney E, Hanson DL, Hendry RM, Dobard C, Heneine W, and García-Lerma JG

Subjects
Animals, Cell Line, Deoxycytidine pharmacology, Drug Combinations, Drug Resistance, Viral, Emtricitabine, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination, HIV genetics, Humans, Macaca mulatta, Simian Acquired Immunodeficiency Syndrome prevention & control, Simian Immunodeficiency Virus genetics, Antiviral Agents pharmacology, Deoxycytidine analogs & derivatives, HIV drug effects, Mutation, Organophosphorus Compounds pharmacology, Simian Acquired Immunodeficiency Syndrome transmission, Simian Immunodeficiency Virus drug effects
Abstract

Daily preexposure prophylaxis (PrEP) with Truvada (emtricitabine [FTC] and tenofovir disoproxil fumarate [TDF]) is a novel HIV prevention strategy recently found to reduce HIV incidence among men who have sex with men. We used a macaque model of HIV transmission to investigate if Truvada maintains prophylactic efficacy against an FTC-resistant isolate containing the M184V mutation. Five macaques received a dose of Truvada 3 days before exposing them rectally to the simian/human immunodeficiency virus mutant SHIV162p3(M184V), followed by a second dose 2 h after exposure. Five untreated animals were used as controls. Virus exposures were done weekly for up to 14 weeks. Despite the high (>100-fold) level of FTC resistance conferred by M184V, all five treated animals were protected from infection, while the five untreated macaques were infected (P = 0.0008). Our results show that Truvada maintains high prophylactic efficacy against an FTC-resistant isolate. Increased susceptibility to tenofovir due to M184V and other factors, including residual antiviral activity by FTC and/or reduced virus fitness due to M184V, may all have contributed to the observed protection.

Published
2011
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