1. Osmosensing, osmosignalling and inflammation: how intervertebral disc cells respond to altered osmolarity
- Author
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Sadowska, Aleksandra, Kameda, Takuya, Krupkova, Olga, and Würtz-Kozak, Karin
- Subjects
lcsh:Diseases of the musculoskeletal system ,transient receptor potential channel ,lcsh:Surgery ,osmotic ,IVD ,inflammatory ,lcsh:RD1-811 ,degenerative disc disease ,Intervertebral disc degeneration ,osmolarity ,Transient receptor potential channels (TRP) ,tonicity-responsive enhancer binding protein ,aquaporin ,540 Chemie und zugeordnete Wissenschaften ,hyper-osmolarity ,lcsh:RC925-935 ,610 Medizin und Gesundheit ,hypo-osmolarity - Abstract
Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD’s extracellular matrix causes osmotic imbalance, which, together with an altered function of cellular receptors and signalling pathways, instigates local osmotic stress. Cellular responses to osmotic stress include osmoadaptation and activation of pro-inflammatory pathways. This review summarises the current knowledge on how IVD cells sense local osmotic changes and translate these signals into physiological or pathophysiological responses, with a focus on inflammation. Furthermore, it discusses the expression and function of putative membrane osmosensors (e.g. solute carrier transporters, transient receptor potential channels, aquaporins and acid-sensing ion channels) and osmosignalling mediators [e.g. tonicity response-element-binding protein/nuclear factor of activated T-cells 5 (TonEBP/NFAT5), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)] in healthy and degenerated IVDs. Finally, an overview of the potential therapeutic targets for modifying osmosensing and osmosignalling in degenerated IVDs is provided., European Cells & Materials, 36, ISSN:1473-2262
- Published
- 2018