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Your search keyword '"W. N. Khan"' showing total 2 results
Start Over Author "W. N. Khan" Publisher american society for microbiology
2 results on '"W. N. Khan"'

1. Penetration of sulbactam and ampicillin into cerebrospinal fluid of infants and young children with meningitis

Author

George H Foulds, A K Knirsch, W N Khan, W J Rodriguez, and T J McBride

Subjects
Adolescent, medicine.drug_class, Antibiotics, Permeability, Cerebrospinal fluid, Pharmacokinetics, Ampicillin, polycyclic compounds, Humans, Medicine, Meningitis, Pharmacology (medical), Child, Pharmacology, business.industry, Infant, Sulbactam, biochemical phenomena, metabolism, and nutrition, medicine.disease, Infectious Diseases, Child, Preschool, Anesthesia, Bacterial meningitis, business, Research Article, medicine.drug
Abstract

Infusions of 50 mg of sulbactam per kg per day and 400 mg of ampicillin per kg per day in divided doses to infants and children with bacterial meningitis produced levels in cerebrospinal fluid approximately one-third those in serum. Concentrations in cerebrospinal fluid of 5.5 micrograms of sulbactam per ml and 16.0 micrograms of ampicillin per ml declined within a few days of therapy to 1.9 microgram of sulbactam per ml and 5.2 micrograms of ampicillin per ml.

Published
1987

2. Spectinomycin disk zone diameter as a predictor of outcome in clinical treatment of gonorrhea

Author

D G McChesney, W N Khan, and John W. Boslego

Subjects
Male, medicine.medical_specialty, Spectinomycin, medicine.drug_class, Antibiotics, Gonorrhea, Urology, Microbial Sensitivity Tests, Biology, urologic and male genital diseases, medicine.disease_cause, Microbiology, Minimum inhibitory concentration, medicine, Humans, Pharmacology (medical), Agar diffusion test, Clinical treatment, Pharmacology, Drug Resistance, Microbial, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Prognosis, medicine.disease, biology.organism_classification, Neisseria gonorrhoeae, female genital diseases and pregnancy complications, Infectious Diseases, Neisseriaceae, Research Article, medicine.drug
Abstract

The MICs for 41 Neisseria gonorrhoeae strains from patients receiving spectinomycin treatment were determined by the agar dilution method and compared with the zones of inhibition produced by disks containing 100 micrograms of spectinomycin. Our data demonstrated a good correlation between the two methods. Moreover, a zone of inhibition of less than or equal to 15 mm was a good predictor of clinical treatment failures with spectinomycin.

Published
1988

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