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Lichen planus pemphigoid is a rare acquired autoimmune dermatosis with characteristics of lichen planus and bullous pemphigoid, which mainly affects young people. The most accepted theory about its origin is "epitope spreading," where the lichenoid inflammatory process damages the epidermal basement membrane, exposing autoantigens. Clinically, it presents classic lichenoid lesions and tense blisters on the lesional skin, as well as on the perilesional skin and healthy skin. In the histopathological study, a lichenoid reaction is found with the formation of a subepidermal blister and the presence of eosinophils. In the direct immunofluorescence there is a deposit of IgG and C3 in the basement membrane. Its treatment is aimed at controlling lichen planus to stop the antigenic stimulation that leads to the formation of autoantibodies against components of the basement membrane. For this, topical or systemic steroids are mainly used, depending on whether the lesions are localized or generalized, respectively. [ABSTRACT FROM AUTHOR]

Among the cutaneous lichen planus, the linear zosteriform subtype is included in those with a lower frequency of appearance; therefore, the report of its clinical form confirmed by the result of pathology of this inflammatory entity should be taken into account as a differential diagnosis of other pathological conditions that can adopt this pattern of distribution. We present the case of a female patient in the fourth decade of life with a 5-week history of appearance of highly pruritic, lichenoid-looking skin lesions, who underwent histopathological confirmation of the suspected clinical diagnosis, and we also observed significant clinical improvement to high potency steroid treatment. [ABSTRACT FROM AUTHOR]

Frontal fibrosing alopecia is a type of scarring alopecia that has been associated with different skin lesions including lichen planus pigmentosus. Both diseases share common pathophysiological mechanisms, which explain their coexistence in the same patient. We report 12 cases of mestizo women with frontal fibrosing alopecia and lichen planus pigmentosus confirmed by histopathology and discuss the pathophysiological mechanisms shared by both diseases. The most important pathophysiological mechanism common to both diseases is the cytotoxic T-lymphocyte response, which is directed against keratinocytes and hair follicle stem cells, causing apoptosis and damage to the basal layer, with consequent tissue remodeling that determines the clinical appearance of the lesions of frontal fibrosing alopecia and lichen planus pigmentosus. [ABSTRACT FROM AUTHOR]

Nail lichen planus is a chronic inflammatory skin disease whose treatment is mandatory to prevent matrix scarring; nevertheless, there are no defined standards of treatment. In this article we report the case of a woman with lichen planus with twenty-nail dystrophy treated successfully with oral isotretinoin, oral biotin, and topical 12% ammonium lactate. [ABSTRACT FROM AUTHOR]